Saturday, 21 October 2017

Alternative Therapy: Yoga in Prevention and Treatment of Binge Eating Disorder

Kyle J. Norton 


Yoga may be used as an integrated form of exercise for prevent and treatment of binge eating disorder, a Catholic University of Leuven study suggested.

Binge eating disorder is a condition characterized by compulsive eating huge amounts of food while feeling out of control and powerless to stop.
The syndrome is a common eating disorder in the United States, affecting 3.5% of females and 2% of males.

Yoga, the accident technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.


In the review of literature from EMBASE, PsycINFO, PubMed, Cumulative Index to Nursing and Allied Health Literature, Physiotherapy Evidence Database and Cochrane Library up to August 2012 for studies compared physical therapy with a placebo condition, control intervention or standard care, including 211 female community patients (age range: 25-63 years) met all selection criteria, researchers found that
1. Yoga participants showed a significantly reduced number of binges
2. Yoga group expressed a decrease of body mass index (BMI)
3. Yoga participants displayed insignificantly ameliorated depression in compared to aerobic exercise and combined aerobic exercise and cognitive behavioural therapy (CBT) groups

Dr. Vancampfort D, the led author said, " Because of severe co-morbid psychiatric and physical conditions, binge eating disorder is one of the most difficult psychiatric conditions to treat. Both yoga and aerobic exercise have shown promise in reducing binge eating pathology and weight".

Other, also in searching databases of PubMed, PsychInfo, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Physiotherapy Evidence Database, the Dutch Journal of Psychiatry (Tijdschrift voor Psychiatrie), het Tijdschrift voor Vaktherapie and Actual Themata derived from psychomotor therapy screened for the period January 1994 to August 2011, 8 studies met the met the inclusion and exclusion criteria suggested that
1. Yoga lessons induced a significant weight loss to attendees
2. Yoga participants displayed fewer symptoms of depression, when used alone or conjunction with cognitive behavioural therapy (CBT)
3. Conbined Yoga and and CBT demonstrated a less eating disorderpathology than does CBT alone

The authors concluded that yoga expressed the beneficial effects on weight-loss as well as on the reduction of binge eating disorder.

More importantly, in a randomised trial undertaken with participants of women between 25 and 63 years of age identified with diagnostic criteria for binge eating disorder (BED) and a BMI>25  assigned to yoga (n=45) or wait-list control (n=45) groups. Of these, 25 in each group were analysed, Dr. McIver S, the led author at the Deakin University filed the following results in compared to control  group
1. Yoga group showed a reduction in binge eating in self-reported
2. Yoga group expressed a statistical significance of more willing to involve in physical activity.
3. Yoga group also showed a small yet statistically significant reductions for BMI, hips and waist

With the information collected, there are no doubt that yoga formal weekly sessions and home-based programs are potentially efficacious for the treatment of binge eating.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A systematic review on physical therapy interventions for patients with binge eating disorder. by Vancampfort D1, Vanderlinden J, De Hert M, Adámkova M, Skjaerven LH, Catalán-Matamoros D, Lundvik-Gyllensten A, Gómez-Conesa A, Ijntema R, Probst M.(PubMed)
(2) [The importance of movement-directed interventions in the multidisciplinary treatment of binge eating disorder: an overview].[Article in Dutch]by Vancampfort D1, Vanderlinden J, Pieters G, De Herdt A, Schueremans A, Adriaens A, Van Der Borght W, De Hert M, Probst M.(PubMed)
(3) Yoga as a treatment for binge eating disorder: a preliminary study by McIver S1, O'Halloran P, McGartland M.(PubMed)

26 Extraordinary Health Benefits of. Black Beans

Kyle J. Norton

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

26 Health Benefits of. Black beans 
1. Black beans (Phaseolus) and Antioxidant effects
2. Black beans (Phaseolus) and Lipoprotein
3. Black beans (Phaseolus) and Prostatic hyperplasia
4. Black beans (Phaseolus) and Colon Cancer
5. Black beans (Phaseolus) and Gastric cancer
6. Food Therapy: Black (Dried, Common) Bean in Promotion of Weight Loss
7. Food Therapy: Black Bean, A Potent Anti Liver Cancer Legume
8. Food Therapy: Black Bean, A Potent Anti Diabetes whole Food Medicine
9. Food Therapy: Black Bean, A Potent Anti Breast Cancer Functional Food
10. Food Therapy: Black Bean In Reduced Risk of CVD and Diabetes in Metabolic Syndrome Adult
11. Food Therapy: Black Bean, The Best to Reduce Risk and Treatment of Liver Fibrosis Naturally
12. Food Therapy: Black Bean, The Best Functional Food for Hypertension
13. Food Therapy: Black Bean, A Potent Chronic Diseases Functional Food
14. Food Therapy: Black Bean, The Best functional food in reduced of CVD and heart Complications In Diabetics
15. Food Therapy: Black Bean the Best on Ameliorated Oxidative Stress in Chronic Diseases
16. Food Therapy: Black bean, the Functional Food In Reduced Risk and Treatment of Osteocarcinoma
19. Food Therapy: Black Bean in Attenuated Risk and Treatment of Prostate Cancer
20. Food Therapy: Black Bean, in Reduced Risk and Treatment of Colon Cancer
21. Food Therapy: Black Bean, A Potent Whole Food For Ameliorated Risk and Treatment of Colon Cancer
22. Food Therapy: Black Bean, Reduced Risk and Treatment of Colitis
23. Food Therapy: Black Bean reduced Risk and Treatment of Hypercholesterol
24. Food Therapy: Black Bean In Attenuated Risk and Treatment of Hyperglyctemia
25. Food Therapy: Black Bean, A Potent Functional Food In Reduced Risk of Cancers
26. Food Therapy: Black Bean The Best Anti Inflammatory Functional Food

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Food Therapy: Coffee in Increased Risk of Lung Cancer Linearly

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Bad news for coffee lovers, the recent study suggested that regular coffee consumptiontion may associate to increased risk of lung cancer.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Lung cancer is a medical condition caused by irregular cell growth in the lung. At the later stage, cancer cells may spread to distant tissues and organs.

Dr. Wang Y, the lead author said, "a linear dose-response relationship exists between coffee consumption and risk of lung cancer".

In the clarified risk of coffee in induced lung cancer, the Shanghai Institute of Pharmaceutical Industry conducted a search in the data base of PubMed and Embase, from 1966 to January 2009. In 5 prospective studies and 8 case-control studies involving 5347 lung cancer cases and 104,911 non-cases selected, researchers found that
1. Coffee high amount intake was associated to a significant positive lung cancer risk
2. Risk of lung cancer increased by 14% for additional 2 cups consumed daily.

Interestingly, prospective studies conducted in America and Japan showed a significantly associated with increased risk of lung cancer in highest coffee consumption, but borderline significantly associated with decreased risk of lung cancer in non-smokers in compared to studies conducted from other countries.
And people drinking decaffeinate coffee showed a decreased risk of lung cancer in all studies.

Other, in the review of seventeen studies (5 cohort and 12 case-control studies) involving 12 276 cases and 102 516 controls met the predetermined inclusion criterion, extracted from data base of literature, the total risk of coffee intake and lung cancer incidence was 1.17 in compared to non drinkers.  Also in compared to non drinkers, the relative risk of lung cancer was associated to numbers of cup per day consumed,
1. 1.10 (95% CI: 0.92-1.31) for ⩽1 cup per day,
2. 1.10 (95% CI: 0.93-1.30) for 2-3 cups per day and
3. 1.20 (95% CI: 1.02-1.39) for ⩾3 cups per day.

More importantly, Dr. Xie Y, the lead author said, " Significant associations for high coffee intake with increased risk of lung cancer were observed in men (OR=1.41 95% CI: 1.21-1.63), but not in women (OR=1.16, 95% CI: 0.86-1.56), in American (OR=1.34 95% CI: 1.08-1.65) and Asian populations (OR=1.49 95% CI: 1.28-1.74), but not in European populations (OR=1.12, 95% CI: 0.74-1.67), and in smokers (OR=1.24, 95% CI: 1.00-1.54), but not in nonsmokers (OR=0.85, 95% CI: 0.64-1.11)".

Taking altogether, there is no doubt that regular coffee intakes of large amounts is associated linearly in increased risk of lung cancer, particularly in men and smokers.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Coffee and tea consumption and risk of lung cancer: a dose-response analysis of observational studies by Wang Y, Yu X, Wu Y, Zhang D.(PubMed)
(2) Coffee consumption and risk of lung cancer: a meta-analysis by Tang N1, Wu Y, Ma J, Wang B, Yu R.(PubMed)

Food Therapy: Black Bean The Best Anti Inflammatory Functional Food

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Inflammation is a natural response of immune system in protect our body against injure and damage induced infection.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Black or common bean with abundant phytochemicals may be considered as function foods in attenuated pro inflammatory expression induced by immunity during injured, a respectable institute postulated.

In a randomized, controlled, crossover trial of 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) study, researchers found that blood sample collection before (fasting) and five hours after the meal, black bean intake group showed a significant expression of plasma antioxidant capacity and inflammatory cytokins in response to meals differences over time.

This result showed a strong support of black bean intake reduced levels oxidative stress induced inflammation and enhanced production of antioxidants.

Dr. Reverri EJ the lead researcher said, " Inclusion of black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints".

In other word, adding portion of black bean may improve insulin resistance and induced anti oxidant activity to modify the risk and treatment of inflammatory metabolic syndrome.

On colon inflammation triggered by high-fat diet (HD)-induced obesity in mice, miced fed with black bean showed a remarkable effect in reduced pro inflammatory expression such as such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, by attenuating changes associated with HD-induced colon inflammation.

Additionally, black bean fed mice also demonstrated a significant improvement of antioxidant through modulated colon mRNA expression and reduced macrophage infiltration into adipose tissue, causing inflammation.

Further more, Dr. the lead author expressed, " BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".


Other study in support to the efficacy of black bean in ameliorated inflammation suggested that bean diets reduced not only mRNA expression of exhibited production of colonic inflammatory cytokines (IL-6, IL-9, IFN-γ and IL-17A) and increased anti-inflammatory IL-10 (P< 0·05),but also systemically reduced circulating cytokines (IL-1β, TNFα, IFNγ, and IL-17A, P< 0·05) and dextran sodium sulphate-induced oxidative stress and colitis in animal model.

The finnings suggested that black bean may be used as function food for prevention of inflammation after body injure or damage by reduced levels of pro inflammatory and increased levels of anti inflammatory mytokins.



Sources
(1) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,7.(PubMed)
(2) Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice by Yook JS1, Kim KA2, Kim M1, Cha YS1.(PubMed)
(3) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1.(PubMed)

Friday, 20 October 2017

Food therapy: Coffee and Coffee Caffeine in Attenuated Risk of Liver Fibrosis

By Kyle J. Norton



Coffee intake daily and regularly may have a potential impact in reduced risk of hepatic fibrosis during recovery of liver injured, a renowned institute study suggested.

Coffee, second to tea, is a popular and social beverage all over the world, particular in the West,  made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Hepatic fibrosis is profusely and abnormally recovery of wound healing, causing excessive connective tissues build up in the liver.

In a experiment model of induced Liver injury by 28-day of chronic bile duct ligation (BDL) in male Wistar rats with conventional coffee, decaffeinated coffee, or caffeine administered daily, researchers at the joint study reported the following results
1. In compared to conventional coffee, caffeine expressed a significant suppression of most of the changes produced by BDL, particularly in antifibrotic effects
2. All types of coffee displays an elevated antioxidant properties in restored redox equilibrium, thus preventing the elevation of liver enzymes and hepatic glycogen depletion
3. Caffeinated coffee and caffeine exhibited a reduced in increased collagen

In fact, the efficacy of coffee and caffeine in ameliorated risk of liver fibrosis may be attributed to phytochemical compounds in increased antioxidant status and decreased over expression of pro inflammatory cytokins as well as regulating protein in over production of collagen.

Other, in support of the above analysis, researchers in the study to evaluate the antifibrotic properties of coffee in in male Wistar rats with liver damage induced by repeated administration of thioacetamide (TAA).  Oral administration of conventional caffeinated coffee or decaffeinated coffee (CC, DC, respectively) for 8 weeks reported the following results
1. Intake of coffee showed a significant effect in suppression of most of the damage produced by TAA in rat liver
2. Coffee reduced expression of on going experimental cirrhosis by blocking the elevation of the profibrogenic cytokine TGF-β and its downstream effector CTGF in induction of inflammation through increased antioxidant status, regardless to types of coffee and numbers of cup intake per day.

Dr. Arauz J, the lead researcher said, " Various components of coffee that have been related to such a favorable effec(in reduced risk of hepatic fibrosis) include caffeine, coffee oils kahweol, cafestol and antioxidant substances".

Interestingly, the Biophysics and Neuroscience cInfectomics and Molecular Pathogenesis study also reconfirmed that effect of coffee and coffee caffeine in attenuated risk of liver fibrosis were resulted from the following demonstrations
1. Caffeine prevents elevation of liver enzymes in reduced liver tissues damage and over expression of collagen in the rats treated with TAA plus.
2. Caffeine elevated antioxidant properties by restoring the redox equilibrium through reduced lipid peroxidation and glutathione peroxidase (GPx) levels
3. Reduced proinflammatory initiation.

Taking altogether, coffee and coffee caffeine regardless numbers of cup intake per day illustrated a significant effect in ameliorated risk and progression of  hepatic fibrosis.


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(2) Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans by Arauz J1, Zarco N2, Hernández-Aquino E3, Galicia-Moreno M1, Favari L3, Segovia J2, Muriel P4.(PubMed)
(2) Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage by Arauz J1, Moreno MG, Cortés-Reynosa P, Salazar EP, Muriel P.(PubMed)
(3) Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-β by Arauz J1, Zarco N, Segovia J, Shibayama M, Tsutsumi V, Muriel P.(PubMed)

Food Therapy: Black Bean, A Potent Functional Food In Reduced Risk of Cancers

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of black(common) bean and other common bean may associate to reduced  risk and treatment of various type of cancers, a study of renowned institute study suggested.

Cancer is a class of chronic condition characterized by the irregular cell growth in the body organs. Sometime, the cancer cells can spread to other tissues or organs depending to stages of cancer..

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Fermentation product of soybean, black bean, and green bean mixture (BN999), showed a significant effect in inhibited the growth of human breast cancer AU565 cells and prostate adenocarcinoma PC-3 cells without harming the normal human cells.

The study also found that in syngenic BALB/c mice, the mixture(BN999) inhibited the growth of mouse CT-26 colon cancer xenografts, without causing adverse effects.

Further more, BN999, also induced cancer cell death in other mechanisms, such as activated the protein gene involved pro cancer cell apoptosis via cell mediatory activities, including a network of membranous anatomical structure and double membrane-bound organelle.in energy conversion.

Additionally, according the joint study lead by the Universidad Autónoma de Querétaro, the efficacy of common bean in attenuated cancer risk factors as shown in animal models and  in cell cultures. may also be attributed to other parameters of non-digested compounds like fiber, phenolics, peptides and phytochemicals.

In fact, black (common) bean whole and non-digestible fraction also exhibited anti-proliferative activity and induced apoptosis in vitro and in vivo against colon cancer.

Dr. Rocio Campos-Vega lead author in the joint study also raised the important role of bean fiber and protein of the bean in ameliorated cancer risks, said, " the potential health benefits and bioactivity of beans on tumor inhibition, highlighting studies involving functional compounds, mainly non-digestible fractions that modulate genes and proteins, thereby, unraveling their preventive role against the development of cancer".

Other researchers in evaluation of phytochemicals of black bean against various types of cancers showed that flavonoids and saponins isolated from black bean exerted a strong antioxidant capacity and antiproliferative activity against numbers of cancer cell lines in concentration depend manner.

The study also insisted that depending to days of germination, total phenolic content extracted from seed coats at the 3 days exhibited the strongest effect in inhibited all cancer cell lines proliferation with no cytotoxicity against control cells.

Specifically, chemical compound genistein showed most effective against mammary cancer cells in compared to more related with hepatic and colon cancers in flavonols and saponins.

The findings suggested that black bean may be considered as functional food as well as integrated form of injection for reduced risk and treatment of various types of malignant tumors
 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Common Beans and Their Non-Digestible Fraction: Cancer Inhibitory Activity—An Overview by Rocio Campos-Vega,1,* B Dave Oomah,2,† Guadalupe Loarca-Piña,1,† and Haydé Azeneth Vergara-Castañeda3(PMC)
(2) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(3) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.) by Guajardo-Flores D1, Serna-Saldívar SO, Gutiérrez-Uribe JA.(PubMed)

Thursday, 19 October 2017

Food Therapy: Coffee and Coffee Caffeine in Inhibition of Genotoxicity

By Kyle J. Norton


Coffee and coffee caffeine may have a profound and positive effect in reduced risk of genotoxicity, caused by environment toxins, a coffee production company opinionated.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In rat liver and primary hepatocytes, regular intake of coffee daily illustrated a enormous effect in cellular antioxidant defenses through regulating exhibited enzymes involved mRNA and protein expression.

The study also suggested that coffee and coffee caffeine through expression of detoxifying enzymes GSTs and AKR(in cellular detoxification) also demonstrated a significant activity in reduced risk of genotoxicity and cytotoxicity caused by injection of aflatoxin B1 (AFB1).

Dr. Cavin C, ther lead author said, " the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses".
(Please note that Nrf2-ARE pathway is an indicator and modulator of oxidative stress)

Other, in the evaluated L5178Y mouse lymphoma cell line to assess modulatory effects of coffee against genotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG), researchers found that
1. 3 doses of instant coffee caffeine injection displayed a decrease in genotoxicity following co-treatment of mouse lymphoma cells.
2. Coffee caffeine pre-treatment or co-treatment exhibited significant antigenotoxic effects against MNNG(an environmental carcinogen that causes DNA mutation) expression.
3. Both caffeinated and decaffeinated instant coffee demonstrated a similar effect against genotoxicity in the experiment samples.

Dr. Abraham SK, the lead authors said, " Results from three or five independent experiments demonstrated significant protective effects of caffeinated instant coffee against MNNG-induced DNA damage in the comet assay, mutation at the Tk locus and chromosomal damage in the cytokinesis-block micronucleus test".

In support of the above analysis, the Swiss Federal Institute of Technology (ETH), in the study of  protective effects of coffee against somatic mutation and mitotic recombination induced by chemo drugs, cyclophosphamide (CPH)(, mitomycin C (MMC) and urethane (URE), using standard (ST) and high bioactivation (HB) crosses of the wing spot test in Drosophila melanogaster assays, suggested that in dose depending, coffee injection showed a strong effect in the genotoxicity of URE in the ST and the genetically susceptible HB cross as well as the genotoxicity caused by MMC application.

Dr. Abraham SK, the lead researcher said, "The magnitude of the protective effects of coffee against these three genotoxins was independent of the genotype of the larvae used for treatment, that is it was independent of the bioactivation capacity of these larvae".

The collective information showed a definitive support in used of coffee and coffee caffeine as functional food in reduced risk against genotoxic expression, including side effects of chemo medicine used in treatment of multi types of cancers.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)
(2) Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells by Abraham SK1, Stopper H.(PubMed)
(3) Protection by coffee against somatic genotoxicity in Drosophila: role of bioactivation capacity by Abraham SK1, Graf U.(PubMed)