Sunday, 30 March 2014

Benign prostatic hyperplasia(BPH) in Vitamin E Points of View

Kyle J. Norton

Benign prostatic hyperplasia(BPH) is defined as a condition of increased in the number of cells of prostate gland, causing partial, or sometimes virtually complete obstruction of the urinary tract. According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50. More than half of men between age of 60-70 are experience symptoms of BPH and only 10% are required treatment.
Vitamin E,  a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Epidemiological studies, linking vitamin E in reduced risk and treatment of benign prostatic hyperplasia have not been consistent(1)(2)(3).
A composition, consisting cernitin, saw palmetto, B-sitosterol, vitamin E has shown to significantly reduce nocturia and frequency and diminish overall symptomatology of BPH, according to the Georgetown University Medical Center(4). Some researchers suggested that Benign prostatic hypertrophy (BPH) may be associated to the long-term exposure of the prostate to the strong androgen 5alpha-dihydrotestosterone (DHT) due to aging induced conversion of free testosterone. Food supplementation with extracts of Serenoa repens and a combination of the antioxidants selenium, (cis)-lycopene and natural vitamin E, together with fish oil rich in long-chain polyunsaturated essential fatty acids of the omega-3 group may be effective as pharmaceutical 5alpha-reductase inhibitors in partial androgen deficiency correct testosterone substitution(5). Vitamin E, as an antioxidant and free radical scavenger may be effective in reduced oxidative stress as patients with BPH were found with significant decrease in plasma alpha-Toc and Asc level(6)(7). Although diet and dietary supplement intervention appeared to slow BPH progression, over consumption of dietary supplements may be harmful(8).

Taken altogether, without going into reviews, vitamin E may be effective in reduced risk and treatment of patients with BPH. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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(1) Preventing diseases of the prostate in the elderly using hormones and nutriceuticals by Comhaire F1, Mahmoud A.(PubMed)
(2) Diet, micronutrients, and the prostate gland by Thomas JA.(PubMed)
(3) Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy by Tavani A1, Longoni E, Bosetti C, Maso LD, Polesel J, Montella M, Ramazzotti V, Negri E, Franceschi S, La Vecchia C.(PubMed)
(4) Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH) by Preuss HG1, Marcusen C, Regan J, Klimberg IW, Welebir TA, Jones WA.(PubMed)
(5) Preventing diseases of the prostate in the elderly using hormones and nutriceuticals by Comhaire F1, Mahmoud A.(PubMed)
(6) Oxidative stress in benign prostate hyperplasia by Aryal M1, Pandeya A, Gautam N, Baral N, Lamsal M, Majhi S, Chandra L, Pandit R, Das BK(PubMed)
(7) Oxidative stress in patients with benign prostate hyperplasia by Aryal M1, Pandeya A, Bas BK, Lamsal M, Majhi S, Pandit R, Agrawal CS, Gautam N, Baral N.(PubMed)
(8) Diet and dietary supplement intervention appeared to slow disease progression by Sebastiano C1, Vincenzo F, Tommaso C, Giuseppe S, Marco R, Ivana C, Giorgio R, Massimo M, Giuseppe M.(PubMed)

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