Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Monday, 18 December 2017

Food Therapy: Lentils (Legume) Ameliorated Risk of Hyperlipidemia

Kyle J. Norton

Intake of lentils daily and regularly may have a profound effect in maintaining and normalizing right levels of cholesterol through expression of ratio of high-density lipoprotein (HDL/total cholesterol number(overall amount of cholesterol found in the blood).
Lentil, a type of pulse or tiny legumes which can be cooked quickly and rich in protein and fiber.is a bushy annual plant of genus Lens the Fabaceaefamily, native to Middle East.

Hyperlipidemia.is a medical condition chreacterized by abnormal high blood cholesterol in the blood stream.

The evaluation of the effect of lentils in risk of high blood cholesterol was found to associate to certain mechanisms through numbers of aspects.

According to the study of the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the metabolic syndrome in two groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults, at week 8, after a 75 g oral glucose load, measurement of HDL increased by 4·5 in the pulse group, in compared to decreased of 0·8 in energy group.

Further more, treatment of pulse diet also expressed a significant improvement in restriction of energy intake to promote weight loss and reduced weight circumference which have been considered as some risk factors in facilitated abnormal blood cholesterol in over weight and obese subjects.

According to general belief, weight loss in obese and over weight adults plays an important role in reduced risk of having high LDL (low density lipoprotein) bad cholesterol and triglyceride levels, and low HDL (high density lipoprotein) good cholesterol.

Additionally, in the investigation of hydroalcoholic extract isolated from lentils to examine the hypocholesterolemic action in diet-induced hypercholesterolemic animal model for 70 days, by studying the plasma cholesterol level and the concentration of bile acids in the feces, researchers found that at day 71, injection of hydroalcoholic extract demonstrated a strong effect in decreased cholesterol level of rats by 16.8%, in compared to non treatment group.

Further analysis also suggested that the extract also increased the level of bile acids, metabolic regulators of lipid, in the feces of rats which is an indication of decreased LDL-cholesterol concentration, and increased HDL-cholesterol concentration.

Dr, Färkkilä M, the lead author in the study of lipid metabolism in bile acid malabsorption said,
"Enhanced cholesterol and bile acid synthesis in ileal dysfunction is reflected by raised concentrations of plasma cholesterol precursors, especially lathosterols, which can be used as an indicator of increased bile acid loss to faeces".

More interestingly, the measured and compared the metabolic variables, weight loss and inflammatory marker concentrations of 30 obese subjects (17 M/13F; BMI: 32.5 ± 4.5 kg/m(2); 36 ± 8 years) randomly assigned to either (4 weeks): Calorie-restricted legume-free diet (Control: C-diet) or calorie-restricted legume-based diet (L-diet, different cooked-servings (160-235 g) of lentils, chickpeas, peas or beans) conducted by the University of Navarra indicated that group treated with L-diet displayed a significant effect in induction of weight loss, reduced both total and LDL cholesterol levels in compared to Calorie-restricted legume-free diet control group.

The weight loss in the treatment group also demonstrated a decrease concentration levels of CRP and C3 which may be an indication of lower inflammatory process in facilitated lipid deposit in the inner wall of arteries induced by oxidative stress through stimulation by reactive oxygen species (ROS).

Dr. Hermsdorff HH, the lead author at the University of Navarra said, " the reduction (%) in CRP concentrations was positively associated with decreases (%) in systolic BP and total cholesterol concentration specifically in the L-diet group, independent from weight loss (p < 0.05)". t

Taken together, lentils and other species of legume may be considered as functional foods in reduced ricks of hyperlipidemia, through lowering levels of low density lipoprotein(LDL), increasing levels of high density lipoprotein(HDL) and improving ratio of high-density lipoprotein (HDL/total cholesterol number, particularly in inducing weight loss in over weight and obese population.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Evaluation of the hypocholesterolemic effect and prebiotic activity of a lentil (Lens culinaris Medik) extract by Micioni Di Bonaventura MV1, Cecchini C2,3, Vila-Donat P4, Caprioli G4, Cifani C1, Coman MM2,3, Cresci A2,3, Fiorini D5, Ricciutelli M4, Silvi S2,3, Vittori S4, Sagratini G4.(PubMed)
(2) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(3) A legume-based hypocaloric diet reduces proinflammatory status and improves metabolicfeatures in overweight/obese subjects by Hermsdorff HH1, Zulet MÁ, Abete I, Martínez JA.(PubMed)
(4) Lipid metabolism in bile acid malabsorption by Färkkilä M1, Miettinen TA.(PubMed)

Herbal Therapy: Green Tea, Bioactive Epigallocatechin-3-O-(3-O-methyl) Gallate (EGCG3"Me) Anti Allergic Effects

Green tea may have a particular and special effect in ameliorated auto immunity in precipitation of allergic diseases, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Allergic diseases are a class of conditions characterized by over reaction of the immune system to substances which cause little or no harm to the body.

Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate to certain mechanisms.

According to the Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibited the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in expression of mmunoglobulin E (IgE), an antibody isotype involved allergy disorder through 67 kDa laminin receptor in mediation of the suppressive effect by epigallocatechin-3-O-gallate.

Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cell by suppressing the myosin light chain phosphorylation in regulated immune response to osinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signalling by modulation of inflammatory cytokines expression.

A double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed a significantly relieved allergic symptoms induced by pollen such as nose blowing, eye itching in compared with the placebo group without effecting the normal immune responses.

More interestingly, in mouse bone marrow-derived mast cells activated by antigens, bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell signaling protein (cytokine) in response to systemic inflammation in the acute phase infection.and macrophage Inflammatory Proteins(MIP-1α), a chemokine involved host response to invading bacteria and virus.

In compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited a much stronger anti allergic activity than 43.5 mg of EGCG, observed by the area under curve AUC (area under the drug concentration time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.

Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered as a functional food for protection against auto immune response stimulated by unharmful allergens.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)

(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,

1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)

Sunday, 17 December 2017

Alternative Therapy: Yoga Exercise in Reduced Symptoms Intensity and Frequency in Patients with Bronchial Asthma

Kyle J. Norton

People with bronchial asthma participated in yoga class are likely to experience lower symptoms intensity and frequency, some researchers suggested.

Yoga, the ancient practice for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the study to evaluate a one month in-patient naturopathy and yoga programme effects for patients with asthma with retrospective data of 159 bronchial asthma patients, yoga participants showed a significant increase in the Forced Vital Capacity and Forced Expiratory Volume from the date of admission up to 6th month post Bonferroni correction, observed by the paired sample t test results.

In compared to the beginning of the invention, yoga group also expressed significantly increase from admission till the date of discharge according to the Maximum voluntary ventilation assay

Furthermore, the Peak Expiratory Flow Rate also significantly increased from admission till the 36th month of follow-up, observed through post Bonferroni correction.

These illustrations demonstrated a strong effect of yoga in reduced over all symptoms through improving the physical lung function. Because of these traumatic results, Dr. Rao YC,, the led authors author suggested that yoga in combined with naturopathy may be considered as a secondary management of bronchial asthma.

In deed, yoga breathing and yoga posts such as Bridge, Cobra, Wheel, and Upward-Facing Dog open and stretch the chest, stimulated the blood circulation to the lung area to improve lung function and strengthened the lung muscles, thus increasing lung diffusion capacity.

Further more, yoga breath and retention with "inhale air into the abdomen and feel it expand into the rib cage, into the chest and collar bone then exhale from the chest, rib cage, and lastly from the abdomen slowly", according to some yogic instructors can increase oxygen absorption and maximize CO2 expelling to prevent blocking of space for air circulation, thus cultivating greater lung capacity in absorption of prana in precitipation of maximized metabolic function of lung cells and reduced symptoms of intensity in patients with bronchial asthma.

Interestingly, German scientists in following up to the above study of long term effect of yoga breathing exercises and yoga intervention in patients with bronchial asthma also found that
yoga interventions demonstrated a significant amelioration of the psychological symptoms such as depression and mood disorder and induced a significant improvement of lung function parameters, observed by the Forced expiatory volume (FEV) assay.

According to the review published in the March, 2013 issue of the “Journal of Alternative and Complementary Medicine.” the Yoga postures (asanas) and breathing (pranayama) showed to improve lung capacity in healthy adults averaging 90 minutes per day over a 10-week period in yoga participation.

In the concerns of yoga class may have any effect in enhanced quality of life in related to mental state of patients with bronchial asthma, researchers conducted a randomized trial with 120 non-smoking male and female patients of asthma in the age group of 17-50 years randomly assigned into two groups i.e. Group A (Yoga group, with patients practiced yoga breathing exercises for 8 weeks) and Group B (control group), after assessing asthma Quality of Life Questionnaire (AQLQ) and diary record returned from patients, and indicated that yoga group expressed a statistically and gradually significant improvement in "symptoms", "activities" and "environmental" domains of AQLQ during the periods, specially in reduction in daily number and severity of attacks in compared to control.

The finding evidences showed that yoga breathing exercises used adjunctively with standard pharmacological treatment significantly improved quality of life and decreased symptoms frequency in patients with bronchial asthma.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Efficacy of naturopathy and yoga in bronchial asthma by Rao YC, Kadam A, Jagannathan A, Babina N, Rao R, Nagendra HR.(PubMed)
(2) Assessment of the quality of life in patients with bronchial asthma, before and after yoga: a randomised trial by Sodhi C1, Singh S, Bery A.(PubMed)
(3) [Long-term effects of breathing exercises and yoga in patients with bronchial asthma].[Article in German] by Flüge T1, Richter J, Fabel H, Zysno E, Weller E, Wagner TO.(PubMed)

Herbal Therapy: Green Tea EGCG, A Potent Iron Chelator in Regulation of Progression of Parkinson's disease

Green tea may be considered as a functional food and iron chelator in reduced risk and progression of Parkinson's disease, some scientists suggested

Iron chelation therapy is a primary and standard treatment for patients with iron overload.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Parkinson's disease (PD) is a progressive neurodegenerative disease, causing severe depletion of glutamatergic and dopaminergic inputs in the striatum.

Investigation of the green tea EGCG effect in risk and progression of PD has been found to associate to many mechanisms involved numbers of aspects.

Application of metal chelation was found to ameliorated the expression of ROS in induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, main leading causes to the onset of PD.

In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to over expression of the iron induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.

Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.

Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in expression of the iron homeostasis.

Indeed, In the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis has shown to increase oxidative stress in damage to neuron cells, green extract GECG effects demonstrated a significant inhibition of free radical and iron free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation; heme oxygenase-1(HO-1) in increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor gamma (PPARγ) in regulated production of pro and anti inflammatory cytokines and mytokines..

By reducing the over expression of oxidative damage to neuron cells through regulation of iron related factors as mentioned above, iron chelator EGCG can counteract these adverse effects and prevent onset of PD.

Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.

Dysregulation of hepcidin production results in a variety of iron disorders.

Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea GECG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.

Interestingly, there was a report suggested that intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.

The findings evidences revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as iron chelator in regulation of PD progression.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University

Saturday, 16 December 2017

Herbal Therapy: Green Tea in Ameliorated Risk and Treatment of Lifestyle-Related Diseases

Green tea is found to consist a therapeutic and sustainable effect in reduced risk and progression life style diseases, some scientists postulated

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Lifestyle diseases are a class of diseases associated with the way a person or group of people lives, including atherosclerosis, heart disease, and stroke; obesity and type 2 diabetes....and diseases precipitated by smoking and alcohol and drug abuse.

Epidemiological studies suggested that lifestyle-related diseases may be preventable with the change of lifestyle accompanied with intake of some nontoxic agents.

Differentiation of the effect of green tea in attenuated risk and treatment of lifestyle related diseases was found to associate to some mechanisms involving numbers of aspect, particularly, in gene facilitation.

In animal model, green tea administration inhibited risk and symptoms and progression of chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis, through regulation of tumor necrosis factor (TNF-alpha) gene in expression of inflammatory cytokines in promoted systematic inflammation in the acute phase of infection caused by damage and injure tissues, in modulated the activation of NF-kappaB signalling pathway related to cellular response in induction of anti and pro inflammatory stimulation and transcription factor complex (AP-1) in initiation of inflammation against foreign invasion.

The inhibition of inflammatory cytokines expression reduced symptoms of pain, reddish skin, swelling without limiting the protective effect of the immune system to prevent damage tissues against invasion of foreign substances.

Further analysis of chronic inflammatory diseases, in transgenic mice model with human idiopathic pulmonary fibrosis suggested that injection of green tea in 4 months demonstrated a significant activity in ameliorated over expression of TNF-alpha in stimulated production of pro inflammatory cytokines and interleukin (IL)-6 in initiated inflammatory expression in cellular defense in response to infections and tissue injuries in the lung.

In life style related diseases of cardiovascular disease, intake of green tea beverage or extract expressed a significant reductions in serum total cholesterol and LDL-cholesterol concentrations, without effecting the levels of HDL-cholesterol.

Additionally, in patients with type 2 diabetes mellitus, green tea extract catechin injection improved fasting glucose levels without affecting the hemoglobin A1c (HbA1c) level, which is an predictor of type 2 diabetes onset and green tea consumed 5 or more cups per day was associated to a strongly and positively inverse association to risk of type 2 diabetes mellitus.
.
More amazingly, after taking into account of other con founders, Dr. Sueoka E, the lead scientist suggested that intake of green tea, containing catechins and caffeine, 5 or more cups per day exhibited a potential and therapeutic effect for body weight management, without going into details.

According to the prospective cohort study in Saitama Prefecture, Japan, green tea injection of over 10 cups per day, displayed a substantial effect in decreased relative risk of death from all causes in patients with cardiovascular disease, particularly, in stroke mortality.

Take together, there is no doubt that green tea with abundantly bioactive phytochemicals may be considered as a function food to reduced risk, progression and treatment of lifestyle related disease, but change of lifestyle is always recommended.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)
(2) A new function of green tea: prevention of lifestyle-related diseases by Sueoka N1, Suganuma M, Sueoka E, Okabe S, Matsuyama S, Imai K, Nakachi K, Fujiki H.(PubMed)

Food Therapy: Chick (Garden) Peas Inhibited Platelet Aggregation in Ameliorated Risk of Cardiovascular Disease

Kyle J. Norton

Methanolic extract of Chick (Garden) Peas may have a potential effect in decreased platelet aggregation and inhibited thrombus formation, thus improving blood circulation for prevention of cardiovascular disease, some scientists suggested.

Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetable, native to Middle East.

Inflammation is a natural process of immune defense against infection caused by injure through removal of injurious agents, necrosed cells and tissues.

Evaluation of pea family effects in reduced platelet aggregation for prevention of cardiovascular disease have been found to associated to numbers of mechanisms involved many aspects.

Methanolic extract isolated from garden pea and Desi chickpea demonstrated an inhibited arachidonic acid (AA) expression in induction of platelet aggregation (IC50 = 35 microg/mL)

Arachidonic acid, an omega-6 unsaturated fatty acid with function in growth and repair of muscle tissue is also important as an proinflammatory and immunosupportive substance in response to actute and chronic tissue damage.

Several reports have suggested that arachidonic acid induced expression of platelet aggregation by mediators thromboxane A2 and/or prostaglandin H2 (PGH2) in signalling expression of thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor occupation.

Thromboxane A2 (TXA2) is a type of thromboxane with function in stimulation of production of new platelets to induce platelet aggregation.

Prostaglandin H2 is a type of prostaglandin acted as mediators involved in physiological processes, including platelet aggregation, muscle movement and inflammation.

Further differentiated the other effects of methanolic extract isolated from garden pea and Desi chickpea on platelet aggregation, showed that the extract isolated from garden pea displayed a positive inhibition of platelet activating factor (PAF)(IC50 = 38 microg/mL) in a dose dependent fashion, in induction of platelet aggregation, but this action was not found in Desi chickpea extract.

Platelet-activating factor (PAF), is a lipid mediator with function in exhibited expression of platelet aggregation, immune response and inflammation.

Interestingly, the methanolic extract isolated from Kabuli chickpea also expressed a strong platelet aggregation effect without activation of either arachidonic acid (AA) or latelet-activating factor (PAF) expressions.

The findings suggested that there must exist other mechanisms in reduced platelet aggregation, other than inhibition of arachidonic acid (AA) and platelet-activating factor (PAF) activities by the testing extract isolated from the above members of pea family.

Further differentiation showed that methanolic extract isolated from the pea family also inhibited platelet aggregation through endothelial cells COX-2 lining the interior surface of blood vessels and lymphatic vessels in production of platelet PGE2 precipitated by inflammatory cytokine expression during the acute phase of tissue damage.

COX-2 is an enzyme with function in response for inflammation and pain.

Prostaglandin E2 (PGE-2) is also released by blood vessel walls with function in response to infection or inflammation.

Indeed, the extract displayed a strongly inhibited effect at dose of concentration 20 microg/mL in lower the levels of synthesis of PGE2 by 92%, 87% and 65% in extract of Garden pea, Desi chickpea and Kabuli chickpea, respectively, according to COX-2 essay.

Taken together, peas family including Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural anti-thrombotic and anti-inflammatory whole foods. People who are in high risk of CVD due to platelet effect may want to add a portion of chickpeas into their daily diet.

Friday, 15 December 2017

Alternative Therapy: Yoga, In reduced Risk and Treatment of Sleep Disturbance

Kyle J. Norton

Yoga may be considered as a feasibility and efficacy program in improved sleep disturbance, some respectable institute studies suggested

An individual may experience sleep disturbance because of a medical condition, such as sleep apnea, restless leg syndrome, or periodic limb movement and/or psychological stress in initiated anxiety, an overactive nervous system, depression.......
Yoga, the ancient technique practice for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the study to test the feasibility and efficacy of a shared yoga (SY) program for sleep disturbance in older adults with osteoarthritis (OA) from ages 50 to 7) with insomnia related to OA by randomizing to 12 weeks of SY (n = 9) or individual yoga (IY; n = 7), in compared to Pre-post testing result, all participants showed statistically significant improvements on the Insomnia Severity Index and Patient-Reported Outcomes Measurement System sleep disturbance scale and yoga overall feasibility of the program, both in the shared and individual formats.

After taking account of other risk factors, researchers said," efficacy data suggest that yoga program may improve sleep, but given the study limitations".

Indeed, yoga simple postures for beginners learned from the experience instructors may reduce tension of participants through induced relaxation and increased body-mind awareness which have been found to benefit the calming effect of the nervous system in reduced risk of night time sleep disturbance.

A few minutes right before bed to do a yoga sequence designed particularly to calm the mind may also be helpful to give rise of.sleep easily.

Other researchers suggested that relaxing activities before bedtime, rather than stressful work tasks or intense exercise are necessary for some people with sleep disorder.

Additionally, the study of the efficacy of gentle yoga for sleep disturbance in women with osteoarthritis with all participants completed an 8-week yoga program that included 75-min weekly classes and 20 min of nightly home practice (13/14 completed the study) also indicate that

all participants expressed a significant improvement at post-intervention versus pre-intervention through observation of The Insomnia Severity Index and diary-reported sleep onset latency, sleep efficiency, and number of nights with insomnia.

Furthermore, all participants also showed improvement on mean scores at post-intervention through analyzed by Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, diary-reported total sleep time and wake after sleep onset.

In fact, the presence of sleep disturbance may be a stress related disease. As stress elevates production of hormone cortisol in activation of the "flight or fight" response which directs blood flow to the nervous system and increased the brain tension in preparation how to respond to the stressful event.

Yoga exercise, using deep relaxation and meditation to create a state of consciousness between waking and sleeping, like the "going-to-sleep" stage with an aim to decrease sleep disturbance risk.

More importantly, in examine the effect of yoga in patients with Osteoarthritis (OA), the University of Washington suggested yoga intervention improved sleep disturbance through expression in reduced pain, sleep disturbance, and disability as well as improved musculoskeletal strengthening,
flexibility, relaxation, reduced of autonomic arousal, and enhanced cognitive patterns (distraction, mindfulness), probably as the result of yoga exercise effect in induced a state of calmness against central nervous tension caused by stress events and created a clear mind to tackle the stress in a positive way through relaxation and breathing.

Dr. Taibi DM, the led author said, ".... when evaluating the potential usefulness and safety of yoga programs: yoga style, instructor qualifications, and amount of time spent in yoga practice".

Particularly, in harmonization of the mind and body, yoga lead us to the stage existed in the present moment and connected mindful, conscious and connected way in solving stress.

Some yoga instructors suggested although yoga may not facilitate all the physical or medical causes of sleep disturbance, the practice with breathing and meditation surely can re-balance the mind and action in response to overactive nervous system through soothing emotional stress by indirectly addressing the roots and experience of image and feeling in inducing pain, confusion, and anxiety while letting go of them or dealing with them in a positive way.

The information findings suggested that yoga may be considered as standardized evening yoga in treatment in sleep disturbance.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Sources

(1)Feasibility and Efficacy of a Shared Yoga Intervention for Sleep Disturbance in Older Adults With Osteoarthritis by Buchanan DT, Vitiello MV, Bennett K.(PubMed)

(2) A pilot study of gentle yoga for sleep disturbance in women with osteoarthritis by Taibi DM1, Vitiello MV.(PubMed)

(3) Yoga for osteoarthritis: nursing and research considerations by Taibi DM1, Vitiello MV.(PubMed)
(4) Yoga Nidra for Sleep Disorders by By David Procyshyn

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Monday, 18 December 2017

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