Herbal Angelica Inhibits Osteoclastogenesis and Bone Resorption Against the Risk of Osteoporosis

By Kyle J. Norton

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries and considered as a major health problem in both elderly men and women.

Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is the common disease among the elderly, probably due to the aging effect that induces nutrition deficiency, vitamin D, reduced hormone production and production of bone mass, and increased bone reabsorption.

Osteoclastogenesis is a procedure processed in many stages. Interferes with the specific stage of the process, can induce the imbalanced osteoclasts and osteoblast.

The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone that leads to bone resorption.

In patients with osteoporosis, this balance shifts in favor of osteoclasts compared to those of osteoblasts.

In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.

Furthermore, the imbalance of osteoclasts and osteoblast also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the protection of bone density, researchers examined the effect of Angelica Sinensis (AS) extract on RANKL-induced osteoclast differentiation.

The study is to examine the osteoclast precursor cell line bone marrow macrophages (BMMs) cultured and stimulated with RANKL followed by treatment with AS at several doses by regulating the complex networks involved in osteoclastogenesis and bone resorption.

According to the results of the experiment, AS extract protected the bone density by inhibiting RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. 

AS extract also inhibited the mRNA expression of transcription factors that are activated in immune cells and other cell types following stimulation by a variety of factors in RANKL-treated BMMs.

In other words, AS protected bone density integrity against osteoclastogenesis and inhibited bone resorption, the expression of cytokines, growth factors, and hormones induced by the treatment of RANKL.

Taken altogether, herbal Angelica may be considered an anti osteoclastogenesis and bone resorption remedy to protect the bone mineral density against the onset of osteoporosis, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis extract inhibits RANKL-mediated osteoclastogenesis by down-regulated the expression of NFATc1 in mouse bone marrow cells by Kong L, Zhao Q, Wang X, Zhu J, Hao D1, Yang C. (PubMed)

Dandelion (Taraxacum officinale) Processes a Strong Antifungal Activity

By Kyle J. Norton

Fungal infection is a common disease caused by the overgrowth of fungus.

In other words, the immune system that protects the body against microorganisms has been overwhelming by the overgrowth of fungus.

Yeasts, molds, and mushrooms are types of fungi. The tiny microorganisms have cells with nuclear.

Most common fungal infections start from the lungs or the skin. Long-term use of antibiotics and people with the weakened immune system are susceptible to fungal infection, epidemiologically.

However, some researchers suggested that common risk factors for fungal infection also include pregnancy, diabetes mellitus, oral contraceptives, and inadequate therapy.
People with weakened immune systems such as cancer treatment, frequent use of antibiotics are associated to increase the risk of fungal infection.

Patients with diabetes are also more prone to fungal infections. Fungal infection associated with diabetes includes jock itch, athlete's foot,..... and ringworm.

Depending on the locations of infection, patients may experience symptoms of common peeling, cracking, scaling redness, blisters Itching,...... and burning sensation.

In women, signs of a yeast infection may include itching and swelling around the vagina. burning sensations or pain during urination or intercourse,........ and unusual vaginal discharge.

In men, signs of a yeast infection may include burning and itching around the head of the penis,
redness, and swelling, pain during urination or sex,..... small, rash-like bumps.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of fungal infectious diseases,
scientists examined the antifungal effects of novel peptide named ToAMP4 isolated from Taraxacum officinale Wigg. flowers by a combination of acetic acid extraction and different types of chromatography.

According to the tested differentiation of the biological activity of ToAMP4 produced in a prokaryotic expression system as a fusion protein with thioredoxin, the peptide  ToAMP4 displayed broad-spectrum antifungal activity against phytopathogens.

Moreover, the two ToAMP4 also exerted significantly mediated inhibition properties, on the tested fungus

In other words, ToAMP4 processed anti-fungal infection depending on the types of fungus.

Taken altogether, dandelion may be considered a remedy for the prevention and treatment of fungal infection, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A novel cysteine-rich antifungal peptide ToAMP4 from Taraxacum officinale Wigg. flowers by Astafieva AA1, Rogozhin EA, Andreev YA, Odintsova TI, Kozlov SA, Grishin EV, Egorov TA. (PubMed)

Legume Protects the Liver Cells Against the Rick of Nonalcoholic Fatty Liver Disease

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

Furthermore, the liver produces bile that not only aids the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affecting everyone from infants to older adults, including infected viri such as hepatitis A, B, C, and medication overloaded.

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.

Nonalcoholic liver disease is a chronic condition caused by fat accumulated over time in the liver, affecting people who drink little to no alcohol.

In other words, if you have fat that makes up over 5% of the liver, you are considered to have fatty liver disease.

Nonalcoholic liver disease can be classified into the noninflammatory fatty liver and inflammatory liver steatohepatitis.

According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world(2). However, due to the economic prosperity of Southeast Asian(3), the disease also was found in a large population in the cities, causing concerns of many scientists in the region(4)(6).

According to the joint assessment of the prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the US, led by the Stanford University School of Medicine, "The prevalence of NAFLD in the United States (U.S.) has risen from 18% in 1988–1991 to 31% in 2011–2012. Estimates of NAFLD prevalence for adults in Western countries are 20–30%, with much higher prevalence in adults with obesity (80–90%), diabetes (30–50%), and hyperlipidemia (90%)"(5).

Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%(6). The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account(7).

The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications(8), genetic preposition(8), insulin resistance(8), high cholesterol(8) and triglycerides(8) in the blood, polycystic ovary syndrome(8), metabolic syndrome(8), obesity(8), and type 2 diabetes(8) are associated with the onset of the disease.

A legume is a plant in the family Fabaceae that fruit or seed of a plant.
On finding a potent ingredient for the treatment of liver diseases, researchers investigated the impact of legume intake, including green bean against the risk of nonalcoholic fatty liver disease (NAFLD.

According to the results of the valid and reliable food frequency questionnaire returned by 169 newly diagnosed patients with NAFLD and 803 controls participated in the study, greater intake of green peas was associated with a lower risk of NAFLD.

According to the adjusted models for higher dietary intake of legumes, 0.73 (0.64-0.84), 0.61 (0.46-0.78), and 0.35 (0.17-0.74), respectively.

In other words, legumes showed the highest effect compared to those of individual legume such as lentils, and beans.

Taken altogether, legume may be considered functional veggies for the prevention and treatment of NAFLD,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Legume intake and risk of nonalcoholic fatty liver disease by Bahrami A1, Teymoori F1, Eslamparast T2, Sohrab G2, Hejazi E2, Poustchi H3, Hekmatdoost A. (PubMed)
(2) Non-alcoholic Fatty Liver Disease (NAFLD)Treatment in Phytochemicals Perspective by Kyle J. Norton

Herbal Ashwagandha Improves Male Steroid Hormones Levels in Aging Male

By Kyle J. Norton

Steroid hormones, secreted by the adrenal cortex, testes, and ovaries and during pregnancy by the placenta refers to any group of hormones associated with steroids.

All steroid hormones are produced by cholesterol, a way substance produced by the liver or from outside sources such as dietary fat.

Steroid hormones can be classified into two classes:
* Corticosteroids produced in the adrenal cortex play a critical role in providing relief for inflamed areas of the body that cause symptoms of swelling, redness, itching, and allergic reactions.

* Sex steroid hormones interacted with androgen or estrogen receptors in men and women respectively, play an essential role in reproduction, differentiation, development, cell proliferation, apoptosis, inflammation, metabolism, homeostasis, and brain function.

In females, estrogens and progestins are synthesized and secreted principally by maturing ovarian follicles, corpora lutea and during pregnancy, the placenta. The dominant estrogen secreted is E2.

In the male, testosterone secreted by the fetal testes that play a critical role to masculinize and defeminize brain structures, physiological processes, and behaviors.

The increase of aging is associated with the change of the levels of steroid hormones in the human body that is easily observed in the perturbed sleep-wake cycles and cognitive decline in the elderly.

Dr. K.G. Sorwell, the lead scientist wrote, "Using remote serial blood sampling we have found the circulating levels of DHEA sulfate, as well as oestradiol and testosterone, decline markedly in old monkeys".

And, "Furthermore, using real-time PCR, we have shown that genes associated with the conversion of DHEA to oestradiol and testosterone (e.g., 3BHSD, 17BHSD, and aromatase) are highly expressed in brain areas associated with cognition and behavior, including the hippocampus, prefrontal cortex, and amygdala".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound which processes antiaging property, researchers examined the effects of Withania somnifera (Ashwagandha) on the promotion of youthful vigor, in enhancing muscle strength and endurance, and improving overall health in aging males.

The 16-week, randomized, double-blind, placebo-controlled, crossover study included overweight men aged 40-70 years, with mild fatigue, received either a placebo or an ashwagandha extract (Shoden beads, delivering 21 mg of withanolide glycosides a day) for 8 weeks.

According to the tested analysis of 57 participants enrolled, with 50 people completing the first 8-week period of the trial and 43 completing all 16 weeks,

* Withania somnifera (Ashwagandha) showed the Improvements in fatigue, vigor, and sexual and psychological well-being were over time.

* However, Ashwagandha intake group demonstrated an 18% greater increase in DHEA-S ( p = .005) and 14.7% greater increase in testosterone, compared to the placebo without affecting the levels of cortisol and estradiol.

In other words, Ashwagandha processes antiaging activity in males by improving the male steroid hormones associated with enhancing youthful vigor, muscle strength, and endurance.

Based on the findings, researchers said, " the intake of a standardized ashwagandha extract (Shoden beads) for 8 weeks was associated with increased levels of DHEA-S and testosterone, although no significant between-group differences were found in cortisol, estradiol, fatigue, vigor, or sexual well-being. Further studies with larger sample sizes are required to substantiate the current findings".

Taken altogether, Ashwagandha may be considered an antiaging functional herb in males, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males by Lopresti AL1,2, Drummond PD1, Smith SJ. (PubMed)
(2) Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord by L Zubeldia-Brenner,1 CE Roselli,2 SE Recabarren,3 MC Gonzalez Deniselle,1,5 and HE Lara. (PMC)
(3) Causes and consequences of age-related steroid hormone changes: insights gained from nonhuman primates by K.G. Sorwell and H.F. Urbanski. (PMC)

Herbal Ashwagandha Process Anti-Parkinson's disease Activity

By Kyle J. Norton

Dementia is a medical and neurodegenerative disease characterized by the loss of mental ability, that is severe enough to interfere with people's every life.

Alzheimer's disease and Parkinson's disease (PD) are the most common types of dementia in aging people.

Dementia accounts for 5-8% of all people over the age of 65, and this number doubles every five years.

Parkinson's disease (PD) is a type of dementia that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.

In other words, Parkinson's disease is a progressive neurological disorder that affects neurons in transmitting messages in controlling the movement.

In the very early stage of PD, patients may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.

As of today, researchers do not know why the neurons in the brain in some people are susceptible to gradually break down or die while others do not even they have similar health conditions and from the same family.

 Epidemiologically aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the prevalent factors involved in the increased risk of the disease.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the prevention and treatment of neurological disorders, researchers examined the effects of Centella asiatica and Withania somnifera root extract consumption on Parkinson's disease in an animal model.

On 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson-like symptoms Balb/c mice, both ethanol extracts significant reduced the tested mice oxidative stress profile.

However, , the combination performed worse than either of the two individual constituents.

In other words, Withania somnifera and Centella asiatica treated individually showed a strong effect in reducing symptoms of Parkinson's disease comapred to the extract combination.

Based on the results, researchers said, " This effect of mixtures highlights the need for testing mixtures in supplements market using ethnomedicine. The necessity of comparing multiple groups in this study to get the most information from the experiments motivated us to design a ladder-like visualization to show comparison with different groups that we call complete comparison display (CCD)".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of Parkinson's disease symptoms, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Complete Comparison Display (CCD) evaluation of ethanol extracts of Centella asiatica and Withania somnifera shows that they can non-synergistically ameliorate biochemical and behavioural damages in MPTP induced Parkinson'smodel of mice by Bhatnagar M1, Goel I2, Roy T3, Shukla SD1,4, Khurana S. (PubMed)

Turmeric Protects the Heart Valve Against the Risk of Cardiac Fibrosis

By Kyle J. Norton

Cardiac fibrosis is a medical condition caused by the abnormal thickening of the heart valves due to the inappropriate proliferation of cardiac fibroblasts.

In other words, cardiac fibrosis is a result of excess deposition of extracellular matrix associated with collagen enzymes, and glycoproteins involving the healing of the myocardial muscle.

According to the statistics, over 6 million people in the US suffer from heart failure, leading to reduce the function of the heart muscle to pump blood and remove waste from the body.

The most common cause of heart failure is associated with cardiac fibrosis, a scarring process that over time affects cardiac structure and function.

Therefore, preventing or reducing cardiac fibrosis progression, the risk of heart failure, and other cardiovascular diseases caused by scarring heart tissues can be reduced.

Conventionally, medications that target the renin-angiotensin system, transforming growth factor-beta, and endothelin showed to inhibit the progression of scarring in various stages of cardiac fibrosis development.

Dr. Armstrong AC, the lead scientist in the examination of the risk of cardiovascular disease and cardiac fibrosis in early cardiac dysfunction in type 1 diabetes.wrote, "Traditional CVD risk factors and elevated HbA1c levels are major factors related to early cardiac dysfunction in type 1 diabetes".

And, "Nonischemic myocardial scar, possibly as a marker of chronic exposure to known risk factors, may predict early cardiac dysfunction mediated by diffuse myocardial fibrosis as seen in diabetic cardiomyopathy".

In other words, older age, male sex, smoking history, obesity, higher blood pressure, lower HDL cholesterol, and higher mean HbA1c are some of the prevalent factors of CVD and myocardial fibrosis in patients with type 1 diabetes.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of heart disease, researchers examined the efficacy of curcumin anti-cardiac fibrosis potential.

According to the tested differentiation, Curcumin, SB431542 (a TGF-βR-Smad2 inhibitor) and SB203580 (a p38 inhibitor) showed a significant effect on the inhibition of the stimulation of pro-inflammatory cytokines (TGF-β1).

α-SMA and ColI associated with pathologic fibroblasts and cardiac fibrosis induced by the TGF-β1were also inhibited by the injection of curcumin and SB431542 and SB203580  via the inhibition of the genes that are regulated by TGF-beta.

Collectively, researchers said, " In conclusion, the results of the present study demonstrated that treatment with curcumin effectively suppresses TGF-β1-induced CF differentiation via Smad-2 and p38 signaling pathways. Thus, curcumin may be a potential therapeutic agent for the treatment of cardiac fibrosis".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardia fibrosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin suppresses transforming growth factor-β1-induced cardiac fibroblast differentiation via inhibition of Smad-2 and p38 MAPK signaling pathways by Liu H1, Liu A2, Shi C3, Li B. (PubMed)
(2) Association of Cardiovascular Risk Factors and Myocardial Fibrosis With Early Cardiac Dysfunction in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study by Armstrong AC1,2, Ambale-Venkatesh B1, Turkbey E1,3, Donekal S1, Chamera E1, Backlund JY4, Cleary P4, Lachin J4, Bluemke DA3, Lima JA5; DCCT/EDIC Research Group. (PubMed)

Ashwagandha the Antiaging Herbal Medicine

By Kyle J. Norton

Skin aging is a natural process that can not be stopped. However, there are some people have younger-looking facial skin compared to their biological age.

The evidence of skin aging can be visible by increasing wrinkles and sagging skin.

Skin is the largest organ in the human body. The skin not only shields us against the invasion of foreigner pathogens but also serves as the third detoxed organ besides the liver and kidney.

Additionally, the skin also protects the skeletons and internal organs against the mechanical impacts and pressure, variations in temperature, micro-organisms, radiation, and chemicals.

However, when skin ages, it also reduces the function of the aforementioned protection, seen in the elderly.

Besides biological causes of skin aging, long-term exposure to sunlight, particularly UVB is one of the major factors associated with damages of elastin, leading to wrinkles, sagging skin that loses stability to rebound from the stretch.

According to the free radical theory of aging, free radical bombardment over time can cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA, leading widespread cell damage including the skin cells after attacking the lipid bilayers of the cell walls.

In other words, according to the theory, free radical cause internal and external cell damage, that lead to aging cells.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the promotion of healthy aging, researchers examined the effects of major component of leaf extract of Ashwagandha (i-Extract) and within one withanone ((i-Factor) protected the normal human fibroblasts against the toxicity.

According to the tested results, in vitro both applications increase the division potential of normal human cells by protecting the cells against oxidative damage and induction of proteasomal activity.

Furthermore, the application also decreased the accumulation of molecular damage, by inhibiting the senescence-specific beta-galactosidase activity and the senescence marker protein, p21(WAF-1)associated with the process of deterioration of cells with age.

Based on the findings, researchers said, "we provide the first example of phytochemical(s) (i-Extract and withanone) that have ... antiaging activities and point to the molecular link between aging and cancer".

Taken altogether, Ashwagandha may be considered a functional herb that protects the cellular damage against aging, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves by Widodo N1, Shah N, Priyandoko D, Ishii T, Kaul SC, Wadhwa R. (PubMed)