Sunday, 12 January 2014

Weight Loss and Non alcoholic liver disease

Healthy Weight loss is defined as a reduction of the total body mass for the purpose in improving heath due to related illness, including heart diseases, stroke, over expression of cholesterol, fatty liver, etc.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

Non alcoholic fatty liver diseases is widespread in Western world with no affirmative treatment. Most physicians suggested healthy diet with less in saturated  and trans fat and reduction of  patients' weight would be beneficial in management of the disease. As n-3 polyunsaturated fatty acids (PUFA)has been found to be effective in treating  patients with nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia with no adverse effects. In the study of the effect of weight reduction diet as an exclusive treatment for NAFLD, in 44 patients with NAFLD whom  received a diet including a 500 to 1000 kcal per day intake reduction as30% fat, 15% protein, and 55% carbohydrate for six months, reduction of body weight, waist circumference and decrease diastolic blood pressure are significant. Total cholesterol, LDL, triglyceride, ALT, AST, GGT and CK18-M30 levels were significantly decreased as well. Of these result, weight reduction diet should be considered as a therapy in managing non alcoholic liver disease.

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References
(1) How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease? by Ghaemi A, Taleban FA, Hekmatdoost A, Rafiei A, Hosseini V, Amiri Z, Homayounfar R, Fakheri H.(PubMed)
(2) Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia by Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW.(PubMed)

Bastard Teak and Non alcoholic Liver disease (NAFLD)

Bastard Teak (Premna tomentosa) is Indian ayurvedic medicine used widely in the treatment of liver disorder.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

The prevalence of non alcoholic of liver disease is worrisome to Western world as it not only effects the organs donors, but also increase the medical cost in the future. AS well known, the liver is the first live of defense in detoxifying toxin accumulated in the body, and healthy liver is associated with  a balanced diet that includes nutrients and herbs that support a healthy liver. In the study of the extracts from the ayurvedic plant, Premna tomentosa (PT), pretreatment of (750 mg/kg, orally) for 15 days and then induced with hepatotoxicity by AA (640 mg/kg, intraperitoneally) in animals, was found to significantly inhibit induced alterations in the levels of cholesterol, triglycerides, free fatty acids, phospholipids, serum lipoproteins, and lipid-metabolizing enzymes, as well as to exert a beneficial effect against liver injury-induced membrane damage. Of that result, the extract may be considered for human trial for it efficacy in treating liver disorder, including Non alcoholic fatty disease.

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References
(1) Assessment of the protective potential of Premna tomentosa (L. Verbenaceae) extract on lipid profile and lipid-metabolizing enzymes in acetaminophen-intoxicated rats by Devi KP, Sreepriya M, Balakrishna K, Veluchamy G, Devaki T.(PubMed)
(2) Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats, by Devi KP, Sreepriya M, Balakrishna K, Devaki T.(PubMed)

Phytochemicals Berberine and resveratrol and non-alcoholic fatty liver disease (NAFLD)

Bernerine is a phytochemical found abundantly in root, bark, stem in plants of  Berberis, including Oregon grape, barberry, tree turmeric, etc.
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts, etc.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Sadly to say, Non alcoholic liver diseases has become most prevalence incidence to cause liver diseases because of uncontrolled diet with high in saturated fat. Conventional medication such as ameliorate, a cholesterol absorption inhibitor, is found to be effective in decreasing cholesterol absorption in the small intestine and ameliorated non-alcoholic fatty liver disease (NAFLD) pathology but with many side effects.
In herbal medicine, certain herbs have found to be effective not only in reducing the symptoms of non alcoholic, but also prevent the abnormal alanine aminotransferase functions and fat accumulation in liver.
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well herbs and herbal formulae such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet, were found not only to improve biochemical and histological change in nonalcoholic fatty liver disease, but also associated with inhibiting lipid accumulation through adenosine monophosphate-activated protein kinase activation or up regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines. In such instance, Berberine and resveratrol, may be considered as a potential treatment for nonalcoholic fatty liver disease in the future.

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Optimal Health And Loose Weight

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References
(1) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(2) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)

Saturday, 11 January 2014

Beeswax and Nonalcoholic fatty liver disease (NAFLD)

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Beeswax is a natural wax produced in the bee hive of honey bees of the genus Apis, containing mainly esters of fatty acids and many types of long chain alcohols.

The benefits
Beeswax has been promoted as a healthy product for commercial profits in many parts of the world. Nonalcoholic fatty liver disease (NAFLD), as a result of abnormal function in fat accumulated in the liver. is associated with insulin resistance, liver fibrosis and cirrhosis, as a result of abnormal function in fat accumulated in the liver. D-002, a mixture of beeswax alcohols, in the study to test it efficacy in 50 NAFLD randomized to receive a placebo or D-002 (100 mg/day) for 24 weeks, D-002 exhibited a normal liver echo pattern on ultrasonography, improved symptoms and reduced insulin levels. Of that result, D002, may be considered as a potential agent in treating Nonalcoholic fatty liver disease (NAFLD).


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Optimal Health And Loose Weight

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References
(1) Beeswax (Wikipedia)
(2) Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease by Illnait J, Rodríguez I, Mendoza S, Fernández Y, Mas R, Miranda M, Piñera J, Fernández JC, Mesa M, Fernández L, Carbajal D, Gámez R.(PubMed)

Potassium and stroke

 Dietary Minerals are the group of minerals essential for our body to sustain normal functions and physical health.

In General, potassium is an essential mineral to our body in building proteins and muscles, breaking down carbohydrates, maintaining normal body growth and normal heart electricity, etc.
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications.

The benefits
Prolonged period intake of low potassium diet may cause lower serum potassium level in diuretic users, and low potassium intake in those not taking diuretic were associated with increased stroke incidence in elder. Lower serum potassium also was associated with a particularly high risk for stroke in the small number of diuretic users. Other in the study of dietary potassium and total energy intake estimated that at baseline by using a 24-hour dietary recall, patients, who follow a low potassium diet of <34.6 mmol potassium per day are at 28% higher hazard of stroke and stroke-associated mortality.

The Side effects
Overdose of potassium, also known as hyperkalemia may result of symptoms of hypotension, stomach cramps, diarrhea, vomiting, irritability, fatigue, etc., and in some cases, it can be life-threatening due to electrolyte abnormality.
 
References
(1) Serum potassium level and dietary potassium intake as risk factors for stroke by Green DM, Ropper AH, Kronmal RA, Psaty BM, Burke GL; Cardiovascular Health Study.(PubMed)
(2) Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies by D'Elia L, Barba G, Cappuccio FP, Strazzullo P.(PubMed)
(3) Dietary potassium and stroke-associated mortality. A 12-year prospective population study by Khaw KT, Barrett-Connor E.(PubMed)

Curcumin and Non alcoholic Fatty liver disease (NAFLD)

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.. Curcumin is one of the natural phenols in the plant.

Turmeric has long been used in herbal medicine in treating diseases and today its curcuminoid, curcumin has attracted many interests from researchers in many parts of the world. Curcumin, as an antihyperlipidemic agents, has been found to lower the "bad cholesterol" low density lipoprotein (LDL),  and increase high density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver. Ecessive fat deposited in hepatocytes may cause metabolic imbalances, causing Non- alcoholic fatty liver diseases. In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in liver, the derivative not only significantly alleviated fibrosis but also decreased the grade of liver steatosis.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

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References
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
 

Hawthorn Fruit and Non alcoholic fatty liver disease (NAFLD)

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.
Hawthorn is a shrubs and trees of the genus Crataegus, belonging to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America. The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.
 
 Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in US as approximate 30% of adult population are obese. Finding the natural treatments become for less or no side effects has become urgency in many scientific community including researchers in Universities. Alternative medicines for the treatment of NAFLD have been proven with many successful histories of controlling disease with no or less side effects, if compares to conventional treatment of the same. In a randomized controlled trials (RCTs) for the efficiency of traditional Chinese medicine (TCM) on the treatment of nonalcoholic fatty liver disease (NAFLD), Chinese herbal formulas have found to be effective in reducing the abnormality of alanine aminotransferase functions and fat accumulation in liver. Out of 246 kinds of Chinese herb, Hawthorn Fruit is found mostly in the list of many formulas. Of that reason, the herb may contain certain chemical constituents effectively in treatments of Nonalcoholic fatty liver disease (NAFLD).

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Optimal Health And Loose Weight

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(1)
Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by  Kim MS, Kung S, Grewal T, Roufogalis BD.(PubMed)
(2) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH.(PubMed)