Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - Coenzyme Q10

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),

4. Coenzyme Q10
CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy number, decreased oxidative stress, and increased mitochondrial biogenesis. The results suggest that CoQ10 could be an alternative therapeutic approach for FM(189). According to the University of SevillaSevilla, CoQ10 inhibited depressive symptoms in fibromyalgia through regulation of serotonin levels(190).
Oral supplementation showed an improvement in clinical symptoms and restored salivary cells (SCs) and mononuclear blood cells (BMCs) levels, in a study of 10 patients with intaking of supplemented daily with 300 mg of CoQ(10) during 3 months(191).

Dr. Alcocer-Gómez E and colleagues at the University of Seville said, " After treatment, all patients showed an important improvement in clinical symptoms in all evaluation methods. According to our results, and evaluated by three methods, patients with FM are candidates for treatment with CoQ10"(192).

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and restore your health naturally with Chinese diet

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References

(189) Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient by Cordero MD1, Cotán D, del-Pozo-Martín Y, Carrión AM, de Miguel M, Bullón P, Sánchez-Alcazar JA.(PubMed)

(190) Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial by Alcocer-Gómez E1, Sánchez-Alcázar JA, Cordero MD.(PubMed)

(191) Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment by Cordero MD1, Santos-García R, Bermejo-Jover D, Sánchez-Domínguez B, Jaramillo-Santos MR, Bullón P.(PubMed)

(192) Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review by Alcocer-Gómez E1, Cano-García FJ, Cordero MD.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - Methylsulfonylmethane

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),

3. Methylsulfonylmethane
Methylsulfonylmethane, also known DMSO2 is an organosulfur compound with the formula (CH3)2SO2 showed to exhibit anti inflammatory effects in attenuated production of mitochondrial reactive oxygen species (ROS)(185).
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(186)(187).
According to the joint study led by the Kangwon National University, Methylsulfonylmethane (MSM) inhibited expression of NLRP3(plays a crucial role in innate immunity and inflammation) in attenuated production of mitochondrial reactive oxygen species (ROS) and pro inflammatory cytokines such as IL-1α, IL-1β, IL-6(188).
In support of the use of sulfur organic compound of Methylsulfonylmethane as clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS, Dr. Parcell S said, " Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, DMSO, and glucosamine sulfate. ......MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders"(181).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(185) Methylsulfonylmethane inhibits NLRP3 inflammasome activation by Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.(PubMed)

(186) Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. by Kim LS1, Axelrod LJ, Howard P, Buratovich N, Waters RF.(PubMed)

(187) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study by Debbi EM1, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.(PubMed)

(188) Methylsulfonylmethane inhibits NLRP3 inflammasome activation by Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - DLPA (dl- phenylalanine)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),

2. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid. Taltirelin, a thyrotropin-releasing hormone analog, showed effectively to relieve inflammatory persistent pain through iots antiallodynic action(182).
Dr. Bai Y and colleagues at the China Medical University, 4-Chloro-DL-phenylalanine, a derivative of DLPA inhibited metalloproteinase (TIMP)-1 and TIMP-2 in in response to many cytokines and hormones , including inflammatory cytokines in reduced pulmonary vascular remodeling and lunginflammatio(183).
Dr. Ehrenpreis S. in the study of D-phenylalanine and other enkephalinase inhibitors, said, "
D-phenylalanine, is also anti-inflammatory. D-phenylalanine has proven to be beneficial in many human patients with chronic, intractable pain" and "... may alleviate other conditions associated with decreased endorphin levels such as opiate withdrawal symptoms"(184).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(181) Sulfur in human nutrition and applications in medicine by Parcell S1.(PubMed)

(182) Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain by Eto K1, Kim SK, Nabekura J, Ishibashi H.(PubMed)

(183) 4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lunginflammation by Bai Y1, Wang HM1, Liu M1, Wang Y1, Lian GC1, Zhang XH1, Kang J2, Wang HL1.(PubMed)

(184) D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application by Ehrenpreis S.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - Glucosamine and chondroitin

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),
1. Glucosamine and chondroitin
Glucosamine used for treatment of osteoporosis and prevent the degenerative collagen, has been found to consist anti-inflammatory properties through reduction of the expression of proinflammatory cytokines such as C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6(177). The supplement also exhibited a significant reduction in pain intensity at movement and resting state, according to a Russian study(178).
Dr. Fishman SM suggested, administration of Glucosamine and chondroitin may be used for management of pain in patients of Fibromyalgia(179). In a total of 71.4% women, and 65.0% with annual incomes of less than 25,000 dollars.researchers at the University of New Mexico Health Sciences Center indicated a higher percentage use of alternative medicine including oral supplement glucosamine and chondroitin for treatment with with osteoarthritis, rheumatoid arthritis, or fibromyalgia(180). Furthermore, the study also showed that use of alternative medicine was significantly associated with female, under 55 years of age, and having some college education(180).
Dr. Parcell S said, " ...sulfur compounds such as SAMe, dimethylsulfoxide (DMSO), taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia,....."(181).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(176) Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity by Geronikaki AA1, Gavalas AM.(PubMed)

(177) Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation by Kantor ED1, Lampe JW, Navarro SL, Song X, Milne GL, White E.(PubMed)

(178) [A role of melatonin in the treatment of low back pain].[Article in Russian] by Kurganova YM, Danilov AB.(PubMed)

(179) Carpal tunnel syndrome, diabetic neuropathy, fibromyalgia, glucosamine and chondroitin, hypnosis in pain management, marijuana for pain by Fishman SM1.(PubMed)

(180) Use of complementary therapies among primary care clinic patients with arthritis by Herman CJ1, Allen P, Hunt WC, Prasad A, Brady TJ.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Free Radical scavengers - Vitamin E

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

                            The Free Radical scavengers

4. Vitamin E
According to Dr. Moriguchi S and Dr. Muraga M., vitamin E plays an essential role in enhanced immunity especially in cellular immunity with aging(171). Deficiency of vitamin E is found to induces the decreased differentiation of immature T cells associated to the increased infectious diseases and the incidence of tumors(171). According to the Suleyman Demirel University, intake of vitamins C and E (VCE) supplementation with exercise (EX) enhanced antioxidant vitamin and lipid peroxidation (LP) levels in blood of patients with fibromyalgia (FM)in protection of against FM-induced by oxidative stress(172).
Dr. Altindag O and Dr. Celik H. said, " patients with fibromyalgia are exposed to oxidative stress and this increased oxidative stress may play a role in the etiopathogenesis of the disease. Supplementation of antioxidant vitamins such as vitamins C and E to the therapy may be indicated"(173).

In support to the above analysis, Dr. Bagis S and colleagues at the Mersin University Medical School insisted, change of oxidant/antioxidant balances induced increase of free radical levels may be responsible for the development of fibromyalgia(174).
In fact, dietary consumption including vitamin E significantly reduced the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(175).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(171) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)

(172) Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients withfibromyalgia: a controlled clinical pilot study by Nazıroğlu M1, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA.(PubMed)

(173) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia by Altindag O1, Celik H.(PubMed)

(174) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? by Bagis S1, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C.(PubMed)

(175) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Free Radical scavengers - Vitamin D

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

                            The Free Radical scavengers
3. Vitamin D
Deficiency of vitamin D is found to associate to nonspecific musculoskeletal pain. According to Maccabi Healthcare Services, improvement of levels of 25OHD reduced Polymyalgia pain induced by the use of statins(167). According to the Spine Unit, Center of Excellence for Orthopaedic Pain Management, oral administration of vitamin D reduced remarkably in pain of patient with FM in visual analog scale scores(168).
Dr. Matthana MH said, "Vitamin D deficiency has to be considered in the management of fibromyalgia syndrome" as "Among the 100 fibromyalgia women, there were 61 women with 25(OH) D deficiency; with vitamin D supplementation, only 42 women showed a significant improvement when their blood level of 25(OH) D became>or=30 ng/mL, this improvement became more significant when their blood level of 25(OH) D exceeded 50 ng/ mL"(169).

In support to the above diagnosis, evaluation of Saudi Arabia women, also showed a significant negative correlation between vitamin D level and widespread pain index(170).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(167) Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins by Kurnik D1, Hochman I, Vesterman-Landes J, Kenig T, Katzir I, Lomnicky Y, Halkin H, Loebstein R.(PubMed)

(168) Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial by Wepner F1, Scheuer R2, Schuetz-Wieser B2, Machacek P2, Pieler-Bruha E2, Cross HS3, Hahne J2, Friedrich M2.(PubMed)

(169) The relation between vitamin D deficiency and fibromyalgia syndrome in women by Matthana MH1.(PubMed)

(170) Vitamin D deficiency in women with fibromyalgia in Saudi Arabia by Abokrysha NT1.(PubMed)

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Phytochemicals: Cucurbitacins

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                       The Phytochemicals

5. Cucurbitacins
Cucurbitacins found in the common pumpkins and gourds has found to process anti-inflammatory and analgesic activity in redued pain through inhibition of the neurogenic (first phase) and inflammatory phase (second phase) of formalin-induced pain(147). The phytochemical also inhibited pain caused by chronic rheumatic disease through anti pro inflammayory cytokine activity(148).
In neuro injure response, cucurbitacins displayed anti nitric oxide, prostaglandins and inflammatory cytokines, activation of complement proteins inducing neuro damage through activation of the neuroprotection of Nrf2/ARE pathway(149).

In chronic inflammatory model, cucurbitacin R, a derivative of Cucurbitacins, reduced over expression of proinflammatory enzymes, through reducetion of all mediators, such as prostaglandin E(2), nitric oxide, and TNF-alpha production in RAW 264.7 macrophages, as well as that for TNF-alpha in human lymphocytes(150).Dr. Yuan G and professors at the Zhejiang University said, "Natural products(including cucurbitacins) play a significant role in human health in relation to the prevention and treatment of inflammatory conditions"(151).

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References

(147) Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata by Peters RR1, Farias MR, Ribeiro-do-Valle RM.(PubMed)
(148) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of thecucurbitacins fraction from Wilbrandia ebracteata by Peters RR1, Baier Krepsky P, Siqueira-Junior J, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M,Castro da Rocha FA, Ribeiro-do-Valle RM(PubMed)

(149) Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition by Park SY1, Kim YH1, Park G2.(PubMed)

(150) Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages by Escandell JM1, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.(PubMed)

(151) Natural products and anti-inflammatory activity. by Yuan G1, Wahlqvist ML, He G, Yang M, Li D.(PubMed)