Angelica Sinensis, A Natural and Potential Anti Liver Fibrosis Herbal Medicine

By Kyle J. Norton

Fibrosis is a medical condition caused by the excessive formation of fibrous connective tissue in an organ or tissue.

The liver is the largest internal organ that not only plays an essential role in cleansing the blood coming from the digestive system before passing them to other parts of the body but also secrets cholesterol to aid digestive function, produce steroid hormones and vitamin D and build strong cell walls.

Hepatic fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the liver. In other words, hepatic fibrosis is a portion of the liver which was affected by scars formation.

The severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death of 12/100,000 of the population every year.

The disease in most cases is associated with the infection of the hepatitis virus. However, not all people with the virus will develop liver fibrosis.

Since liver fibrosis is a very slowly progressive disease, people who carry the disease may not experience any symptoms until the advanced stage.

Truly, people who consume excessive alcohol and carry the hepatitis virus may not develop the diseases until their later life.

The exact causes of liver fibrosis are unknown. However, certain risk factors such as repeated liver injury caused by a virus infection, and a blockage in the bile ducts are found to elaborate on the onset of liver fibrosis.

Liver fibrosis can also be induced by lactose intolerance, fructose, artificial sweeteners and other digestive disorder such as Crohn's disease, ulcerative colitis, celiac disease.

Long-term untreated liver fibrosis can lead to cirrhosis, a condition of the severe scarring of the liver and life-threatening liver disease.

Symptoms of liver fibrosis include appetite loss, difficulty thinking clearly, fluid in the abdomen, bleeding in the intestines, unexplained weight loss, weakness,..... and poor blood clotting.

On finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the effects of Levistilide A (C24H28O4, molecular weight = 380.48) derived from Angelica sinensis (Danggui) on liver fibrosis relating to angiogenesis.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis of rats that were subcutaneously injected with CCl4 twice a week for six weeks to duplicate the liver fibrosis model and then treated with 10 mL/kg of normal saline, 4 mg/kg of sorafenib, and 3 and 6 mg/kg of Levistilide A for three weeks from the fourth week,
* Levistilide A attenuated LX-2 cell activation and HHSEC proliferation, inhibited the HHSECs to form tube-like structures in the formation of blood vessels and decreased the number of functional vessels in transgenic zebrafish.

* Furthermore, Levistilide A reduced collagen deposition in the induction of liver scar and the number of new microvessels ameliorated sinusoid capillarization and downregulated the expression of CD31, VEGF, and VEGF-R2 in forming new blood vessels.

In other words, Levistilide A can inhibit liver fibrosis through antiangiogenesis by alleviating sinusoid capillarization via the VEGF signaling pathway in the promotion of the new vessel development.

Based on the results, researchers suggest, "Levistilide A can inhibit liver fibrosis through antiangiogenesis by alleviating sinusoid capillarization via the vascular endothelial growth factor signaling pathway".

Taken altogether, Angelica may be considered a remedy for the treatment of liver fibrosis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway by Zhao ZM1,2, Liu HL1, Sun X1, Guo T1, Shen L1, Tao YY1, Liu CH. (PubMed)

Elecampane (Inula helenium) Eradicates Colorectal Cancer Cells in Vitro and Vivo

By Kyle J. Norton

Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Rectal cancer is also the slowest growing cancer. Therefore, most cases of colorectal cancer are diagnosed at the advanced stage in the older population.

Although there are a number of risk factors associated with the onset of colorectal cancer, some researchers suggested the increased obesity in the general population induced colorectal cancer over the past few decades may have a strong implication by the promotion of Western diet.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.

In general, the 5-year survival rate for people with colorectal cancer is 65%. However, the 5-year survival rate of localized colorectal cancer is about 90%.

On finding a natural ingredient for the prevention and treatment of colonic diseases, scientists the potential beneficial effects of Inula viscosa (IV) leaf aqueous extract on the growth of colorectal cancer cells in vitro and in vivo.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* IV extract that exposure of colorectal cancer cells significantly reduced cell viability in a dose and time-dependent manner.

* Treatment of cells with 300 μg/ml of IV extract induced apoptosis by activating pro-apoptotic caspases.

* In vivo, treatment with 150 or 300 mg/kg IV extract inhibited tumor growth in mice transplanted with MC38 cells and the tumors' weight and volume were significantly (P < 0.001) reduced when compared to the untreated control group.

* Furthermore, IV treatment also inhibited cell proliferation and induced apoptosis in vitro and vivo.

Based on the results, researchers suggest, " (The) active doses of IV extract are not toxic. Further studies are needed in order to identify the structure of the active compounds ".

Taken altogether, Dandelion may be considered a remedy for the treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inula Viscosa Extract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo Through Induction of Apoptosis b y Bar-Shalom R1, Bergman M2, Grossman S2, Azzam N1, Sharvit L1, Fares F. (PubMed)

Omega-3 Fatty Acids Improve the Symptoms of Rheumatoid Arthritis

By Kyle J. Norton

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.

There is no single cause of RA. Changes in the female hormonal environment such as in pregnancy, breastfeeding and the use of the oral contraceptive (OC) pill appear to have a role.  Cigarette smoking has been associated with a consistently increased risk that might also apply to the passive inhalation of smoke. Occupation probably has a minor influence, although exposure to silica dust is of aetiological importance. Recent studies have highlighted a role for diet, with suggestions that diets high in caffeine, low in antioxidants and high in red meat may contribute to an increased risk. 

The most plausible environmental exposure is an infection and although several decades of study have produced few definitive candidate organisms, Epstein-Barr virus (EBV) remains an interesting target(22).

According to the CDC, Musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions. 

Patients with rheumatoid arthritis (RA) often associate with valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot.

 The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...

Long-term bone damage and the prolonged onset of the disease can induce deformities of hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of rheumatoid arthritis, researchers evaluated the effects of omega -3 fatty acids on rheumatoid arthritis (RA).

The meta-analysis includes reviewing the published randomized controlled trials (RCTs) associated with potential changes in RA disease activity, inflammation, and CVD risk.

According to the results of 20 RCTs, involving 717 patients with RA in the intervention group and 535 RA patients in the control group,

* Consumption of ω-3 fatty acids was found to significantly improve eight disease-activity-related markers.

* Regarding inflammation, only leukotriene B4 was reduced compared to other pro-inflammatory markers.

* Omega 3 fatty acids was found to reduce blood triacylglycerol levels.

Collectively, researchers said, "The beneficial properties of ω-3 polyunsaturated fatty acids on RA disease activity confirm the results of previous meta-analyses. Among the five proinflammatory markers evaluated, only leukotriene B4 was found to be reduced. However, a positive effect on the blood lipid profile of patients with RA was evident".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of rheumatoid arthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis by Gioxari A1, Kaliora AC2, Marantidou F1, Panagiotakos DP. (PubMed)
(2) The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial by Rajaei E1, Mowla K, Ghorbani A, Bahadoram S, Bahadoram M, Dargahi-Malamir M. (PubMed)
(3) Risk factors for the development of rheumatoid arthritis by Oliver JE1, Silman AJ. (PubMed)

Lycopene in the Promotion of Lung Function Against Obstructive Lung Functioning

By Kyle J. Norton

The lungs formed part of the respiratory system are a pair of spongy, air-filled organs located on either side of the chest with the main function to process of gas exchange during breathing.

In other words, lung transfer life-giving oxygen into the blood supply and remove carbon dioxide produced by cells metabolism from the blood.

Additionally, the lung is also the first-line defense against inhaled particles and prevent the circulation of emboli such as blood clot (thrombus), a fat globule (fat embolism), a bubble of air or other gas (gas embolism), or foreign material.

Additonally, the lung also processes other ability of
* Balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body. 

* Removing small blood clots the lung protects the body against the forming air embolisms.

* Protecting lung infection through the secretion of immunoglobulin A.

Any part of the lung injury can reduce the lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

Obstructive lung diseases are the condition in which the lungs are unable to expel air properly during exhalation. Diseases associated with obstruction lung diseases such as asthma, bronchiectasis, COPD, and emphysema.

Besides smoking, second-hand smoke is the most common cause of obstructive lung disease. Dr.Mark D. Eisner said, "Secondhand smoke (SHS) has been extensively studied as a risk factor for obstructive lung disease, including decreased lung function, asthma, and chronic obstructive pulmonary disease (COPD) (1–5)".

And, "Epidemiologic studies have played a key role in evaluating the respiratory health effects of SHS because they are the only feasible method for studying the impact of exposure, as it occurs naturally, on large numbers of the subject".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound for the treatment of lung disease researchers examined the prospective associations between concentrations of α- and β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, Se, vitamin C, and α-tocopherol and all-cause mortality among US adults with obstructive lung function.

The study included a total of 1492 adults aged 20-79 years with obstructive lung function in the National Health and Nutrition Examination Survey III (1988-94) that cause 629 deaths during a median follow-up period of 14 years.

α-carotene (P= 0·037); β-carotene (P= 0·022); cryptoxanthin (P= 0·022); lutein/zeaxanthin (P= 0·004); total carotenoids (P= 0·001) vitamin C (P< 0·001) concentration were invesely associated with all-cause mortality among adults with obstructive lung function.

However, in maximally adjusted models, only the concentrations of lycopene (P= 0·013) and vitamin C (P= 0·046) were found to be significantly and inversely associated with all-cause mortality comapred to other tested antioxidants.

Additionally, lutein/zeaxanthin concentrations and all-cause mortality varied by smoking status were associated between lutein/zeaxanthin concentrations.

Based on the findings, researchers said, "The concentrations of lycopene and vitamin C were inversely associated with all-cause mortality in this cohort of adults with obstructive lung function".

Taken altogether, lycopene found in tomato may be considered a remedy for the improvement of obstructive lung function, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Associations between antioxidants and all-cause mortality among US adults with obstructive lung function by Ford ES1, Li C2, Cunningham TJ1, Croft JB. (PubMed)
(2) Secondhand Smoke and Obstructive Lung Disease, A Causal Effect? by Mark D. Eisner. (ATS Journals)

Ursolic Acid, A Potential Breast Cancer Therapy

By Kyle J. Norton

Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, most cases of breast cancer start in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.

Most patients at the early may have a lump when touching with no symptoms.

However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.

According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Genetic preposition, one of the prevalent risk factor associated with the increased risk of breast cancer has been under intensifying study in scientists over the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.

Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.

The 5 years of the survival rate of localized breast cancer are closed to 100%.

The risk factors of breast cancer can be divided into 2 groups
* Preventable risk factors include exposure to ionizing radiation, hormone replacement therapy, use of oral contraceptives, alcohol, being obese and physical inactivity.

* Unpreventable risk factors include family and personal history, age, race, genetic preposition, dense breast, and reproductive history.

If you are at a higher risk of breast cancer, please make sure your self check your breast every month for preventive measures.

Since breast cancer is so sensitive to levels of the hormone, some scientists suggested that hormonal changes may have a critical impact on the disease.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the ursolic acid, a naturally synthesized pentacyclic triterpenoid, widely distributed in different fruits and vegetables anti0breast cancer property.

According to the analysis,
* Ursolic acid and its derivatives exhibited anticancer activity, anti-inflammatory effects, and induction of apoptosis in several human cancer cells.

* Furthermore, ursolic acid inhibited breast cancer proliferation by inducing cell G1/G2 arrest.

* Moreover, ursolic acid regulated the expression of key proteins in signal transduction pathways against the promotion of breast cancer.

* Additionally, ursolic acid-induced apoptosis in human breast cancer cells through intrinsic and extrinsic apoptotic pathways.

* Ursolic acid scavenged free radicals and p[rocesses a potent anti-inflammation activity.

Taken altogether, Ursolic acid may be considered adjunct therapies in the treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ursolic acid, a potential anticancer compound for breast cancer therapy by Yin R1, Li T1, Tian JX1, Xi P1, Liu RH. (PubMed)

Pinto Beans (Phaseolus), the Natural Anti-Oxidative Stress Legume

By Kyle J. Norton

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction can also be caused by the long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

Free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.

Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

On finding a natural ingredient for the prevention and treatment of diseases associated with oxidative stress, scientists examined the effects of bioactive peptide fractions from de-hulled hard-to-cook (HTC) bean on enzyme targets of oxidative stress.

Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to tested analysis of proteins isolated from Pinto Durango and Negro 8025 beans that were hydrolyzed (120min) with either alcalase® or bromelain and separated into five peptide fractions (<1, 1-3.5, 3.5-5, 5-10, and >10kDa) 

* Hydrolysates and peptide fractions showed antioxidant capacity (ORAC: 159.6±2.9 to 932.6±1.1mmolTE/g) and nitric oxide inhibition (57.5±0.9 to 68.3±4.2%).

* The <1kDa pinto Durango-bromelain fraction showed the best inhibition of α-amylase (49.9±1.4%), and the <1kDa pinto Durango-alcalase fraction inhibited both, α-glucosidase (76.4±0.5%), and dipeptidyl peptidase-IV (DPP-IV, 55.3±1.6%) induced by the oxidative stress response.

In other words, pinto beans demonstrated significant activity against the onset of oxidative stress through its antioxidant activity.

Taken altogether, pinto beans may process antioxidant properties against chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hard-to-cook bean (Phaseolus vulgaris L.) proteins hydrolyzed by alcalase and bromelain produced bioactive peptide fractions that inhibit targets of type-2 diabetes and oxidative stress by Oseguera-Toledo ME1, Gonzalez de Mejia E2, Amaya-Llano SL. (PubMed)

Healthy Potatoes (Solanum), Processes a Strong Antioxidant Property

By Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating oxidative stress that causes damage to proteins, lipids, and cell DNA.

Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.

There are 3 main types of antioxidants found in nature, including antioxidant enzymes produced by the host, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases, antioxidants vitamins, that may be injected from the dietary sources such as fruits and vegetables, including vitamins A, C, D, and E and antioxidant-phytochemicals found in the plant including second metabolites.

Potato is a genus Solanum, belongs to the family Solanaceae. It is a good source of protein and according to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. The root veggie now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.

On finding a potential plant for the prevention and treatment of diseases associated with oxidative stress, researchers examined the potential of peptide fractions isolated from dehydrated potatoes on intestinal epithelial cells (IEC-6) under oxidative and inflammatory conditions.

Based on the results of differentiation,

* Peptide fractions demonstrated a significantly inhibit the pro-inflammatory protein expression such as tumor necrosis factor-α and cycloxygenase-2 and inducible nitric oxide synthase.

* More importantly, the tested peptides also showed significant antioxidant activity by reducing reactive oxygen species (ROS) release-induced from mitochondria, and nitrotyrosine formation

* Furthermore, the applications also increase the antioxidant response by heme oxygenase-1 and superoxide dismutase expression.

Additionally, the peptide fractions were able to significantly increase the wound repair in IEC-6 induced by oxidative-inflammatory damage.

Collectively, researchers said, "The obtained results indicate the anti-inflammatory and antioxidant potential of dehydrated potatoes at the intestinal level".

Taken altogether, potatoes may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells by Basilicata MG1,2, Pepe G1, Rapa SF1, Merciai F1,2, Ostacolo C3, Manfra M4, Di Sarno V1, Autore G1, De Vita D5, Marzocco S1, Campiglia P. (PubMed)