Thursday 26 March 2020

Herbal Eyebright ( Euphrasia) Protects the Human Corneal Cell Integrity

By Kyle J. Norton

Human Corneal Epithelial Cells (HCEpC) isolated from the epithelium of the Human Cornea have been used in a wide range of basic ocular studies involving problems associated with the cornea.

The corneal epithelium is the barrier function that plays a critical role to defend against many types of injury, trauma, or infection.
The cornea accounting for approximately two-thirds of the eye's total optical power covers,
* The iris
the iris (plural: irides or irises) is a thin, circular structure in the eye that controls the diameter and size of the pupil to allow the amount of light reaching the retina.
* The pupil
The pupil is a black hole located in the center of the iris that allows light to reach the retina
The anterior chamber
The anterior chamber (AC) is space in the eye that is behind the cornea and in front of the iris.

In other words, the cornea, with the anterior chamber and lens, refracts light, with the cornea

Corneal disease happened mostly in the aging population, is a medical condition that can cause clouding, distortion, scarring and eventually blindness.

Other common causes of corneal diseases are infection, cataract, genetic proposition, use of contact lense, eye injury, and diseases, including retinitis pigmentosa, retinopathy of prematurity, and vernal keratoconjunctivitis, Ehlers-Danlos syndrome, and Down syndrome.

On finding a natural ingredient for the prevention and treatment of eye inflammation, scientists examined the protective effects of eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells.

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe. 

The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

According to the tested analysis of HCEC-12 cells exposed to UVB radiation and treated with the eye drops at various concentrations,
* The administration of eye drops protect corneal epithelial cells from UVB-induced cell death and ameliorated the wound healing.

* The eye drops exhibited a strong antioxidant activity in the inhibition of ROS expression and protein and lipid oxidative damage.

* Furthermore, the eye drops also exerted anti-inflammatory activities by decreasing the proteins in activating the pro-inflammatory cytokines such as COX-2, IL-1β, iNOS expression,

* Moreover, the eye drops counteracted UVB expression by inducing antioxidants expression of glutathione synthetase (GSS) and superoxide dismutase 2(SOD-2) expression and restoring the HO-1 levels to control levels.

Based on the results, researchers suggest, "These findings suggest that an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts exerts positive effects against UVB induced oxidative stress and inflammation and may be useful in protecting corneal epithelial cells from UVB exposure".

Taken altogether, Dandelion may be considered a remedy for the protection of human corneal cells, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells by Bigagli E1, Cinci L1, D'Ambrosio M1, Luceri C2. (PubMed)

Tocopherols Deficiency In the Risk of Age-Related Macular Degeneration

By Kyle J. Norton

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.

The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increase in size.

The advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to the epidemiological studies.

According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.

Age-related macular degeneration can be classified into 2 types
* The common AMD is the dry form caused by the gradual degeneration of the central retinal tissues, affecting 90% of patient s with AMD. Some patients with the dry form of AMD have been found to develop into the wet form over time.

* The wet form of AMD is caused by the breaking of capillary under the macula, accounting only 10% of AMD.


Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of degenerative diseases, researchers compared the effects of dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene on age-related macular degeneration.

According to the results of a brief-type self-administered questionnaire of the case-control study that reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) from of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects in Japan, 
* Low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD.

In other words, low levels of serum of tocopherols were associated with increased risk of AMD.

* There was no association with retinol or cryptoxanthin intake and neovascular AMD.

These results were adjusted based on smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of AMD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan by Aoki A1,2, Inoue M3, Nguyen E4, Obata R1, Kadonosono K3, Shinkai S2, Hashimoto H5, Sasaki S4, Yanagi Y. (PubMed)

Wednesday 25 March 2020

Healthy Food Broccoli's Sulforaphane (SFN) Blocks the Onset of Diabetic Cardiomyopathy in Diabetes

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.

Cardiomyopathy is a disease associated with heart muscle, leading to reduce functions of the heart to pump blood to the rest of the body.

Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of diabetic complications, researchers examined the effect of sulforaphane (SFN) on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy.

The study included male C57BL/6J mice fed a high-fat diet for 3months to induce insulin resistance, followed by treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia as the T2DM mouse model compared to age-matched mice fed a normal diet as control.

According to the tested analysis,
* SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM.

* SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression involved in oxidation.

* SFN upregulated the expression of the gene associated with the promotion of antioxidant enzyme and decreased the expression in enhancing the initiation of oxidative stress.

* SFN also reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets associated with the regulation of lipid, cholesterol and glucose metabolism.

Based on the results, researchers wrote, " SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy".

Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.



Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway by Zhang Z1, Wang S1, Zhou S1, Yan X2, Wang Y1, Chen J3, Mellen N3, Kong M4, Gu J5, Tan Y2, Zheng Y6, Cai L. (PubMed)

Herbal Elecampane (Inula helenium) Displays a Strong Hepatoprotective Effect

By Kyle J. Norton

The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.

The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.

Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.

The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins.

Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and a tendency to bruise easily.

There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.

Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.

In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.

Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.

On finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the hepatoprotective effect of Inula Britannica using fermentation on HepG2 cells.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* The Epigallocatechin gallate (EGCG) found I. Britannica extract was enhanced from 2.06 to 10.28 μg/mg during fermentation (p < 0.001).

* The fermentation also increased the DPPH radical-scavenging ABTS radical-scavenging, and superoxide anion-scavenging abilities to 92.65%, 694.25 μM Trolox/mL, and 86.38%, respectively.

* At 500 μg/mL (p < 0.05). Cupric-ion-reducing capacity with formation of the Cu+-neocuproine complex increased by 5.88%, 6.38%, 3.24%, and 8.55% at 62.5 to 500 μg/mL. Ferric-ion-reducing capacity of the fermented extract increased by 20%, 7.16%, 3.85%, and 5.45% at each concentration (p < 0.05).

* Furthermore, compared to the unfermented extracts yielded cell viability of 91.42%, 90.59%, 88.38%, and 79.17%, the fermented extract yielded 100.28%, 99.66%, 96.15%, and 89.90%, respectively.

* Moreover, the fermented extract decreased liver stress marker of alanine transaminase activity from 117.2 to 61.7 U/mL in the ethanol-damaged HepG2 cell line (p < 0.01).

Based on the results, researchers suggest, " Overall, both antioxidant and hepatoprotective effect increased by fermentation in I. Britannica extract.

Taken altogether, Elecampane may be considered a liver protective remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Improved in vitro antioxidant properties and hepatoprotective effects of a fermented Inula britannica extract on ethanol-damaged HepG2 cells by Bae WY1, Kim HY1, Park EH2, Kim KT3, Paik HD. (PubMed)

Tuesday 24 March 2020

Herbal Angelica Induces Apoptosis of Human Neuroblastoma Cells

By Kyle J. Norton

The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.

The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role in processing and transmitting the information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.

Cancer most commonly affects children age 5 or younger compared to less often in older children.

According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.

And 90% of children affected by neuroblastoma are younger than 5.

Sadly, the the-5-year survival rate of cancer is less than 50%.

Most common symptoms are totally depending on the area that has been effected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.

* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size

Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.

On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.

* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with the cell death in the SH-SY5Y cells.

Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".

Taken altogether, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)

Healthy Food Cabbage Inhibits the Liver and Cardio Oxidative Stress

By Kyle J. Norton

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "Antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Liver oxidative stress markers such as serum MDA refer to oxidative stress in the liver tissues caused by the overexpression of free radicals or reduced levels of antioxidant enzymes in the liver.

Dr. Halina Cichoż-Lach, the lead scientist said, "Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases.".

And, "Hepatocytic proteins, lipids, and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver".

In other words, liver oxidative stress over the long-term induced damage of proteins, and lipid and alternation of cell DNA can lead to liver diseases, including cancer.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the treatment of cardio-diseases, researchers examined the effects of cabbage extract on oxidative stress in H9c2 cardiomyoblasts.

Based on the results of the experiment,
* Cabbage extract protected against H2O2-induced cell death and did not elicit any cytotoxic effects.

* Cabbage extract suppressed ROS production and increased expression of antioxidant proteins (SOD-1, catalase, and GPx).

* Cabbage extract also inhibited apoptotic responses and activation of MAPK proteins in the initiation of cellular response in oxidative stress-exposed H9c2 cells.

* Cabbage extract preserved mitochondrial functions upon oxidative stress.

Based on the results, researchers wrote, "cabbage extract protects against oxidative stress and suggests that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".

Taken altogether, cabbage may be used for the treatment of oxidative stress-induced cardiovascular diseases,  pending to the confirmation of the larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)
(2) Oxidative stress as a crucial factor in liver diseases by Halina Cichoż-Lach and Agata Michalak (PMC)

Sunday 22 March 2020

Herbal Cramp Bark(Viburnum Opulus), the Best Antioxidant Remedy

By Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.

A free radical is a highly reactive atom with a single electron in the outer ring.

Free radicals produced in our body are a natural process derived either from essential metabolism through the processes of food intake or from external sources through directly contacting the skin or the air we breathe including ozone, cigarette smoking, air pollutants, and industrial chemicals.

Some foods are antioxidants producers such as fruits and vegetables and whole-grain, while others such as processed meats, alcohol are radicals producers. Particularly, fats and oils can easily be oxidized if they are cooked in high heat.

In order to counter the overexpression of free radicals which add to the body's burden, our body produces enzymes antioxidants and metal carrier proteins to neutralize them before they can cause damage.

Depending on the degrees of free radical invasion, antioxidant enzymes can be categorized into first, second, third and even fourth line of defense.

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.

In other words, oxidative stress is either caused by overexpression of free radical or depletion of antioxidant enzymes in the body.

Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.

On finding a potential herbal medicine for the prevention and treatment of associated with oxidative stress diseases, researchers examined the antioxidant properties of fruit juices of six Viburnum opulus genotypes.

According to the antioxidant assays,
* V. opulus var. sargentii fruit juice demonstrated a remarkably stronger antioxidant activity, compared to others juice.

* Chlorogenic acid, the main phenolic compound in berry juices) depending on plant cultivar varied in the range of 0.54-6.93 mg/ml was found to be the dominant radical scavenger in V. opulus P3 (74%), compared to epicatechin and catechin (the main antioxidants in V. opulus var. sargentii) contributed to 40% and 23%, respectively.

More precisely, V. opulus var. sargentii followed by V. opulus P3 and V. opulus var. americanum possessed the highest antioxidant capacity.

Based on the findings, researchers said, "The obtained results may assist in selecting the most valuable V. opulus genotypes for the production of fruits possessing the strong antioxidant capacity and containing beneficial phenolic constituents".


Taken altogether, cramp bark(Viburnum opulus) depending on the types may be considered a functional herb for the prevention and treatment of diseases caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant properties and polyphenolic compositions of fruits from different European cranberrybush (Viburnum opulus L.) genotypes by Kraujalytė V1, Venskutonis PR, Pukalskas A, Česonienė L, Daubaras R. (PubMed)