Saturday, 26 June 2021

Topical Turmeric Extract Processes Anti Aging Activity in Vitro

By Kyle J. Norton

Aging is a natural and biological process that cannot be prevented.

Skin aging is one of the most visible processes which occurs constantly in our skin organ.

However, actively engaging healthy living lifestyle by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans, and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc. accompanied with moderate exercise has been found to delay aging progression.

In other words, it is possible that a person has physiological younger than his or her biological age.


There many theory that explains the aging processes. According to the free radical theory, oxidative damage to the enzymes, other proteins, unsaturated fatty acids, phospholipids, DNA and RNA, etc., caused by free radical chain reaction can lead to aging of the organisms by attacking the lipid bilayers of the cell walls.

You can view other theories of aging by click this link.

There are many risk factors associated with aging and premature aging processes. Dr. Bhatt N in the assessment of the risk factors and self-perception for facial aging among the Nepalese population wrote, "Around 50% of attendees were conscious about facial health, 53% perceived their facial age as their chronological age, 39% used some facial care products, and 68% were aware of the risk factors for facial aging".

And "The major perceived risk factors were unhealthy eating habits, stress, less exercise, dehydration, diseased state, and sleeping habits. A significant association was found between increasing age, place of birth in hills or mountains and sun exposure with high wrinkling score".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a better compound for the treatment of skin aging, researchers determined the antiaging activity of Curcuma heyneana to prove its traditional use as skincare, for cosmetic and body freshness.

In vitro, according to the tested assay, the extracts showed a dose-dependent manner in the final concentration range from 62.5 to 500 µg/mL in the inhibition of free radical expression and 31.25 to 250 µg/mL for tyrosinase and collagenase.

The extract containing a high amount of curcuminoid (CUR), the active principle of Curcuma is the best antioxidant, that acts as a tyrosinase inhibitor, and collagenase inhibitor, compared to those with a low concentration of CUR.

The topical application of the crude extract also induced significant improvement effects on the UV-induced skin structure damage.


By examining the efficacy of constituent of the extracts, researchers found that total CUR content was correlated with the anti-aging activity.


Based on the findings, researchers said, "The results show that C. heyneana contains antioxidant compounds and has potent anti-aging activity, indicating that it can be used as an anti-aging drug candidate or as a phyto-cosmeceutical".

Taken altogether, turmeric in form of extract may be considered supplements used for the treatment of skin aging, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography

Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition by Kusumawati I1, Kurniawan KO2, Rullyansyah S2, Prijo TA3, Widyowati R2, Ekowati J4, Hestianah EP5, Maat S6, Matsunami K7. (PubMed)
(2) Development and evaluation of topical films containing phytoestrogenic diaryheptanoids from Curcuma comosa extract by Tuntiyasawasdikul S1, Limpongsa E1, Jaipakdee N1, Sripanidkulchai B. (PubMed)
(3) Risk factors and self-perception for facial aging among Nepalese population by Bhatt N1, Agrawal S1, Mehta K. (PubMed)

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