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Monday, 31 March 2014

Cascara Sagrada (Rhamnus purshiana) and Ovarian cancer



Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths


The Ingredients

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

The health benefits
Study in combined treatment of emodin and survivin-targeted shRNA (a sequence of RNA) with
sur-shRNA plasmid constructed and transfected into the ovarian cancer cell lines SKOV3 and HO8910, showed positive effect of the shRNA specific for survivin effectively reduced the expression of survivin at the mRNA and protein levels in SKOV3 and HO8910 cells. Combination of emodin and shRNA-mediated knockdown of survivin significantly inhibited cell proliferation, induced apoptosis, and suppressed invasion in SKOV3 and HO8910 cells. Other treatment with concentration of emodin alone or combined with paclitaxel, indicated an effective of emodin induced apoptosis alone at a high concentration and increased paclitaxel-induced apoptosis at a low concentration. These results suggested the possibility of an innovative chemotherapeutic strategy in treating drug resistant ovarian tumor.


Ovarian Cysts And PCOS Elimination
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References
(1) The combined effect of survivin-targeted shRNA and emodin on the proliferation and invasion of ovarian cancer cells by Xue H, Chen Y, Cai X, Zhao L, He A, Guo K, Zheng X.(PubMed)
(2) Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro by Li J, Liu P, Mao H, Wanga A, Zhang X.(PubMed)