#Healthyfood #Carrots Protect Prostate Cells' Viability Against the Risk of #ProstateCancer, Researchers Find

By Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression, and treatment of prostate cancer, some scientists suggested.

Prostate cancer is a condition characterized by cell growth disorderly and uncontrollably in prostate tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

Carrot, a root vegetable with orange color is a sub-spice of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

The study to verify the effect of carrots on the risk of prostate cancer by reviewing the publication of literature in August 2013 of PubMed, EMBASE, Scopus, Web of Science, the Cochrane Register, and the Chinese National Knowledge Infrastructure databases, and the references of the retrieved articles, researchers at the Zhejiang University found that intake of carrot demonstrated a significantly reduced risk of prostate cancer with the odds ratio of .82 in compared to now serving group.

The risk of prostate cancer was decreased by 5% and 6% in intake of a weekly portion of 10 g of carrot increment without precipitating adverse effects.

Dr. Xu X, the lead author suggested that the intake of carrots frequently with limited volume may have a profound effect on reduced prostate cancer risk.

Further analysis of the potential effect of lycopene extract found abundantly in tomato and carrot in decreased risk of onset and treatment of prostate cancer indicated that lycopene inhibited prostate cancer proliferation through modulated the expression of PI3K/Akt pathway prostate cancer cell lines in regulating cancerous cellular functions including metabolism, growth, proliferation.

Dysfunction of the PI3K/Akt pathway was associated with a number of human diseases including cancer, diabetes, cardiovascular disease, and neurological diseases.

Moreover, the application of lycopene also displayed a strong effect in inhibiting the proliferation of androgen-dependent prostateLNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor-gamma (PPARγ) with the function to act as a tumor suppressor in prostate cells due to its activity in the induction of agonist ligands in inhibited growth of prostate cancer cells.

Additionally, the phytochemical also expressed a significant activity in exhibiting the liver X receptor alpha (LXRα) in reducing proliferation of human oral cancer cells by promoting cell cycle arrest through increased expression of the cyclin-dependent kinase inhibitor p27, a tumor suppressor and promoted function of extracellular ATP-binding cassette transporter 1 (ABCA1) pathway in inhibited tumor growth through modulation of macrophage function within the tumor, and in established a link between cholesterol homeostasis and cancer.

Application of lycopene (10 μM) in the presence of a specific antagonist of PPARγ (GW9662) or LXRα (GGPP) exerted a huge effect in reduced liver X receptor α knockdown in the induction of resistance against LXRα in promoted the proliferation of DU145 cells.

Interestingly, lycopene in combination with the LXRα agonist T0901317, a potent chemical compound used in assays, exhibited anti-prostate cell proliferative activity through interaction with protein expression of PPARγ, LXRα, and ABCA1 in initiated cancer cell apoptosis.

In conclusion, Dr. Yang CM, the lead author said, "These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARγ-LXRα-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects".

The result findings strongly suggested that long-term intake of carrots in moderate amounts may have substantial implications in the prevention and treatment of prostate cancer. But Intake of carrot supplements should be taken with care to prevent acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Dietary carrot consumption and the risk of prostate cancer by Xu X1, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, Mao Q, Xie L(PubMed)
(2) The effect of lycopene on the PI3K/Akt signaling pathway in prostate cancer by Chen J, O'Donoghue A, Deng YF, Zhang B, Kent F, O'Hare T(PubMed)
(3) Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway by Yang CM1, Lu YL, Chen HY, Hu ML(PubMed)