Herbal Artichoke Enhanced Nonpathogenic Intestinal Microflora for the Promotion of Digestive Health

By Kyle J. Norton

Gut microbiota or gastrointestinal microbiota is the complex community of over 10 trillions microorganisms living in our digestive tracts.

Use of antibiotics, diet, drugs, may alter the composition of the microbiota.

Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.

In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens. 

In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.

In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease. 

In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the improvement nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter. 

The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.

Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in digesta from colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.

Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.

JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.

Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)

Herbal Bilberry, the Natural Inhibition of Cardiometabolic Risk Factors According to Human Studies

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole fruit for the inhibition of cardiometabolic risk factors (CRFs) associated with the onset of cardiovascular disease,, according to studies.

Cardiovascular disease is a class of diseases involving the blood vessels and heart, depending on the location or area that has been affected.

Cardiometabolic risk factors (CRFs) are conditions that cause damage to the heart and blood vessels. Some researchers suggested that cardiometabolic risk factors are a cluster of condition that causes the onset of diabetes, heart disease or stroke.

Cardiometabolic risk factors can be classified by preventable and nonpreventable risks
* Preventable risk factors can be lower by making a change of lifestyle such as following a healthy diet, quitting smoking, losing weight and exercising daily and moderately.

According to epidemiological studies, a healthy lifestyle has been found to reduce risks of metabolic syndrome, a cluster of conditions associated with the cardiometabolic risk, including lower high blood sugar, cholesterol, and pressure.

* Nonpreventable risks are the risk cannot be changed including aging, ethnicity, family history, medical condition,...

Out of a number of risk factors, some researchers suggested that the prevalent obesity may be the major culprit that causes the onset of diabetes and cardiovascular disease in the Western world.

According to the data provided by the Center for Disease Control and Prevention, "Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis".

The results are according to the measurement of elevated blood pressure (systolic ≥130 mm Hg or diastolic >85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0–405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol (<40 mg/dL for men or <50 mg/dL for women or ICD-9-CM 272.5); and prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4% or ICD-9-CM 790.2x). 

The results strongly suggested if you are overweight or obese, you are at an increased risk of diabetes and cardiovascular disease compared to those who do not.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a natural whole food for the inhibition of cardiometabolic risk factors that increase the risk of CVD and diabetes, researchers examined the effect of baseline metabolome on the overall metabolic responses to berry intake.

The study included 80 overweight women completed the randomized crossover study randomly assigned to consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries.for 30 days.

By comparing the metabolic profile that reflected higher cardiometabolic risk(group B) at baseline, and participants who had a lower-risk profile (group A), researchers showed that bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

In other words, bilberry exerted a protective effect against people with cardiometabolic risk without causing harm to people with lower risk profiles.

In order to reveal more information about bilberry inhibition of cardiovascular risk factors researchers investigated regular consumption of bilberries effects on CVD risk reduction, such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C).

The study involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.

During the experiment, the consumption of bilberries led to a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C (P=.044). In both women and men.

However, in men, additionally, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C.

Dr. the lead scientist said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".

Taken altogether, bilberry may be considered a functioning remedy for the inhibition of cardiometabolic risk factors and prevention of CVD, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(2) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(3) Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012–2013. ORIGINAL RESEARCH — Volume 14 — March 9, 2017. (CDC)

Phytochemical 3,3'-Diindolylmethane, the Natural Treatment for Breast cancer in Vivo and Human Studies

By Kyle J. Norton


Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

Breast cancer (malignant breast neoplasm) is a medical condition characterized by irregular cells growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. 

There are also rare cases that breast cancer started in other areas of the breast. 

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the US and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Breast cancer is first noticed as a painless lump in the breast or armpit and most often discovered by the women themselves.

In some cases, breast cancer can also be noticed by the woman partner or during the doctor a routine physical exam.

In the early stage of breast cancer, patients may experience symptoms of the lump (mass) in the breast. and in the armpit (lymph nodes), nipple discharge, inverted or retracted nipple, scaly or pitted skin on nipple,  persistent tenderness of the breast and unusual breast pain or discomfort.

If you experience some of the aforementioned symptoms, please check with your doctor right the way to rule out the possibility. Breast cancer diagnosed in the early stage have a 5-year survival rate of 100%. 

However, at the advanced stage, due to the oversize of the tumor, patients may experience symptoms of bone pain (secondary tumors in bone), shortness of breath (secondary tumors in lung) and Headaches, neurological pain or weakness (secondary tumors in the nervous system) accompanied by the general symptoms shared with other types of cancer.

Out of many risk factor associated with the onset of breast cancer, genetic preposition may be one of the major prediction of the disease.

Dr. Amir Mehrgou, the lead scientist said, "Early detection of mutation carriers in these genes, in turn, can play an important role in its prevention. Because this disease has a high prevalence in half of the global population, female screening of reported mutations in predisposing genes, which have been seen in breast cancer patients, seems necessary. In this review, a number of mutations in two predisposing genes (BRCA1 and BRCA2) that occurred in patients with a family history,..".

In fact, women who carry the BRCA1 and BRCA2 genes have a 68% of lifetime risk to develop breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers examined the promising 3,3'-Diindolylmethane (DIM) anticancer effects of breast cancer patients with high HER-2/neu levels.

DIM combined with Herceptin enhances the effectiveness of Herceptin by significantly reducing cancer cell viability, and increasing apoptosis-induction and inhibition of colony formation, compared to the use of the chemo drug alone.

The combination also induced cancer cell death by inhibiting the expression of proteins associated with the production of proinflammatory cytokines, cancer cell division and proliferation and migration.

Furthermore, the combination also significantly exhibited the expression of miR-200, which plays an essential in blocking tumor cell invasion and metastasis and reduction of FoxM1 expression in the promotion of cancer cell proliferation.

Dr. Ahmad A, the lead scientist said, "DIM-plus Herceptin therapy could be translated to the clinic as a therapeutic modality to improve treatment outcome of patients with breast cancer, particularly for the patients whose tumors express high levels of HER-2/neu".

Moreover, in order to know more information about DIM anti-breast cancer activity, researchers investigated the bioactive compound against the transcription factor Forkhead Box M1 (FoxM1) associated with aggressive human carcinomas, including breast cancer.

3,3'-diindolylmethane (DIM), a nontoxic dietary chemopreventive agent showed to inhibit the FoxM1 in various breast cancer cell lines, according to the observation of gene transfection, real-time reverse transcription-PCR, and Western blotting.

Similar to the aforementioned results, DIM combined with Taxotere enhanced Taxotere-induced growth inhibition of breast cancer cells and decreased the invasive capacity of breast cancer cells compared to treatment alone.

Most importantly, the combination treatment also significantly inhibited tumor growth in severe immunodeficiency (SCID) mice,

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane enhances the effectiveness of herceptin against HER-2/neu-expressing breast cancer cells by Ahmad A1, Ali S, Ahmed A, Ali AS, Raz A, Sakr WA, Rahman KM. (PubMed)
(2) 3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1 by Ahmad A1, Ali S, Wang Z, Ali AS, Sethi S, Sakr WA, Raz A, Rahman KM. (PubMed)
(3) The importance of BRCA1 and BRCA2 genes mutations in breast cancer development by Amir Mehrgou 1 and Mansoureh Akouchekian. (PMC)

Turmeric/ Curcumin, the Bioactive Compound from Turmeric Suppress the Onset of Arthritis

By Kyle J. Norton

Arthritis is a general form of inflammatory diseases associated with the inflammation of one or more of joints.

Most common symptoms are joint pain and stiffness found mostly in the aging population.

Most common types of arthritis that affect people in the US are osteoarthritis and rheumatoid arthritis.

Most common caused of arthritis is a joint injury that did not heal properly, metabolic abnormalities caused by overexpression of uric acid and infection-induced bacteria or virus.

However, there are some cases of arthritis caused by autoimmunity, a condition in which the immune system mistakenly attacks the joint tissues, such as in rheumatoid arthritis and systemic lupus erythematosus.

According to the information provided by the Arthritis Foundation, in the US, approximately 54 million adults are living with the condition.

Believe it or not, Almost 300,000 babies and children have arthritis or a rheumatic condition.

Most common symptoms associated with the disease are all involved in the joints, including fatigue. joint pain, tenderness, swelling, redness, stiffness, particularly, the loss of joint range of motion.

Some researchers in the comparison of the history of arthritis development suggested that the severity of the condition probably is a result of the promotion of Western diet over the past few decades.

Miss. Sadhana Bharanidharan in the article "Western Diet, With Its High-Fat Content, Linked To Arthritis" wrote, "A team of researchers, from the University of Rochester Medical Center in New York, fed mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen. After three months, the mice became obese and diabetic. Their fat percentage was double as much as those rodents who were fed a healthy, low-fat diet".

And, "High levels of pro-inflammatory bacteria were observed in the colons of the obese mice, while beneficial, probiotic bacteria was almost not present at all. This coincided with signs of inflammation across the body. The researchers induced a tear in a certain tissue of the knee to induce osteoarthritis. Compared to the healthy mice, the condition progressed much faster in the obese rodents, and within three months after the tear, all their cartilage disappeared".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of arthritis researchers examined the effects of turmeric and its curcumin-enriched extracts by reviewing the database of online medical literature. 

According to 8 studies met specific selection criteria out of 29 selected,
* Turmeric/curcumin treatment showed a reduction of A pain visual analog score (PVAS) compared to placebo in RCTs.

* Turmeric/curcumin treatment showed a decrease of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in a meta-analysis of four studies.

Further differentiation of the conclusion of the viewing studies, the researchers suggested that there is no publication bias in the meta-analysis and concluded that these RCTs provide scientific evidence to support the efficacy of turmeric extract (about 1000 mg/day of curcumin) in the treatment of arthritis.

In rat adjuvant-induced arthritis (AIA), researchers investigated the efficacy of turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes.

Turmeric and ginger used alone at dose 200 mg/kg body weight significantly suppressed the incidence and severity of arthritis by increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines, respectively.

Turmeric and ginger used alone also suppressed the overexpression of oxidative stress in the affected area by stimulating production antioxidant enzymes.

Compared to ginger, the anti-arthritic activity of turmeric exceeded the effects of that of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.

More importantly,  turmeric exerted additional arthritis recovery of a percentage of 4.6-8.3% and 10.2%, compared to ginger and indomethacin, respectively. 

Based on the findings, researchers wrote in the final report, "(The result) proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin".

Taken altogether, turmeric may be considered supplements for the and treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials by Daily JW1, Yang M2, Park S. (PubMed)
(2) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(3) "Western Diet, With Its High-Fat Content, Linked To Arthritis" by Sadhana Bharanidharan. (Medical Daily)

Whole Food Honey, the Natural Antibiotic with No Side Effects

By Kyle J. Norton


Antibiotics are conventional medicines used for the treatment of microbial infection except for the virus. The aim of the medicines is to kill off the microbial pathogens that cause the disease.

However, epidemiological suggested that antibiotics also kill the good bacterias and cells in the host, leading to weakened body functioning, including the immune system.

Furthermore, overuse of antibiotics over the past many decades has also caused genetic mutation in the bacteria, inducing the bacterial resistance superbugs that have caused a resurgence in some illnesses.

Out of billions of bacteria existed in the world, only a few hundreds have been known to cause infectious diseases. And bacterial pneumonia was probably the leading cause of death among the elderly.

Bacteria after entering the body and found a specific site to incubate, at the time permitted also secret toxins to attack the cells in the area, leading to infection and signs and symptoms of an illness.

Most common symptoms of the acute phase of infection are associated with an immune system response by stimulating the production of pro-inflammatory cytokines with an aim to kill off the pathogens, including fever, malaise, headache, rash. 

People with a weakened immune system such as elderly and taking immune suppressive medicines and immature immune system such as infants are prone to the bacterial infection.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural therapy to replace the antibiotic with no side effects, researchers examined the antimicrobial activity and composition of a locally produced Portobello honey (PBH) on three bacteria known to infect wounds, compared to Manuka honey (MH).

The study included selected honeys were tested at four concentrations: 75%, 50%, 10% and 1% (v/v) and compared with untreated control.

According to the tested assays, both honeys at 75% and 50% inhibited the majority of the three bacteria tested. However, the 10% PBH exhibited antimicrobial activity to a lesser extent than 10% MH.

Both honeys were acidic with pH 4, and both produced H2O2 .

The results suggested although both honeys exert the similar antibacterial effects, the MH has significantly higher levels of the polyphenols and antioxidant activity than PBH.

Also, in the comparison of the antibacterial property of other types of honey and Manuka honey, researchers showed that Manuka honey was the most effective against Staphylococcus aureus Oxa R and S. aureus Oxa S with a Minimum Inhibitory Concentration (MIC) of 6% and 7%, respectively, compared to the wild carrot honey with a MIC of 12%.

Furthermore, tested Manuka honey contained the highest content of polyphenols, with 899.09 ± 11.75 mg gallic acid/kg, whereas lavender honey had the lowest, with 111.42 ± 3.54 mg gallic acid/kg. 

Dr. the lead scientist wrote in the final report, "The differences between honey samples in terms of antibacterial and antioxidant activity could be attributed to the natural variations in floral sources of nectar and the different locations".

In other words, the antibacterial effect of honeys probably is associated with the levels of polyphenols content.

Taken altogether, honey processed a high amount of polyphenols may be considered antibacterial infection remedies with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-microbial activity and composition of manuka and portobello honey by Schneider M1, Coyle S, Warnock M, Gow I, Fyfe L. (PubMed)
(2) Antibacterial and antioxidant potency of floral honeys from different botanical and geographical origins by Alzahrani HA1, Alsabehi R, Boukraâ L, Abdellah F, Bellik Y, Bakhotmah BA. (PubMed)

Herbal Artichoke, the Best Anti-Aging Functional Remedy

By Kyle J. Norton


Skin aging is a natural process which can not be stopped. However,  some people may look younger compared to their biological age.

 According to the prominent oxidative stress theory, long-term accumulation of cells damage due to overexpression of free radicals in the skin can lead to early skin aging.

The joint study led by the University of Texas Health Science Center at San Antonio suggested, alterations in oxidative damage/stress also play a role in aging. Rodents with resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules) showed an increased lifespan, compared to oxidative stress control.

Some researchers suggested that genetic preposition may play a critical role in the promotion of delayed aging. Dr. Viviana I Pérez, the lead scientist in the study of free radical theory wrote, "Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan".

Regardless of free radical or other theories associated with the aging processes, there are many risk factors that can lead to reduced life span and delayed the skin aging process, even in people with a longevity gene.

In other words, long-term unhealthy lifestyle such as excessive alcohol drinking, substances abuse, smoking, physical inactivity not only can reduce the gene effect on longevity but also increase the risk of early skin aging and shorten the proposed life span.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutic which processed antiaging property investigated the anti-age effect of a polyphenolic artichoke extract on endothelial cells.

Injection of the extract showed a significant anti-aging activity by exhibiting the important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, through its anti-inflammatory function, and protecting the lymphatic vessels from oxidative damage by ROS formation, and enhancing the cellular cohesion by reinforcing the tight junction complex.

In other words, the polyphenolic artichoke extracts exhibited anti-age effect against the skin and subcutaneous tissue damage caused by overexpression of proinflammatory cytokines associated with the production of free radical and depletion of antioxidant enzymes produced by the host.

The anti-aging efficacy was attributed to the combined activity of constituents found in the herbal medicine, including 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids.

Furthermore, polyphenolic artichoke extract improved the expression of genes involved in anti-aging mechanisms.

On human subjects, an artichoke extract cosmetic formulation also reduced 19.74% of roughness and enhanced 11.45% of elasticity, compared to a placebo cream.

Furthermore, in UVB-induced photoaging, researchers examined antioxidant activity of Cynaropicrin (Cyn), a sesquiterpene lactone, and major bioactive phytochemical in the artichoke.

Cynaropicrin (Cyn) attenuated  UVB-induced oxidative stress by activating the AhR-Nrf2-Nqo1 pathway associated with the production of antioxidants and anti-inflammatory factors against oxidative stress.

In other words, in anti-aging perspective, Cyn not only actively inhibited the generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB), but also the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-α from UVB-treated keratinocytes.

Taken altogether, artichoke processed high amounts of bioactive compounds may be used as a functional antiaging remedy with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality by D'Antuono I1, Carola A2, Sena LM3, Linsalata V4, Cardinali A5, Logrieco AF6, Colucci MG7,8, Apone F. (PubMed)
(2) Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway byTakei K1, Hashimoto-Hachiya A1, Takahara M1, Tsuji G1, Nakahara T2, Furue M. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)

Whole Food Ginger, the Natural Treatment of Premenstrual Syndrome With No Side Effects, according to A Human Study

By Kyle J. Norton

Scientists may have found a natural kitchen spice for the treatment of premenstrual syndrome symptoms (PMS) with no side effects.

Premenstrual syndrome is a condition caused by the faulty function of the ovaries related to the women's menstrual cycle, due to hormone fluctuation in one to two weeks before menstruation and then declines when the period starts.

PMS affects over 70% to 90% of women in the US compared to a lesser affection to women in Southeast Asia because of the different living style and social structure. 

 Most common symptoms of PMS include fatigue, fluid retention breast tenderness, acne, sleep disturbances and appetite changes with overeating or food cravings.

PMS can be classified into 4 types, categorizing by the symptoms including

1. Anxiety
Anxiety is a common symptom for women with PMS, caused by a hormone imbalance between estrogen and progesterone(1). Most women with PMS is found to have a very high level of estrogen and low levels of progesterone(4) before menstruation. 

Withdrawal from chronic exposure to the female sex steroid progesterone (P) may also contribute to the occurrence of PMS anxiety(2).

2. Craving
Some women with PMS may experience the symptom of food craving, caused by an abnormal liver function in carbohydrate synthesis due to dietary habits(6) and abnormal levels of serotonin(10)(8). 

Other theories suggest that when a woman under stress before period, she may grasp for everything which makes her feel more comfortable(7).

3. Hyperhydration(11)
Breast tenderness and water retention(12) are always a problem for some women with PMS. Breast tenderness is caused by overproduction of prolactin due to the abnormal function of the pituitary gland(13). Water retention is either caused by overproduction of prolactin-induced renal sodium and potassium excretion(16) or abnormal function of lymphatic function(14)(15).

4. Depression
Researchers found that women with the symptom of depression always have unbalanced levels of estrogen(3) and progesterone as a result of liver abnormal function in fat and protein metabolism(5). This unbalance also induces nervous tension, that causes nervous disorder including depression(3).

Conventionally, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics and hormonal contraceptives. are the most common medicine used for the treatment of PMS, depending on the types of symptom.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of premenstrual syndrome (PMS), evaluated the effects of ginger on the severity of symptoms of PMS.

The clinical trial, double-blinded work, included 70 participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. All persons suffering from PMS were asked to complete the daily record scale questionnaire for two consecutive cycles before treatment.

According to the returned questionnaire, there were no significant differences between the mean scores of PMS symptoms in the two groups before intervention.

Each participant received two ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded the severity of the symptoms by daily record scale in the questionnaire. 

By comparing the date 1, 2, and 3 months after intervention, the ginger treatment group showed a significant improvement of the PMS symptoms compared to control.

Dr. Khayat S, and colleagues wrote in the final report, "Based on the results of this study, maybe ginger is effective in the reduction of severity of mood and physical and behavioral symptoms of PMS and we suggest ginger as a treatment for PMS".

Take all together, ginger may be considered a functional alternative for the treatment of premenstrual syndrome (PMS) pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effect of treatment with ginger on the severity of premenstrual syndrome symptoms by Khayat S1, Kheirkhah M2, Behboodi Moghadam Z3, Fanaei H4, Kasaeian A5, Javadimehr M. (PubMed)