Food Therapy: Coffee and Coffee Caffeine in Risk of Mutagenesis?

By Kyle J. Norton


Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West,  made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Coffee and coffee caffeine may have a direct effect in mutagenicity in bacteria and fungi, but lesser in mammalian cells, a France study suggested.

According to the Université de Nancy, Coffee and caffeine showed a significant effect in gene mutation in bacteria and fungi, but in high concentrations, they expressed also a similarly mutagenic influence to mammalian cells in culture.

The mutagenic activity of caffeine can be observed through its potentiate in induced chromosomal aberrations through transforming sublethal damage of mutagenic agents into lethal damage. But conversely, intake of coffee and caffeine denostrated a protective effect in inhibit these mutagenic properties through theirs' numerous chemicals depending to the time consumption in the presence of mutagenic agent.

Furthermore, the study also revealed that chemically reactive components such as aliphatic dicarbonyls from the caffeine were some of the culprits attributed to these mutagenic exhibition.

The findings suggested the duo effect of coffee and coffee caffeine on one hand, inhibited the gene mutation but on the hand displayed a significant mutagenic DNA damage to living organisms, but less in human even with moderated drinking habit.

Also in bacterial experiments, according to the observation from bacteria mutation assays, trigonelline, found in caffeine alone or in combination with most of the single amino acids found in caffeine and mixtures of amino acids, showed a potent mutagenic activity in Salmonella typhimurium strains.

Dr. Wu X, the lead author said, "Trigonelline and amino acids are natural components in green coffee beans. Model systems mimicking coffee roasting were used to produce heated samples of trigonelline, amino acids and glucose".

Contractively, according to the coffee producing company, Nestlé Research Center, coffee intake have shown a strong effect in induced enzymes involved in xenobiotic detoxification processes and primary hepatocytes. 

In animal study, the experiment also found that coffee induce the mRNA and protein expression of enzymes involved in promotion of cellular antioxidant defenses.

More importantly, coffee also exhibited chemoprotective effects of against toxic Aflatoxin B1 in duced genotoxicity in either human liver cell line and primary hepatocytes.

Taking altogether,  coffee and coffee showed conflict results in inhibited and exhibited mutagenesis, but epidemiological studies agreed that coffee decreased risk of genetoxicity against many chronic illness through regulating AFB1-DNA and protein.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Potential genotoxic, mutagenic and antimutagenic effects of coffee: a review by Nehlig A1, Debry G.(PubMed)
(2) Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee? by Wu X1, Skog K, Jägerstad M.(PubMed)
(3) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)

Food Therapy: Light and Moderate Coffee Intake in Attenuated Risk of Suicide

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of data from 36,689 adult (age range 25-64 years) men and women, participated in the population surveys between 1972 and 1992 yielded 169 suicides.in a mean of 14.4 years, researchers found that
1. In compared to no heavy user, heavy user of coffee showed a relative ratio of 1.55
2. The adjusted relative risk of suicide increased substantially in heavy coffee user if combined to increasing level of joint heavy use of alcohol and cigarettes.

In other words, heavy coffee intake of participants showed a significant increased risk of suicide if accompanied with heavy use of alcohol and cigarettes.

Dr. Tanskanen A, the led author said, " Clustering of the heavy use of ........coffee could serve as a new marker for increased risk of suicide".

To further support the differentiation of heavy coffee use in increased risk suicide, researchers at the
Center for Health Sciences, SRI International conducted a study of a multivariate structural equation modeling in a large cohort of male twins (N = 2,220 monozygotic and 2,373 dizygotic twin pairs; mean age = 62.1 years) from the National Academy of Sciences-National Research Council's World War II Twin Registry, strongly agreed that although genetic and environmental factors may account for the independent cluster risks, heavy coffee user displayed a enormous risk of suicide.

Other, in a 10-year follow-up study (1980 to 1990) in an ongoing cohort of 86 626 US female registered nurses aged 34 to 59 years in 1980, with free of diagnosed coronary heart disease, stroke, or cancer and Information on coffee and caffeine intake collected by a semiquantitative food frequency questionnaire in 1980, researchers filed the following reports
1. There was 56 cases of suicide occurred during 832 704 person-years.
2. In compared to non drinker, coffee drinkers expressed a relative odd risk ratio of 0.34 women who consumed two to three cups per day
3. For women consumed four or more cups per day, the relative suicide risk was .42
4. After adjusting to other risk factors, the relative odd ratio remain constant

The finding showed a importantly correlated association of light and moderate coffee intake in reduced risk of suicide.
The efficacy in ameliorated risk of suicide among these women may be attributed to coffee activity in reduced incidence of depression as seen in other studies.

Taking altogether, There is no doubt that regular light and moderate coffee intake daily have a strong effect in reduced suicide risk excluding heavy coffee users in exhibited a opposite outcome

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Joint heavy use of alcohol, cigarettes and coffee and the risk of suicide by Tanskanen A1, Tuomilehto J, Viinamäki H, Vartiainen E, Lehtonen J, Puska P.(PubMed)
(2) A prospective study of coffee drinking and suicide in women by Kawachi I1, Willett WC, Colditz GA, Stampfer MJ, Speizer FE.(PubMed)
(3) Heavy consumption of cigarettes, alcohol and coffee in male twins by Swan GE1, Carmelli D, Cardon LR.(PubMed)

Food Therapy: Dried Peas In Reduced Risk and Treatment of Hyperlipidemia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Epidemiological studies suggested that intake of dried peas fiber daily and regularly may have a significant effect in reduced risk of hyperlipidemia.

Dried peas is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae processed healthy source of proteins, fibers, vitamins and minerals.

Hyperlipidemia is a condition chareacterized by high levels of cholesterol in the blood stream.

In a study of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomizedly assigned to a high-fibre bean-rich diet that achieved mean (SD) fibre intakes of 35.5 (18.6) g day for women and 42.5 (30.3) g day for men, or a low-carbohydrate diet, researchers found that
1. High bean fiber intake showed a better weight loss and weight control in compared to low carbohydrate diet group.
2. Intake of bean fiber group expressed a significant decreased of Low-density lipoprotein (LDL)-cholesterol and total cholesterol levels in compared to other group.

Dr. Tonstad S, the led author said, "A high-fibre bean-rich diet was as effective as a low-carbohydrate diet for weight loss, although only the bean-rich diet lowered atherogenic lipids".

Additionally, in dyslipidemia rats study to evaluate the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding by randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group, researchers after adjusting to other risk factors filed the following results
1. Rats in hyperlipidemic model group showed a increased total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) in compared to groups
2. In compared to hyperlipidemic model group, grain-bean package group, grain-bean package DF group, expressed significantly decreased total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose and significantly increased HDL-C levels.

The results of these findings demonstrated that dietary fiber can improve blood lipids levels indyslipidemic subject, decrease FAS activity and regulating SREBP-1c mRNA in glucose metabolic expression.

Dr. Ullrich IH. in the review literature of a high-fiber diet in hyperlipidemia suggested that fiber from sources such as bean and karaya, have a strong effect in decreased total cholesterol due primarily to a decrease in the low-density lipoprotein cholesterol fraction and adding large amounts of sucrose into fiber may offer some protection against an increase in cholesterol and triglyceride levels as both normal and elevated triglyceride levels appear to be more resistant to change with dietary fiber.

Taking altogether, just like other bean fiber, intake of dried bean fiber may have a profound effect in reduced risk and treatment of hyperlipidemia, one of major cause of heart disease and stroke.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(2) [Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].[Article in Chinese] by Liu Y, Zhai C, Sun G, Zhang H, Jiang M, Zhang H, Guo J, Lan X.(PubMed)
(3) Evaluation of a high-fiber diet in hyperlipidemia: a review by Ullrich IH.(PubMed)

Food Therapy: Coffee, Moderate Consumption Is Associated to Reduced Risk of Gestational Diabetes

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.
Coffee consumption was not only associated with a decreased risk of type 2 diabetes in healthy people, but also showed a strong effect in ameliorated diabetic risk during pregnancy, a renowned institute study suggested.

Gestational diabetes mellitus (GDM) is an exhibition of  abnormal high blood glucose during pregnancy.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a prospective study of 1744 non-diabetic pregnant women questioned during early gestation about their coffee consumption, researchers found that according to returned report, moderate coffee intake per day exerts a significant decreased risk  of Gestational Diabetes Mellitus in expected mothers in compared to non coffee intake pregnant women.

Dr. Adeney KL, the lead author said, "Moderate pre-pregnancy caffeinated coffee consumption may have a protective association with GDM".

Also, in the study of first trimester coffee and tea consumption and risk of gestational diabetes mellitus (GDM) on-diabetic women with singleton pregnancies in the Danish National Birth Cohort (n = 71,239), researchers showed that pregnant women with coffee heavy consumption showed a substantial high percentage(81.2%) of complication of GDM, in compared to only 1.5% in non drinkers.

Importantly, the incidence of GDM of this study was highest in pregnant women who drink more than 8 cups of coffee/day but without significant difference across intake in other levels.

With collective information from above study, it is safe to say, moderate coffee drinking in first trimester may have a protective effect in reduced risk of  GDM but increased risk of complication in diabetic expected mothers who drank over 8 cups of coffee per day.

The examine of the protective effect of coffee in pregnancy women, researchers performed a study included 168 pregnant women aged 18-40 years, recruited at routine 20-week ultrasound with all participants kept a 4-day weighed food record following recruitment (commencement: gestational weeks 19-24), a prudent dietary pattern including moderated coffee intake accompanied with seafood; eggs; vegetables; fruits and berries; vegetable oils; nuts and seeds; pasta; breakfast cereals; and coffee, tea and cocoa powder is associated to reduced risk of GDM in pregnancy.

The findings evidences suggested that moderated coffee consumption  with less than 8 cups/day expressed a protective effect against GDM and GDM complications.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Coffee consumption and the risk of gestational diabetes mellitus by Adeney KL1, Williams MA, Schiff MA, Qiu C, Sorensen TK.(PubMed)
(2) First trimester coffee and tea intake and risk of gestational diabetes mellitus: a study within a national birth cohort by Hinkle SN1, Laughon SK, Catov JM, Olsen J, Bech BH.(PubMed)

Food Therapy: Coffee Intake for Longevity

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer in easing symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, second to tea consumption, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee may have a profound effect in strengthen the telomere length, a biomarker of living longer, a renowned study suggested.

In a cross-sectional association between coffee consumption and telomere length in 4780 women , using the data from the Nurses' Health Study (NHS) from a prospective cohort study of female nurses began in 1976 with relative telomere length measured in peripheral blood leukocytes by the quantitative real-time polymerase chain reaction, after adjusting to other risk factors, researchers found that
1. Higher total coffee use were significantly associated with longer telomeres in compared to non drinkers
2. Intake of 2 to <3 and ≥3 cups of coffee/d showed a relative ratio of 1.29 and 1.36, respectively
3. Telomere length was associated linearly to caffeine consumption from all dietary sources

The result of findings, showed a strong indication of correlation between coffee caffeine intake and the length of telomeres among female nurses.

Dr. Liu JJ, the led author said, " ... better understand the influence of coffee consumption on telomeres, which may uncover new knowledge of how coffeeconsumption affects health and longevity".

Other, in a study of total of 5826 adults from the National Health and Nutrition Examination Survey (NHANES) cross-sectionally, using the quantitative polymerase chain reaction method, telomere length compared to standard reference DNA, after adjusting to other risk factors, including age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use,.. researchers showed that
1. Caffeine consumption was inversely related to telomere length
2. For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter
3. For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter
4. Among non-coffee drinkers only, 40.0 base pairs shorter

In compared to non drinker(40.0 base pairs shorter), coffee caffeine( 36.7 base pairs shorter) and caffeine( 35.4 base pairs shorter) intake expressed a positive effect in increased genetic telomeres length.

Taking altogether, coffee (regardless caffeinated or not and numbers of cups intake per day) expressed a significant effect in increased telomeres length, the DNA implication of living longer in both gender.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee Consumption Is Positively Associated with Longer Leukocyte Telomere Length in the Nurses' Health Study by Liu JJ1, Crous-Bou M2, Giovannucci E3, De Vivo I4.(PubMed)
(2) Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES) by Tucker LA1.(PubMed)

Food Therapy: Coffee In Risk of Kidney Stone?

By Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes. In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.
Epidemiological studies linking coffee and caffeine intake in risk of kidney stone formation have been contradictory.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Kidney stone is a deposit of insoluble calcium compounds in the kidney, affecting over 10% of world population, according to statistic.

According to the Warsaw Agricultural University, coffee and tea consumed daily and regularly expressed an increased risk of kidney stone by more than 80% in compared to risk of other factors, probably due to presence of oxalates found in coffee.

In fact, in the analyzed nutritional habits of 22 stone formers with special regard to oxalate content as one of the main nutritional lithogenic factors associated with kidney stones, researchers found that  risk of kidney stone increased substantially for men and women if dietary oxalate intake was over 354 mg and 406 mg, respectively

Contrastively, a prospective study in investigated relation between intake of 21 different beverages and risk of symptomatic kidney stones in a cohort of 45,289 men, 40-75 years of age conducted by the Harvard School of Public Health, suggested that the risk of stone formation decreased by 10%. of the amount for each 240-ml (8-oz) serving consumed daily in caffeinated coffee.

Other, in the analyzed association between intake of caffeine and incidence of kidney stones in 3 large ongoing cohort studies, and the Nurses' Health Studies (NHS) I and II also found a contradictory result in related to coffee and other plant base caffeine products.

In a total of 217,883 participants; over a median follow-up of >8 y, 4982 incident cases of kidney stone occurred studies, researchers files the following results.
1. The highest quintile of caffeine intake (95% CI: 12%, 38%) showed a significant reduced risk of developing stones by 26%, according to the Health Professionals Follow-Up Study (HPFS).
2. Caffeine inkate showed a 29 % lower risk in the NHS I cohort, and
3. and 31% lower risk in the NHS II cohort

Dr. the lead author said. "Among 6033 participants with 24-h urine data, the intake of caffeine was associated with higher urine volume, calcium, and potassium and with lower urine oxalate and supersaturation for calcium oxalate and uric acid".

Taking altogether, the findings demonstrated a contradictory result between caffeine and caffeinated and decaffeinated coffee intake and risk of formation of kidney stones, therefore, a cohost with large sample size study are warranted.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Tea and coffee as the main sources of oxalate in diets of patients with kidney oxalate stones by Gasińska A1, Gajewska D.(PubMed)
(2) Caffeine intake and the risk of kidney stones by Ferraro PM1, Taylor EN1, Gambaro G1, Curhan GC1.(PubMed)
(3) Prospective study of beverage use and the risk of kidney stones by Curhan GC1, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ.(PubMed)

Food Therapy: Green Coffee, The Best to Against Risk and Treatment of Obesity

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Green coffee intake may have a profound effect in reduced risk and treatment of obesity, a renowned institute study suggested.

According to the joint study led by the Huanggang Normal University, the health benefits of coffee studies over last 10 years, expressed a significant improvement of risk and treatment of obesity in decreased lipid accumulation in cells through regulating the cell cycle during fat metabolism.

Additionally, coffee consumption induced changes in transcription factors in fat deposit, decreased body weight and visceral fat form of animal and humans studies

Furthermore,  coffee influenced gut microbiota in obese animals and humans also played an important role for used as a functional and integrated food in reduced risk and treatment of obesity.

Other in the study of obesity induced in mice using a HFD for four weeks, fed only HFD or HFD with GCBE at 50, 100, and 200 mg/kg suggested that
1.Mice treated with green coffee intake showed a significantly decreased body weight gain, liver weight and white adipose tissue weights with regulation of adipose tissue lipolysis hormones, such as adiponectin and leptin.
2. Mice treated with green coffee intake also demonstrated a decreased mRNA expression levels of adipogenesis and adipocyte metabolis  related genes in adipose tissues and the liver, and decreased the corresponding protein expression.
3. GCBE treated mice had a lower fat mass with decreased relative body weight and fat mass in compared to HFD alone fed mice.

According to the information collected, Dr. Choi BK, the led author said, "GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver".

More importantly, in the study of male ddy mice fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 day, researchers at the Oryza Oil & Fat Chemical Co,, Ltd, indicated that
1. GCBE with  0.5% and 1% reduced visceral fat content and body weight
2. Caffeine and chlorogenic acid showed a tendency to reduce visceral fat and body weight
3. Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days showed a tendency to reduce hepatic TG in mice
4. Chlorogenic acid (60 mg/kg. day) reduced hepatic TG level

The findings displayed a strong effect of coffee and its phytochemicals in reduced weight gain and fat accumulation by inhibition of fat absorption and activation of fat metabolism in the liver may be considered as a functional and integrated food  against risk and treatment of obesity

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice by Shimoda H1, Seki E, Aitani M.(PubMed)