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Saturday, 4 July 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM Herbal Medicine for Spleen Yang deficiency - Cordyceps militaris


By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Polycystic Ovarian Syndrome


Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

In Traditional Chinese Medicine Perspective


While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

PCOs Treatment according traditional Chinese medicine


Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into



Spleen yang deficiency


Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....


Herbal Medicine recommended for Treatment of PCOs induced by spleen yang deficiency

2.  Cordyceps militaris(Dong Chong Xia cao)
Dong chong xia cao, the sweet and warm herb also known as cordyceps sinensis, used in traditional Chinese medicine as immune enhancer(2229)(2230), anti microbial(2231)(2232), anti oxidant(2233)(2234), anti inflammatory(2235)(2236), anti cancer(2237)(2238), cardio-protective(2239)(2240)(2241) agent and for treatment of cirrhosis(2242)(2243), lower back pain (due to it analgesic property)(2244), chronic cough and asthma(2245)(2246), ... as it tonifies yang, nourishes lung yin, transforms phlegm, by enhancing the function of kidney and lung channels(2229).

Phytochemical constituents(2228)
1. Cordyceps polysaccharide
2. Ergosterol
3. Cordycepic acid
4. Amino Acids
5. Lysine
6. Aspartic acid
7. Threonine
8. Taurine
9. Etc.

On metabolic syndrome, in diabetics rat model, Dong chong xia cao inhibited significantly the level of glucose metabolic disorders(2250)(such as hyperglycemia(2251)(2252) by enhancing the glyconeogenesis in serum glucose and lipid profiles(2247), by promoting anti-lipid peroxidation activities and inhibit accumulation of cholesteryl ester in macrophages via suppression of LDL oxidation(2253), regulating the expression of lipoprotein lipase (LPL) and hepatic lipase (HL) activity(2253) and activating protein kinase (AMPK)(2254), improved insulin sensitive(2248)(2249) by inhibiting the activity of human protein tyrosine phosphatase 1B (PTP1B) activity(2249) though metabolism of glucose and lipid(2247)(2248), the microcirculation disturbance(2247)(2248) and the oxidative stress(2247)
On obesity, dong chong xia cao has found to improve the obesity(2255)(2256) through decreased body weight and improved energy uptake(2255) by inhibiting alpha-glycosidase(2255) and adipogenic(2256) and lipid accumulation(2256) activity.
On metabolic syndrome's complications, the herbal medicine reduced risk of diabetes(2259)(2260) and cardiovascular disease(2259) through inhibition of low grade inflammation(2259)(2260) and platelet activation(2263)via immunomodulatory(2259)(2260) and antioxidant activity(2261)(2262).
According to Jenteh Junior College of Medicine and Nursing Management and National Cheng Kung University Medical College, dong chong xia cao improved sex desire(2257), and fertility(2258) through increasing serum testosterone and estradiol-17 (E2) concentrations in production of quality of maturing oocyte, respectively without effecting follicle stimulating hormone (FSH), luteinizing hormone (LH) or prolactin(2257).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(2228) Dong chong xia cao(Complementary and Alternative Healing University)
(2229) [Effect of cordyceps sinensis on cellular immunity in rats with chronic renal insufficiency]. [Article in Chinese] by Cheng Q1.(PubMed)
(2230) Comparisons on enhancing the immunity of fresh and dry Cordyceps militaris in vivo and in vitro by Zhu SJ1, Pan J, Zhao B, Liang J, Ze-Yu W, Yang JJ.(PubMed)
(2231) Phytochemical and antimicrobial activities of Himalayan Cordyceps sinensis (Berk.) by Sacc. Mamta, Mehrotra S, Amitabh, Kirar V, Vats P, Nandi SP, Negi PS, Misra K.(PubMed)
(2232) Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters by Koh JH1, Suh HJ, Ahn TS.(PubMed)
(2233) Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis by Yamaguchi Y1, Kagota S, Nakamura K, Shinozuka K, Kunitomo M.(PubMed)
(2234) Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia by Li SP1, Li P, Dong TT, Tsim KW.(PubMed)
(2235) Anti-inflammatory principles from Cordyceps sinensis by Yang ML1, Kuo PC, Hwang TL, Wu TS.(PubMed)
(2236) Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts by Rao YK1, Fang SH, Tzeng YM.(PubMed)
(2237) Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells by Lee S1, Lee HH, Kim J, Jung J, Moon A, Jeong CS, Kang H, Cho H.(PubMed)
(2238) Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity by Aramwit P1, Porasuphatana S2, Srichana T3, Nakpheng T3.(PubMed)
(2239) [Current studies and prospect of anti-thrombotic effect of Cordyceps fungi]. [Article in Chinese] by Li XG1, Xiao JH1.(PubMed)
(2240) Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats by Liu Z1, Li P, Zhao D, Tang H, Guo J.(PubMed)
(2241) Role of dongchongxiacao (Cordyceps) in prevention of contrast-induced nephropathy in patients with stable angina pectoris by Zhao K1, Li Y, Zhang H.(PubMed)
(2242) [Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis]. [Article in Chinese] by Wang XB1, Liu P, Tang ZP, Li FH, Liu CH, Hu YY, Xu LM.(PubMed)
(2243) [Acting mechanism of Cordyceps mycelia extract for antagonizing hepatic sinusoidal capillarization in rats with dimethylnitrosamine induced liver cirrhosis]. [Article in Chinese] by Wang XB1, Liu P, Tang ZP.(PubMed)
(2244) Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis by Qian GM1, Pan GF, Guo JY.(PubMed)
(2245) Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process by Yang X1, Li Y1, He Y1, Li T1, Wang W2, Zhang J3, Wei J4, Deng Y5, Lin R6.(PubMed)
(2246) The extract of Cordyceps sinensis inhibited airway inflammation by blocking NF-κB activity by Chiou YL1, Lin CY.(PubMed)
(2247) [Investigation of compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment VI--improving hyperglycemia-mediated renal damage]. [Article in Chinese] Fu JY1, Zhang XL2, Tian JY2, Huang LW2, Zhang PC3, Ye F2.(PubMed)
(2248) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rhum palmatum, on metabolic syndrome treatment. IV--Improving liver lipid accumulation]. [Article in Chinese] by Li J1, Zhang XL, Liu YY, Chen L, Tian JY, Han JY, Zhang PC, Ye F.(PubMed)
(2249) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment I--improving insulin resistance]. [Article in Chinese] by Li J1, Chen L, Zhang X, Fu J, Han J, Tian J, Zhang P, Ye F.(PubMed)
(2250) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment. V--Mechanisms on improving glucose metabolic disorders]. [Article in Chinese] Wang L1, Zhang XL, Li MH, Tian JY, Zhang PC, Ye F.(PubMed)
(2251) Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice by Ma L1, Zhang S2, Du M3.(PubMed)
(2252) Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Lo HC1, Hsu TH, Tu ST, Lin KC.(PubMed)
(2253) Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats by Gao J1, Lian ZQ, Zhu P, Zhu HB.(PubMed)
(2254) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase by Guo P1, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA, Zhu HB.(PubMed)
(2255) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment II - improving obesity]. [Article in Chinese] by Tian JY1, Chen L, Zhang XL, Li J, Han J, Fu JY, Yang XM, Zhang PC, Ye F.(PubMed)
(2256) Blockade of adipocyte differentiation by cordycepin. Takahashi S1, Tamai M, Nakajima S, Kato H, Johno H, Nakamura T, Kitamura M.(PubMed)
(2257) Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats by Chang Y1, Jeng KC, Huang KF, Lee YC, Hou CW, Chen KH, Cheng FY, Liao JW, Chen YS.(PubMed)
(2258) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium by Huang BM1, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ.(PubMed)
(2259) Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines by Shin S1, Moon S, Park Y, Kwon J, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2260) Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages by Shin S1, Lee S, Kwon J, Moon S, Lee S, Lee CK, Cho K, Ha NJ, Kim K.(PubMed)
(2261) Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors by Yan XF1, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, Jia YL, Wang RW.(PubMed)
(2262) Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats by Liu Z1, Li P, Zhao D, Tang H, Guo J.(PubMed)
(2263) , inhibit Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation by Chang YI, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR1.(PubMed)