Bilberry Protects the Retinal Structures Against Retinal Diseases

By Kyle J. Norton


The retina is a thin membranous lining at the back of the eye located near the optic nerve that allows us to see by sensing light and sending signals to the brain.

People with the retinal disease may experience symptoms of seeing floating specks or cobwebs,  blurred or distorted (straight lines look wavy) vision depending on the location of retinal damage.

In serious cases,  the retinal disease may cause complete loss of the vision.

Treatment of retinal disease completely depends on the condition. Most cases of the treatment goals are to stop or slow the disease. Untreated retinal diseases have been found to induce severe vision loss or blindness.

The exact causes of retinal disease are not identified. However, high blood cholesterol, glucose, and hypertension, smoking, exposure to sunlight are some major risk factors associated with the onset of retinal diseases.

Some researchers suggested that genetic preposition may have a strong implication in the facilitation of retinal diseases.

Dr. Peter J Francis, in the study of the genetics of inherited retinal disease, wrote, "Over the subsequent 150 years, a huge number of articles have been dedicated to the description of the various patterns of hereditary retinal diseases, also known as retinal dystrophies".

And, "One of the genes, RPE65, has become of particular significance following the finding of a spontaneously occurring mutation in the equivalent gene in the Briard dog. Trials of gene replacement therapy have proved successful in restoring sight to such affected dogs and in the next couple of years the first human trials of gene therapy by replacing human photoreceptor RPE65are timetabled".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists with an aim to find a natural and active compound for the treatment of retinal diseases examined the complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola Rosea retinal functions in an animal model.

Without treatment of complex lutein formula (CLF), animals exposed to light for 7 days decreased significantly retinal function.

 However,  animals received the CLF exhibited superior performance of a retinal function, despite light exposure.

Injection of CLF animals also preserved a greater portion of the outer nuclear layer (ONL) (i.e. the nuclei of photoreceptors) compared with the animals that had not received the formula after 7 days of light exposure.

Dr. Cheng YP, the lead scientist wrote, " These results revealed that our dietary CLF supplement attenuated retinal function loss resulting from long-term light exposure".

In order to expose more information about bilberry anti retinal diseases, researchers investigated the neuroprotective effects of bilberry extract against photo-stress in murine retinas.

Light-induced visual function impairment through a stomach tube in Balb/c mice (750 mg/kg body weight) visual function impairment was restored by the injection of bilberry extract.

The retinal protective activity of bilberry extract was associated with the suppression of photo-induced apoptosis in the photoreceptor cell layer and shortening of the outer segments of rod and cone photoreceptors.

Bilberry extract treatment also inhibited the production of reactive oxygen species that reversed transcriptase polymerase chain reaction and the endoplasmic reticulum (ER) stress markers by enhancing the levels of antioxidant.

Dr. Osada H and colleagues said, " bilberry extract attenuates photo-induced apoptosis and visual dysfunction most likely, and at least in part, through ROS reduction, and subsequent ER stress attenuation in the retina".

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of retinal diseases with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of a complex lutein formula in an animal model for light-induced retinaldegeneration by Cheng YP1, Ke CY2, Kuo CC1, Lee YJ2. (PubMed)
(2) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina by Osada H1, Okamoto T1,2, Kawashima H1,2, Toda E1, Miyake S1,3, Nagai N1,2, Kobayashi S3, Tsubota K2, Ozawa Y. (PubMed)
(3) Genetics of inherited retinal disease by Peter J Francis. (PMC)

Ginger, May Be the Best Anti Hyperglycemic Functional Remedy

By Kyle J. Norton


Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body inability to make enough insulin.

Most cases of hyperglycemia can be controlled by the following diabetes guidance. 

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.

Some researchers suggested that hyperglycemia may be harder to control in obese patients with type 2 diabetes due to the alternation of mechanisms associated with the production of insulin.

Dr. Martyn JA, the lead scientist at the Massachusetts General Hospital wrote, "Obesity is a major cause of type 2 diabetes, clinically evidenced as hyperglycemia".

And,  "The altered glucose homeostasis is caused by faulty signal transduction via the insulin signaling proteins, which results in decreased glucose uptake by the muscle, altered lipogenesis, and increased glucose output by the liver".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists on finding a natural compound for the treatment of hyperglycemia examined the anti-high blood glucose of [6]-gingerol, a major chemical compound found in ginger.

The study included C57BL/6 mice fed with [6]-gingerol at two different doses on a high-fat diet or standard diet for a period of 17weeks.

[6]-gingerol supplementation fed group showed a significantly reduced plasma glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), advanced glycation end-products (AGEs) and insulin levels caused by high-fat diet.

Where levels of alanine aminotransferase, aspartate aminotransferase are normally used for the testing of liver damage.

Prolonged hyperglycemia also activated the formation of advanced glycation end-products (AGEs), particularly in diabetes population.

Further analysis of the anti-hyperglycemic activity of [6]-gingerol supplement, researchers found that

[6]-gingerol group inhibits the complications of prolonged high blood glucose by reducing the production of the advanced glycation end-products (AGEs) through proteins associated with the stimulating the production antioxidants.

Moreover, the anti-hyperglycemia of  [6]-gingerol supplement also was observed by the balancing of antioxidants enzymes produced by the tested mice against levels of overexpression of free radicals caused by the high-fat diet.

Additionally, the levels of oxidative stress also inhibited by the injection of [6]-gingerol supplement observed by enhancing levels of heme oxygenase-1 and glyoxalase 1, the detoxified enzymes.

Dr. Sampath C, the lead scientist at the final report wrote, "[6]-gingerol are potential dietary compounds that can alleviate diabetes-induced complications".

In order to reveal more information about ginger anti-high blood glucose property, researchers evaluated the ginger efficacy in the disruption of slow-wave rhythm caused by acute hyperglycemia.

The study included 22 healthy humans underwent fasting electrogastrography during hyperglycemic clamping to 250 to 290 mg/dl after double-blind placebo or ginger root (1 g). 

 Ginger treatment group displayed a significant reduction of cardiac dysrhythmia, an abnormal heartbeat caused by acute hyperglycemia.

However, the application of ginger showed no effect on the heartbeat if cardiac dysrhythmia was elicited by a prostaglandin E(1) analog.

The finding suggested that ginger exerted anti-hyperglycemia-induced complications through inhibiting the production of prostaglandins which has a strong effect on the central nervous system in the regulation of blood sugar homeostasis.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of diabetic complications caused by prolonged hyperglycemia, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3. (PubMed)
(2) Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins by Gonlachanvit S1, Chen YH, Hasler WL, Sun WM, Owyang C. (PubMed)
(3) Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms by Martyn JA1, Kaneki M, Yasuhara S. (PubMed)

Artichoke Raises the Levels of "Good Bacteria" in the Gut

By Kyle J. Norton


Gut microbiota is a complex community with over trillion microorganisms that live in our digestive tracts.

In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.

In fact, balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production vitamins, improvement of digestive functioning and modulation of the immune function.

Use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illness such as inflammatory bowel disease, obesity, cancer, and autism. 

Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.

Compared to probiotics, the prebiotics is compound in food that induce the growth or activity of beneficial microorganisms in the gut.

In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.

In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.

In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutic which promotes probiotics examined the artichoke preparation on microbiota ecology and immune status.

The study included 48 piglets divided into 6 groups (n = 8), which received from day 10 of life probiotic-unsupplemented (PU) or probiotic-supplemented (PS, containing 0.5 g/kg diet and contained: Lactococcus lactis, Carnobacterium divergens, Lactobacillus casei, Lactobacillus plantarum, and Saccharomyces cerevisiae) diets.

The PU and PS diets were formulated without prebiotic addition (control) or with the addition of 2% of inulin from chicory root (IN) or 4% of dried Jerusalem artichoke tubers (DJA).

Feeding DJA diets showed to improve the balance of the gut microbiota by increasing the caecal valeric acid level, and decreasing the concentration of isoacids in the colon,

Furthermore, DJA diets also reduced β-glucosidase and β-glucuronidase activity induced gut toxicity in the middle colon and increased Bifidobacterium spp. populations in the proximal and distal colon.

These results suggested that DJA modified the microbiota ecology in the large intestine of young pigs to a greater extent as a prebiotic.

Taken altogether, artichoke may be considered a functional remedy as a  prebiotic for the treatment of patients with unbalanced gut microbiota with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)

Honey, the Potential Remedy in Speeding Up Bone Healing, According to Studies

By Kyle J. Norton


Bone healing is a natural process of broken bone healing. The bone healing process goes through three overlapping stages, including inflammation, soft and callus production, and bone remodeling.

Improper bone healing occurred when two ends of the broken bone are not lined up properly, leading to the bone healing with a deformity called a malunion.

Most cases of improper bone healing have been found to involve angulation (bend) and/or rotation flexibility or extension. In some cases, improper bone healing can also cause stiffness in the finger, hand, wrist or elbow.

If you experience some of the above symptoms after a broken bone, you may have an improper bone healing. Please check with your doctor to rule out the possibility.

Some researchers in the concern of the risk of improper bone healing in obese patients wrote, "Obesity is a risk factor for various orthopedic diseases, including fractures. Obesity's influence on circulating hormones and cytokines and bone mineralization ultimately influence the body's osteogenic response and bone mineralization, potentially increasing the risk of fracture and impacting fracture healing".

Luckily, the doctor continued, "Obese/overweight children did not have a delay in release to activities compared with children of normal weight".

The results strongly suggested the correlation between obese and the risk of bone fracture and fracture healing in children.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural remedy for speed-up bone healthy investigation honey activity on
alveolar osteitis (OA).

Alveolar osteitis (AO) is a complication of tooth extraction.

50 patients of AO were included in the study. After cleansing of the affected socket, honey dressings applied were changed daily for the first 2 days and then alternatively.

Honey application sped up the bone and granulation tissue healing and gingiva healing in about one week on most patients.

According to the reading of the CRP levels, treatment of AO with honey dressing showed a significant decrease from the pre-treatment values, an indication of fast recovery for inflammation.

The microbiological assay also showed the presence of normal commensal flora at AO sites including Streptococcus, Staphylococcus, and Enterococcus.

The results suggested that honey topical dressing speeds up bone healing and tissue recovery through inhibiting microbial overexpression and production of pro-inflammatory cytokines.

In order to reveal more information about bone healing of honey, researchers examined the honey on the healing of mandibular bone defects in a rat model.

24 wild-type Wistar rats included in the study were shaved, disinfected and extraoral incised with a 2 × 2 mm defect at mandibular angle. Only the experimental group defect was filled with sterile honey.

After 4 weeks, the defects were filled in four samples of the honey treatment group, compared to all samples of the control group which is still in the mineralization stage.

According to the histomorphometric assay, honey treatment showed a significant improvement in the mean new bone formation compared to those of the control group, both after 2 and 4 weeks.

Taken altogether, honey may speed up bone healing without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of Topical Honey on Mandibular Bone Defect Healing in Rats by Hajizadeh F1, Derakhshan B2, Peimani A3, Abbasi Z. (PubMed)
(2) Effects of honey in the management of alveolar osteitis: A study by Soni N1, Singh V1, Mohammad S1, Singh RK1, Pal US1, Singh R2, Aggrwal J3, Pal M. (PubMed)
(3) Does obesity affect fracture healing in children? by Lee RJ1, Hsu NN, Lenz CM, Leet AI. (PubMed)

Phytochemical Sinigrin, the Potential Anti Lung Cancer Bioactive Ingredient with No Side Effects, According to Medical Literature

By Kyle J. Norton


Lung cancer is a chronic condition characterized by cells growth disorderly in the tissue of the lungs.

According to the statistic provided by the American Cancer Society, lung cancer is the leading cause of cancer death among both men and women. More people die of lung cancer than from colon, breast, and prostate cancers combined each year in the US.

In 2018, in the US 234,030 new cases of lung cancer were diagnosed in the US including 121,680 in men and 112,350 in women.

Most cases of lung cancers are diagnosed in people who are 65 or older. The lifetime risk of lung cancer in men is 1/15 and in women 1/17.

Certain risk factors such as long-term smoking, exposure to second-hand smoke, radon gas and toxic chemicals and family history are associated with the onset of lung cancer.

However, most people with some of the above risk factors do not develop lung cancer.

Some researchers suggested people with a weakened immune system such as elderly, long term use of antibiotic and immune suppressive medicine may be prone to getting lung cancer.

Dr. Joanna Domagala-Kulawik, in the examination of the role of the immune system in non-small cell lung carcinoma, wrote, "Very low and heterogonous antigenicity of lung cancer cells leads to passive escape from the anti-cancer immune defense. The cytotoxic lymphocytes (CTLs) that play a main role in the anticancer response are actively suppressed in the tumor environment and following regulatory mechanisms inhibit the recognition of tumor antigens by antigen presenting cells".

The results clearly suggested that immune cytotoxicity against cancer cells is suppressed in patients with lung cancer. In other words, by restoring the genes associated with programming cancer cell death and tumor suppression, lung cancer may be preventable.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on the finding a natural ingredient for the treatment of lung cancer examined the effects of dietary sinigrin or indole-3-carbinol on tumorigenicity in F344 rats.

During the experiment, dietary sinigrin at a concentration of 3 mumol/g diet decreased 7-methylguanine formation in hepatic DNA but had no effect on 7-methylguanine levels of lung or nasal mucosa DNA. 

No effects on O6-methylguanine--DNA-transmethylase activity were observed in tissue extracts derived from the livers, lungs and nasal mucosae of rats fed diets containing sinigrin or I3C.

Where O6-methylguanine--DNA-transmethylase activity is a DNA repair protein.

The findings strongly suggested that dietary sinigrin or indole-3-carbinol do not inhibit lung cancer expression through DNA repair.

However, dietary sinigrin plus nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco cancer induced chemical resulted in a significant incidence of lung and nasal cavity tumors in F344 rats.

These results clearly suggested that dietary sinigrin inhibits lung cancer proliferation through some unknown mechanisms other than DNA methylation and O6-methylguanine repair.

Taken altogether, sinigrin may be used as a supplement for the prevention of lung cancer and combined with primary therapy for the treatment of lung cancer, pending to the confirmation of large sample size and multicenter study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats by Morse MA1, Wang CX, Amin SG, Hecht SS, Chung FL. (PubMed)
(2) The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention by Joanna Domagala-Kulawik. (PMC)

Turmeric, the Natural Treatment for Hyperlipidemia with No Side Effects

By Kyle J. Norton


Hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.

The condition is normally known as high blood cholesterol in the general population.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

Believe it or not, about half of the U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol. 

There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.

Some researchers suggested the promotion of high-fat diet over past decades may be one of the silent cause of the hyperlipidemia in the Western world.

Dr. Charles Desmarchelier in the examined the risk of high blood cholesterol in a high-fat diet model said, "Mice on Western diet showed increased plasma cholesterol levels, associated with the higher dietary cholesterol supply, yet, significantly reduced cholesterol levels were found in intestine and liver".

And, "(The) intestine and liver react to a high dietary fat intake by activation of de novo cholesterol synthesis and other cholesterol-saving mechanisms, as well as with major changes in phospholipid metabolism, to accommodate to the fat load'.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.

The study included 40 male Wistar rats divided into four groups with 10 rats in each. Two groups were fed with standard rodent diet and the other two with 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups. 

After 10 weeks of the experiment, researchers found that curcumin decreased the levels of hyperlipidemia observed by reducing body weight, liver weight, adipose weight.

The plasma levels of triglyceride by inhibited the proteins associated with fat cell fat metabolism, lipid ratios and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats were also lower by the injection of curcumin.

Furthermore, curcumin also suppressed the lipogenic enzymes involved in regulating lipogenesis in fat cells.

Taken altogether, turmeric processed a high amount of curcumin may be used for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals by Kocher A1, Bohnert L1, Schiborr C1, Frank J, (PubMed)
(3) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia by Charles Desmarchelier,1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)

Artichoke Protects the Brian Neurons Against Learning and Memory Impairment

By Kyle J. Norton


Learning is an action of acquired skill or knowledge in a short or lifelong process.

Memory is an action of storing the acquired knowledge expressed them when they are needed.

In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.

There are many causes of neurons loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.

Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.

Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.

Environmental pollutant, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.

Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, genetic mutation also have a strong implication on cognitive functions that can lead to either impairment in learning and memory.

Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation  in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".

"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats was stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".

The findings strongly suggested that gene alternation due to long-term exposure to toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.

Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.

Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.

Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.

In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract. 

These results suggested, chorogi or ginkgo extract protected the neurons integrity and viability by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.

Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)