Carrots may have a profound and positive effect on reduced risk, progression, and treatment of lung cancer, some scientists suggested.
Lung cancer is a condition characterized by cell growth disorderly and uncontrollably in lung tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.
Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
In the evaluation of a total of 417 lung cancer cases and 849 controls of a hospital-based case-control with 'cases' of lung cancer patients diagnosed during the period 1979/80 at seven hospitals in the Lombardy region by interviews on their life-long tobacco usage and their current intake of four food items rich in retinol or carotene, the researcher found that risk of lung cancer increased 3-4 fold in current smokers who did not consume carrots in compared with those who ate them more than once a week.
The odd ratio of carrot consumption reduced significantly and linearly to the risk of lung cancer.
However, among ex-smokers or non-smokers, the intake of carrots did not offer a decrease in lung cancer risk.
Dr. Pisani P the lead author, after taking into account another cofounder such as vegetables said, "The effect of carrots is independent of histological type of lung cancer while the effect of green vegetables was confined to epidermoid carcinomas".
Further analysis of the antiproliferative effect of retinoic acid amide found abundantly in carrots suggested that retinoic acid amide at a dose of 30 μM expressed a significant activity in the inhibition of lung cancer cell lines and clonogenic growth.
Application of retinoic acid amide also induced cancer cell apoptosis in the G2/M-phase cell cycle arrest through inhibition of JAK2 in cancer cell line in signaling cell functions by transmitting messages between cells in initiated growth and proliferation; inhibited STAT3, and STAT5 in cancer cell in expression of inflammatory cytokine to fuel the cancer development and expansion and level of p21WAF1, a key mediator of p53-dependent in cell cycle arrest with function as a tumor suppressor in cancer
In the meantime, the application of retinoic acid amide stimulated the decreased cyclin A, and cyclin B1 in the induction of cell mitosis, and Bcl-XL in the expression of anti-apoptotic activity in lung cancer cell line by preventing the release of mitochondrial contents such as cytochrome c.
Additionally, researchers also discovered that the compound injection also increases the expression of caspase-3 and caspase-9 in tumors with the function of being responsible for executing cell death following cytochrome c release.
In comparison to those of conventional medicine, Dr. Li HX, the lead author said, "Retinoic acid amide exhibits promising antiproliferative effects against human lung cancer cells in vitro and in vivo and enhances the antiproliferative effect of methotrexate".
The above differentiation was supported by reviewing the 16 studies selected for elevation between lung cancer and vitamin A in humans, conducted by Dr. Palgi A.
According to the study, a high intake of dietary vitamin A has a protective effect against the development of squamous and small cell carcinoma of the lung in smokers and people who consumed carrots daily have a lower risk of lung cancer compared to nonconsumers.
However, due to the limitation of several factors, the researcher postulated, "(A sample size study with) more complete vitamin A indices, examination of the histological type of lung cancer, a large enough pool of both male and female patients for statistical analysis, and proper adjustment for the effects of age, sex, smoking, and socioeconomic status (are necessary for the viability".
The result findings strongly suggested that long-term intake of carrots in moderate amounts may have a substantial implication in the prevention and treatment of lung cancer. But Intake of carrot supplements should be taken with care to prevent acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Carrots, green vegetables and lung cancer: a case-control study by Pisani P, Berrino F, Macaluso M, Pastorino U, Crosignani P, Baldasseroni A.(PubMed)
(2) Vitamin A and lung cancer: a perspective by Palgi A(PubMed)
(3) Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis by Li HX1, Zhao W1, Shi Y1, Li YN1, Zhang LS1, Zhang HQ1, Wang D2(PubMed)
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