Herbal Ashwagandha Protects the Heart Tissues Against Cardio-Toxicity

By Kyle J. Norton

Cardiotoxicity is a condition caused by toxin accumulated in the heart that leads to damage to the heart muscle.

Cardiotoxicity reduced the heart pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.

The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention and shortness of breath.

If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.

The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and the intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.

Cardiomyopathy is a severe case of cardiotoxicity.

Cardiomyopathy in most occurs in patients under chemotherapy. However, a group of diseases or disorders can also lead to the damaged heart muscle. Injury to the heart muscle may induce cardiomyopathy, including viruses - such as human immunodeficiency virus (HIV), infection, long-standing high blood pressure, chronic or long-term alcohol use, and diabetes.

Conventionally, treatment of cardiotoxicity depending on the cause of the disease may include
* Beta-blockers, for the improvement of the blood flow and reduction of palpitations, arrhythmias, and high blood pressure.

*ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow.

* Diuretics, by getting rid of excess fluids that reduce heart function in blood pumping

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention of cardiovascular diseases, researchers examined the protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats.

According to the results of the experiment, doxorubicin (10 mg/kg) -induced cardiac toxicity in male Wistar rats showed an increase of necrosis and apoptosis in heart tissues.

Furthermore, the elevation of malondialdehyde and protein carbonyl levels and catalase activity associated with the expression of oxidative stress also wee found in the doxorubicin (10 mg/kg) rats.

The doxorubicin (10 mg/kg) rats also exhibited depletion of total antioxidant capacity and of superoxide dismutase level in cardiac tissues, accompanied by the increases of myeloperoxidase activity, total calcium content, and the expression of Bcl-2 protein in heart tissues.

Most importantly, all parameters induced by the injection of doxorubicin alterations were effectively attenuated by the administration of the purified standardized extract (1.5% withanolides; manufactured by Idea Sphere Inc., American Fork, UT, USA) of Withania somnifera (300 mg/kg).

Based on the evidence, researchers said, "Thus, Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is the cancer-treating drug".

Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of Cardiotoxicity induced by medications,  pending to the confirmation of the larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats by Hamza A1, Amin A, Daoud S. (PubMed)

Cruciferous Vegetables Kill Non-Small Cell Lung Cells in Vitro

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

The lung is a vital organ of the humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the US.

Most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung,

* Large-cell carcinoma found in the center of the lung by an air tube

* Adenocarcinoma found in any part of the lung.

Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.

The most common risk factors of non-small cell lung cancer (NSCLC) are long term smoking and people exposed to long-term second-hand smoke.

According to the statistics, 2019, approximately 228,150 adults including 116,440 men and 111,710 women in the United States will be diagnosed with non-small cell lung cancer (NSCLC). Lung cancer makes up about 13% of all new cancer diagnoses. Black men are about 20% more likely to get lung cancer than white men.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the treatment of lung cancer, researchers examined the anti-metastatic activity of Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables on two non-small cell lung cancer (NSCLC) cell lines, A549, and CL1-5 cells.

SFN exhibited more potent cytotoxicity against suspending rather than adherent cancer cells.

The inhibition of SFN was attributed to the induction of anoikis. evidenced by a loss of normal cell-matrix interactions, markers of apoptosis, and activation of the mitochondrial apoptotic pathway.

Furthermore, SFN also inhibited NSCLC cell to form spherical colonies, to induce proliferation.

Moreover, SFN also suppressed the activation of signaling pathways to induce cancer cell adhesion.

Based on the findings, researchers said, "These results provide new insight into mechanisms underlying the chemopreventive ability of SFN and suggest a potential benefit of SFN to interfere with tumor metastasis".
 

Taken altogether, Cruciferous vegetables may be considered functional foods for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells by Tsai JY1, Tsai SH1, Wu CC. (PubMed)

Omega -3 Fatty Acids May Be Effective Against Psoriasis, Some Studies Show

By Kyle J. Norton

Psoriasis is a skin condition characterized by the speeds up of the life cycle of skin cells, leading to cells build up rapidly on the surface of the skin.

Symptoms of psoriasis caused by the extra skin cells form scales and red patches can be itchy and painful.

Epidemiologically, psoriasis patches can range from a few spots or large areas. A most common form of psoriasis is plaque psoriasis, a condition that induces dry, raised, red skin lesions (plaques) covered with silvery scales.

The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causative factors that induce the onset of the condition.

Certain risk factors such as family history, viral and bacterial infections, weakened immune systems, persistent stress, are associated with the risk of psoriasis.

Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long term use of certain medicines such as oral steroids.

Some researchers suggested smoking that has a strong impact on the immune system may also be one of the major causes of psoriasis in smokers.

Conventionally, topical corticosteroids are the most commonly prescribed medication for the treatment fo the condition, particularly in patients with mild to moderate psoriasis.

According to the joint study led by the University of Trieste, the increased incidence of a large number of diseases that share an inflammatory origin probably due to the pro-inflammatory cytokine spillover from active psoriatic lesions, leading to a large inflammation on distant tissues(95).

Additionally, the Brigham and Women's Hospital, and Harvard Medical School, Boston joint study suggested, individuals with psoriasis have increased blood levels of uric acid. In the documented 2217 incident cases of gout during follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of skin diseases, researchers examined the efficacy and mechanism of action of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on psoriasis.

The Cochrane Central Register of Controlled Trials that search the databases of the PubMed/MEDLINE and EMBASE all randomized controlled trials and prospective observational studies compared the 3 PUFAs effects versus control in adult patients with psoriasis.

Out of 12 articles identified in a total of 732 articles that were searched, some studies found that n-3 PUFAs were associated with improvements in the PASI score, erythema, scaling, itching, an area involved and infiltration.

However, some studies did not find a reduction in scaling, erythema, area involved or thickness in the treatment group.

Based on the findings researchers said, "It is still inconclusive whether the use of n-3 PUFAs in patients with psoriasis is associated with improvements in the severity of psoriasis and other outcomes".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of psoriasis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of omega-3 fatty acids on disease severity in patients with psoriasis: A systematic review by Upala S1,2, Yong WC1, Theparee T3, Sanguankeo A. (PubMed)
(2) Efficacy of ω-3 supplementation in patients with psoriasis: a meta-analysis of randomized controlled trials by Clark CCT1, Taghizadeh M2, Nahavandi M2, Jafarnejad S. (PubMed)
(3) Increased airway inflammation in patients with psoriasis by Damiani G1, Radaeli A2, Olivini A2, Calvara-Pinton P3, Malerba M2. (PubMed)

(4) Psoriasis, psoriatic arthritis and risk of gout in US men and women by Merola JF1, Wu S2, Han J3, Choi HK4, Qureshi AA5.(PubMed)

Omega -3 Fatty Acids Lowers the Risk of Oral Cancer in Vivo

By Kyle J. Norton


Oral cancer is a medical condition characterized by irregular cell growth in the oral cavity, due to the alternation of cell DNA.

In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.

Early diagnosed oral cancer may have a close to 100% recovery.

According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration the stage of cancer.

According to the Oral Cancer Foundation in the article "Oral Cancer Fact", in the US, approximately, 50000 Americans will be diagnosed with oral pharyngeal cancer this year. It will cause about 10,000 deaths.

Family history, smoking, alcohol drinking, infected by HPV virus, poor hygiene and genetic preposition are some of the risk factors associated with the disease.

Most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting for over 90% of all cases and arises from the squamous cell layer in the lining of the oral cavity and oropharynx.

* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. Cancer can spread deeply into the surrounding tissue.

* Minor salivary gland cancers
The cancer is originated from the salivary gland accounted for less than 1% of all cases.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic diseases, researchers investigated the chemopreventive effects of various dietary n-6 and n-3 fatty acids in a 9,10-dimethyl-1,2-benz[a]-anthracene (DMBA)- and betel quid extract (BQE) -induced hamster oral cancer model.

The selected thirty 6-week-old adult male hamsters included in the study were divided into normal, low, and high dietary n-6 and n-3 fatty acid groups under DMBA + BQE treatment for 16 weeks.

According to the tested analysis,
* The low dietary n-6/n-3 fatty acid group exhibited a significantly lower tumor number, volume, and burden than those of the other groups.

In other words, high levels of n-3 fatty acids compared to low levels of n-6 fatty acids induced a strong inhibition of the initiation and progression of oral cancer cells.

In the right buccal pouch tissue, the low dietary n-6/n-3 fatty acid group had significantly lower nuclear factor-κB associated with pro-inflammatory expression, proliferating cell nuclear antigen, and cyclin D1 expression in cell cycle division.

More precisely, high levels of n-3 fatty acids compared to low levels of n-6 fatty acids inhibited the parameters involved in oral cancer proliferation.

Collectively, researchers concluded, " the lower dietary n-6/n-3 fatty acid ratio exerted chemopreventive effects in the DMBA- and BQE-induced hamster oral cancer model".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Low dietary n-6/n-3 polyunsaturated fatty acid ratio prevents induced oral carcinoma in a hamster pouch model by Lee HC1, Liang A1, Lin YH2, Guo YR1, Huang SY. (PubMed)

Herbal Dandelion(Taraxacum officinale) in the Promotion of Anti-inflammatory Activity

By Kyle J. Norton

The immune system formed part of the body's defense plays a critical role in the protection of the body against infectious organisms.

The immune system executes the defense strategy through a series of the immune response by attacking foreign substances that invade body systems to cause disease.

A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.

Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

Acute inflammation is a natural and systematic immune response to protect our body against the invasion of foreign bacteria and viruses by the initiated production of inflammatory cytokines to the site of infection.

However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby tissues.

These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs functioning, such as liver scars caused by hepatitis virus infection.

Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.

Furthermore, chronic inflammation occurred that lasts for months or years when the immune system response to the site of infection failure to eliminate agents that cause acute inflammation.

An autoimmune disorder that attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.

Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the promotion of immune functioning, scientists examined inflammatory effects and the mechanism of taraxasterol in LPS-stimulated BV2 microglial cells.

According to the tested differentiation of BV2 microglia cells that were treated with taraxasterol 12 h before LPS stimulation, taraxasterol showed an inhibition activity on LPS-induced TNF-α and IL-1β production of pro-inflammatory cytokines.

The western blot analysis suggested that taraxasterol also demonstrated an inhibitory effect in the activation of proteins associated with the initiation of the innate immune response induced by the LPS stimulation.

More precisely, taraxasterol dose-dependently inhibited LPS-induced TNF-α and IL-1β production and NF-κB activation.

Furthermore, the injection of taraxasterol also disrupted the formation of lipid rafts, the subdomains of the plasma membrane that contain high concentrations of cholesterol and glycosphingolipids, and inhibited the translocation of TLR4associated with activation of pro-inflammatory cytokines in the lipid rafts.

Moreover, taraxasterol was found to activate the signaling pathway involved in cholesterol efflux from cells.

Collectively, researchers said, " the anti-inflammatory effect of taraxasterol was attenuated by transfection with LXRα siRNA. In conclusion, these results suggested that taraxasterol inhibits LPS-induced inflammatory response in BV2 microglia cells by activating the LXRα-ABCA1 signaling pathway".

Taken altogether, Dandelion may be considered a remedy for modulation of the immune response, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol Inhibits LPS-Induced Inflammatory Response in BV2 Microglia Cells by Activating LXRα by Liu B1, He Z2, Wang J2, Xin Z3, Wang J2, Li F3, Fu Y. (PubMed)

Herbal Angelica Protects The Stomach Cells Against the Onset of Gastric Cancer

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract. The pyloric sphincter is a muscular valve that opens to allow food to pass from the stomach to the small intestine.

The stomach secretes acid and enzymes to digest food.  The stomach muscles contract periodically, churning food to aid digestion.

Gastric/Stomach cancer is a chronic condition characterized by irregular cell growth in the tissues of the stomach. Adenocarcinoma is the most common type of gastric cancer.

Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.

More precisely, common site metastasises from primary gastric cancer is the secondary liver (48%), peritoneum (32%), lung (15%), and bone (12%).

Most cases of gastric cancer start in the cells on the surface of the inner lining of stomach tissue.
Due to the small size at the early stage, gastric cancer is asymptomatic.

However, at the later stage, after penetrating into the deeper layers of the stomach, the cancer cell may travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

At this stage, most patients with gastric cancer may experience symptoms of severe abdominal pain caused by the suppressing of the oversize tumor on the nerve cells, or vague discomfort in the abdomen, usually above the navel, particularly heartburn and indigestion, accompanied by general symptoms shared with other types of cancer.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

In Canada, Gastric cancer affects 2.1% of male cancer patients and 1.3% of female cancer patients.

The most common causative risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis,.

On finding a natural ingredient for the prevention and treatment of digestive diseases, scientists examined the effects of danggui (Chinese angelica) isolated compound N-butylidenephthalide (BP) on gastric cancer.

Angelica or danggui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to results that angelica used for the treatment in patients with gastric cancer, using data from Taiwan's National Health Insurance Research Database (NHIRD),
* Danggui users showed an increased survival rate, compared with non-danggui users.

* Treatment of danggui are highly associated with decreased mortality.

* Furthermore, in vitro results BP inhibited gastric cancer cell proliferation, and induced cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.

* Moreover, BP caused an increase of REDD1 expression associated with the regulation of cell damage that inhibits mTOR signaling involved in tumor formation and angiogenesis.

Additionally, BP also suppressed the growth of AGS xenografts tumor in vivo.

Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BPDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells. BP inhibited the in vivo growth of AGS xenograft tumors".

Taken altogether, Danggui processed abundantly bioactive compound N-butylidenephthalide (BP)  may be considered an herbal medicine for the treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)

Healthy Veggie Broccoli Inhibits the Onset of Stomach Cancer in Vitro

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Gastric/Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric/stomach cancer.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

The causes of gastric cancer are debatable, but some researchers suggested that people with chronic
gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease(4).

Other diseases associated with the early onset of gastric cancer are obesity and smoking(4).

According to the Universidad de Salamanca, bacteria and viruses, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development(5).

Most patients with stomach cancer in the early stage are asymptomatic.

However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On findings a natural wholefood for the prevention of chronic disease, researchers examined the inhibitory effect of SFN, a bioactive compound found in broccoli on gastric cancer.

According to the results of differentiation, SFN treatment significantly decreases the tumorsphere formation and the expression levels of gastric cancer stem cells (CSCs) markers.

Furthermore, SFN exerted inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs.

Moreover, Intriguingly, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs.

Based on the results, researchers wrote, "Collectively, these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of the Sonic Hh pathway, which might be a promising agent for gastric cancer intervention".

Taken altogether, broccoli may process anti stomach cancer activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway by Ge M1, Zhang L1, Cao L1, Xie C2, Li X2, Li Y2, Meng Y2, Chen Y2, Wang X2, Chen J2, Zhang Q2, Shao J1, Zhong C. (PubMed)
(2) Stomach cancer by Mayo Clinic
(3) [Microorganisms and cancer: scientific evidence and new hypotheses].[Article in Spanish] by Velázquez E1, Peix A, Gómez-Alonso A(PubMed)
(4) Stomach cancer statistics (Canadian cancer society)