Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday 6 November 2019

Green Peas, the Potential Anti Cancer Whole Food

By Kyle J. Norton

Cancer is a group of cell mutated diseases caused by the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.

At the later stage, due to the size and the tumor, patients may experience the general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort and loss of appetite and localized symptoms such as severe pain and bleeding.

The exact causes of cancer are not identified. However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,..... the list goes on and on, depending on the types of cancer.

Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.

Dr. Karen Basen-Engquist, in the evaluation of obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".

And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".

The findings strong indicated the risk of cancer is increased substantially in obese.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of cancer, researchers investigated the impact of green pea (GP) extracts anti-DNA alternative activity.

According to the studies,

* The extracts of P. sativum have been found to be pharmacologically active inducing anticancer effects.

* Compared to the effect of Bowman-Birk trypsin-chymotrypsin inhibitor, a potential cancer chemopreventive agent, with the protease inhibitors, rTl1B and rTl2B, P. sativum seed showed similar significant activity.

* In human colorectal adenocarcinoma HT-29, P. sativum extracted lectins from Egypt exhibited the antiproliferative property to liver cancer cell line.

* In MCF-7 (breast), HepG-2 (liver), HEP-2 (larynx), and HCT-116 (colon). an extracted lectin from leaves and buds of P. sativum demonstrated cytotoxic property.

* Recently, the seed extracts also showed the cytotoxic effects on LS174 (colon), MDA-MB-453 (breast), A594 (lung), and K562 (blood) cell lines.

Taken altogether, green peas may be considered a functional food for the prevention of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Pea, Pisum sativum, and It's Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (PMC)

Cranberry Promotes the Cardio-Metabolic Health

By Kyle J. Norton

Cardiometabolic risk is a condition that estimates the possibilities of developing atherosclerotic cardiovascular (CV) disease and diabetes mellitus.

Cardioprotection is a process including the use of substances associated with the preserve of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.

Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.

More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke, depending on the location of the blockage or disruption,

According to the statistics provided by the American Heart Association, approximately 84 million people in this US living with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.

Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.

Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.

However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.

Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery

Most people with atherosclerosis are asymptomatic at the early stage.

Diabetes is a medical condition characterized by insufficient insulins in the bloodstream. or insulins in the bloodstream are not used properly to convert glucose to energy.

Epidemiologically, diabetes is caused by either the beta cells in the pancreas died-off or insulin receptors with a function that use insulin to convert glucose to energy clogged-up by fat or cholesterol.

In a healthy individual, after eating, the rise of blood glucose triggers the production of insulin by the pancreas into bloodstream After you eat, your blood sugar (glucose) rises. This rise in glucose triggers your pancreas to release insulin into the bloodstream that travels through the blood to your body's cells before converting glucose into energy or store it to use later.

In other words, insulin released by the pancreas joints with the Insulin receptors on the outer part of a cell that binds insulin in the blood to convert glucose to energy.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of cardiometabolic health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors.

In cardiometabolic health, cranberry constituents and their bioactive catabolites improved the
serum lipid profiles reduced the levels of blood pressure.

Furthermore, the endothelial functions associated with vascular relaxation and contraction, glucoregulation involved in the regulation of glucose metabolism. and a variety of biomarkers associated with inflammation and oxidative stress in the induction of CVD and diabetes were also inhibited by the cranberry constituents and their bioactive catabolites

Based on the findings, researchers said, " These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products.".

Taken altogether, cranberry may be considered a remedy for the improvement of the cardiometabolic health, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)

Tuesday 5 November 2019

Herbal Turmeric Processes Anti Colorectal Cancer Activity

By Kyle J. Norton

Colorectum including the large intestine and the rectum is the second part of the digestive system involved in the absorption of water from the small bowel contents and breaks down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by irregular cell growth in the tissue of the colon or rectum.

Most cases of colorectal cancer start in the cells on the surface of the inner lining in the colon and rectum, before penetrating into deeper layers to form a tumor through proliferation.

Colorectal cancer is relatively very common and slowly growing and progresses cancer in a predictable way.

According to the statistics provided by the American Cancer Society, excluding skin cancers, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States.

In 2019, approximately 101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.

The 5-year survival rate of colorectal cancer diagnosed at the localized stage is 90%. Sadly, only 39% of patients are diagnosed at this early stage.

The exact causes of colorectal cancer are unknown. Epidemiologically, the most common risk factors associated with the onset of the disease are

* Age
The disease is more common in people over the age of 50. Regular colonoscopy after age of 50 is valuable to detect the disease in the early stage.

* Bowl inflammatory diseases
A prolonged period of inflammatory diseases of the colon, such as ulcerative colitis and Crohn’s disease, can increase your risk of colon cancer due to long term inflammation of the lining of the colon.

* Family History of colorectal cancer
People with parents, siblings, children who have had colorectal cancer are more likely to develop colon cancer.

* Inherited Syndromes
Genetic syndromes passed through generations can increase the risk of developing colon cancer.

However, most people with some of the aforementioned prevalent factors have never developed colorectal cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, etc.

With an aim to find a potential compound for the treatment of colorectal cancer, researchers investigated the effects of curcumin nanoformulations anti-cancer activity by overcoming the limitations of the compound.

Application of the nanoformulations not only displayed a greater anticancer activity compared to free curcumin but also extended at the same time non-toxic to the normal cells.

Furthermore, curcumin also demonstrated a strong anti colorectal cancers effect in the regulation of multiple cell signaling pathways associated with tumor growth and anti-apoptosis.

Moreover, curcumin also promoted the expression of tumor suppressor gene which is crucial in cancer development and progression.

The joint study led by the Ahvaz Jundishapur University of Medical Sciences in the examination of curcumin, a bioactive substance originating from turmeric root anticancer properties showed that curcumin inhibited the expression of a gene associated with involved in tumor initiation and progression. In other words, through inhibition of this gene, curcumin reduced the risk of tumor metastasis.

Additionally, by inhibiting the insulin and insulin-like growth factor-1 receptor curcumin showed a greater decrease in the proliferation and migration of chemoresistant colorectal cancer cells.

Based on the results, Dr. Hosseini SA, the lead scientist said, "These results suggest the possible therapeutic effects of curcumin in adjuvant therapy in metastatic colorectal cancer".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells by Hosseini SA1, Zand H2, Cheraghpour M. (PubMed)
(2) Curcumin Nanoformulations for Colorectal Cancer: A Review by Wong KE1,2, Ngai SC3, Chan KG4,5, Lee LH1,2,6, Goh BH1,2,6, Chuah LH. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton

Herbal Coltsfoot(Tussilago farfara), A Natural Neuro-Protective Remedy

By Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.

Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).

Alzheimer's disease is an irreversible, progressive brain disorder caused by the slowly lost of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into advanced stage.

According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.

Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.

Conventionally, as of today, there is no cure for dementia. Treatment of dementia is focusing to improve dementia symptoms and slow down the progression of the disease.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of the neurological disorder, researchers examined the neuroprotective effect of Tussilagone (TSL) on LPS-induced neuronal cell death.

According to the tested assays, 4 sesquiterpenoids isolated from the TSL showed a significant effect against the production of nitric oxide, prostaglandin E2 and tumor necrosis factor-α in LPS-treated BV-2 cells.

In other words, the sesquiterpenoids inhibited the production of free radicals and proinflammatory expression associated with the BV-2 cells oxidative stress induced by LPS.

More precisely, the inhibition against the initiation of oxidative stress was attributed to the sesquiterpenoids activity in blocking the activation of the proinflammatory (NF-κB) pathway

Furthermore, the sesquiterpenoids also inhibited LPS-induced neuronal cell death in the co-culture system by inhibiting the expression of NF-κB pathway and scavenging of ROS.

Based on the findings, researchers said, "sesquiterpenoids from Tussilago farfara may have beneficial therapeutic potential for the treatment of neurodegenerative diseases through inhibition of microglial activation".

Taken altogether, coltsfoot may be considered a remedy for the treatment of neurological disease, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) In vitro neuroprotective activity of sesquiterpenoids from the flower buds of Tussilago farfara by Lim HJ1, Dong GZ, Lee HJ, Ryu JH. (PubMed)
(2) Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara by Lee J1, Song K1, Huh E2, Oh MS3, Kim YS. (PubMed)

Monday 4 November 2019

Herbal Ashwagandha Gobbles Up Human Head and Neck Cancer Cells In Vitro

By Kyle J. Norton

Cancer is a group of diseases associated with cell growth disorderly and uncontrollably in the tissue of a specific organ. Over time cancer can become progressively worse and damage other healthy tissues.

Most cases of cancer start in the cells on the surface in the inner lining tissue of a specific organ, before traveling a distance away to affect other nearby tissue and organ.

Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. Patients with head and neck cancer at the very early stage are asymptomatic due to the very small size of the tumor.

However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.

The exact causes of head and neck cancer are not identified. However, researchers found that excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust are prevalent factors associated with an increased risk of head and neck cancer.

Dr. Kazuhiro Kobayashi in the investigation of the risk of HPV on head and neck cancer (HNC) wrote, " Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of cancers, researchers examined the apoptotic activity of methanol extract of Ashwagandha (MEAG) and in human head and neck squamous cell carcinoma (HNSCC) cells.

In vitro, in human head and neck squamous cell carcinoma (HNSCC) cells treated by MEAG showed dose-dependent growth-inhibitory activity involved in caspase-dependent apoptosis.

The inhibition of human head and neck squamous cell carcinoma (HNSCC) was attributed to induce the loss of mitochondrial membrane, the release of cytochrome c, accompanied by the activation of caspase 9 the apoptotic pathway.

Furthermore, Bim, truncated Bid (t-Bid), cleaved caspase-8, and death receptor 5 (DR5), associated with pro-apoptotic activity was also a significant increase upon the injection of MEAG.

Moreover, the major constituent withaferin A (WA), a bioactive component of MEAG.also expressed similar effects to those of MEAG.

Based on the findings, researchers said, " MEAG and WA may be potential natural materials for the treatment of HNSCC.".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of head and neck squamous cell carcinoma (HNSCC), pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anticancer activity of Ashwagandha against human head and neck cancer cell lines by Lee HE1, Shin JA1, Jeong JH2, Jeon JG3, Lee MH4, Cho SD. (PubMed)
(2) Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells by Park JW1, Min KJ2, Kim DE1, Kwon TK. (PubMed)
(3) A Review of HPV-Related Head and Neck Cancer by Kazuhiro Kobayashi,1 Kenji Hisamatsu,1 Natsuko Suzui,1 Akira Hara,1,2 Hiroyuki Tomita,2,* andTatsuhiko Miyazaki. (PMC)

Healthy Food Onion Protects the Gallbladder Against Cholesterol Gallstone Formation

By Kyle J. Norton

Cholesterol gallstones caused by the accumulation of cholesterol in the gallbladder is the most common type of gallstone with yellow in color.

Gallstone is a condition caused by the hardening of deposits of digestive fluid formed in the gallbladder.

The digestive fluid or bile is produced by the gallbladder that releases into the small intestine to aid digestion.

If the cholesterol gallstone blocks the gallbladder duct, it can induce symptoms of cudden and rapidly intensifying pain in the upper right portion of your abdomen and intensifying pain in the center of your abdomen, and pain between your shoulder blades and right shoulder.

Some patients may also experience gastrointestinal symptoms such as nausea and vomiting.

Conventionally, surgery for cholesterol gallstones is only for patients who have experienced symptoms of pain.

Some researchers suggested there are evidence that the rise of cholesterol gallstone in the US may

be correlated to the promotion of the Western diet over the past few decades.

Dr. Yongsoon Park wrote, "Patients with cholesterol gallstone consumed more lipid, animal lipid, beef, pork, and fried food than those with pigment gallstones and control, while patients with pigment gallstone consumed more carbohydrate and noodles than patients with cholesterol gallstone and control".

And, "consumption of fat from meat and fried foods increased the risk of cholesterol gallstone, and intake of carbohydrate from noodles increased the risk of pigment gallstone".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential and natural compound for the prevention of cholesterol gallstone formation, researchers evaluated the anti-lithogenic effect of a combination of dietary fenugreek seeds and onion.

The study included Lithogenesis induced mice fed with a high (0.5%) cholesterol diet (HCD) for 10 weeks with Fenugreek (12%) and onion (2%) included individually and in combination in this HCD.

According to the tested analysis,

* Fenugreek, onion, and their combination reduced the incidence of cholesterol gallstones by 75%, 27%, and 76%, respectively.

*Total cholesterol content in mice fed with Fenugreek, onion, and their combination was also reduced by 38-42%, 50-72%, and 61-80%, respectively.

* These results have a strong effect on the reduction of cholesterol/phospholipid ratio involved in gallstone formation in serum, liver, and bile.

* The cholesterol saturation index of bile was reduced from 4.14 to 1.38 and 2,33 in mice fed with the combination of fenugreek and onion respectively.

* The phospholipid and bile acid contents of the bile were increased in all groups.

* Hepatic lipid peroxidation was reduced by 19-22% and 39-45% with fenugreek, onion and their combination included in the diet along with the HCD.

* Interestingly, the increased accumulation of fat in the liver and inflammation of the gallbladder membrane produced by HCD were totally reduced by fenugreek, onion, and their combination.

Based on the results, researchers suggested that Fenugreek and onion inhibited the parameters involved in the cholesterol formation of gallstone.

After taking into account of co and confounders, Dr. Reddy RR, the lead scientist wrote, "The anti-lithogenic influence was highest with fenugreek alone, and the presence of onion along with it did not further increase this effect".

According to Dr. Vidyashankar S, the lead researchers in the study of cholesterol gallstones by dietary garlic and onion in mice fed with a lithogenic diet for 10 weeks, the efficacy of onion in the inhibition of cholesterol formation of gallstone stone was attributed to the acceleration of the regression of preformed CGS by promoting cholesterol desaturation in bile.

Taken altogether, onion may be considered a remedy for the prevention of cholesterol gallstone formation, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Dietary fenugreek and onion attenuate cholesterol gallstone formation in lithogenic diet-fed mice by Reddy RR1, Srinivasan K. (PubMed)
(2) Regression of preestablished cholesterol gallstones by dietary garlic and onion in experimental mice by Vidyashankar S1, Sambaiah K, Srinivasan K. (PubMed)
(3) Association between diet and gallstones of cholesterol and pigment among patients with cholecystectomy: a case-control study in Korea by Yongsoon Park,

#1 Doyeon Kim,1 Ju Seon Lee,1 Yu Na Kim,1 Yoon Kyung Jeong,2Kyeong Geun Lee,2 and Dongho Choi. (PMC)

Sunday 3 November 2019

Turmeric Inhibits Tumor Angiogenesis In Vitro

By Kyle J. Norton

Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.

In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the new forming small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.

Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis".

More precisely, the angiogenesis process a function of a double sword. On one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.

Dr. Papetti M continued, "tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"

Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".

Therefore, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.

Dr. Dai X, the lead researchers in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of cancer, researchers examined the Trivalent arsenic [As(III)] induced damaging effects on human health such as angiogenesis.

Epidemiologically, Trivalent arsenic [As(III)] has been found to induce the development of cardiovascular disease, diabetes, and cancer, and angiogenesis.

According to tested analysis, administration of curcumin, an active ingredient in the dietary turmeric has shown to demonstrate potent antiproliferative, anti-inflammatory by inhibiting the angiogenic activity.

In HCT-116 human colon cancer cells exposed to As(III), both curcumin and turmeric inhibit the expression of vascular endothelial growth factor associated with the promotion of the growth of new blood vessels from the existing blood vessels.

In the chicken chorioallantoic membrane assay model, curcumin or turmeric.also inhibited the extensive increase in blood vessel density.

Based on the findings, researchers wrote, " the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of cancer-associated with angiogenesis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo by Pantazis P1, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. (PubMed)
(2) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
(3) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Xingbin Dai,1,2 Pengjun Jiang,2 Yanhua Ji,3 Xuejun Zhu,2 and Xuemei Sun2. (PMC)