Friday 8 October 2021

Broccoli Processes Anti-Metastatic Activities in Vitro

By Kyle J. Norton

Cancer is a class of diseases associated with irregular cell growth on the tissue of the specific organ.

Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.

Metastasis is the spread of cancer cells to other organs and tissues, via the lymph system or bloodstream. 

In other words, cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.

Anti-metastasis is an action in which substances or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.

Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.

In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential whole food for the treatment of cancer, researchers examined the anti-metastatic activities of purified polysaccharides (BCE-I, -II, and -III) in broccoli, polysaccharides (BCE-I, -II, and -III) isolated by fractionation of broccoli enzyme extracts and subsequent ethanol precipitation.

Where BCE-I mainly consisted of galactose and arabinose, whereas BCE-II mainly consisted of galacturonic acid and rhamnose, and BCE-III mainly consisted of rhamnose and galactose.

According to the tested results
* BCE-I exerted the greatest effect to inhibit the cancer activity by increasing the pro-inflammatory expressions such as the tumor necrosis factor-α, interleukin (IL)-12, and IL-6 compared to the II and III.

* Intravenous (i.v.) administration of BCE-I promoted the cytotoxic activity of natural killer (NK) cells on YAC-1 tumor cells significantly and dose-dependently in an ex vivo experiment of NK cell activity.

* In the experimental model using lung metastasis of Colon26-M3.1 carcinoma cells, prophylactic i.v. and oral administration of BCE-I also significantly inhibited lung metastatic activity in a dose-dependent manner.

* Moreover, the efficacy of BCE-I against lung metastasis was totally dependent on the presence of NK cell function.

Collectively, researchers said, "BCE-I has potent antitumor metastatic activity, and that its anti-metastatic activity has relevance to the stimulation of NK and other immune cells".

Taken altogether, broccoli may be considered a functional food for the prevention of cancer spreading, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation by Kwak BS1, Hwang D2,3, Lee SJ1, Choi HJ4, Park HY5, Shin KS. (PubMed)

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