Kyle J. Norton
Artichoke may be the next target to extract the ingredients needed for the treatment of chronic myeloid leukemia (CML), according to studies.
Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved in cell cycle division and tumor suppression.
Epidemiologically, most people with CML are associated with risk factors of aging, male gender, and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.
According to the statistics provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also caused the death of 1,090 people, including 620 men and 470 women.
The most common symptoms of CML include easy bleeding and tired, unintended weight loss, pain or fullness below the ribs on the left side, and pale skin.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent and for the treatment of digestive disorders, abdominal pain gas bloating, etc.
Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin and showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.
In other words, the study was carried out to examine the effect of CCL extract on human K562 CML and K562 imatinib-resistant (IMAR) cell proliferation and on p210BCR/ABL expression.
Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.
Injection of CCL extract was shown to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.
In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.
In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.
In the depth differentiation, researchers also found that CCL extract showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.
Taken together, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)
Tuesday 31 October 2023
#Healthyfood #Onion and Garlic Extracts Inhibit the Incidences of LiverToxicity, According to Studies
Kyle J. Norton
The liver is the largest internal organ and the only organ in the human body that can regenerate itself.
The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building a strong cell wall, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizes drugs.
The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, inclduing cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in many recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound that processes liver protective activity, researchers examined the effects of onion and garlic extracts on cadmium (Cd)-induced liver oxidative damage in rats.
The study included
* The Cd group was challenged with 3CdSO(4).8H(2)O (as Cd; 1.5 mg/kg bw per day per oral) alone, and
* The extract-treated groups were pretreated with varying doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and after that co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks.
Based on the tested differentiation, the Cd group showed a significant increase in the levels of lipid peroxidation and glutathione S-transferase. In contrast, antioxidant enzymes such as glutathione, superoxide dismutase, and catalase levels were decreased in the liver.
Furthermore, liver oxidative stress markers such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase were also found to increase in the Cd group.
In other words, Cd showed induced oxidative damage in rat liver.
Injection of garlic and onion extract not only inhibited all parameters in the Cd group but also exerted a liver protective effect in a dose-dependent manner.
Based on the findings, researchers wrote, "high dose of onion and a moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity".
Taken together, onion may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of quercetin: From chemistry to medicine by Miltonprabu S1, Tomczyk M2, Skalicka-Woźniak K3, Rastrelli L4, Daglia M5, Nabavi SF6, Alavian SM7, Nabavi SM. (PubMed)
(2) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats by Obioha UE1, Suru SM, Ola-Mudathir KF, Faremi TY. (PubMed)
The liver is the largest internal organ and the only organ in the human body that can regenerate itself.
The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building a strong cell wall, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizes drugs.
The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, inclduing cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in many recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound that processes liver protective activity, researchers examined the effects of onion and garlic extracts on cadmium (Cd)-induced liver oxidative damage in rats.
The study included
* The Cd group was challenged with 3CdSO(4).8H(2)O (as Cd; 1.5 mg/kg bw per day per oral) alone, and
* The extract-treated groups were pretreated with varying doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and after that co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks.
Based on the tested differentiation, the Cd group showed a significant increase in the levels of lipid peroxidation and glutathione S-transferase. In contrast, antioxidant enzymes such as glutathione, superoxide dismutase, and catalase levels were decreased in the liver.
Furthermore, liver oxidative stress markers such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase were also found to increase in the Cd group.
In other words, Cd showed induced oxidative damage in rat liver.
Injection of garlic and onion extract not only inhibited all parameters in the Cd group but also exerted a liver protective effect in a dose-dependent manner.
Based on the findings, researchers wrote, "high dose of onion and a moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity".
Taken together, onion may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of quercetin: From chemistry to medicine by Miltonprabu S1, Tomczyk M2, Skalicka-Woźniak K3, Rastrelli L4, Daglia M5, Nabavi SF6, Alavian SM7, Nabavi SM. (PubMed)
(2) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats by Obioha UE1, Suru SM, Ola-Mudathir KF, Faremi TY. (PubMed)
Monday 30 October 2023
Ingredients Found in #Cucumber Work Synergistically Against the Risk of #Diabetes, Researchers Say
Kyle J. Norton
Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.
In other words, diabetes is a condition associated with the inability of the body to use insulin properly.
Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged up by fat and cholesterol.
Hallmarks of diabetes are hyperglycemia and insulin resistance.
According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes
The most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.
* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.
* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.
* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin
* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.
* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, and an increase in urine specific gravity.
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a natural compound that processes anti-diabetes properties, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.
The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,
Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.
* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.
* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better-reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL
* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.
In other words, all ingredients in cucumbers work synergistically to exhibit anti-diabetes activity compared to a single compound.
Taken together, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton
Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.
In other words, diabetes is a condition associated with the inability of the body to use insulin properly.
Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged up by fat and cholesterol.
Hallmarks of diabetes are hyperglycemia and insulin resistance.
According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes
The most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.
* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.
* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.
* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin
* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.
* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, and an increase in urine specific gravity.
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a natural compound that processes anti-diabetes properties, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.
The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,
Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.
* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.
* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better-reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL
* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.
In other words, all ingredients in cucumbers work synergistically to exhibit anti-diabetes activity compared to a single compound.
Taken together, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton
#Onion Promotes Antiproliferative and Anti-Inflammatory Effects. Against the Risk of #Endometriosis, According to Studies
Kyle J. Norton
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.
More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, and some of the endometriosis tissues grow somewhere else in the body.
Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.
According to the statistics, 20% of reproductive-age women with endometriosis present without symptoms, and 55% of women have developed the new onset of severe menstrual cramps.
Additionally, endometriosis also induces sub-fertility (less fertile than a normal couple) in 25% of women.
Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.
* Hormone therapy may be accompanied by pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.
In a surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.
* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.
In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells),
* Quercetin inhibited the proliferation and induced the cell cycle arrest.
* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, and loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.
* Quercetin also suppressed the expression of signaling pathways associated with endometrial cell survival and growth.
On endometriosis auto-implanted mouse models,
* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.
* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis.
In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.
Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".
Taken together, onion processed with an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits the proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.
More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, and some of the endometriosis tissues grow somewhere else in the body.
Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.
According to the statistics, 20% of reproductive-age women with endometriosis present without symptoms, and 55% of women have developed the new onset of severe menstrual cramps.
Additionally, endometriosis also induces sub-fertility (less fertile than a normal couple) in 25% of women.
Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.
* Hormone therapy may be accompanied by pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.
In a surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.
* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.
In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells),
* Quercetin inhibited the proliferation and induced the cell cycle arrest.
* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, and loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.
* Quercetin also suppressed the expression of signaling pathways associated with endometrial cell survival and growth.
On endometriosis auto-implanted mouse models,
* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.
* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis.
In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.
Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".
Taken together, onion processed with an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits the proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)
#Ginger Bioactive Compounds and Extract Process Anti Lung Cancer Activity, Researchers Show
Kyle J. Norton
Scientists may have found a pungent spice which processes the potential to treat lung cancer, according to studies.
Lung cancer is a medical condition characterized by irregular cell growth in the lung tissue.
In Canada, according to the statistics, lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.
The 5-year survival rate for people with stage IB NSCLC is about 68%.
At the advanced stage, the lung cancer cell may suppress the nearby blood vessels and nerves leading to vomiting blood and localized severe pain accompanied by other general symptoms of cancer such as weight loss, reduced appetite.
In this stage, lung cancer also can travel a distance away to infect other healthy cells of tissue and organs, leading to secondary metastasis.
The most common glands and organs of lung cancer metastases are the adrenal gland, bones, brain, and liver.
Although there are many factors associated with the onset of lung cancer, some researchers suggested that current and past smoking accounts for most of the cases. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.
Dr. Ozlü T, the lead scientist in examining the risk of lung cancer from smoking, wrote, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers. In recent decades, there has been a shift from squamous and small cell lung cancer types to adenocarcinoma, due to increasing rates of smoking among the female population and rising light cigarette usage".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of lung cancer with no side effects compared to chemo medication examined the anti-lung cancer of bioactive compounds isolated from ginger.
[6]-shogaol, [6]-paradol and [6]-gingerol, potentiate the anti-NSCLC activity, however, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth.
[6]-Shogaol also induced cell cycle arrest (G1 or G2/M) and apoptosis as well as the cascades associated with the programming cell deaths.
Furthermore, [6]-shogaol inhibited protein (Akt kinase activity), associated with cancer proliferation and survival In NCI-H1650 lung cancer cells by inhibiting the regulator involved in cell cycle progression.
Dr. Myoung Ok Kim and colleagues in the final report said, "The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC".
In order to reveal more information about ginger anti-lung cancer activity, researchers examined the [6]-gingerol and [6]-shogaol and a ginger extract with a high level of shogaols (GEHS) against lung cancer cells.
[6]- shogaol has greater growth inhibitory activity (about 10-fold) on lung and colon cancer cell lines than [6]- gingerol.
Shogaols of ginger preparations and GEHS has a stronger cancer-preventive effect, compared to other ginger extracts.
The inhibitory activities of GEHS and extract from fresh ginger, as well as [6]-shogaol and [6]-gingerol inhibited an NNK-induced lung carcinogenesis model in A/J mice.
These results provide the basic information on key active cancer preventive constituents in ginger extracts. The development of a standardized and more active ginger extract preparation will facilitate future pre-clinical and clinical studies on the health benefits of ginger extracts, according to the author.
Taken together, ginger processed with a high amount of bioactive compounds may be considered a function alternative for prevention and combined primary therapy for the treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 by Myoung Ok Kim, 1 , 2 , † Mee-Hyun Lee, 1 , 3 , † Naomi Oi, 1 , † Sung-Hyun Kim, 1 , 2 , †Ki Beom Bae, 1 Zunnan Huang, 1 , 4 Dong Joon Kim, 1 , 5 Kanamata Reddy, 1 Sung-Young Lee,1 , 6 Si Jun Park, 2 Jae Young Kim, 2 Hua Xie, 1 , 7 Joydeb Kumar Kundu, 8 Zae Young Ryoo, 2Ann M. Bode, 1 Young-Joon Surh, 3 and Zigang Dong. (PMC)
(2) Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect by Sang, Shengmin. (NIH)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Scientists may have found a pungent spice which processes the potential to treat lung cancer, according to studies.
Lung cancer is a medical condition characterized by irregular cell growth in the lung tissue.
In Canada, according to the statistics, lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.
The 5-year survival rate for people with stage IB NSCLC is about 68%.
At the advanced stage, the lung cancer cell may suppress the nearby blood vessels and nerves leading to vomiting blood and localized severe pain accompanied by other general symptoms of cancer such as weight loss, reduced appetite.
In this stage, lung cancer also can travel a distance away to infect other healthy cells of tissue and organs, leading to secondary metastasis.
The most common glands and organs of lung cancer metastases are the adrenal gland, bones, brain, and liver.
Although there are many factors associated with the onset of lung cancer, some researchers suggested that current and past smoking accounts for most of the cases. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.
Dr. Ozlü T, the lead scientist in examining the risk of lung cancer from smoking, wrote, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers. In recent decades, there has been a shift from squamous and small cell lung cancer types to adenocarcinoma, due to increasing rates of smoking among the female population and rising light cigarette usage".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of lung cancer with no side effects compared to chemo medication examined the anti-lung cancer of bioactive compounds isolated from ginger.
[6]-shogaol, [6]-paradol and [6]-gingerol, potentiate the anti-NSCLC activity, however, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth.
[6]-Shogaol also induced cell cycle arrest (G1 or G2/M) and apoptosis as well as the cascades associated with the programming cell deaths.
Furthermore, [6]-shogaol inhibited protein (Akt kinase activity), associated with cancer proliferation and survival In NCI-H1650 lung cancer cells by inhibiting the regulator involved in cell cycle progression.
Dr. Myoung Ok Kim and colleagues in the final report said, "The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC".
In order to reveal more information about ginger anti-lung cancer activity, researchers examined the [6]-gingerol and [6]-shogaol and a ginger extract with a high level of shogaols (GEHS) against lung cancer cells.
[6]- shogaol has greater growth inhibitory activity (about 10-fold) on lung and colon cancer cell lines than [6]- gingerol.
Shogaols of ginger preparations and GEHS has a stronger cancer-preventive effect, compared to other ginger extracts.
The inhibitory activities of GEHS and extract from fresh ginger, as well as [6]-shogaol and [6]-gingerol inhibited an NNK-induced lung carcinogenesis model in A/J mice.
These results provide the basic information on key active cancer preventive constituents in ginger extracts. The development of a standardized and more active ginger extract preparation will facilitate future pre-clinical and clinical studies on the health benefits of ginger extracts, according to the author.
Taken together, ginger processed with a high amount of bioactive compounds may be considered a function alternative for prevention and combined primary therapy for the treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 by Myoung Ok Kim, 1 , 2 , † Mee-Hyun Lee, 1 , 3 , † Naomi Oi, 1 , † Sung-Hyun Kim, 1 , 2 , †Ki Beom Bae, 1 Zunnan Huang, 1 , 4 Dong Joon Kim, 1 , 5 Kanamata Reddy, 1 Sung-Young Lee,1 , 6 Si Jun Park, 2 Jae Young Kim, 2 Hua Xie, 1 , 7 Joydeb Kumar Kundu, 8 Zae Young Ryoo, 2Ann M. Bode, 1 Young-Joon Surh, 3 and Zigang Dong. (PMC)
(2) Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect by Sang, Shengmin. (NIH)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
#Cucumber Inhibits the Cytokines Associated with the Onset of Cardiovascular Disease (CVD), Reserachers Suggest
Kyle J. Norton
Cardiovascular disease (CVD) is a class of diseases associated with blockage of blood vessels that heart disease and stroke, depending on the affected location.
Most cases of CVD are caused by reduced oxygen-rich blood inducing heart damage or the death of neurons in the brain.
In other words, if the reduced oxygen-rich blood flow occurs in the heart, it causes heart disease. On the other hand, if the reduced rich oxygen blood occurs in the brain, it causes a stroke.
Most cases of CVD in the Western world is coronary heart disease involved in plaque accumulated on the arterial wall due to an unhealthy diet with high saturated and trans fat and a lifestyle such as smoking accompanied by an overdose of the supplement of calcium.
According to the US statistics, from 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Believe it or not, CVD has caused a significant burden in the US healthcare system with the annual total cost at $351.2 billion in 2014-2015, with $213.8 billion in direct cost, including 46% for inpatient care.
Some researchers suggested that the increase of CVD, particularly in coronary heart disease at the alarming rate in the US, is probably associated with the promotion of a high-fat diet over the past few decades, accompanied by a sedentary lifestyle.
Dr. Jane E Freedman wrote, "Over the past two decades, significant progress has been made in the treatment of acute and chronic cardiovascular disease".
"According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease".
Additionally, "Dietary intake of specific nutrients has been suggested as a means of modifying the progression of cardiovascular disease. One such example is the proposed use of foods rich in select vitamins or flavonoids. Epidemiologic studies have reported an inverse relationship between the total dietary intake of plant flavonoids and the incidence of cardiovascular disease".
In other words, if you follow a high-fat diet, you are at substantial risk of diseases associated with obesity, including CVD.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural compound that has a potential effect on endothelium in the onset of cardiovascular diseases(CVD), researchers examined the water/ethanol extract of Cucumis sativus L. (CSE) fruit anti CVD activity.
The study included water/ethanol extract of Cucumis sativus L. (CSE) fruit effect in the attenuation of the damaging effect of pro-inflammatory lipopolysaccharide (LPS) in vitro model of endothelial cells associated with the onset of CVD.
According to the tested assay, administration of CSE reduced LPS-induced cytotoxicity and decreased cellular detachment, restoring the expression of tight junction ZO-1 in the contribution to barrier function.
In protein analysis, Cucumis sativus L. inhibited the early secretion of inflammatory IL-8 and Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory cytokines IL-6 and IL-1α occurred late at 7 and 24 h respectively.
Additionally, in the prevention of the overexpression of pro-inflammatory cytokines, CSE stimulated the secretion of anti-inflammatory IL-10 and increased the production of IL-18 and IFN-γ in the modulation of the immune response.
Furthermore, according to the tested dose differentiation, the angiogenetic activity induced by inflammatory LPS was also prevented by the injection of Cucumis sativus L. extract.
Dr. wrote, at the end of the experiment, " Our results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells (associated with the risk of CVD)".
Moreover, in vivo, the compounds of Cucumis melo L. protected the impairment of the endothelial barrier associated with the risk of CVD induced by intraperitoneal injection of a high dose of CuEC (2 mg/kg).
In other words, cucurbitacins at a higher dose can induce toxicity to the cells of the endothelium, however, at low doses, CuEC (1 mg/kg) can lead to a decline in systolic blood pressure (SBP) without causing toxicity in mice by suppressing the angiotensin II (Ang II)-induced SBP increase.
Interestingly, the efficacy of CuEC's antihypertensive property was involved in facilitating acetylcholine-mediated vasodilation in the mesenteric arteries of tested mice.
Researchers after taking into account co and con-founders said, " In vitro studies showed that CuEC induced vasodilation in a dose-dependent manner in mesenteric arteries of both mice and rats. Pretreatment with CuEC inhibited phenylephrine-mediated vasoconstriction".
Taken together, cucumber and its bioactive compound cucurbitacin B (CuB) at the lower dose may be used for the treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (Hypertensive Research)
(3) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (Journal of the American College of Cardiology)
Cardiovascular disease (CVD) is a class of diseases associated with blockage of blood vessels that heart disease and stroke, depending on the affected location.
Most cases of CVD are caused by reduced oxygen-rich blood inducing heart damage or the death of neurons in the brain.
In other words, if the reduced oxygen-rich blood flow occurs in the heart, it causes heart disease. On the other hand, if the reduced rich oxygen blood occurs in the brain, it causes a stroke.
Most cases of CVD in the Western world is coronary heart disease involved in plaque accumulated on the arterial wall due to an unhealthy diet with high saturated and trans fat and a lifestyle such as smoking accompanied by an overdose of the supplement of calcium.
According to the US statistics, from 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Believe it or not, CVD has caused a significant burden in the US healthcare system with the annual total cost at $351.2 billion in 2014-2015, with $213.8 billion in direct cost, including 46% for inpatient care.
Some researchers suggested that the increase of CVD, particularly in coronary heart disease at the alarming rate in the US, is probably associated with the promotion of a high-fat diet over the past few decades, accompanied by a sedentary lifestyle.
Dr. Jane E Freedman wrote, "Over the past two decades, significant progress has been made in the treatment of acute and chronic cardiovascular disease".
"According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease".
Additionally, "Dietary intake of specific nutrients has been suggested as a means of modifying the progression of cardiovascular disease. One such example is the proposed use of foods rich in select vitamins or flavonoids. Epidemiologic studies have reported an inverse relationship between the total dietary intake of plant flavonoids and the incidence of cardiovascular disease".
In other words, if you follow a high-fat diet, you are at substantial risk of diseases associated with obesity, including CVD.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural compound that has a potential effect on endothelium in the onset of cardiovascular diseases(CVD), researchers examined the water/ethanol extract of Cucumis sativus L. (CSE) fruit anti CVD activity.
The study included water/ethanol extract of Cucumis sativus L. (CSE) fruit effect in the attenuation of the damaging effect of pro-inflammatory lipopolysaccharide (LPS) in vitro model of endothelial cells associated with the onset of CVD.
According to the tested assay, administration of CSE reduced LPS-induced cytotoxicity and decreased cellular detachment, restoring the expression of tight junction ZO-1 in the contribution to barrier function.
In protein analysis, Cucumis sativus L. inhibited the early secretion of inflammatory IL-8 and Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory cytokines IL-6 and IL-1α occurred late at 7 and 24 h respectively.
Additionally, in the prevention of the overexpression of pro-inflammatory cytokines, CSE stimulated the secretion of anti-inflammatory IL-10 and increased the production of IL-18 and IFN-γ in the modulation of the immune response.
Furthermore, according to the tested dose differentiation, the angiogenetic activity induced by inflammatory LPS was also prevented by the injection of Cucumis sativus L. extract.
Dr. wrote, at the end of the experiment, " Our results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells (associated with the risk of CVD)".
Moreover, in vivo, the compounds of Cucumis melo L. protected the impairment of the endothelial barrier associated with the risk of CVD induced by intraperitoneal injection of a high dose of CuEC (2 mg/kg).
In other words, cucurbitacins at a higher dose can induce toxicity to the cells of the endothelium, however, at low doses, CuEC (1 mg/kg) can lead to a decline in systolic blood pressure (SBP) without causing toxicity in mice by suppressing the angiotensin II (Ang II)-induced SBP increase.
Interestingly, the efficacy of CuEC's antihypertensive property was involved in facilitating acetylcholine-mediated vasodilation in the mesenteric arteries of tested mice.
Researchers after taking into account co and con-founders said, " In vitro studies showed that CuEC induced vasodilation in a dose-dependent manner in mesenteric arteries of both mice and rats. Pretreatment with CuEC inhibited phenylephrine-mediated vasoconstriction".
Taken together, cucumber and its bioactive compound cucurbitacin B (CuB) at the lower dose may be used for the treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (Hypertensive Research)
(3) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (Journal of the American College of Cardiology)
#Eggplant Inhibits Enzymes Associated with the Risk the Type 2 #Diabetes, Scientists Show
Kyle J. Norton
Eggplant, the night shape fruit or vegetable may have a strong effect in reducing the risk and treatment of type 2 diabetes, some researchers suggested.
Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
According to the US statistics in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that the widespread type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.
Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".
These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods, and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.
Therefore, by changing to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases the intake of dietary fiber by consuming more vegetables and fruits and whole-grain cereal products, diabetes is preventable.
Dr. Matti Uusitupa, MD, in the article "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and
"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the concerns of the widespread type 2 diabetes among Americans, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation of an eggplant-based diet as a choice for the management of type 2 diabetes.
The recommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant.
Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.
By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for managing type 2 diabetes by controlling glucose absorption.
Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Further analysis of the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) in chronic diseases including diabetes, by searching the database of online medical literature.
* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects were found in some studies.
* CGA was found to exert pivotal roles in glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory, and anti-obesity impacts, which may provide a non-pharmacological and non-invasive approach.
Taken together, eggplant processed with a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD
Eggplant, the night shape fruit or vegetable may have a strong effect in reducing the risk and treatment of type 2 diabetes, some researchers suggested.
Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
According to the US statistics in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that the widespread type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.
Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".
These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods, and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.
Therefore, by changing to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases the intake of dietary fiber by consuming more vegetables and fruits and whole-grain cereal products, diabetes is preventable.
Dr. Matti Uusitupa, MD, in the article "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and
"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the concerns of the widespread type 2 diabetes among Americans, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation of an eggplant-based diet as a choice for the management of type 2 diabetes.
The recommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant.
Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.
By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for managing type 2 diabetes by controlling glucose absorption.
Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Further analysis of the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) in chronic diseases including diabetes, by searching the database of online medical literature.
* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects were found in some studies.
* CGA was found to exert pivotal roles in glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory, and anti-obesity impacts, which may provide a non-pharmacological and non-invasive approach.
Taken together, eggplant processed with a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD
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