Food Therapy: Intake of Raw and Incompletely Cooked Kidney Bean May Induce Toxicity

By Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Hemagglutinating lectin, a main component isolated from several varieties of kidney bean (Phaseolus vulgaris) may induce toxicity, affecting abnormal development of microvilli of tiny hairlike folds in the plasma membrane of the small intestine, a respectable institute study suggested.

In South Africa, dried red kidney beans are prohibited for cultivation or consumption because of the potential toxicity to humans. However, the toxicity levels of hemagglutinating lectins activity in uncooked and incompletely cooked kidney bean is not higher in compared to the other bean varieties sold in the regions.

Researchers, in the compared toxicity of uncooked red kidney bean and other dried bean found that toxic potentials and health risks associated with red kidney beans are similar to those of other dry beans already commercially available to South Africans. Therefore, red kidney should have a commercial preference as of other beans.

Kidney bean is popular food, with  kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of its enormous health benefits with a good source of protein and minerals.

According to the recent advanced study, intake of raw kidney bean may cause lectin-induced disruption of intestinal in interference with the intermediate and final stages of nutrient break down in the gut.

Dr.Pusztai A, the lead author said, "In nitrogen balance studies it was found that rats ingesting pure bean lectins were in negative nitrogen balance" and "These nitrogen losses may have been partly the result of systemic effects, possibly caused by a selective uptake of lectins by the gut".

The poorly digested chemical compound actually disrupted borders cells and intestinal absorptive cells of duodenum.

Taking together, regardless to levels of toxicity of bean varieties, epidemiological studies agreed that consumption of fully cooked kidney bean provides many nutrients with numerous health benefits. but kidney beans should not be eaten as raw.

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Impact In Rice, Pasta, And Potatoes In Half  

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Author Biogrphy
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The nutritional toxicity of Phaseolus vulgaris lectins by Pusztai A, Clarke EM, King TP.(PubMed)
(2) Recent advances in the study of the nutritional toxicity of kidney bean (Phaseolusvulgaris) lectins in rats by Pusztai A, King TP, Clarke EM.(PubMed)
(3) Red kidney beans--to eat or not to eat? by Venter FS1, Thiel PG.(PubMed)

Food Therapy: Black Bean, The Best in Reduced Risk and Treatment of Liver Fibrosis Naturally

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black or common bean may be a potential function foods used for reduced risk and treatment of liver

fibrosis, a research institute supposed.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Liver fibrosis is a condition of excessive accumulation of extracellular collagen caused by abnormal liver response to injure.

According to the Tecnológico de Monterrey, School of Medicine, Basic Research Laboratory, oral administrated black bean extraxt exerted a significantly decreased type I and type IV collagen gene expression.

In an eight weeks of carbon tetrachloride (CCl4)induced liver injury in rat model, black bean extract of 70 mg/kg treatment showed a reduced hepatic fibrosis index by 18% compared to positive controls.

The study also indicated that the efficacy of black bean extract in ameliorated risk of liver fibrosis due to injure may be attributed to legume strong antifibrotic compounds in treatment of diseases with increase in inflammation and oxidative burst in their pathogenesis, including liver fibrosis.

Furthermore in the application of 0.1 g of crude biomass obtained from seed coats of Perla black bean dissolved in 400 mL of H2 O, and 100 g of NaCl added in liver injure mice model, back bean treatment group expressed evidence of improvement of pathological changes, including interstitial fibrosis, inflammatory infiltration, collagen deposition and steatosis in compared to normal group.

Histological analysis showed that the test group presented a significant reduction of collagen deposition of which exhibited a reduced risk of developed liver scaring in the recover phase.

The study also insisted that antioxidant effect against liver intoxication, a widely use laboratory application in induced lipid peroxidation and trichloromethyl radical (CCl3 ), to cause severe liver cell damage in animal model, may represent a new perspective in liver injury and fibrosis prevention, the researcher concluded.

Taking together, black bean, contains various phytochemicals, such as naringenin, Nacetylcysteine, vitamin E, sylimarin, quercetin in exhibited antioxidant activity, may be considered as a integrated form of diet therapy for reduced risk and treatment of liver fibrosis.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury by López-Reyes AG1, Arroyo-Curras N, Cano BG, Lara-Díaz VJ, Guajardo-Salinas GE, Islas JF, Morales-Oyarvide V, Morales-Garza LA, Galvez-Gastelum FJ, Grijalva G, Moreno-Cuevas JE.(PubMed)(Annals of Hepatology)

Food Therapy: Kidney(Common) Bean, The Whole Food in Reduced Risk and Treatment of Colon Cancer

By Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Intake of thoroughly cooked  kidney bean may reduce risk and inhibit the progression of colon cancer, the recent study suggested.

Kidney bean is popular food, with  kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Colon cancer is a condition of the abnormal proliferation of cells in the colon.

According to the Hannam University Daedeok Valley Campus, Korean kidney bean husk extract, ameliorated risk of colon cancer through the ability in control the messenger initiated chemical reactions of intracellular signaling responsible for inducing antitumor activities in colon cancer cells.

The anti preoperative effect of the extract also exhibited the protein in resposible in inducing cell death by interfering phases of tumor cell cycle division.

Dr.Lee YK, the lead author in the study said, " the ability of carcinogenesis control by Korean kidney bean husk extract with high potency suggests its value as an antitumor agent in colon cancer therapy."

Further more, in the evaluated composition and chemopreventive effect of a polysaccharide extract (PE) from cooked common beans ( P. vulgaris L), including kidney bean, in Negro 8025 with azoxymethane (AOM) induced colon cancer, rats group fed with polysaccharide extract (PE) showed a significantly decreased clusters of abnormal tissues in the lining of the colon and rectum.

The study also insisted, the anti colon cancer activity can also be attributed to cell apoptostic expression and action of butyrate concentration found in the beans.

In support to the above differentiation, the Querétaro State University study concluded that the efficacy of common bean in treatment of colon cancer is a result of chemoprevention against aberrant crypt foci, clusters of abnormal tube-like glands in the lining of the colon and rectum through a combination of cell-cycle arrest in phase I and II.

Additionally, the study also suggested that through modulation of gene expression profiles in the colon tissue, non-digestible fraction (NDF) of cooked bean (cultivar Bayo Madero) may contribute to the chemoprotective effect on early-stage colon cancer.

Taking together, intake of kidney bean regularly may have a potential effect in reduced risk and treatment of early stage of colon cancer.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway by Lee YK1, Hwang JT, Lee MS, Kim YM, Park OJ.(PubMed)
(2) Composition and chemopreventive effect of polysaccharides from common beans(Phaseolus vulgaris L.) on azoxymethane-induced colon cancer by Feregrino-Pérez AA1, Berumen LC, García-Alcocer G, Guevara-Gonzalez RG, Ramos-Gomez M, Reynoso-Camacho R, Acosta-Gallegos JA, Loarca-Piña G.(PubMed)
(3) Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats by Haydé VC1, Ramón GG, Lorenzo GO, Dave OB, Rosalía RC, Paul W, Guadalupe LP.(PubMed)

Food Therapy: Kidney Bean, The Best Natural Weight Loss Functional Food

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Kidney bean, one of the functional food and its supplement may have a profound effect on weight loss to benefit people of overweight and obese, the recent study suggested.

Kidney bean is popular because of its kidney shape, strong flavor and color that is reddish brown in nature, genus Phaseolus, belonging to the family Fabaceae. The bean is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the Medicus Research LLC, Food with a low glycemic index such as kidney bean  consisted the ability to cause weight loss with doses of 500 to 3000 mg per day, in either a single dose or in divided doses in oral administration.

Dr. Barrett ML, the lead author said, "Experiments conducted incorporating Phase 2 into food(including kidney bean) and beverage products have found that it can be integrated into various products without losing activity or altering the appearance, texture or taste of the food" and " ...has the potential to induce weight loss and reduce spikes in blood sugar caused by carbohydrates through its alpha-amylase inhibiting activity".

Other studies showed that extracts of kidney beans (Phaseolus vulgaris)suppress appetite to induce weight loss in animal and human. The efficacy of the extract induced weight loss of obese subjects may be depended to doses intake without promoting toxicity.

The efficacy of weight loss effects is attributed to function of kidney beans in inhibition of protein enzymes in breaking down the bond in long starch or glycogen molecules, interfering hormone in regulation of release stored bile into the intestine and the central mechanism(s) in regulating appetite, food intake, and food palatability.

In animal study, standardized extracts of P. vulgaris and C. scolymus and their combination, expressed a significant control of appetite, food intake, and postprandial glycemia.

With all information collected, one can believe that Kidney Bean and Kidney Bean supplement may represent a successful example of translational research in the nutraceutical field for production of commercial benefit weight loss products.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control by Barrett ML1, Udani JK.(PubMed)
(2) Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats by Fantini N1, Cabras C, Lobina C, Colombo G, Gessa GL, Riva A, Donzelli F, Morazzoni P, Bombardelli E, Carai MA.(PubMed)
(3) Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats by Loi B1, Fantini N, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P, Carai MA.(PubMed)

Food Therapy: Black Bean In Reduced Risk of CVD and Diabetes in Metabolic Syndrome Adults

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of black bean and other common bean may associate to ameliorated risk of metabolic syndrome induced type 2 diabetes and cardiovascular disease, a joint study of renowned institutes suggested.

Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes.
Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

In a pilot study consisted 12 men and women with metabolic syndrome randomly assigned to eat three standard meals in a crossover design on three different occasions that contained either no added fiber (control (NF)), extrinsic or added fiber (AF), or whole black beans as the source of intrinsic fiber (BN). 5 hours after meal intake, black bean injection group showed a remarkable improvement of blood glucose, insulin, cholecystokinin (CCK) and the GI hormones in compared to other groups.

Unfortunately, even with such results, black bean meal was not the meal of choice of tested adult in compared to NF meal which tended to result in more satisfaction.

Dr. Reverri EJ, the lead author said, "incorporating whole blackbeans into a meal has acute beneficial metabolic and GI hormone responses in adults with metabolic syndrome and are preferred over adding equivalent amounts of fiber from a supplement."

Other, in the study of 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions with included blood collection before (fasting) and five hours postprandially, black beam intake group showed an improvement of insulin resistance, antioxidant capacity, oxLDL and inhibited pro inflammatory expression against risk factor of metabolic syndrome in increased risk of diabetes and cardiovascular disease.

The study also suggested black bean group according to observed plasma antioxidant capacity may be less at beginning in compared to AM group, but at the end point, BB group showed a significant antioxidant levels in compared to other 2 groups.

The finding evidences suggested that black bean may be considered as a therapeutic functional food in reduced risk of metabolic syndrome which is an early indicator of onset of diabetes and cardiovascular disease.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Assessing beans as a source of intrinsic fiber on satiety in men and women with metabolicsyndrome by Reverri EJ1, Randolph JM2, Kappagoda CT3, Park E4, Edirisinghe I5, Burton-Freeman BM6.(PubMed)
(2) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,7.(PubMed)

Food Therapy: Coffee and Coffee Caffeine In Reduced Risk and Management of Obesity

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, second to green tea is popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Obesity is a medical condition of excess body fat accumulated overtime. According to the Body Mass Index(BMI),  a BMI of over 30 is an indication of obesity.

Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.

According to the joint study lead by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factors expression

According to animal studies.

In human, it is the result from decreased body weight and visceral fat stored within the abdominal cavity.

Further more, the study also expressed the important of coffee intake in influence the gut microbiota in obese animals and humans.

Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. GCBE treated group showed a significantly decreased body weight gain, liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.
2. The efficacy of treatment group in reduced obesity risk may also benefit to the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.
3. In compared to other treated group, GCBE treated mice displayed a lower fat mass and relative body weight and decreased fat mass.

More importantly, in the review of papers from in vivo, ex vivo, in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study lead by the South University School of Pharmacy said, " there are mounting evidences of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".

Taking altogether, there is no doubt that coffee and coffee caffeine have a significant and potential effect in reduced risk and management of obesity, through various active biochemicals in dose deepening manner.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Coffee consumption, obesity and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)

Herbal Therapy: Andrographis in Reduced Risk and Treatment of Leukemia

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

A renowned institute study suggested that andrographolide, a major compound isolated from andrographis may consist a potentially therapeutic effects in reduced risk and controlling the progression of leukemia.

Leukemia is condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

According to the joint study lead by the Jining No 1 People's Hospital, andrographolide (Andro) showed to possess antitumor activities against T-cell acute lymphoblastic leukemia (T-ALL) through induced cytotoxicity in tumor and cell apoptosis.

10 μg/mL Andro could significantly induce tumor cells' death, depending on the inhibition of PI3K/AKT pathway in regulating the cell cycle and increased expression of cancer cell apoptosis.

Flavonoid, chemical compounds isolated from the aerial parts of Andrographis paniculata also exhibited antiproliferative effects against human leukaemia HL-60 cells with with IC50 of 3.50 μM.

Furthermore, the study in the evaluation of the potential effect of andrographolide against three acute promyelocytic leukaemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2,  andrographolide was 2- and 3-fold more active in inhibiting the growth of HL-60 and NB4-R2 cells compared with NB4 cells, through cell differentiating activity via a retinoic acid receptor-independent pathway.

In fact, according to Dr. Manikam SD, the lead researcher, andrographolide and its derivatives, apparently demonstrated a novel cell differentiating mechanism with ability to induce apoptosis.

There is no doubt that Andrographis with a novel mechanism of drug action may be a new candidated therapy for reduced risk and treatment of Leukemia, but large amount intake should be taken with care.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemiaJurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways by Yang T, Yao S, Zhang X, Guo Y.(PubMed)
(2) A new flavonoid from the aerial parts of Andrographis paniculata by Chen LX1, He H, Xia GY, Zhou KL, Qiu F.(PubMed)
(3) Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis by Manikam SD1, Stanslas J.(PubMed)