Celery is a species of Apium graveolens, belonging to the family Apiaceae.
It is cultivated all around the globe as a vegetable. Celery can grow
to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape
joined at a common base.
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol
(2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5),
isofraxidin (6), eugenic acid (7), trans-ferulic acid (8),
trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10),
caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12),
sedanolide (13), lunularin (14), lunularic acid (15),
2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17),
beta-sitosterol (18), benzolic acid (19), succinic acid (20), according
to Shenyang Pharmaceutical University(a).
Celery and lung cancer
Lung cancer is defined as a condition of the abnormal growth of
the cells in the lung's tissue. Most common form of primary lung
cancers are derived from epithelial cells. In Us, Lung cancer is the
leading cause of cancer deaths, causing 158,683 people deaths,
including 88,329 men and 70,354 women, according to 2007 statistic.
The study of dietary intake of vegetables and fruit and lung cancer
risk in Harbin, Heilongjiang province, northeast China(b) and Tin
Corporation (YTC) miners in Yunnan(c), showed a positive effect of
intake of celery daily in reduced risk of lung cancer. According to Dr. Belanger JT. research, Perillyl alcohol, a monoterpene isolated from the essential oils of celery
seeds, exhibited the effect of inducing apoptosis in tumor cells
without affecting normal cells and reverting tumor cells back to a
differentiated state in very cancer cells, including lung cancer,
through increased mannose-6-phosphate/insulin-like growth factor II
receptors, tissue growth factor beta receptors, Bak and decreased ras
protein prenylation, ubiquinone synthesis, and induced Phase I and Phase
II detoxification systems(d).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Dietary intake of fruit and vegetable and lung cancer risk: a case-control study in Harbin, northeast China by Galeone C1, Negri E, Pelucchi C, La Vecchia C, Bosetti C, Hu J.(PubMed)
(c) [A cohort study on the relationship between vegetable intake and risks of lung cancer in the Tin Corporation (YTC) miners in Yunnan].[Article in Chinese] by Lu Q1, Yao S, Huang C, Lan Y, Cang S, Qiao Y, Wang R.(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
Tuesday 8 April 2014
Phytochemical allicin and Stomach cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced apoptosis and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
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References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced apoptosis and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
Monday 7 April 2014
Skin aging in Vitamin B5 points of view
By Kyle J. Norton
Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.
According to 1Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by 1Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reduced skin roughness and inflammation(6).
Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aging progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)
Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.
According to 1Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by 1Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reduced skin roughness and inflammation(6).
Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aging progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)
Phytochemical allicin and endometrium cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM) attributed to the ability of allicin to transiently deplete the intracellular GSH level(1). Other study also indicated that this main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems(2).
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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM) attributed to the ability of allicin to transiently deplete the intracellular GSH level(1). Other study also indicated that this main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems(2).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
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References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)
Food therapy - Celery and Alzheimer's disease
Celery is a species of Apium graveolens, belonging to the family Apiaceae.
It is cultivated all around the globe as a vegetable. Celery can grow
to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape
joined at a common base.
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
L-3-n-butylphthalide (L-NBP), containing in the extract from seeds of Apium graveolens Linn (Chinese celery) on cerebral ischemic, vascular dementia and amyloid-β (Aβ)-induced animal models, showed to inhibit oxidative injury, neuronal apoptosis and glial activation, regulating amyloid-β protein precursor (AβPP) processing and reducing Aβ generation(b), improved cognitive impairment such as learning and memory and reduces amyloid-beta in a transgenic model of Alzheimer's disease, through regulating APP(soluble amyloid precursor protein secretion) processing, and reducing glial activation and oxidative stress(c) and protected neurons against Abeta-induced neurotoxicity via inhibiting tau protein hyperphosphorylation(d).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
(c) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)
(d) l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells by Peng Y1, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X.(PubMed)
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.
L-3-n-butylphthalide (L-NBP), containing in the extract from seeds of Apium graveolens Linn (Chinese celery) on cerebral ischemic, vascular dementia and amyloid-β (Aβ)-induced animal models, showed to inhibit oxidative injury, neuronal apoptosis and glial activation, regulating amyloid-β protein precursor (AβPP) processing and reducing Aβ generation(b), improved cognitive impairment such as learning and memory and reduces amyloid-beta in a transgenic model of Alzheimer's disease, through regulating APP(soluble amyloid precursor protein secretion) processing, and reducing glial activation and oxidative stress(c) and protected neurons against Abeta-induced neurotoxicity via inhibiting tau protein hyperphosphorylation(d).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
(c) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)
(d) l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells by Peng Y1, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X.(PubMed)
Sunday 6 April 2014
Skin aging in Vitamin B3 points of view
Skin aging is one of most visible process which occurs
constantly in our skin organ. According to the Clinical Centre of Nis,
certain plant extracts may have the ability to scavenge free radicals,
to protect the skin matrix through the inhibition of enzymatic
degradation, or to promote collagen synthesis in the skin, affect skin
elasticity and tightness(a). Other suggested that free
radicals induced domino effects in production of reactive oxygen
species, can react with DNA, proteins, and fatty acids, causing
oxidative damage and impairment of antioxidant system, leading
injuries damage regulation pathways of skin, including wrinkles,
roughness, appearance of fine lines, lack of elasticity, and de- or
hyperpigmentation marks(b).
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.
Vitamin B3 may be effective to protect against skin-aging through its antioxidant activity(1)(2)(3) such as allowness, wrinkling, red blotchiness and hyperpigmented spots(3a)
In the comparison of the effect on aging skin among a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen, researchers showed that the composition significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks with well tolerate adverse effects(4). In facial hyperpigmentation, composition of topical niacinamide and N-acetyl reduced the appearance of irregular pigmentation including hypermelaninization(5) and niacinamide alone enhanced skin lightening, and hyperpigmented lesions(6) through inhibiting melanosome transfer from melanocytes to keratinocytes(7). A daily facial lotion application containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women, 30-60 years of age, for 10 weeks, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, and positive effects on skin texture, as early as 6 weeks(8). In Global gene expression skin aging process, compounds niacinamide and hexamidine, may effect the skin hydration, barrier, matrix, pigmentation through theirs' antioxidant capacity(9). According to Kinki University School of Medicine, application of composition containing 4% niacinamide in 30 healthy Japanese females who had wrinkles in the eye areas showed to reduced wrinkles through a marked and moderate improvement in 64% of the subjects with a significant difference as compared with the control site(10) and niacinamide alone exhibited a significant reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing)(11)(12).
Taken altogether, strong evidence suggested that vitamin B3 used alone or combination with other antioxidants may be beneficial in reduced the early onset skin aging and skin aging progression. Overdoses of vitamin B3 may induce symptoms of severe skin flushing combined with dizziness, rapid heartbeat, itching, nausea, vomiting, abdominal pain, etc. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) [Anti-aging creams. What really helps?].[Article in German] by Kerscher M1, Buntrock H.(PubMed)
(2) Practical application of cellular bioenergetics to the care of aged skin by Osborne R1, Carver RS, Mullins LA, Finlay DR(PubMed)
(3) Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration by Osborne R1, Hakozaki T, Laughlin T, Finlay DR.(PubMed)
(3a) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.([PubMed)
(4) A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen by Fu JJ1, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR.(PubMed)
(5) Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial by Kimball AB1, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL(PubMed)
(6) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible by Greatens A1, Hakozaki T, Koshoffer A, Epstein H, Schwemberger S, Babcock G, Bissett D, Takiwaki H, Arase S, Wickett RR, Boissy RE(PubMed)
(7) The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer by Hakozaki T1, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE(PubMed)
(8) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)
(9) Understanding metabolic pathways for skin anti-aging by Osborne R1, Mullins LA, Jarrold BB.(PubMed).
(10) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.(PubMed)
(11) Niacinamide: A B vitamin that improves aging facial skin appearance by Bissett DL1, Oblong JE, Berge CA(PubMed)
(12) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin by Bissett DL1, Miyamoto K, Sun P, Li J, Berge CA.(PubMed)
Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.
Vitamin B3 may be effective to protect against skin-aging through its antioxidant activity(1)(2)(3) such as allowness, wrinkling, red blotchiness and hyperpigmented spots(3a)
In the comparison of the effect on aging skin among a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen, researchers showed that the composition significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks with well tolerate adverse effects(4). In facial hyperpigmentation, composition of topical niacinamide and N-acetyl reduced the appearance of irregular pigmentation including hypermelaninization(5) and niacinamide alone enhanced skin lightening, and hyperpigmented lesions(6) through inhibiting melanosome transfer from melanocytes to keratinocytes(7). A daily facial lotion application containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women, 30-60 years of age, for 10 weeks, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, and positive effects on skin texture, as early as 6 weeks(8). In Global gene expression skin aging process, compounds niacinamide and hexamidine, may effect the skin hydration, barrier, matrix, pigmentation through theirs' antioxidant capacity(9). According to Kinki University School of Medicine, application of composition containing 4% niacinamide in 30 healthy Japanese females who had wrinkles in the eye areas showed to reduced wrinkles through a marked and moderate improvement in 64% of the subjects with a significant difference as compared with the control site(10) and niacinamide alone exhibited a significant reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing)(11)(12).
Taken altogether, strong evidence suggested that vitamin B3 used alone or combination with other antioxidants may be beneficial in reduced the early onset skin aging and skin aging progression. Overdoses of vitamin B3 may induce symptoms of severe skin flushing combined with dizziness, rapid heartbeat, itching, nausea, vomiting, abdominal pain, etc. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) [Anti-aging creams. What really helps?].[Article in German] by Kerscher M1, Buntrock H.(PubMed)
(2) Practical application of cellular bioenergetics to the care of aged skin by Osborne R1, Carver RS, Mullins LA, Finlay DR(PubMed)
(3) Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration by Osborne R1, Hakozaki T, Laughlin T, Finlay DR.(PubMed)
(3a) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.([PubMed)
(4) A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen by Fu JJ1, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR.(PubMed)
(5) Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial by Kimball AB1, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL(PubMed)
(6) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible by Greatens A1, Hakozaki T, Koshoffer A, Epstein H, Schwemberger S, Babcock G, Bissett D, Takiwaki H, Arase S, Wickett RR, Boissy RE(PubMed)
(7) The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer by Hakozaki T1, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE(PubMed)
(8) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)
(9) Understanding metabolic pathways for skin anti-aging by Osborne R1, Mullins LA, Jarrold BB.(PubMed).
(10) Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide by Kawada A1, Konishi N, Oiso N, Kawara S, Date A.(PubMed)
(11) Niacinamide: A B vitamin that improves aging facial skin appearance by Bissett DL1, Oblong JE, Berge CA(PubMed)
(12) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin by Bissett DL1, Miyamoto K, Sun P, Li J, Berge CA.(PubMed)
Food therapy - Celery and liver cancer
Celery is a species of Apium graveolens, belonging to the family Apiaceae.
It is cultivated all around the globe as a vegetable. Celery can grow
to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape
joined at a common base.
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Liver cancer is defined as a condition of abnormal cell growth in the liver. Commonly, proliferation starts at bile ducts, blood vessels or connective tissue of the liver.
According to the study at Shanghai Jiaotong University School of Medicine, dietary intake high amounts of celery was associated with reduced liver cancer risk(b). Methanolic extract of celery seeds, in Wistar rats study, showed to protect against diethylnitrosoamine (DEN)+2-acetylaminofluorine (AAF)+partial hepatectomy (PH) induced hepatocarcinogenesis in dose dependent manner, through modulation of cell proliferation, metabolism and altered hepatic foci development(c). Perillyl alcohol(d), its essential oils(e) and chemical compound phthalides(f) found in celery seed may be potent in treating liver tumors, with Perillyl alcohol also acting as a chemopreventative agent for other cancers, such as colon, skin, and lung cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies by Zhang W1, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO(PubMed)
(c) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(e) Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver by Banerjee S1, Sharma R, Kale RK, Rao AR.(PubMed)
(f) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK.(PubMed)
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Liver cancer is defined as a condition of abnormal cell growth in the liver. Commonly, proliferation starts at bile ducts, blood vessels or connective tissue of the liver.
According to the study at Shanghai Jiaotong University School of Medicine, dietary intake high amounts of celery was associated with reduced liver cancer risk(b). Methanolic extract of celery seeds, in Wistar rats study, showed to protect against diethylnitrosoamine (DEN)+2-acetylaminofluorine (AAF)+partial hepatectomy (PH) induced hepatocarcinogenesis in dose dependent manner, through modulation of cell proliferation, metabolism and altered hepatic foci development(c). Perillyl alcohol(d), its essential oils(e) and chemical compound phthalides(f) found in celery seed may be potent in treating liver tumors, with Perillyl alcohol also acting as a chemopreventative agent for other cancers, such as colon, skin, and lung cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women's and men's health studies by Zhang W1, Xiang YB, Li HL, Yang G, Cai H, Ji BT, Gao YT, Zheng W, Shu XO(PubMed)
(c) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(e) Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver by Banerjee S1, Sharma R, Kale RK, Rao AR.(PubMed)
(f) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK.(PubMed)
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