By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
PCOs Treatment according traditional Chinese medicine
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into
Spleen yang deficiency
Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....
1. Essential amino acids
8. Beta carotene
9. vitamin C
10. vitamins D
12. Vitamin K
16. Derivatives of coumarin
In diabetes, alfalfa exhibited prevention of the onset of developing Type 1 Diabetes(1056)
diabetogenic or anti-diabetic potentials(1055), through its estrogenic activity in modulation of diabetes(1055), protection against pancreas from autoimmune destruction(1056), antihyperglycaemic, insulin-releasing and insulin-like activity(1057).
In insulin resistance, dietary of alfalfa exhibited insulinaemic effects, according to University of Leipzig(2300) and Kitasato University(2301) in animal studies.
In cardiovascular disease, the was found effectively in prevention of the onset of heart disease and stroke(2302), through its nutrient and phytochemical compositions(2302), enhancement of cholesterol efflux in the liver(2303) and this reduced of cholesterol depositions(2303)(2304).
In take of mordanted alfalfa fiber has also shown to effect body weight and in contribution to anti obesity activity in animal study(2305)(2306).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(2284) Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia by Mölgaard J, von Schenck H, Olsson AG.(PubMed)
(2285) Digital gene-expression profiling analysis of the cholesterol-lowering effects of alfalfa saponin extract on laying hens by Zhou L1, Shi Y1, Guo R1, Liang M1, Zhu X1, Wang C1.(PubMed)
(2286) Experimental models of atherosclerosis regression by Malinow MR.(PubMed)
(2287) Effect of alfalfa meal on shrinkage (regression) of atherosclerotic plaques during cholesterol feeding in monkeys by Malinow MR, McLaughlin P, Naito HK, Lewis LA, McNulty WP.(PubMed)
(2288) Cytotoxicity and apoptosis induced by alfalfa (Medicago sativa) leaf extracts in sensitive and multidrug-resistant tumor cells by Gatouillat G1, Magid AA, Bertin E, Okiemy-Akeli MG, Morjani H, Lavaud C, Madoulet C.(PubMed)
(2289) Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: suppression of serine/threonine and tyrosine kinases by Manna SK1.(PubMed)
(2290) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne) by Gray AM1, Flatt PR.(PubMed)
(2291) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice by Swanston-Flatt SK1, Day C, Bailey CJ, Flatt PR.(PubMed)
(2292) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(2293) [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent]. [Article in Italian] by De Leo V1, Lanzetta D, Cazzavacca R, Morgante G.(PubMed)
(2294) Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult by Bora KS1, Sharma A.(PubMed)
(2295) Phytochemical and pharmacological potential of Medicago sativa: a review by Bora KS1, Sharma A.(PubMed)
(2296) The effect of dietary alfalfa and flax sprouts on rabbit meat antioxidant content, lipid oxidation and fatty acid composition by Dal Bosco A1, Castellini C2, Martino M2, Mattioli S2, Marconi O2, Sileoni V2, Ruggeri S2, Tei F2, Benincasa P2.(PubMed)
(2297) Pseudomonas fluorescens Pf-5 genome-wide mutant screen for resistance to the antimicrobial peptide alfalfa snakin-1. Ayub ND1, Fox AR1, García AN2, Mozzicafreddo M3, Cuccioloni M3, Angeletti M3, Pagano E2, Soto G4.(PubMed)
(2298) Estrogenic activity of fermented alfalfa by Jorgensen NA, Freymiller DD.(PubMed)
(2299) [Anti-estrogenic action of some alfalfa varieties]. [Article in Bulgarian] by Bonkov N, Petrova S, Khadzhiiski D.(PubMed)
(2300) The effect of mixing and changing the order of feeding oats and chopped alfalfa to horses on: glycaemic and insulinaemic responses, and breath hydrogen and methane production by Vervuert I1, Voigt K, Hollands T, Cuddeford D, Coenen M.(PubMed)
(2301) Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep by Takahashi H1, Kurose Y, Sakaida M, Suzuki Y, Kobayashi S, Sugino T, Kojima M, Kangawa K, Hasegawa Y, Terashima Y.(PubMed)
(2302) Nutritional quality of legumes, and their role in cardiometabolic risk prevention: a review by Bouchenak M1, Lamri-Senhadji M.(PubMed)
(2303) Digital gene-expression profiling analysis of the cholesterol-lowering effects of alfalfa saponin extract on laying hens. Zhou L1, Shi Y1, Guo R1, Liang M1, Zhu X1, Wang C1.(PubMed)
(2304) Effects of alfalfa on lipoproteins and fatty streak formation in hypercholesterolemic rabbits. Asgary S1, Moshtaghian J, Hosseini M, Siadat H.(PubMed)
(2305) Effects of dietary fiber of young adult genetically lean, obese and contemporary pigs: rate of passage, digestibility and microbiological data by Varel VH1, Jung HG, Pond WG.(PubMed)
(2306) Effect of dietary fiber on young adult genetically lean, obese and contemporary pigs: body weight, carcass measurements, organ weights and digesta content by Pond WG1, Jung HG, Varel VH.(PubMed)