Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Lung cancer is defined as a condition of the abnormal
growth of the cells in the lung's tissue. Most common form of primary
lung cancers are derived from epithelial cells. In Us, Lung cancer is
the leading cause of cancer deaths, causing 158,683 people deaths,
including 88,329 men and 70,354 women, according to 2007 statistic.
The health benefits
Anacardic acid (AA), a chemical conpound
found in some foods and herb has exerted its cytotoxicity property to
causes cell on A549 lung adenocarcinoma cells through the activation of
mitochondrial-mediated involved in initiating a caspase-independent
pathway and an contact activation pathway executioner such as cytochrome
c. The phytochemical on the other hand also expresses its
anticancer, anti-inflammatory, and
radiosensitization through suppresion of a protein complex that controls
transcription of DNA, the NF-kappaB signalling pathway. These results
may demonstrate a novel role for anacardic acid in potentially preventing or treating cancer through modulation of certain pathways.
Chinese Secrets To Fatty Liver And Obesity Reversal
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References
(1) Anacardic acid induces
mitochondrial-mediated apoptosis in the A549 human lung
adenocarcinoma cells by Seong YA, Shin PG, Kim GD.(PubMed)
(2) Anacardic acid (6-nonadecyl salicylic
acid), an inhibitor of histone acetyltransferase, suppresses expression
of nuclear factor-kappaB-regulated gene products involved in cell
survival, proliferation, invasion, and inflammation through inhibition
of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading
to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T,
Chaturvedi MM, Liu M, Aggarwal BB.(PubMed)
Thursday, 23 January 2014
HerbalCascara Sagrada and RV-induced asthma
Cascara sagrada is a species of buckthorn, genus Rhamnus,
belonging to the family Rhamnaceae, native to western North America,
it's bark has been used in traditional medicine for gastrointestinal
support. and it is thought to have a laxative and natural cleansing, etc., effect.
Rhinoviruses are viral infective agents in humans, associated to the cause of the common cold
The ingredients
Beside the main compound of anthraquinones, otyher compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The effects
Mitoxantrone, a anthraquinone derivative found in Cascara Sagrada may be the next potential agent in treating severe asthma caused the Rhinoviruses. It is known that severe asthma is associated the immune response to infection and inflammation and a family of enzymes involved in cellular functions (PI3K). In the study of the effects of Mitoxantrone allergic mice infected with RV1B, showed an effective potential in RV-induced asthma by blocking pro-inflammatory pathways regulated by multiple cellular processes of PI3K. The effect of the herb may be more profound as the chemical constituent of emodin showed a significantly anti inflammatory activity with capable of interacting with several major inflammatory molecular targets. The result re-emphasizes its potential therapeutic role in the treatment of inflammatory diseases.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
References
(1) Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer by Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G.(PubMed)
(2) Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates TH2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation by Cesar de Souza Alves C, Collison A, Hatchwell L, Plank M, Morten M, Foster PS, Johnston SL, França da Costa C, Vieira de Almeida M, Couto Teixeira H, Paula Ferreira A, Mattes J.(PubMed)
Rhinoviruses are viral infective agents in humans, associated to the cause of the common cold
The ingredients
Beside the main compound of anthraquinones, otyher compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The effects
Mitoxantrone, a anthraquinone derivative found in Cascara Sagrada may be the next potential agent in treating severe asthma caused the Rhinoviruses. It is known that severe asthma is associated the immune response to infection and inflammation and a family of enzymes involved in cellular functions (PI3K). In the study of the effects of Mitoxantrone allergic mice infected with RV1B, showed an effective potential in RV-induced asthma by blocking pro-inflammatory pathways regulated by multiple cellular processes of PI3K. The effect of the herb may be more profound as the chemical constituent of emodin showed a significantly anti inflammatory activity with capable of interacting with several major inflammatory molecular targets. The result re-emphasizes its potential therapeutic role in the treatment of inflammatory diseases.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
References
(1) Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer by Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G.(PubMed)
(2) Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates TH2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation by Cesar de Souza Alves C, Collison A, Hatchwell L, Plank M, Morten M, Foster PS, Johnston SL, França da Costa C, Vieira de Almeida M, Couto Teixeira H, Paula Ferreira A, Mattes J.(PubMed)
Herbal Butterbur and Neuroprotective effects
Butterbur, found in wet, marshy, damp
land, including wetland, riverside, forest, etc., is a creeping
underground plant, genus Petasites of 15 -20 species, belonging to the
family Asteraceae, native to Northern Hemisphere. It has been used in
herbal medicne used as an pain reliever in digestive system, including
stomach, bile ducts, and duodenum, etc.
Neuroprotective effects are defined of a protection against harmful of the brain and spinal cord
The Ingredients
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The benefits
Bakkenolides is the major chemical costutuent of Petasites trichinous Franch. is examined for its neuroprotective effects in a rat transient focal cerebral ischemia-reperfusion model, showed significantly attenuated cell death and apoptosis in primarily cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation. Other in the study of the same, also supported the result of the neuro protective effects of Bakkenolides of that may be result from its antioxidant properties.
Petaslignolide A (PA), a furfuran lignan isolated from butanol fraction of Petasites japonicus (Sieb. et Zucc.) (Compositae) leaves, on the oxidative damage in the brain of mice, is also a major neuroprotective agent against kainic acid-induced neurotoxicity.
Side effects
1. Butterbur may be liver-toxic to liver and cause cancer due to the presence of pyrrolizidine alkaloids(a)
2. If you are pregnant please do not use Butterbur with out the permission of the related special field specialist
3. Allergic effect to certain people who are allergic to ragweed, marigold, daisy, etc.
4. Overdoses may cause indigestion, headache, nausea, vomiting, diarrhea, etc.
5. Etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The benefits
Bakkenolides is the major chemical costutuent of Petasites trichinous Franch. is examined for its neuroprotective effects in a rat transient focal cerebral ischemia-reperfusion model, showed significantly attenuated cell death and apoptosis in primarily cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation. Other in the study of the same, also supported the result of the neuro protective effects of Bakkenolides of that may be result from its antioxidant properties.
Petaslignolide A (PA), a furfuran lignan isolated from butanol fraction of Petasites japonicus (Sieb. et Zucc.) (Compositae) leaves, on the oxidative damage in the brain of mice, is also a major neuroprotective agent against kainic acid-induced neurotoxicity.
Side effects
1. Butterbur may be liver-toxic to liver and cause cancer due to the presence of pyrrolizidine alkaloids(a)
2. If you are pregnant please do not use Butterbur with out the permission of the related special field specialist
3. Allergic effect to certain people who are allergic to ragweed, marigold, daisy, etc.
4. Overdoses may cause indigestion, headache, nausea, vomiting, diarrhea, etc.
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
Follow me on Twitter https://twitter.com/kylejnorton
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
Follow me on Twitter https://twitter.com/kylejnorton
References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI.(PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE.(PubMed)
.
Wednesday, 22 January 2014
Herbal Andrographis
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
1. The benefits of Andrographis paniculata on Rheumatoid Arthritis
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than in men and generally occurs after the ages of 40 and diminishes the quality of life of many elders.
Andrographis paniculata (AP) possesses anti-inflammatory effects, as a result of its main constituent andrographolide proposed as alternative in the treatment of autoimmune disease, according to the study of Tablets (Paractin) made of an extract of A. paniculata (30% total andrographolides) were administered three times a day for 14 weeks, after a 2-week washout period to 60 patients with active RA. In the study of osteoclast formation, AP suppressed RANKL-induced osteoclastogenesis through attenuating NF-κB and ERK/MAPK signalling pathways in vitro, thus preventing bone loss in vivo. of which may be a potential therapeutic natural compound for the treatment of osteoclast-related bone diseases. Other in the study of he pseudo-tumoral expansion of fibroblast-like synoviocytes is a hallmark of rheumatoid arthritis (RA), showed that andrographolide exerts anti-growth and pro-apoptotic effects on RAFLSs, thus may have therapeutic potential for the treatment of RA. by induced cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
References
1. Andrographis paniculata, http://essenherb.com/plant1.html
2. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial, by Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres DD. (PubMed)
3. Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. by Yan J, Chen Y, He C, Yang ZZ, Lü C, Chen XS.(PubMed)
4. Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
2. Herbal Andrographis Hepatoprotective effect
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Cirrhosis is defined as a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(a). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.
The Herbal Andrographis Hepatoprotective effect
Administration of containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae) PHF found to be pepatoprotective effect by significantly inhibited paracetamol, CCl(4) and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH with little side effect, according to the study. Other in the study to evaluate the hepatoprotective effect of Andrographis lineata (Acanthaceae) extracts in carbon tetrachloride-induced liver injury in rats, showed that the extracts exhibited hepatoprotective action and may be be considered to be used as a hepatoprotective agent. Also the chemical constituent andrographolide (AN) found in Andrographis, significantly restores serum glutamate oxalacetate transaminase and serum glutamate pyruvate transaminase level.
References
(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.
Tatiya AU, Surana SJ, Sutar MP, Gamit NH.(PubMed)
(2) Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. by Sangameswaran B, Reddy TC, Jayakar B.(PubMed)
(3) Enhancement of absorption and hepatoprotective
potential through soya-phosphatidylcholine-andrographolide vesicular
system. by Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
3. Herbal Andrographis and Cancers
Cancer
is a class of diseases in which a group of cells growing and
multiplying disordered and uncontrollable way in our body, have become
progressively worse and damaged other healthy tissues, sometimes spreads
to other organs in the body via lymph or blood and results may be in
death.
The benefits of Herbal Andrographis in Cancers
Andrographolide (Andro) is a diterpenoid that is isolated from Andrographis paniculata, has exerted it anti-proliferative and pro-apoptotic effects from sequenced
combinations of andrographolide and cisplatin on ovarian cancer cell
lines. In other study, Andrographolide, a chemical constituent isolated from the Leaves of Andrographis
paniculata Nees, significantly reduced the expression of hVEGF-A165
compared with a mock group in the Clara cells of the lungs and its
anticancer and immunomodulatory activities may be potential to provide a
cure for pulmonary tumors and a cancer therapeutic agent in the future.
Reference
(1) Anti-proliferative and pro-apoptotic effects from sequenced
combinations of andrographolide and cisplatin on ovarian cancer cell
lines. by Yunos NM, Mutalip SS, Jauri MH, Yu JQ, Huq F.(PubMed)
(2) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas. by Tung YT, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.(PubMed)
(3) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. by Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
4. Herbal Andrographis and Gastric Ulcer
Gastric ulcers is defined as a
condition of a localized tissue erosion in the lining the stomach. as a
result of bacteria Helicobacter pylori (H pylori) in most cases.
4. Herbal Andrographis gastroprotective effects
Andrographolide, a chief component of the leaves of Andrographis paniculata has been found to be gastroprotective effects as its antioxidants and mucin levels were significantly maintained in the gastric tissue of drug-pretreated animals with toxic effects in normal rats. hydroalcoholic extract of Andrographis paniculata (HAEAP), another chemical compound of Andrographis, has also exerted its overprotective effect by regulating effect on H(+)K(+)ATPase activity and /or mucin preserving effects and flavonoids presence in maintaining the antioxidants and thiol status in the gastrointestinal tract.
In some other studies pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property.
References
(1) A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. by Saranya P, Geetha A, Selvamathy SM.(PubMed)
(2) A biochemical study on the gastroprotective effect of hydroalcoholic extract of Andrographis paniculata in rats. by Panneerselvam S, Arumugam G.(PubMed)
(3) Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. by Wasman SQ, Mahmood AA, Chua LS, Alshawsh MA, Hamdan S.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
5. Herbal Andrographis and common cold
Cold and flu are the most commonly occurring illnesses in the entire world, with more than 1 billion colds per year reported in the United States alone. The common cold is a self-limiting illness caused by any 1 of more than 200 viruses. Influenza is no minor illness. If you are senior or have a serious heart and lung disease, you are at the greatest risk for coming down with a dangerous case of flu because your immune system might not be strong enough to fend off the infection.
The benefits
In United States, common old causes 189 million lost school days and Influenza infection leads of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year, Andrographis paniculata and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) that may help in the prevention and treatment of these conditions. Andrographis paniculata SHA-10 extract, had found to be very effective supplement in reducing the prevalence and intensity of the symptoms in uncomplicated common cold beginning at day two of treatment. Andrographis paniculata dried extract found in Kan Jang tablets, attributable protective effect of Kan Jang of 33%, against common colds during the winter period.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations by Roxas M, Jurenka J.(PubMed)
(3) Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study by Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK.(PubMed)
(4) Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial by Cáceres DD, Hancke JL, Burgos RA, Wikman GK. (PubMed)
6. Herbal Andrographis and Heart diseases
(1) A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. by Saranya P, Geetha A, Selvamathy SM.(PubMed)
(2) A biochemical study on the gastroprotective effect of hydroalcoholic extract of Andrographis paniculata in rats. by Panneerselvam S, Arumugam G.(PubMed)
(3) Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. by Wasman SQ, Mahmood AA, Chua LS, Alshawsh MA, Hamdan S.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
5. Herbal Andrographis and common cold
Cold and flu are the most commonly occurring illnesses in the entire world, with more than 1 billion colds per year reported in the United States alone. The common cold is a self-limiting illness caused by any 1 of more than 200 viruses. Influenza is no minor illness. If you are senior or have a serious heart and lung disease, you are at the greatest risk for coming down with a dangerous case of flu because your immune system might not be strong enough to fend off the infection.
The benefits
In United States, common old causes 189 million lost school days and Influenza infection leads of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year, Andrographis paniculata and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) that may help in the prevention and treatment of these conditions. Andrographis paniculata SHA-10 extract, had found to be very effective supplement in reducing the prevalence and intensity of the symptoms in uncomplicated common cold beginning at day two of treatment. Andrographis paniculata dried extract found in Kan Jang tablets, attributable protective effect of Kan Jang of 33%, against common colds during the winter period.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations by Roxas M, Jurenka J.(PubMed)
(3) Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study by Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK.(PubMed)
(4) Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial by Cáceres DD, Hancke JL, Burgos RA, Wikman GK. (PubMed)
6. Herbal Andrographis and Heart diseases
Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
There are many causes of heart diseases. Most of heart diseases are
caused by high blood pressure contributes to hardening of the arteries.
High levels of bad cholesterol (LDL) build up in the arteries as a
result of uncontrolled diet with high levels of saturated fat and trans
fat. All these add to the formation of atherosclerosis lesions and
eventually arterial blockage or anything that serves to damage the inner
lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart.
The benefitsNeutrophils and inflammatory cytokines have been implicated in ischemia/
Andrographolide, a novel nuclear factor-κB (NF-κB) inhibitor, with the various medicinal properties of andrographolide may have a potential value in treating patients with thromboembolic disorders as andrographolide may involve an increase in cyclic GMP/PKG, followed by inhibition of the p38 MAPK/(·)HO-NF-κB-ERK2 cascade in activated platelets. Other study also indicated that andrographis paniculata protective effects of on post-infarction myocardium in experimental dogs, due to its acts on reversibly ischemic myocardium.
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats by Ojha SK, Bharti S, Joshi S, Kumari S, Arya DS.(PubMed)
(3) Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway by Lien LM, Su CC, Hsu WH, Lu WJ, Chung CL, Yen TL, Chiu HC, Sheu JR, Lin KH. (PubMed)
(4) Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade by Lu WJ, Lin KH, Hsu MJ, Chou DS, Hsiao G, Sheu JR.(PubMed)
(5) Protective effects of andrographis paniculata nees on post-infarction myocardium in experimental dogs by Zhao HY, Fang WY.(PubMed)
7. Herbal Andrographis and Immunity
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
The Benefits
HN-02, an extract containing a mixture of andrographolides, found in Andographis paniculata, not only significant increases in total WBC count in mice during 30 days of treatment with HN-02, but alsoenhances the immune function, possibly through modulation of immune responses altered during antigen interaction, and to reverse the immunosuppression induced by cyclophosphamide (CYP). Other in the study of modulation of immune responses in tumor cell destruction, treatment of Andrographis paniculata extract (APE) and isolated compound andrographolide (ANDLE) significantly elevated the production of interleukin-2 and interferon-gamma and and IFN-gamma by T cells in normal and Ehrlich ascites carcinoma-bearing animals.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2|) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(3) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(4) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)
8. Herbal Andrographis and Colitis
Colitis is defined as a condition of inflammation of the large intestine, including the colon, caecum and rectum.
The benefits
Recent randomised, double-blind, multicentre, 8-week parallel group study of HMPL-004, the Andrographis paniculata extract, when compares to mesalazine found to demonstrate the safety and effectiveness for induction of clinical response, remission, and mucosal healing in patients with mild to moderate ulcerative colitis (UC). In colitis, the extract reduced the splenic cell counts, CD4(+), and IL-17(+), and IFN-γ T(+) cells and inhibited the proliferation of CD4 T cells and differentiation into TH1/TH17 cells.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed) (2) HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses by Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR.(PubMed)
(3) HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses by Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR.(PubMed)
9. Herbal Andrographis and Anti-inflammatory effects
Inflammation is a condition of Immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.
The Benefits
Xiang-Qi-Tang (XQT), a herbal formular containing Andrographis paniculata, it found to be effective in inhibition of the expression of inflammatory and coagulant mediators via mitogen-activated protein kinase (MAPKs) and NF-κB signaling pathways on lipopolysaccharide (LPS)-induced inflammatory model of rat cardiac microvascular endothelial cells (RCMECs). Andrographolide (andro), one of the major components, also exerted it anti microbial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells. In other study, Andrograpanin, another isolated from Andrographis paniculata showed inhibition of productions of NO and pro-inflammatory cytokines through down-regulating iNOS and pro-inflammatory cytokines gene expression levels.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed) (2) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells BY He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD. (PubMed)
(3) Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells by Shao ZJ, Zheng XW, Feng T, Huang J, Chen J, Wu YY, Zhou LM, Tu WW, Li H.(PubMed).
(4) Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways by Liu J, Wang ZT, Ge BX.(PubMed)
10. Herbal Andrographis and malaria
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Malaria is a mosquito-borne infectious disease caused by parasitic protozoans.
The benefits
The crude extract of E. alba and A. paniculata was an excellent potential for controlling An. stephensi mosquitoes which caused malaria by exerting its mosquito adulticidal and repellent activities. In the study to compare the anti-malarial effect among sambiloto extract, chloroquine and artemisinin-only as well as those of their combination showed that the extract of sambiloto in a single dose or in a combination evidently has the effect of anti-falciparum malaria. Other study of the extract of Andrographis paniculata (AP) and Hedyotis corymbosa (HC) showed that a 50% inhibitory concentration (IC50) of AP (7.2 microg/ml) was found better than HC (10.8 microg/ml). Combination of these two herbal drugs showed substantial enhancement in their anti-malarial activity.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed) (2) Comparative study of antimalarial effect of sambiloto (Andrographis paniculata) extract, chloroquine and artemisinin and their combination against plasmodium falciparum in-vitro by Zein U, Fitri LE, Saragih A.(PubMed)
(3) Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin by Mishra K, Dash AP, Swain BK, Dey N.(PubMed)
(4) Mosquito adulticidal and repellent activities of botanical extracts against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae) by Govindarajan M, Sivakumar R.(PubMed)
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11. Herbal Andrographis and Renoprotective effects
Renoprotective effect is defined of a protection against harmful of the kidney.
The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
The Benefits
Renal failure is an increasingly common condition with limited treatment options in developing world. In the study to evaluate the antirenal failure activity of A. paniculata, aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively by exhibiting a significant renoprotective effect in gentamicin-induced nephrotoxicity in rats. Other in the study of the effect of various herbal adaptogens, including on cadmium (Cd)-induced oxidative stress and its accumulation in broiler chicken, found that the increase in TBARS and decrease in GSH concentrations of liver and kidney tissues in cadmium intoxicated birds were significantly reversed by the above-said herbs. The liver and kidney functional markers were also restored to normal levels. Unfortunately, Andrographolide was found to cause acute kidney injury shortly after intravenous infusion of andrographolide, with symptoms including flank pain, decreased urine output, and nausea or vomiting.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats by Singh P, Srivastava MM, Khemani LD.(PubMed)
(3) Andrographolide induced acute kidney injury: Analysis of 26 cases reported in Chinese Literature by Zhang WX, Zhang ZM, Zhang ZQ, Wang Y, Zhou W.(PubMed)
(4) Prevention of cadmium bioaccumulation by herbal adaptogens by Bharavi K, Reddy AG, Rao GS, Kumar PR, Kumar DS, Prasadini PP.(PubMed)
12. Herbal Andrographis and Oral Cancer
Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
The benefits
The NF-κB family, sequestered in the cytoplasm by a family of inhibitors, is essential for promoting cell proliferation and preventing cell apoptosis. Andrographolide (Andro) isolated from an herbal plant, Andrographis paniculata reduced phosphorylation of p65 (Ser536) and IκBα (Ser32/36) for inhibiting aberrant NF-κB activation, suppressed c-Myc and cyclin D1 expression and attenuated neoplastic cell proliferation, promoted cancerous cell apoptosis, and mitigated tumor-induced angiogenesis, may be considered as potential component to treats chemically induced oral squamous cell carcinogenesis. Other researchers consider Andrographolide, is a promising strategy for the development of a novel class of anti-inflammatory and anticancer drugs as its bioactive molecules have exhibited anti-inflammatory and anticancer activities in both in vitro and in vivo.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation.
Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG.(PubMed)
(3) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. by Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS(PubMed)
13. Herbal Andrographis and Hepatitis.
Hepatitis is characterized by the destruction of a number of liver cells and the presence of inflammatory cells in the liver tissue caused by excessive alcohol drinking, disorders of the gall bladder or pancreas, including medication side effects, and infections. There are many other infective agents that can cause inflammation of the liver, or hepatitis. However, the term is unfortunately commonly used to refer to a particular group of viruses such as Hepatitis A, B, and C.
The benefits
Picroliv (active principle from Picrorrhiza kurroa) with major chemical constituent of andrographolide (active constituent of Andrographis paniculata) was tested in HBsAg positive serum samples obtained from hepatitis B virus (HBV) associated acute and chronic liver diseases and healthy HBsAg paitnets, found that Picroliv also inhibited purified HBV antigens (HBsAg and HBsAg) prepared from healthy HBsAg carriers amd may be considered as a potential agent against HBV. In anti-hepatitis C virus (HCV) study of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata, reseachers found that activated p38 MAPK phosphorylation, which stimulated nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated HO-1 expression, and this was found to be associated with its anti-HCV activity. Other in the study of infective hepatitis, Kalmegh(Andrographis paniculata Nees)showed as a promised agent as on the total assessment 80% cases of this series were cured and 20% patients were relieved.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) In vitro studies on the effect of certain natural products against hepatitis B virus by Mehrotra R, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN.(PubMed)
(3) Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells by Lee JC, Tseng CK, Young KC, Sun HY, Wang SW, Chen WC, Lin CK, Wu YH.(PubMed)
(7) Clinical studies on kalmegh (andrographis paniculata nees) in infective hepatitis by Chturvedi GN, Tomar GS, Tiwari SK, Singh KP.(PubMed)
14. Herbal Andrographis and Anti-fertility
Anti-fertility is an act with intention to prevent, reduce or destroy fertility by using substances such as contraceptives, herbal medicine in under developing world.
The Benefits
Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus, although the herbal mix extract revealed no significant negative effect on male semen quality and fertility, but rather a positive trend with respect to the number of spermatozoids in the whole ejaculate, the percentage of active (normokinetic) forms of spermatozoids, and fertility indexes, together with a decrease in the percentage of inactive (diskinetic) forms of spermatozoids. Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility. But in other study, Extract of Andrographis paniculata Nees (A paniculata) standardized to >or=10% andrographolide, have found to be no effect on total sperm count and sperm motility and levels of testosteroneand fertility indices in treatment groups were found to be comparable with that of the control in rats.
The Side effects
People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.
References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats, by Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)
Chinese Secrets To Fatty Liver And Obesity Reversal
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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Herbal Cascara Sagrada and Herpes simplex virus
Cascara sagrada is a species of buckthorn, genus Rhamnus,
belonging to the family Rhamnaceae, native to western North America,
it's bark has been used in traditional medicine for gastrointestinal
support. and it is thought to have a laxative and natural cleansing, etc., effect.
Herpes is defined as a viral disease caused by both Herpes simplex virus type 1 (HSV-1), type 2 (HSV-2).
The ingredients
Beside the main compound of anthraquinones, otyher compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The benefits
Anthraquinone derivatives such as emodin have recently been found to protect against deposit of amyloid plaques and tau aggregation-induced cell death. In the study to evaluate the anti viral effects of emodin against HSV infection, emodin showed a positive result in inhibiting the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with antiviral index of 2.07 and 3.53, respectively as well as enhancing the survival rate of HSV-infected mice ad may be considered as a promising agent in the clinical therapy of HSV infection. Other in the study of the same indicated that emodin also inhibits the yields of HSV-1 but via the suppression of a novel target, UL12.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(2) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by Hsiang CY, Ho TY.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH.(PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ.(PubMed)
Herpes is defined as a viral disease caused by both Herpes simplex virus type 1 (HSV-1), type 2 (HSV-2).
The ingredients
Beside the main compound of anthraquinones, otyher compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The benefits
Anthraquinone derivatives such as emodin have recently been found to protect against deposit of amyloid plaques and tau aggregation-induced cell death. In the study to evaluate the anti viral effects of emodin against HSV infection, emodin showed a positive result in inhibiting the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with antiviral index of 2.07 and 3.53, respectively as well as enhancing the survival rate of HSV-infected mice ad may be considered as a promising agent in the clinical therapy of HSV infection. Other in the study of the same indicated that emodin also inhibits the yields of HSV-1 but via the suppression of a novel target, UL12.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
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References
(1) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(2) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by Hsiang CY, Ho TY.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH.(PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ.(PubMed)
Herbal Butterbur and Somatoform disorders
Butterbur, found in wet, marshy, damp
land, including wetland, riverside, forest, etc., is a creeping
underground plant, genus Petasites of 15 -20 species, belonging to the
family Asteraceae, native to Northern Hemisphere. It has been used in
herbal medicne used as an pain reliever in digestive system, including
stomach, bile ducts, and duodenum, etc.
Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.
The Ingredients
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The benefits
Extracts from butterbur have been in therapeutic use for more than 2,000 years
in a pharmaco-clinical trial to examine the effects of butterbur in a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders., treatment after 2 week showed (Ze185), the combination containing butterbur to be an efficacious and safe short-term treatment in patients with somatoform disorders with no serious side effects.
Side effects
1. Butterbur may be liver-toxic to liver and cause cancer due to the presence of pyrrolizidine alkaloids(a)
2. If you are pregnant please do not use Butterbur with out the permission of the related special field specialist
3. Allergic effect to certain people who are allergic to ragweed, marigold, daisy, etc.
4. Overdoses may cause indigestion, headache, nausea, vomiting, diarrhea, etc.
5. Etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The benefits
Extracts from butterbur have been in therapeutic use for more than 2,000 years
in a pharmaco-clinical trial to examine the effects of butterbur in a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders., treatment after 2 week showed (Ze185), the combination containing butterbur to be an efficacious and safe short-term treatment in patients with somatoform disorders with no serious side effects.
Side effects
1. Butterbur may be liver-toxic to liver and cause cancer due to the presence of pyrrolizidine alkaloids(a)
2. If you are pregnant please do not use Butterbur with out the permission of the related special field specialist
3. Allergic effect to certain people who are allergic to ragweed, marigold, daisy, etc.
4. Overdoses may cause indigestion, headache, nausea, vomiting, diarrhea, etc.
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
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References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)
Phytochemical Anacardic acids and Breast cancer
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that
supply the ducts with milk. there is also rare cases that breast cancer
starts in other areas of the breast. In 2010, over 250,000 new cases of
breast cancer were expected to be diagnosed in women in the U.S. alone
and the risk of getting invasive breast cancer during life time of a
women is 1/8.
The health benefits
Dietary foods with Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid) may be potential to reduce the risk of breast cancer as its AnAc 24:1(omega5) purified from geranium inhibits breast cancer cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner. Other in the study of Synthesis of benzamides related to anacardic acid, showed a exhibited activities similar to that of AA, In U937 cells, it induced cell-cycle arrest in the G1 phase, caused apoptosis in about 20 % of the cells and increased the acetylation levels of H3.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM.(PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)
The health benefits
Dietary foods with Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid) may be potential to reduce the risk of breast cancer as its AnAc 24:1(omega5) purified from geranium inhibits breast cancer cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner. Other in the study of Synthesis of benzamides related to anacardic acid, showed a exhibited activities similar to that of AA, In U937 cells, it induced cell-cycle arrest in the G1 phase, caused apoptosis in about 20 % of the cells and increased the acetylation levels of H3.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
Follow me on Twitter https://twitter.com/kylejnorton
References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM.(PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)
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