Phytochemical Indicaxanthin Inhibits Factors Associated with Beta Thalassemia Anemia

By Kyle J. Norton

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.

Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout the body.

People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.

Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.

Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia, is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the red blood cells loss.

* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in heart and other organs, that can lead to heart failure.

Most common symptoms of beta-thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.

There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, an ulcer, cancer and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential compound for the treatment of beta-thalassemia red blood cells, researchers examined the antioxidant activity of indicaxanthin.

In vitro, human beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide, application of indicaxanthin at 1.0-10 microM enhanced the resistance to hemolysis associated with the destruction of red blood cells in a dose-dependent manner.

Furthermore, the phytochemical also exerted a significant antioxidant activity by preventing lipid and hemoglobin (Hb) oxidation and enhancing the levels of vitamin E and GSH depletion.

Moreover, indicaxanthin also stimulated the recovery of the soluble cell compartment of the RBCs in the blood from thalassemia patients.

According to the A spectrophotometric study, the antioxidant also showed to reduce the a reactive intermediate that makes an abnormal form of hemoglobin in solution caused by the oxidative stress, compared to those of Trolox or vitamin C.

Based on the findings, researchers said, "Collectively our results demonstrate that indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of beta-thalassemia anemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)

Herbal Ashwagandha Inhibits Testosterone Deficiency in Vivo

By Kyle J. Norton

Testosterone is a steroid hormone found in humans produced mostly from the testicles in men and a small amount in women's ovaries.

According to epidemiological studies, treatment for hypogonadism is on the rise, particularly in the population due to natural reduced production of levels of testosterone other than normal aging.

Testosterone production starts to produce significantly during puberty and dip after age 30.

In males, the early onset of reduced production of levels of testosterone is associated with a highly prevalent burden of comorbid medical conditions and polypharmacy complicates, compared to those of normal aging,

Also, low levels of testosterone in males are associated with the early onset of metabolic syndrome in the induction of cardiovascular disease and type 2 diabetes.

Apart from normal aging, low levels of testosterone are found to induce symptoms of decreased sex drive, low energy, weight gain, the risk of depression, and moodiness, loss of hair and thinner bones.

If you are experiencing some of the above symptoms, you may have low levels of testosterone. Please make sure you check with your doctor to rule out the possibility.

Dr. Giagulli VA, in examining the complications of testosterone in men wrote, "Testosterone deficiency syndrome (TDS) induces several negative effects that generally involve different organs such as testis, bone, skeletal muscle, and heart, leading to reduction in testis function, causing osteoporosis, strongly reducing muscle mass, decreasing exercise capacity and strength and facilitating heart failure".

And, " Approximately 25% of patients affected by chronic heart failure (CHF) is characterized by plasma Testosterone (T) levels below normal ranges also related to disease progression".

These results clearly suggested apart from normal aging, males with testosterone deficiency are associated with the complications of many ailments.

Conventionally, testosterone replacement therapy has been found to increase sexual function, lean muscle mass and strength, mood and cognitive function, with a possible reduction in frailty and osteoporosis.

However, Dr. E. Charles Osterberg and colleagues in the examining the benefits and risk of TRT wrote, "The benefits seen with TRT, such as increased libido and energy level, beneficial effects on bone density, strength and muscle as well as cardioprotective effects, have been well-documented. TRT is contraindicated in men with untreated prostate and breast cancer. Men on TRT should be monitored for side-effects such as polycythemia, peripheral edema, cardiac and hepatic dysfunction".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of testosterone deficiency, researchers examined the effect of a methanolic extract of Withania somnifera (L.) Dunal roots on sexual competence in an animal model.

Male rats selected to the study prior to treatment day 3 and 7 of treatment, and day 7, 14 and 30 post-treatment before orally administering 3000 mg.kg-1.day-1 of root extract for 7 days by pairing each male with a receptive female.

Based on the tested differentiation, the root extract showed a significant activity by improving the impairment in libido, and sexual performance, comapred to baseline.

Furthermore, sexual vigor and penile erectile dysfunction in the tested rats were also strongly improved by the administration of root extract in a time-dependent manner.

Most importantly, cessation of treatment of the extract partly reversed this efficacy.

However, the injection of the extract showed an antimasculine side effect that was not attributed to the change of testosterone levels but the promotion of hyperprolactinemic, GABAergic, serotonergic or sedative activities.

Based on the findings, researchers said, "Use of W. somnifera roots may be detrimental to male sexual competence".

Taken altogether, Ashwagandha may be considered a functional herb for the treatment of testosterone deficiency in male, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats by Rahmati B1, Ghosian Moghaddam MH2, Khalili M1, Enayati E3, Maleki M2, Rezaeei S. (PubMed)
(2) Effect of Withania somnifera root extract on the sexual behavior of male rats by Ilayperuma I1, Ratnasooriya WD, Weerasooriya TR. (PubMed)
(3) Testosterone deficiency in male: a risk factor for heart failure by Giagulli VA1, Guastamacchia E, De Pergola G, Iacoviello M, Triggiani V. (PubMed)
(4) Testosterone Replacement Therapy and Mortality in Older Men by Hackett GI. (PubMed)
(5) Risks of testosterone replacement therapy in men by E. Charles Osterberg, Aaron M. Bernie, and Ranjith Ramasamy. (PMC)

Herbal Turmeric, the Best Anti-Neuroinflammatory Remedy

By Kyle J. Norton

Neuroinflammation is a medical condition characterized by the inflammation of the central nervous tissues, including the brain and spinal cord.

There many risk factors associated with the onset of neuroinflammation similar to other tissues inflammation, including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Inflammation is a natural response of the immune system in which the macrophages of the first defense stimulates the production of blood palette to cover the wound in case of injury and production of proinflammatory cytokines to the site of infection to fence off the foreign pathogens. 

Inflammation also can be triggered by the immune mistakenly attacked the body tissues in cases of autoimmune disease.

The neuroinflammatory disease can be acute or chronic. Chronic neuroinflammation that leads to the activation of glial cells and the recruitment of inflammatory cytokines into the brain is found to associate with neurodegenerative diseases.

Most cases of the neuroinflammatory disease associated with the loss of neuronal structure and function.can be measured by the typical inflammatory markers, including CSF Aβ1-42, tau and p-tau181, and a panel of 37 neuroinflammatory markers in patients with Alzheimer's disease.

Dr. WEI-WEI CHEN, the lead scientist in the investigation of the role of neuroinflammation in neurodegenerative diseases, wrote, "recent data have identified the inflammatory process as being closely linked with multiple neurodegenerative pathways, which are associated with depression, a consequence of neurodegenerative disease".

And, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia. These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments".

In other words, an acute neuroinflammatory response that, if unresolved, can lead to chronic neuroinflammation, leading to chronic low-grade neurodegenerative disease.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of neuroinflammation, researchers examined the neuron protective activity on curcumin, amain curcuminoid present in turmeric.

According to the tested assays, curcumin dose-dependently inhibited Pam3CSK4, the inflammatory mediators induced the release of proinflammatory cytokines such as nitric oxide, PGE2, and TNF-α secretion.

The secretion of inflammatory mediators was stimulated by the increase in the expression of HO-1, a cytoprotective and antiapoptotic enzyme, which plays an important protective role by modulating oxidative stress.

Furthermore, curcumin also inhibited neuroinflammation by decreasing the production of macrophages found in the central nervous system (CNS) induced by the inflammatory mediators.

Based on the findings, researchers said, "The results of the present study suggest that curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders".

In vivo, curcumin also exerted a significantly anti-nociceptive and anti-neuroinflammatory effect on arthritic pain in rats.

Moreover, repeated intrathecal injection of curcumin reversed CFA-induced pain hypersensitivity with affecting the joint edema.

Levels of proinflammation observed by the presence of glial cells and the production of inflammatory mediators induced by the injection of CFA were reduced by the injection of curcumin.

Additonally, the protein associated with the regulation of the migration and infiltration of monocytes/macrophages in the spinal cord was also inhibited in the curcumin treatment group.

Dr. Chen JJ, the lead scientist said, " intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord, suggesting a new application of curcumin for the treatment of arthritic pain".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of neuroinflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells by Jin M1, Park SY2, Shen Q1, Lai Y1, Ou X1, Mao Z1, Lin D1, Yu Y1, Zhang W. (PubMed)
(2) Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis by Chen JJ1, Dai L2, Zhao LX3, Zhu X4, Cao S4, Gao YJ. (PubMed)
(3) Role of neuroinflammation in neurodegenerative diseases (Review) by WEI-WEI CHEN, XIA ZHANG, and WEN-JUAN HUANG. (PMC)

Bromelain Modulated the Immune System Against the Development of Diseases

By Kyle J. Norton

The immune system is a network of cells, tissues, and organs that provide the body's defense against infectious organisms and pathogens.

The immune system can be classified into innate immunity and adaptive immunity

* Innate immunity comprised the cells and mechanisms is the process of the immune response against infection in a non-specific manner.

* Adaptive immunity or acquired immunity is the process to destroy pathogens or prevent their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.

Diseases associated with the immune system can also be classified into under active immunity and overactive immunity

* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly and children with immature immunity.

People with a weakened immune system are prone to infectious diseases.

* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.

In inflammatory perspective, the chronic inflammatory diseases are also caused by the immune system failure in destroying all foreign invaders in the acute infection in a set period of time, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.

Diseases associated with chronic inflammation include type II diabetes, cardiovascular disease.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.

Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10. 

In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocyte.

In order to obtain more information of bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely encephalomyelitis disseminate (ED) as well as from healthy controls.

The experiment carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain and with trypsin (final concentrations 10-1000 microg/ml).

Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.

Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cell associated with the adaptive immunity process independently from the underlying disease.

Taken altogether, bromelain may be considered a remedy for the modulation of immune function, pending to the confirmation of large sample size and multicenter study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)

Herbal Coltsfoot (Tussilago farfara) Inhibits Myelotoxicity

By Kyle J. Norton

Myelotoxicity is a medical condition that causes the decrease of the production of cells responsible for immunity (leukocytes), carrying oxygen (erythrocytes), and/or for normal blood clotting (thrombocytes) due to bone marrow suppression.

Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.

Myeloperoxidase (MPO) processes a critical role that protects our body against the invasion of microorganisms.

In cellular levels, myeloperoxidase (MPO) plays a critical role as a local mediator of tissue damage by stimulating the production of proinflammatory cytokines to protect the cell against foreign pathogens in the induction of acute phase of infection.

In other words, MPO deficiency induces the exaggerates of the inflammatory response that affects neutrophil functions including cytokine production in the acute phase of infection that can lead to chronic low-grade inflammatory disease.

MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.

However, genetic preposition may be the primary condition that causes the onset of PMO deficiency.


Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degree of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in the primary form".

And, " Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of neutropenia, researchers examined the effects of Tussilago farfara L. polysaccharides on the immune response of lung cancer animal model.
The study included selected C57Bl/6 mice with Lewis lung carcinoma treated by conventional cisplatin/paclitaxel polychemotherapy before administrating additional Tussilago farfara L. polysaccharides.

According to the tested analysis, Tussilago farfara L. polysaccharides not only reduced the side effects of cisplatin/paclitaxel polychemotherapy induced myelotoxicity associated with moderated neutropenia but also enhanced the efficacy of the chemo drugs activity.

Moreover, the stimulating effect of polysaccharides on the granulopoiesis lineage cells involved in myelopoiesis that differentiate into unipotent neutrophil progenitors in the lung tumor cells compared to those of CSF Neupogen.that increase production of white blood cells in the body.

In other words, polysaccharides exhibited immune-modulating activity against myelotoxicity induced by chemo drugs side effects.

Taken altogether, coltsfoot may be considered a remedy for the improvement of myelopoiesis, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L by Safonova EA1, Lopatina KA2, Razina TG2, Zueva EP2, Fedorova EP2, Gur'ev AM3, Belousov MV. (PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa, and Ishwarlal Jialal. (NCBI)

Cranberry Protects the Body Against Bacterial Infection

By Kyle J. Norton

Infection is a condition caused by  a harmful microbial invasion of the body tissues

Most cases of bacterial infection are treated with antibiotics. However, bacterias are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.

Out of trillions of strains of bacteria in the world, only a few cause diseases in humans. Believe it or not, our gut contains trillion microorganisms, most of them are bacteria.

Most common symptoms of bacterial infection are redness and heat, swelling, fever, pain at the site of infection.

In severe cases, the patient may also experience symptoms of swollen lymph glands.

Most cases of bacterial infection are treated successfully if the types of bacteria that cause the infection are identified.

There are many risk factors associated with the onset of bacterial infection,  people with severe chronic disease may increase the prevalence of bacterial infection, particularly in those with cirrhosis.

Dr. Deschênes M, the lead scientist at the Université de Montréal wrote, "Bacterial infection is a frequent and severe complication of cirrhosis. Cirrhotic patients admitted for gastrointestinal bleeding are at high risk of such a complication and have been targeted in trials of antibiotic prophylaxis".

And, " patients with severe cirrhosis who are admitted for gastrointestinal bleeding have a higher risk of developing a bacterial infection during their hospitalization than other cirrhotic patients".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of bacterial infection, researchers examined the effect of cranberry antibacterial activity against uropathogenic strains of Escherichia coli (UPEC).

According to tested analysis, the whole extract showed a powerful antibacterial activity against UPEC compared to the selected fractions that presented a different behavior.

 Myricetin and quercitrin demonstrated the highest decrease of  E. coli biofilm formation compared with the control and other fractions.

However, other chemical constituents such as dihydro ferulic acid glucuronide, procyanidin A dimer, quercetin glucoside, myricetin, and prodelphinidin B led to a significant decrease of the surface hydrophobicity compared with the control.

In other words, all fractions in the cranberry extract worked synergistically to protect the host against the infection caused by E. coli 

Based on the results, researchers said, "apart from proanthocyanidins, other compounds, mainly flavonoids, can act against E. coli biofilm formation and also modify UPEC surface hydrophobicity in vitro."

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of bacterial infection, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli by Rodríguez-Pérez C1, Quirantes-Piné R2, Uberos J3, Jiménez-Sánchez C1, Peña A4, Segura-Carretero A. (PubMed)
(2) In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against FimH-Dominated Uropathogenic Escherichia coli: A Combined in Vivo, ex Vivo, and In Vitro Study of an Extract from Vaccinium macrocarpon by Rafsanjany N1, Senker J1, Brandt S1, Dobrindt U2, Hensel A. (PubMed)
(3) Risk factors for the development of bacterial infections in hospitalized patients with cirrhosis by Deschênes M1, Villeneuve JP. (PubMed)

Indicaxanthin, Might Protect the Skin Against Melanoma

By Kyle J. Norton

The skin is the largest external organ that protects us against infection and physical trauma by guarding the underlying muscles, bones, ligaments, and internal organs.

Furthermore, the skin accompanied by liver and kidney detoxes toxins in the body

Melanoma is a type of skin cancer caused by the alternation of cell DNA in the pigment-containing cells known as melanocytes.  Most cases of melanomas are found in the skin.

According to the statistics,  approximate 120,000 new cases of melanoma in the US are diagnosed in a year. The skin cancer tends to spread along the skin in most of the cases, but also can grow down to the deeper layers of the skin. 

At the advanced stage, skin melanoma can also travel a distance aways to infect other healthy tissues through blood and fluid circulation.

Most common symptoms of melanoma skin cancer are

* Asymmetry

The mole on the skin is no longer symmetric as one half of the mole is different from the other half.

* Borders irregular
Border of the mole has become irregular, such as uneven or notched.

* Color
The color of the mole is different than other moles on the skin.

* Diameter
The mole is larger than other mole and evolved over time
Accompanied by pain, swelling, and bleeding in the affected skin

There are 3 main types of melanoma skin cancer, including

* Superficial spreading
This is the most common type of melanoma, accounting for over 70% of all cases. The cancer cell usually starts with a normal mole, but for whatever reason, it begins to change malignantly with irregular borders and color variations.

* Nodular type
This type of melanoma is more aggressive growth than superficial spreading and found most on the trunk, upper arms, and thighs. The nodular type of melanoma is usually detected as a lump with blue and black color.

* Acral melanoma
Acral melanoma is mostly founded on the hands, feet, and nail beds. The risk increases for people with darken-skin color.

*  Lentigo maligna melanoma
Found mostly on the face of elderly caused by great exposure to sunlight.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

With an aim to find a potent ingredient for the treatment of cancer, researchers investigated the effects of Indicaxanthin, against human melanoma both in vitro and in vivo.

According to the tested analysis, the growth of A375 cells was inhibited by the injection of the phytochemical

Furthermore, Indicaxanthin also induced apoptosis and decreased the invasiveness of A375 cells.

In other words,  indicaxanthin effectively inhibits the proliferation of highly metastatic and invasive and anti-apoptotic activity of the A375 cells.

In mice, induced melanoma, oral administration of Indicaxanthin also significantly reduced tumor developing.

Additional differentiation of the anti-cancer activity of Indicaxanthin, researchers found that the efficacy of the bioactive compound was attributed to the inhibition of the NF-κB pathways associated with the antiproliferative effect of indicaxanthin.

Based on the results, researchers wrote, " indicaxanthin represents a novel phytochemical able to significantly inhibit human melanoma cell proliferation in vitro and to impair tumor progression in vivo".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indicaxanthin from Opuntia Ficus Indica (L. Mill) impairs melanoma cell proliferation, invasiveness, and tumor progression by Allegra M1, De Cicco P2, Ercolano G2, Attanzio A1, Busà R1, Cirino G2, Tesoriere L1, Livrea MA1, Ianaro A. (PubMed)
(2) Melanoma Skin Cancer (Malignant Melanoma) by Kyle J. Norton