Wednesday, 29 November 2017

Food therapy: Green Tea A Potent Beverage in Reduced Risk and Treatment of Osteosarcoma

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Green tea may have a strong implication in reduced risk and treatment of osteosarcoma, some researchers suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Osteosarcoma is a medical condition of bone cancer characterized by producing immature bone and occurred mostly in children and young adults between the ages of 10 and 30.

According to the study in investigation of the effects of Epigallocatechin-3-gallate (EGCG), in reduced risk of osteosarcoma expression in compared to miR-126 in the proliferation, invasion, migration, and chemotherapeutics resistance in cancer, application of Epigallocatechin-3-gallate (EGCG)
1. Exerted a significant effect in suppresses proliferation of human cell line osteosarcoma MG63 and U2OS cells in a concentration-dependent and time-dependent manner
2. Inhibited cancer cell line at the concentration of 0.05 g/L  on U2OS cells were equivalent to 20 μM cisplatin (DDP)

In compared to green tea extract induced cell death by interfering in cell cycle arrest, miR-126, the chemo suppressor drug induced apoptosis and inhibited proliferation in U2OS cell line but without significant effects on phase 1 of cancerous cell cycle division.

Further analysis, researchers suggested application of Epigallocatechin-3-gallate (EGCG) may increase the effect of tumor suppressing drug miR-126 and  for treatment of osteosarcoma. 

In fact, the inhibition of miR-126 osteosarcoma cells without inducing apoptosis and cells proliferation in cell cycle division is attributed to the medicine in target of sequences in reducing the expression of the targeted genes.

In other words,  the medicine can bind directly to inhibit DNA transcription and prevented  mRNA in transmitting such transcription in initiated cancer development. 

Other researchers suggested that the inhibition of Epigallocatechin-3-gallate (EGCG) in reduced cancerous cell death does not limit to the function of cell cycle arrest, the phytochemical compoud also expressed the apoptotic effect through modulating gene expression of cancer cell line and induced degradation of cancerous cellular structure.

Additional evaluation of the phytochemical Epigallocatechin-3-gallate (EGCG) and the tumor suppressed drug miR-1 effect in osteosarcoma, researchers also found that Epigallocatechin-3-gallate has a profound and positive effect in improved the efficacy of miR-1 in induced cell apoptosis and proliferation observed in cancer cell lines MG-63 and U-2OS.

More importantly, MG-63 and U-2OS treated by miR-1 and Epigallocatechin-3-gallate (EGCG) decreased c-MET expression, which is an indication of cancers development.

Further more, combined application of Epigallocatechin-3-gallate (EGCG) and c-MET inhibitor (crizotinib) also displayed a significant inhibition of MG-63 and U-2OS cancer cell proliferation.

More interestingly, in the study of the effects of Se-enriched Ziyang green tea, containing chemical compound mannose, rhamnose and fucose in anti tumor activity on human osteosarcoma U-2 OS cells in vitro and in vivo, researchers found that Se-ZYTP at concentration of 25, 50, 100 and 200 μg/ml exetred a significantly inhibition of proliferation of human osteosarcoma U-2 OS cells in a concentration-dependent fashion.

In cancer cell line In U-2 OS cancer induced in BALB/c athymic mice model, Se-ZYTP oral administration at three doses of 100, 200 and 400mg/kg body weight (B.W.) daily for 28 days resulted in tumor regression as compared to model control without causing any serious side effects.

Once again, we illustrated that other chemical compounds found in green tea may also have the  potential in suppression of  proliferation  and induced apoptosis of osteosarcoma.

In deed, the anti osteosarcoma activities of Se-enriched Ziyang green tea may be attributed to the stimulation in increased pro-apoptotic protein Bax expression(upregulated by the tumor suppressor protein p53 in induced apoptosis) and decreased  expression levels of anti-apoptotic protein Bcl-2(regulator proteins that regulate cell death) and NG2(involved cell survival, migration and angiogenesis), some researchers suggested.

Taking altogether, green tea with plenty of phytochemicals in suppression of the development and progression of cancer may be considered as an adjunct therapy in reduced risk and combination with chemo drugs for treatment of osteosarcoma.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate by Jiang L, Tao C, He A, He X1.(PubMed)
92) Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1 by Zhu K1, Wang W2.(PubMed)
(3) Tumoricidal effects of a selenium (Se)-polysaccharide from Ziyang green tea on human osteosarcoma U-2 OS cells by Wang Y1, Chen J, Zhang D, Zhang Y, Wen Y, Li L, Zheng L.(PubMed)



Food Therapy: Beet or Beet Root, The Best Anti Inflammatory Functional Food


Kyle J. Norton

Beet may be one of function food, having an anti inflammatory potential in reduced pain in damage tissues or local infection.

Inflammation is a natural reaction of immune system in protection of our body during tissues damage, injure and infection

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the Meerut Institute of Engineering & Technology, in carrageenan induced paw oedema method for acute inflammation and cotton pellet granuloma for chronic inflammation in rat model, injected aqueous extract of leaves of Beta vulgaris exhibited anti-inflammatory effects at dose level of 1000 mg/kg in comparison to those of indomethacin, a group of nonsteroidal anti-inflammatory drugs (10 mg/kg).

Also in carrageenan (100 µg/paw)-induced paw edema and neutrophil migration to the paw skin tissues.treatment with betalain (100 mg/kg, i.p.) significantly inhibited the expression of paw edema. caused by carrageenan, a common food additive and complete Freund's adjuvant (10 µl/paw) used in animal experiment to induce infection.

Neutrophils are white blood cells formed an important role in defense against infection and inflamamtion caused by injure and microorganisms invasion and neutrophil migration is a rapid movement of white blood cells to the location of infection or inflammation.

According to the study, the anti inflammatory effect of aqueous extract of leaves of Beta vulgaris probably was attributed to phytochemicals found in the extract such as flavonoids, carbohydrates, pentose, amino acids, saponins, tannins and steroid in promoted and increased movement of plasma and leukocytes from the blood into the injured tissues to counteract the invasion of foreign substances and disease.and exhibited the release of histamine in generation of mass and white blood cells and serotonin induced platelets binding to a clot, then ameliorating inflammation through regulation of inflammatory mediators including leukotrienes and prostaglandins,

Please note that
1. Hhormone prostaglandins play a key role in the generation of the inflammatory response and stimulation of constriction and clotting of platelets.
2. Leukotrienes (LTs) is a family of lipid and inflammatory mediators with a function in response to pathogenesis of inflammation
 

The study emphasized that in compared to a group of nonsteroidal anti-inflammatory drugs, aqueous extract of leaves of Beta vulgaris at specific dose exhibited a stronger and higher inhibition of acute inflammation induced by prostaglandin synthesis, including the inflammatory response to diverse stimuli in induced temporary increase of physiological activity.
Further analysis also suggested that in chronic inflammatory diseases induced by cotton pellet granuloma, such as arthritis, aqueous extract of leaves of Beta vulgaris although less effective than the conventional drug of indomethacin, had a profound effect in reduced symptoms and prevented inflammatory process of cells at the site of inflammation by healing of the tissue through the initiated cells shift to induced apoptosis.

In other words, aqueous extract of leaves of Beta vulgaris ameliorated risk of  chronic inflammation by healing the affected tissue, thus preventing cell being damage caused by prolonged inflammation.

Furthermore, application of betalain (100 mg/kg), isolated from beet root also suppressed free radical production and inflammatory activity through enhanced antioxidant activity and inhibited the over expression of proinflammatory proteins such as

TNF-α, a tumor necrosis factor, a protein with function in regulated the production of inflammatory cytokins in the acute phase of invasion by foreign substances, and nterleukin (IL)-1β has a duo functions in activated either pro-inflammatory cytokine or anti-inflammatory myokines.and promoted
 IL-10 expression in production of anti-inflammatory cytokine

In healthy adult, with inflammatory bowel diseases (IBD), betanin, the major component of beet (Beta vulgaris var. rubra) also demonstrated a significant anti inflammatory property in modulated reactive oxygen species (ROS) production and oxidative stress cause of DNA damage as well as increasing apoptosis in neutrophils by analyzing the blood samples of tested subjects.

Dr. Zielińska-Przyjemska M the lead author said, "Betanin treatment at the concentration of 100 μM for 24 h increased DNA damage assessed by comet assay in IBD patients' neutrophils. A similar effect although less pronounced was observed in Caco-2 cells(colon cancer cell line)".

The finding evidences suggested that beet with plenty phytochemicals, may have a therapeutic potential to be utilized in the treatment of inflammation-associated diseases.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anti-inflammatory activity of aqueous extract of Beta vulgaris L by Jain S1, Garg VK1, Sharma PK1.(PubMed)
(2) Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production by Martinez RM1, Longhi-Balbinot DT, Zarpelon AC, Staurengo-Ferrari L, Baracat MM, Georgetti SR, Sassonia RC, Verri WA Jr, Casagrande R.(PubMed)
(3) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W1.(PubMed)

Tuesday, 28 November 2017

Food therapy: Dried Peas, the Best and Potent Anti inflammatory Agent

Kyle J. Norton


Intake of dried peas daily and regularly may reduce risk and treatment of chronic inflammatory diseases, some institute studies suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

Inflammation is a natural process of the immune system to heal body damage and injure caused by invasion of foreign substances, including bacteria and virus.

In the study to evaluate the preventive effects of two pea (Pisum sativum) seed albumin extracts, either in the presence (pea seed extract [PSE]) or absence (albumin fraction from PSE [AF-PSE]) of soluble polysaccharides, in the dextran sodium sulfate (DSS) induced colitis in mice assigned to five groups: one noncolitic and four colitic, researchers found that
1. All treatment groups displayed a significantly intestinal anti-inflammatory effect, observed by reduced microscopic histological damage in comparison with nontreated mice
2. Peas extract treatment group was found to ameliorate pro inflammatory markers through regulating the colonic mRNA expression.
3. The chemical isolated also improve the proteins expression involved in maintaining the epithelial barrier function in prevent the passage of foreign antigens, microorganisms and toxins.

In other words, pea (Pisum sativum) seed albumin extracts not only inhibited auto immune response in expression of RNA in transmitting information to proteins involved production of pro inflammatory cytokins but also strengthened colonic cells in prevented permeation of noxious agents, 

Further differentiation, researchers also indicated that application of peas extract also improved gut bacterial function, partially or totally  in compared to healthy mice.

The findings may provide people with high risk chronic inflammatory diseases to  reconsider adding a portion of dried peas into their daily diet for preventive measure.

Truly, peas extract not only have a profound effect in reduced symptoms implicated by inflammatory cytokins but also hold an important key to restore the gut bacteria partially and totally, particularly in patient with colitis.

Other researchers, in a murine model. study to investigate the effect of enzymatic protein hydrolysates isolated from yellow pea seed in risk of inflammation showed that
1. the isolated protein demonstrated a significant activity in inhibited the secretion of pro-inflammatory cytokines, TNF-α- and IL-6, up to 35 and 80%, respectively
2. Peas proetein also expressed a strong effect in regulate up-regulation of IL-6 secretion by small intestine epithelial cells (IEC), in reduced risk inflammation caused by B-cell terminal differentiation to IgA-secreting cells.

TNF-α, tumor necrosis factor tumor necrosis factor is a protein with function in regulated the production of inflammatory cytokins in the acute phase of invasion by foreign substances.

Interleukin 6 (IL-6) is an interleukin has a duo functions in activated either pro-inflammatory cytokine or anti-inflammatory myokine.

With the amazingly collective information Dr. Ndiaye F, the lead authors suggested, "the resulted peptides could be used as an alternative therapy for the prevention of inflammatory-related diseases".


More importantly in the study to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of garden pea, researchers after considering to other con founders postulated that
1.  Methanol extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 microg/mL) 
2. In compared to 2 other plants, garden pea (Pisum sativum) demonstrated a strongest effect in inhibited PGE2 by 92% in comparison with untreated control wells), Desi chickpea by 87% and Kabuli chickpea extracts by 65%.

Prostaglandin E2 (PGE-2) is another pro inflammatory protein with function in response to infection or inflammation produced by blood vessel walls.

Arachidonic acid is a polyunsaturated omega-6 fatty acid with function in mediated or modulated inflammatory reactions.

Since all ingredients displayed a significant activity in protect the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body without elevating the inflammatory production, Dr. Zia-ul-Haq M, the lead author said, " Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials".

The information collected from above studies, demonstrated that the specific factions or ingredients isolated from peas may have a significant effect in reduced expression of pro inflammatory substances with out taking account of complete picture of the whole food.

Therefore, intake of a large portion dried peas daily of patients with chronic inflammatory diseases does not automatically mean a completely recovered from such illness.

In fact, most studies in the article have used either a small sample size or in a early stage of animal experiment, thus clinical studies are necessary to re confirm these validation.

However, it is safe to suggest that intake of dried peas may have a strong implication in ameliorated risk of inflammation without altering the function of immune modulating effect.




Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis by Utrilla MP1, Peinado MJ, Ruiz R, Rodriguez-Nogales A, Algieri F, Rodriguez-Cabezas ME, Clemente A, Galvez J, Rubio LA.(PubMed)
(2) Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds by Ndiaye F1, Vuong T, Duarte J, Aluko RE, Matar C.(PubMed)
(3) Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. by Zia-ul-Haq M1, Khan BA, Landa P, Kutil Z, Ahmed S, Qayum M, Ahmad S.(PubMed)




Food Therapy: Green Tea In Reduced Risk and Treatment of Lung Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Green tea may have a profound and extrinsic effect in reduced risk and treatment of lung cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neurtalize the yin over expression.

Ginger, is a warm herb used in TCM to warm the Middle Burnner and the Lungs, rescues Yang, transforms Phlegm by enhancing the functions of lung, spleen and stomach channels.

Lung cancer is a medical condition characterized by cells growth disorderly and uncontrollably of lung tissues. At the late stage, the cancerous cells may travel a distance from the original site to infect other organs and tissues.

In the study to investigate the anti lung cancer effect of Epigallocatechin-3-gallate (EGCg), the major polyphenolic compound present in green tea, after taking inot account of other con founders, researchers at the joint study lead by the Kyushu University of Health & Welfare, suggested that
1. The phychemical induced apoptosis of lung cancer through suppression of cell division, in cell culture
2. In human A549 human non-small-cell lung cancer cell line, EGCg inhibited cancerous cell proliferation by interfering mRNA expression in modulation of apoptotic cell death
3. Additionally, application of 100 μM EGCg for 24 h. exhibited cancerous morphological changes, thus reducing cell proliferation

The study also revealed that the efficacy of EGCg inhibited B-cell lymphoma-extra large (Bcl-xL) through expression of mRNA and suppression of gene in related to cell death.

Further analysis of Epigallocatechin-3-gallate (EGCg) in inhibited gene expression in risk of lung cancer by binding HIF-1α, in promoted cell proliferation and anchorage-independent growth, researchers launched a study to elucidate the role of microRNA in the EGCG inhibition of tobacco carcinogen-induced lung tumors in A/J mice found that 26 potential targeted genes of the 21 microRNAs. with the mRNA expression profiles may have some implications in increased lung cancer risk.

Interestingly, application of EGCg, indeed, demonstrated a significant effect in improved cell regulation and reduced cell proliferation through many mechanisms, including regulation of
1. AKT pathway in promoted survival and growth in response to extracellular signals. 
2. NF-κB expression in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation and 
3. MAP kinases, involved variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

In other words, Epigallocatechin-3-gallate (EGCg) effect reduced risk and treatment of lung cancer is attributed to the inhibition of expression of RNA in transmitting information to proteins with function to initiated cancer cell change, including cell proliferation and apoptosis.

The findings also suggested that green tea Epigallocatechin-3-gallate (EGCg) has a strong effect in reduced risk lung cancer through both expression of mutate and cancer-related genes.

More importantly, mutated genes expression has been identified in contribution to cancer development and progression, therefore by target the expression of such genes may help scientists in explore the origins of abnormal gene expression in compared to normal cells.

Other researchers suggested that by targeting both DNA and RNA data to identify alternative expression of mutated gene in patients of lung cancer  may open the door by offering specific treatment only for such patients

More precisely, by identified such gene in cancer cell patients, scientist may prescribe gene targeting technology, specific medication and treatment to stop cancer from growing and spreading.

Further differentiation of the effect of green tea extract in lung cancer risk, researchers at the University in Toruń filed the following report
1. Green tea extract catechins demonstrated a significant effect in inhibition of lung cancer line A549 independent to doses applied and
2. Increased cell and marker of cell degradation
3. Green tea extract catechins also expressed a strong protective effect in reduced self cause of toxicity

Collectively, this illustration indicated that green tea extract catechins exerted anti lung cancer progression through protection against destruction and damage of redundant cellular components occurring in vacuoles within the cell without induced side effects

The evidences indicated that certain phytochemicals found in green tea may have a potential in attenuated risk and treatment of lung cancer. But intake of green tea extract supplements have been found to induce liver toxicity, particularly if overdosed.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression by Sonoda JI1, Ikeda R2, Baba Y3, Narumi K1, Kawachi A1, Tomishige E1, Nishihara K1, Takeda Y2, Yamada K4, Sato K5, Motoya T1.(PubMed)
(2) Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer by Zhou H, Chen JX, Yang CS, Yang MQ, Deng Y, Wang H.(PubMed)
(3) Green tea extract induces protective autophagy in A549 non-small lung cancer cell line by Izdebska M1, Klimaszewska-Wiśniewska A1, Hałas M1, Gagat M1, Grzanka A1.(PubMed)

Monday, 27 November 2017

Alternative Therapy: Yoga in Attenuated Complications and Improved High-Risk Pregnancy Outcome

Kyle J. Norton .


According to the literature published online in PubMed, Yoga may be be used as an adjunct therapy in reduced risk of high-risk pregnancy.

Yoga, the ancient technique practice for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

Women who are classified as high risk pregnancy are more likely to encounter more health problems in themselves and the babies during pregnancy, birth, or after delivery.

Age, first time pregnancy, chronic conditions, preexisted medical conditions, drug usage.... are all associated to increased risk to the health problems of both mother and baby and pregnancy outcome, particularly to women with previous history of pregnancy risk.

According to the study of sixty-eight pregnant women assigned to he yoga group (n=30) received standard care plus one-hour yoga sessions, three times a week, from the 12th to the 28th week of gestation. and control group (n=38) received standard care plus conventional antenatal exercises (walking) during the same period, researchers found that
1. Yoga participants showed a fewer fewer pregnancy induced preeclampsia, gestational diabetes (GDM) and intrauterine growth restriction (IUGR) cases in compared to control
2. Yoga group also expressed a significantly fewer Small for Gestational Age (SGA) babies and newborns with low APGAR scores were born in the yoga group

Dr. Rakhshani A, the led author, after examining the results indicated that " yoga can potentially be an effective therapy in reducing hypertensive related complications of pregnancy and improving fetal outcomes".

Psychologically, yoga practice of breath and meditation have a significant effect in ameliorated maternal stress and distress and improved heart rate by induced calming, reduced tension  and promoted relaxation which are asociated to reduced risk of preeclampsia, gestational diabetes (GDM), some of complications in high risk pregency.

Additionally, according to Dr, Rondó PH and colleagues, yoga exercised attenuated maternal psychological stress also have demonstrated a strong implication in decreased expression of low birth weight (LBW), prematurity and intrauterine growth retardation (IUGR) in high risk pregnancy women at a gestational age (GA) lower than 16 weeks, from 20 to 26 weeks and from 30 to 36 weeks.

More importantly, in the letter responded to the above study, Dr. Siddharudha Shivalli wrote, "Authors have used outcome measures such as fetal biparietal diameter, head circumference, abdominal circumference, femur length, and estimated fetal weight (Table 3). However, maternal hemoglobin, anemia status, physical activity, dietary, and iron-folate/other supplement intake have an effect on all these fetal parameters [2]. These are the potential confounders in this study and they must have been addressed" and "Nonetheless, this study highlights the need of higher level of evidence to assess the effect of yoga on maternal and fetal outcomes".

Further to demonstrate yoga effect in decrease risk of women with high risk pregnancy, researchers at the S-VYASA University, conducted a study included 68 pregnant women (38 in the control group with standard antenatal care and 30 in the YT group) with 27.2 (5.2) years of mean age recruited from the outpatient services of medical college and hospital in Bangalore, South India, reported the following results
1. Yoga therapy reduced significant stress levels measured by stress assay at the second follow-up (28(th) week of pregnancy) in compared to control group
2. Yoga participants reported a significantly fewer pregnancy discomforts, such as nausea and sometimes vomiting in the first trimester, body ache and tightening or cramping in the uterus, at late pregnancy.

After taking into account of other con founders, researchers suggested that yoga therapy may be as secondary intervention combined with standard treatment in reduced level in high-risk pregnancy women.

Dr. CS Deshpande, the led author said, " practicing YT during high-risk pregnancy is not only a cost-effective option but also a feasible and safe option. Additional well-designed studies are needed before a strong recommendation can be made".

Taking altogether, there is no doubt that yoga intervention may be considered as an adjunct in combined with standard treatment in high risk pregnancy for a better outcome.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effects of yoga in prevention of pregnancy complications in high-risk pregnancies: a randomized controlled trial by Rakhshani A1, Nagarathna R, Mhaskar R, Mhaskar A, Thomas A, Gunasheela S.(PubMed)
(2) Yoga for high-risk pregnancy: a randomized controlled trial by Deshpande CS1, Rakhshani A, Nagarathna R, Ganpat TS, Kurpad A, Maskar R, Nagendra HR, Sudheer DC, Abbas R, Raghuram N, Anura K, Rita M, Ramarao N.(PubMed)
(3) Effects of yoga on utero-fetal-placental circulation in high-risk pregnancy: a randomized controlled trial by Rakhshani A1, Nagarathna R1, Mhaskar R2, Mhaskar A2, Thomas A2, Gunasheela S3.(PubMed)
(4) Maternal psychological stress and distress as predictors of low birth weight, prematurity and intrauterine growth retardation by Rondó PH1, Ferreira RF, Nogueira F, Ribeiro MC, Lobert H, Artes R.(PubMed)

Food Therapy: Dried Pea, An Antioxidant Functional Food

Kyle J. Norton


Dried peas may be considered a functional food in enhanced antioxidant activities, some renowned institute studies suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

Antioxidant is a natural substances protect our body against cellular damage caused chain reaction of ROS by inhibiting free radical over expression.

In the study to evaluate the The hepatoprotective and antioxidant activities of the hydroalcoholic extract (PE) of pea (Pisum sativum L.) using CCl4-induced oxidative stress and hepatic damage in rats, researchers at the Cairo University revealed that peas demonstrated a significant hepatoprotective and antioxidant activities mostly in n-butanol fraction, a major chemical compound in peas.

After taking into account of other analysis, including Chromatographic fractionation, Dr, said, "pea by-product contained biologically active constituents which can be utilised to obtain high value added products for nutraceutical use".

The hepatoprotective and antioxidant effect of peas one again were attributed to enhanced production of antioxidants such as glutathione (GSH) glutathione-peroxidase (GSH-Px), glutathione-S-transferase (GST) activities in inhibited ROS and its domino effects.

The information may provide additional reason for people with weaken immune system to add additional portion of dried peas into their diet in stimulated antioxidant status in their body.

And, the extra portion of dried peas intake daily will improve immune function in reduced risk diseases caused by bacterial and viral infection and inflammation,....

Other researchers in provide more information of the effects of anti-oxidant and anti-inflammatory properties of peptides from yellow field pea proteins (Pisum sativum L.) through LPS/IFN-γ-activated RAW 264.7 NO⁻ macrophages. researchers at the University of Ottawa, showed that
1. Pea protein hydrolysate, after a 12 h pre-treatment, inhibited NO production by activated macrophages up to 20%.
2. The tested chemical compound also demonstrated a strong inhibition of secretion of pro-inflammatory cytokines, TNF-α- and IL-6, up to 35 and 80%, respectively.
3. Oral administration of PPH in mice enhanced the white blood cell activity in stimulated the gut mucosa immune response.

The findings information showed that the powerful antioxidants properties of pea protein hydrolysate, exerts a significant effect in reduced the expression of pro inflammatory cytokins in regulated immune response.

Dr. Ndiaye F, after taking into account of other con founders said, "Enzymatic protein degradation confers anti-oxidant, anti-inflammatory and immunomodulating potentials to pea proteins, and the resulted peptides could be used as an alternative therapy for the prevention of inflammatory-related diseases".

Furthermore, in the investigated the antioxidant of the broad bean and pea by-products as sources of fiber-rich ingredients, researchers at the after differentiation of v the main monomers such as uronic acids, glucose, arabinose and galactose in broad bean pods, researcher postulated that the most antioxidant activities also are result of extractable polyphenols found in road bean and pea by-products as sources of fibre-rich.

Taking together, dried peas may be used as a functional food in increased antioxidant activity of people with weaken immunity and provided an additional source for treatment of auto immune and inflammatory diseases.



Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of peaby-product by Seida AA1, El Tanbouly ND, Islam WT, Eid HH, El Maraghy SA, El Senousy AS.(PubMed)
(2) Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds by Ndiaye F1, Vuong T, Duarte J, Aluko RE, Matar C.(PubMed)
(3) Broad bean and pea by-products as sources of fibre-rich ingredients: potential antioxidant activity measured in vitro by Mateos-Aparicio I1, Redondo-Cuenca A, Villanueva-Suárez MJ.(PubMed)


Alternative Therapy: Yoga in Improvement of Energy Expression

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)


Yoga may have strong and profound effect in improved energy expression, some scientists suggested.

Yoga, the ancient practical  technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the study to investigate study the effects of yoga poses on subjective sense of energy and self-esteem. in compared to the effects of 'power poses, after taking into account of other confounders, researcher found that yoga group participating meditation score a significantly increased subjective sense of energy in compared to control.

Further analysis, the study also suggested that yoga posts with performing open, expansive body postures may be driven by processes other than the poses' in association with interpersonal power and dominance.

Interestingly, Dr. Golec de Zavala A, the lead author said, " positive effects of yoga practice can occur after performing yoga poses for only 2 min".

Other researchers in the evaluation of the feasibility, acceptability, and patient-reported effectiveness of a clinical yoga program at a Veterans Affairs Medical Center and assessed whether these outcomes differed between those participating in-person and those participating via telehealth based on 64 Veterans completed the survey researchers concluded that more than 80% of veterans showed an improvement of energy levels after participating yoga class.

Furthermore, the returned survey also indicated that yoga participated demonstrated a overall improvement, or improvement in any of 16 specific health problems.


Other study in comparison of the energy expenditure during acute bouts of vinyasa yoga and 2 walking protocols of participants (20 males, 18 females) performed 60-minute sessions of vinyasa yoga (YOGA), treadmill walking at a self-selected brisk pace (SELF), and treadmill walking at a pace that matched the heart rate of the YOGA session (HR-Match) suggested that
Energy expenditure was significantly lower in YOGA compared with HR-Match (difference = 79.5 ± 44.3 kcal; P < .001) and SELF (difference = 51.7 ± 62.6 kcal; P < .001), but not in SELF compared with HR-Match (difference = 27.8 ± 72.6 kcal; P = .054). A similar pattern was observed for metabolic equivalents (HR-Match = 4.7 ± 0.8, SELF = 4.4 ± 0.7, YOGA = 3.6 ± 0.6; P < .001). Analyses using only the initial 45 minutes from each of the sessions, which excluded the restorative component of YOGA, showed energy expenditure was significantly lower in YOGA compared with HR-Match (difference = 68.0 ± 40.1 kcal; P < .001) but not compared with SELF (difference = 15.1 ± 48.7 kcal.

The reduced expenditure of energy in yoga participation may be another indication of yoga participants oashowed significantly energetic expression after yoga class.

Physically, yoga certain postures were also found to improved digestive system  in absorption of nutrients as well as  blood circulation in transport them to the body tissues and organs, thus increasing energy in 2 ways
1. By improving digestive problems such as indigestion, cramping, bloating, constipation.
2. For healthy people, yoga enhanced energy balance, through regulating gut peptides in expression of autocrine signalling

Psychologically, yoga breathing and mediation promoted calmness and relaxation of central nervous system have strong implications in reduced psychic symptoms such as anxiety, depression, stress...improving sleep pattern, particularly in insomnia.

Truly, people with a high level of psychological distress caused psychic problems are often difficult falling and staying asleep and have a tendency to dozing off early and waking up feeling exhausted and decreased energy levels.

Taking altogether, yoga exercise may be considered as primary therapy in improving daily energy  levels for people encountering a hectic life.with full of incessant or frantic activity. 

However, The over all information may only serve as preliminary evidences for the effectiveness of a clinical yoga program before supporting the use of yoga in healthcare settings, specially in energy enhancing.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Yoga Poses Increase Subjective Energy and State Self-Esteem in Comparison to 'Power Poses' by Golec de Zavala A1,2,3, Lantos D1, Bowden D1.(PubMed)
(2) Results from a clinical yoga program for veterans: yoga via telehealth provides comparable satisfaction and health improvements to in-person yoga by Schulz-Heik RJ1, Meyer H2,3, Mahoney L2, Stanton MV2,4, Cho RH2, Moore-Downing DP2, Avery TJ2,3,4, Lazzeroni LC4, Varni JM2, Collery LM2, Bayley PJ2,4.(PubMed)
(3) Energy Expenditure in Vinyasa Yoga Versus Walking by Sherman SA, Rogers RJ, Davis KK, Minster RL, Creasy SA, Mullarkey NC, O'Dell M, Donahue P, Jakicic JM.(PubMed)