Turmeric, the Natural Treatment for Hyperlipidemia with No Side Effects

By Kyle J. Norton


Hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.

The condition is normally known as high blood cholesterol in the general population.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

Believe it or not, about half of the U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol. 

There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.

Some researchers suggested the promotion of high-fat diet over past decades may be one of the silent cause of the hyperlipidemia in the Western world.

Dr. Charles Desmarchelier in the examined the risk of high blood cholesterol in a high-fat diet model said, "Mice on Western diet showed increased plasma cholesterol levels, associated with the higher dietary cholesterol supply, yet, significantly reduced cholesterol levels were found in intestine and liver".

And, "(The) intestine and liver react to a high dietary fat intake by activation of de novo cholesterol synthesis and other cholesterol-saving mechanisms, as well as with major changes in phospholipid metabolism, to accommodate to the fat load'.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.

The study included 40 male Wistar rats divided into four groups with 10 rats in each. Two groups were fed with standard rodent diet and the other two with 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups. 

After 10 weeks of the experiment, researchers found that curcumin decreased the levels of hyperlipidemia observed by reducing body weight, liver weight, adipose weight.

The plasma levels of triglyceride by inhibited the proteins associated with fat cell fat metabolism, lipid ratios and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats were also lower by the injection of curcumin.

Furthermore, curcumin also suppressed the lipogenic enzymes involved in regulating lipogenesis in fat cells.

Taken altogether, turmeric processed a high amount of curcumin may be used for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals by Kocher A1, Bohnert L1, Schiborr C1, Frank J, (PubMed)
(3) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia by Charles Desmarchelier,1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)

Artichoke Protects the Brian Neurons Against Learning and Memory Impairment

By Kyle J. Norton


Learning is an action of acquired skill or knowledge in a short or lifelong process.

Memory is an action of storing the acquired knowledge expressed them when they are needed.

In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.

There are many causes of neurons loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.

Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.

Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.

Environmental pollutant, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.

Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, genetic mutation also have a strong implication on cognitive functions that can lead to either impairment in learning and memory.

Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation  in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".

"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats was stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".

The findings strongly suggested that gene alternation due to long-term exposure to toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.

Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.

Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.

Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.

In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract. 

These results suggested, chorogi or ginkgo extract protected the neurons integrity and viability by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.

Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)

Bilberry Inhibits the Risk and Progression of Colon Cancer, According to Researchers

By Kyle J. Norton

Colon cancer is a medical and chronic condition characterized by the cells growth disorderly and uncontrollably in the colon tissue.

Most cases of colon cancers begin in the cells on the surface of the inner lining due to the alternation of DNA.

Colon cancer is one most slow growing cancer. It may take years before patients experiencing the symptoms.

At the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized severe pain and bleeding.

Most common symptoms of colon cancer in the advanced stage, besides the general symptom of cancer such as reduced appetite, unintended weight loss include a change of bowel movement, rectal bleeding, and persistent abdominal pain and cramp.

If you experience some of the above symptoms, please check with your doctor to rule out the possibility of colon cancer.

According to the statistics, in 2017, approximately 26,800 Canadians were diagnosed with colorectal cancer, representing 13% of all new cancer cases.

Depending on the stage, early diagnosis of localized colon cancer has a 5-year relative survival rate of over 90%. 

Out of a number of the risk factors, obesity may be one which causes the majority of colon cancer in the Western world, particularly in the North American.

Dr. E E Frezza, the lead scientist in the assessment of obesity on the risk of developing colon cancer, said, "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".

And, "Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements is recommended to assess the obesity-related risk of developing colon cancer".

The results suggested that if you are obese, your risk of colon cancer is increased much fold compared to healthy weight individual.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compounf for the treatment of colon cancer examined the bilberry derived anthocyanins chemopreventive properties.

The study included 50 female Balb/c mice induced colonic carcinogenesis by AOM and DSS 3 or 5%, respectively, Mice then are given either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract.

According to the colonoscopy taken place at week 4 and 9 after initiation of carcinogenesis, mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation.

Furthermore, mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumor numbers, compared to control (n = 14) and anthocyanin 1% treated mice.

The results suggested that anthocyanins inhibited the formation and growth of colorectal cancer in an animal model.

In order to reveal more information about anthocyanins anti-colon cancer activity, researchers examined the compound on human colon and colorectal cancer cells (DLD-1 and COLO205). 

Using the optimum process of A(V.uli) extraction involved conditions of temperature 20°C, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. A(V.uli), 5 main components: delphinidin (40.70 ± 1.72)%, cyanidin (3.40 ± 0.68)%, petunidin (17.70 ± 0.54)%, peonidin (2.90 ± 0.63)% and malvidin (35.50 ± 1.11)% were found in the anthocyanins extract.

Malvidin, the derivatives found in the extracts exerted the strongest anti-colon cancer cell properties with dose-dependent repression of cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml, compared to other derovatives.

Dr. Zu XY and colleagues wrote in the final report, "The extraction protocol and conditions we used were effective for anthocyanin extraction. A(V.uli) could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers".

Taken altogether, bilberry processed abundantly bioactive compounds anthocyanin and malvidin may be considered a functional remedy for the prevention and treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model by Lippert E1, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)

Phytochemical Betanin Gobbles Up Breast Cancer Cells in Vitro

By Kyle J. Norton


Breast cancer is a chronic and medical condition characterized by cell growth irregularly in the breast tissues due to DNA alternation.

Most cases of breast cancer begin in the cell on the surface of the inner lining of the breast tissues before penetrating into the deeper layers.

According to the statistics, in the US the lifetime of breast cancer in women is 1/8. In other words, if you are women, your risk of breast cancer development during your lifetime is 12.5%.

According to the prediction using the historical data, in 2019, approximately 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The exact causes of breast cancer are not identified. However, according to the epidemiological studies, certain conditions may increase the risk of the disease such as being overweight, diet, inactivity, excessive alcohol consumption, smoking and exposure to xenoestrogen.

Some researchers suggested that the discovery of oral contraceptive pill over the past few decades may correlate to the rise if breast cancer.

In other words, if you currently use an oral contraceptive, you are at a higher risk of the disease onset.

Dr. Kathleen E. Malone in the examined the breast cancer risk in women who use oral contraceptives wrote, "Breast cancer incidence in Western countries is relatively high and apparently is increasing. That breast cancer appears to be influenced by other hormonally mediated factors leads to the hypothesis that the high rate of exposure to oral contraceptives among American women may also be associated with this increase".

And, "an increasing number of studies have appeared that suggest an elevated risk in relation to some aspects of oral contractive use".

Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.


With an aim to find a potential ingredient in plant phytochemicals for the treatment of breast cancer without inducing adverse effect compared to those of conventional medicine, researchers examined the extracts containing betanin and its stereoisomer isobetanin, which belongs to the betalain group of highly bioavailable antioxidants.

The study involved the analysis of the cytotoxicity of applying betanin-enriched extract then characterized on cancer and normal cells.

Betanin/isobetanin concentrate significantly decreased cancer cell proliferation and viability of MCF-7-treated cells, by inducing the production of proteins associated with proapoptosis and gene associated with tumor suppression. 

Observation of the increased alternation of the mitochondrial membrane potential suggested that the extracts cause cancer cell death by both intrinsic and extrinsic apoptotic pathways.

The death of MCF-7-treated cells is also attributed to betanin/isobetanin induced autophagy.

Interestingly, injection of betanin-enriched extract showed no obvious effect towards normal cell lines.

Dr. Nowacki L, the lead scientist said, "the betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".

In other words, betanin/isobetanin mix extracts processed anti-breast cancer cell proliferation by inducing cell death without affecting the integrity and viability of the normal breast cells.

In the analysis of the FDA approved red food color E162, used in suppressing the development of multi-organ tumors in experimental animals, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the estrogen receptor-positive human breast cancer cells (MCF-7).

Beetroot extract exerted a significantly lower cancer cell inhibition compared to that doxorubicin.

The findings suggested that betanin, the major betacyanin constituent, may play an important role in the cytotoxicity exhibited by the red beetroot extract, according to the study.

Taken altogether, betanin used alone or combined with other phytochemicals may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M2. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(3) Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)

Ginger Protects Our Eyes Against Cataract

By Kyle J. Norton

A cataract is a condition with a decrease in vision, caused by the clouding of the lens in the eye found mostly in older adults. Eye injuries, inflammation, and some other eye diseases are also found to initiate the condition.

According to the statistic provided by the World Health Organization, 51% of world blindness, which represents about 20 million people (2010) worldwide are the result of a cataract. The condition can be reversed by surgery.

Aging cataract can be classified into 3 primary types, including

* Nuclear sclerotic cataracts

It is the most common type of cataract in the elderly caused by the gradual clouding of the central portion of the lens.

* Cortical cataracts
It is a type of cloudiness that develops in the lens cortex outside the edge of the lens.

* Posterior subcapsular cataracts
It is a type of cataract begins with a cloudy area on the back surface of the lens.

Epidemiological studies suggested that people who are smokers, occupation associated with ultraviolet light exposure, diabetes mellitus and overweight are susceptible to the higher risk of the disease.

However, some researchers suggested that the widespread cataract in the aging population over the past few decades may be associated with the promotion of a high-fat diet.

Dr. Chung-Jung Chiu, the lead scientist said, "Two major dietary patterns were identified by principal component analysis and named Oriental and Western patterns. The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".

And, "Our data indicate that consuming a Western dietary pattern is significantly associated with increased odds of early nuclear opacity".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of diabetic cataract caused by advanced glycation end products (AGE) examined ginger anti AGE activity.

The study included diabetes Wistar-NIN rats induced by intraperitoneal injection of streptozotocin (35 mg/kg body weight) and the control rats received vehicle alone.

In diabetics rats, a set of diabetic animals was given the AIN-93 diet, another set was given either 0.5 or 3% ginger in their diet for a period of two months.

According to the tested assays, ginger not only delayed the onset but also the progression of cataract in rats.

Ginger significantly inhibited the formation of various AGE products including carboxymethyl lysine in the eye lens.

Furthermore, the injection of ginger also inhibited the hyperglycemia-induced osmotic stress in the lens.

The results suggested ginger protects the eye against cataract in rats through a number of mechanisms involved the development of several pathophysiologies, including diabetic cataract.

Dr. Saraswat M, the lead scientist wrote at the end of the study, "The results indicated that ginger was effective against the development of diabetic cataract in rats mainly through its antiglycating potential and to a lesser extent by inhibition of the polyol pathway".

Moreover, in the study of oxidative stress and aldose reductase induced diabetic complications, researchers analyzed the protective effect against diabetic eye complication of purple waxy corn and ginger.

The study included streptozotocin-induced diabetics with the blood glucose levels >250 mg·dL(-1) orally given the extract at doses of 50, 100, and 200 mg/kg·BW(-1) for 10 weeks. 

All doses of PWCG showed significant inhibition of decreased lens opacity, the levels of oxidative stress Malondialdehyde (MDA) and anti-reflective coating (AR) in the lens of diabetic rats.

PWCG also improved the antioxidant profile in the treated rats.

Most importantly, the antiretinopathy property of the combined extract was also confirmed by the increased number of neurons in the ganglion cell layer and thickness of total retina and retinal nuclear layer in diabetic rats.

Dr. Thiraphatthanavong P, the lead researcher said, "PWCG is the potential functional food to protect against diabetic cataract and retinopathy. However, further studies concerning toxicity and clinical trial are still essential".

Take all together, ginger processed a high amount of bioactive compounds may be considered a function alternative for prevention and treatment of cataract, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats by Saraswat M1, Suryanarayana P, Reddy PY, Patil MA, Balakrishna N, Reddy GB. (PubMed)
(2) The combined extract of purple waxy corn and ginger prevents cataractogenesis and retinopathy in streptozotocin-diabetic rats by Thiraphatthanavong P1, Wattanathorn J2, Muchimapura S2, Thukham-mee W2, Lertrat K3, Suriharn B. (PubMed)
(3) American Major Dietary Patterns and Age-related Cataract by Chung-Jung Chiu,  Gary Gensler, and Allen Taylor. (FASEB Journal)

Phytochemical Sinigrin, the Potential Anti Liver Cancer Proliferation Bioactive Ingredient, According to Studies

By Kyle J. Norton

Sinigrin may be the next-generation natural and bioactive compound processed an antiproliferative activity against the progression of cancer, according to studies.

In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.

In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.

In a suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.

In programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.

In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.

Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.

Dr. Albanes D, in the study of cell proliferation as a major risk factor for cancer, said, "Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans".

And, "A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is postulated that cancer risk is proportional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue".

Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a bioactive compound for the treatment of liver cancer, one of the leading causes of cancer death worldwide. investigated the anti-proliferative activity of sinigrin, the major ingredients present in Brassica nigra.

In a model of carcinogen-induced hepatotoxicity in rats, the selected animals were orally administered with sinigrin on a daily basis for three months before sacrifice.

During the experiment, the injection of sinigrin significantly inhibited the proliferation of liver tumor cells, observed by the reduction of the number of surface tumors in the rat liver.

Sinigrin induced apoptosis of liver cancer cells by exhibiting the expression of a protein associated with the tumor suppression in the host rats, namely, the p53.

Further, the application of sinigrin induced cancer apoptosis by stimulating the production of a protein involved in cell death programming and gene involved cellular differentiation.

Interestingly, additional analysis of the sinigrin anti-liver cancer activity, researchers showed that the bioactive compound not only inhibits cancer cells from proliferation through cell cycle arrest but also restores the liver function without inducing liver toxicity.

The results strongly suggested that sinigrin processed significant anti-liver cancer properties via several genes and pathways.

Dr. Jie M, the lead scientist wrote in the final report, "sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlight the potential of sinigrin as an anti-cancer agent for liver cancer".

Taken altogether, sinigrin found in Brassica nigra may be considered a functional supplement for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(2) Are cell number and cell proliferation risk factors for cancer? by Albanes D1, Winick M. (PubMed)

Phytochemical 3,3'-Diindolylmethane Ameliorates Renal Fibrosis

By Kyle J. Norton


Renal fibrosis is a progressive condition caused by excessive accumulation of extracellular matrix including collagen, enzymes, and glycoproteins which provided structural and biochemical support of surrounding the renal cells during aging and chronic kidney disease (CKD).

According to the statistics, CKD and renal fibrosis affect approximately half of the adult's age 70 and over and 10% of the world's population.

In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.

Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.

At the early stage of renal fibrosis, patients may experience symptoms of dull pain in the abdomen or back, pain on one side between your upper abdomen and back, leg pain. discoloration swelling in one or both legs. 

If you have some of the aforementioned symptoms, you may have renal fibrosis, please make sure that you check with your doctor to rule out the possibility.

In dialysis point of view in patients with renal fibrosis, Dr. Menn-Josephy H in the examined the risk of dialysis in patients with renal fibrosis wrote, "Surprisingly, 13.9% of patients with normal renal function had 25-49% fibrosis and 5% had more than 50% fibrosis on biopsy, and 5 years after undergoing biopsy 21% of patients with >50% fibrosis still remained dialysis-free. Conclusion: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the urgency to discover the potential compound for the treatment of renal fibrosis, researchers examined the effects of 3,3'-Diindolylmethane (DIM) a natural acid condensation extracted from cruciferous plants, on renal fibrosis.

Where DIM has been found to process anti-hepatic and cardiac fibrosis models in a number of studies.

The study included the established unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models.

Injection of DIM reduced kidney injury and production of interstitial collagens fibrosis. 

In the UUO model, DIM inhibited expression of fibronectin, collagen-1 associated with the formation of scars but retain E-cadherin involved the formation of adherens junctions to bind cells with each other. 

In other words, DIM protected the renal cells against the induction of renal fibrosis.

In vivo and in vitro, administration of DIM is also found to suppress local fibroblast activation observed by the levels of myofibroblast markers α-SMA and vimentin.

Most importantly, DIM significantly inhibited the levels of pro-inflammatory cytokine-induced abnormal proliferation of NRK49F cells, in a time- and dose-dependent manner.

Furthermore, DIM also inhibited the expression of Smad2 phosphorylation in the formation of renal scar tissue. 

Based on the results, researchers concluded that DIM protects the renal cell integrity by inhibiting TGF-β/Smad2/3 signaling against the formation of renal fibrosis.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)
(2) Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient by CohortsMenn-Josephy H.a · Lee C.S.a · Nolin A.a · Christov M.c · Rybin D.V.d · Weinberg J.M.e · Henderson J.b · Bonegio R.a · Havasi A.(PubMed)