Bromelain-based Enzymatic Debridement with Nexobrid® (#Mediwound) in the Healing of Diabetic Foot Wounds, Researchers Find

By Kyle J. Norton

Eschar is a dry, dark scab of dead skin associated with a certain skin condition.
Most cases of eschar are associated with burning or cauterizing that stops bleeding, or prevent the spread of infection.
wounds
The most common causes of eschar are burns, a condition that causes severe skin damage. Burn wound can recover without serious health consequences in a few days or weeks depending on the size of the burns.

Burns depending on the severity can be classified into
* First-degree burns affect only the epidermis or outer layer of the skin accompanied by the symptoms of red, pain, dry, with no blisters on the affected site.

* Second-degree burns affect the epidermis and part of the dermis layer of the skin accompanied by the symptoms of red, blistered, swollen, and painful on the affected site.

* Third-degree burns not only destroy the epidermis and dermis but also damage the underlying bones, muscles, and tendons accompanied by no symptoms due to complete damage of the nerves in the area.

Believe it or not, 10 percent of burns on a child's body and 15 to 20 percent of burns on, an adult's body are considered to be major injuries and require medical attention and hospitalization.

The most common types of burns are* Thermal burns caused by external heat sources.

* Radiation burns caused by prolonged exposure to ultraviolet rays of the sun or radiotherapy.

* Chemical burns caused by acids, alkalies, detergents, or solvents.

* Electrical burns caused by electrical current.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In finding a potential compound for the treatment of diabetic foot burns, researchers examined the effect of bromelain-based enzymatic debridement with Nexobrid® (Mediwound) on surgical tangential excision of deep dermal and full-thickness burns.

According to the retrospective case series that identified four patients with diabetic foot burns,
Nexobrid® debridement showed significant activity in the development of further eschar and deepening of their wounds a few days after NexoBrid was applied.

In other words, Nexobrid® debridement protects the skin against the formation of dry, dark scabs or the falling away of dead skin due to surgical tangential excision of deep dermal and full-thickness burns.

Based on the finding, Dr. Berner JE, the lead scientist said, "We would recommend judicious use of this new product in patients with diabetic foot wounds".

Moreover, the joint study led by the University of Heidelberg based on the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists suggested that the degree of consensus was remarkably high, with a unanimous consensus in 88.2% of statements, and the lowest degree of consensus of 70% in only 3 statements.

More precisely, most patients support the use of Nexobrid® debridement for the treatment of removed eschar in burn wounds and reduced blood loss.

After taking other factors into account, Dr. Hirche C, the lead researcher wrote, "This consensus document may serve as a preliminary guideline for the use of enzymatic debridement with user-oriented recommendations until further evidence and systematic guidelines are available".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of eschar in burn wounds, pending to the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results by Berner JE1,2, Keckes D1, Pywell M1, Dheansa B. (PubMed)
(2) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(3) Burn Stages and Types of burn by the Stanford Health Care