Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday 3 September 2017

Food Therapy: Cruciferous Vegetables, the Best Natural Whole Food Medicine in Reduced risk Postprandial Metabolism

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Postprandial metabolism is the chemical processes after eating, such as consumption of red meat is associated with an increased risk of cancer due to heat induced production of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), involved in the development of human carcinogen.

According to evaluation of the the effect of cruciferous vegetable consumption on the metabolism of PhIP in 20 non-smoking Caucasian male subjects, with three 12-day phase, intake of Cruciferous Vegetables increased the metabolism and synthesis of cholesterol, steroids and other lipids and inhibited levels of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) caused by intake of cooked red meat.

Dr. Walters DG, the lead author in the study said, " Cruciferous vegetable consumption significantly increased the urinary excretion of N(2)-hydroxy-PhIP-N(2)-glucuronide in 0-48 h urine samples to 127 and 136% of levels" and "cruciferous vegetable consumption can induce both the phase I and II metabolism of PhIP in humans"

In support of the above, in a three-period, dietary intervention study carried out with 20 non-smoking Caucasian male subjects consuming cooked meat meals containing known amounts of these carcinogens, the high cruciferous vegetable diet (250 g each of Brussels sprouts and broccoli per day) during period 2 reduced levels of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) and induced hepatic CYP1A2(metabolism and synthesis of cholesterol, steroids and other lipids) activity.

In fact, the examination of the after another 12 days without cruciferous vegetables consumption (period 3 of the study) levels of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) also was still reduced by 17 and 30%,.
This prolong response of metabolism of cruciferous vegetables may suggested that other enzymes may involve in reduced levels of PhIP, instead of only metabolism and synthesis of cholesterol, steroids and other lipids.

Taking altogether, there is no doubt that intake of cruciferous vegetable may reduce levels of heat induced chemical agents in exhibition of cancers, particular in cancers caused by intake of cooked red meat.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans by Walters DG1, Young PJ, Agus C, Knize MG, Boobis AR, Gooderham NJ, Lake BG.(PubMed)
(2) Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man by Murray S1, Lake BG, Gray S, Edwards AJ, Springall C, Bowey EA, Williamson G, Boobis AR, Gooderham NJ.(PubMed)

Saturday 2 September 2017

11 Significant Health Benefits of Garlic

Kyle J. Norton

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

11 Significant Health Benefits of Garlic

1. Food Therapy: Garlic, The Best anti caners in Whole food medicine
2. Food Therapy: Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Breast Cancer
3. Food Therapy: Garlic, The Best anti Colorectal Cancer in Whole food medicine
4. Food Therapy: Garlic - The Testosterone Booster Whole Food Medicine?
5. Food Therapy: garlic, The Best whole food medicine for reduced risk and complications of Cardiovascular diseases
6. Food Therapy: Garlic: Whole food medicine for Reduced Risk and Treatment of Lung Cancer
7. Food Therapy: Garlic, The Whole Food Medicine for Reduced Risk and Treatment of Gastric Cancer
8. Food Therapy: Whole Food Garlic for Reduced Risk and Treatment of Hypertension
9. Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Hyperlipidemia
10. Food Therapy: Garlic - The Whole Food Medicine for Antiplatelet Aggregation
11. Herbal Therapy: Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Progression of Atherosclerosis

Side Effects
1. Do not use the herb if you have ulcer
2. Raw garlic or overdoses may cause irritation of or even damage to the digestive tract
3. PLease consult with your doctor before taking garlic if you are taking blood thiner medication
4. It may cause allergic effect to some people
5. Etc.

Food Therapy: Cruciferous Vegetable, the Antioxidant Natural Whole Food

Intake of cruciferous vegetables has shown to express the chemopreventive and/or chemotherapeutic effect against abnormal cell growth in some cancer.

Sulforaphane and cisplatin, the major compound found in cruciferous vegetables, exhibited the interaction or cooperation growth‑inhibiting and apoptosis‑promoting activities, through their pro-oxidant activity, according to the Soonchunhyang University,

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Antioxidant is types of chemical compound inhibited the free radicals to protect the body against oxidative damage.

In the study of phenolic compounds, kaempferol and quercetin, from the ethanol extract of Chinese cabbage (EtCC) revealed that the phytochemicals suppressed tumor necrosis factor (TNF)-α-(a cell signaling protein (cytokine) involved in systemic inflammation) induced inflammatory response and activation of antioxidant response against free radical expression.

Furthermore, in support of the antioxidant effect of Cruciferous vegetables, isothiocyanates, another phytochemical compound found in the vegetable also inhibited the generation of reactive oxygen species (ROS) and protected against the induction of cytoprotective genes against oxidare stress.

Taking altogether, Cruciferous vegetables no doubt consist a strong antioxidant capacity in inhibited

free radical causes of cellular damage.

Dr. Joo HK, the lead researcher said, " regular consumption of vegetables containing dietary phytochemicals might be a potential therapeutic strategy to protect against various stresses, to prevent several pathological conditions, and to treat chronic vascular inflammation".

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells by Lee YJ1, Lee SH1.(PubMed)
(2) Ethanol Extract of Brassica rapa ssp. pekinensis Suppresses Tumor Necrosis Factor-α-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells by Joo HK1, Choi S1, Lee YR1, Lee EO1, Park MS2, Lim YP3, Park JT4, Jeon BH1.(PubMed)
(3) Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress by Yoda E1,2, Paszek M1, Konopnicki C1, Fujiwara R3, Chen S1, Tukey RH1.(PubMed)

Herbal Therapy: Green Tea, the Best in Prevention and Treatment of Prostate Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stage of the treatment which directly address to the cause of disease.

Prostate cancer is a condition in which the cells of prostate has become cancerous, causing abnormal cell growth with possibility of spreading to the distant parts of the body.
Most prostate cancers are slow growing and prostate cancer may be detected during physical (rectum) exams.

Green tea may be used as functional food in prevention and treatment of prostate cancer, a renowned institute study suggested

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.

According to the Fu Jen Catholic University, New Taipei City, catechin nanoemulsion preparation showed a highest inhibition of growth of PC-3 tumor cells, with concentration being 15.4 μg/mL and 8.5 μg/mL.
The inhibition of prostate cancer cell line is observed in cell cycle arrest by regulated proteins involved cell cycle division, namely cyclin A, cyclin B, cyclin-dependent kinase 2, and cyclin-dependent kinase 1 expression and activated cell atopotosis and survival.

Dr. Tsai YJ, the lead author said, " catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression( in induction of apoptosis) for activation of caspase-3, caspase-8, and caspase-9 (involved cell death)".

Furthermore, in the recruited 404 PCA cases and 395 controls from the same hospital who completed data on habitual tea consumption, including green, oolong, black and pu'er tea regular green drinkers have a significantly reduced risk in prostate cancer development.

The review of inverse relation of tea drinkers and risk of prostate cancer has shown explicitly:
1. total of 32 cases and 50 controls reported habitual green tea drinking, showing an adjusted OR of 0.60 (95% confidence interval (CI): 0.37, 0.98).
2. A moderate excess risk was observed among the habitual pu'er tea drinkers (OR=1.44, 95% CI: 1.02, 1.91).
3. A significantly lower intake of EGCG was observed among cases (54.4 mg) than the controls (72.5 mg).

Additionally, the differentiation of 7 observational studies and 3 randomized controlled trials retrieved from Cochrane Library, PubMed, Sciencedirect Online, and hand searching.the database, also reveal an interest correlated incidence of PCa decrease with each 1 cup/day increase of green tea.

According of the study, "higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa".

Collectively, green tea consumption is associated inversely to risk of PCA but injection of large amount of green tea supplement should be taken with care in prevented toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3 by Tsai YJ1, Chen BH1.(PubMed)
(2)Reduced prostate cancer risk with green tea and epigallocatechin 3-gallate intake among Hong Kong Chinese men by Lee PMY1, Ng CF2, Liu ZM3, Ho WM4, Lee MK5, Wang F1, Kan HD6, He YH7, Ng SSM2, Wong SYS1, Tse LA1.(PubMed)
(3) Green tea and the risk of prostate cancer: A systematic review and meta-analysis by Guo Y1, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X.(PubMed)

Friday 1 September 2017

Herbal Therapy: Aloe Vera, The Immunomodulatory Whole Food Medicine

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating various diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

Immunomodulatory effect is an action involved regulation of immune system against invasion of foreign subjects in promoted infection and inflammation.

According to the joint study lead by the Sahlgrenska Academy at University of Gothenburg, oral administrated (AVH200®), an aloe vera extract modified the protein involved activation, proliferation and cytokine secretion of healthy human blood T cells, in a dose dependent manner.

Aloe-emodin(AE), a major constituent found in Aloe Vera exerted a positive effect in significantly enhanced dabrafenib (a BARF inhibitor) antiproliferative activity of mutant cell lines through immunomodulatory activity

The study also confirmed that AE possesses remarkable antineoplastic properties of drug(dabrafenib) used in treatment of metastatic colon cancer, against melanoma cells.

In candida albicans, A. vera extract and its fractions on infected macrophages demonstrated an anti fungal effect through activated and modulated the immune response.

Furthermore, the extract also significantly increased cell viability of macrophages, in comparison with control group.

Additionally, polysaccharide isolated from Aloe Vera explictly also enhanced immune function in producing specific antibody and inducing delayed hypersensitivity in mice model.

Collectively, chemical constituents found in Aloe vera have showed to exhibit immunomodulatory effects in regulated immune function against foreign invasion and allergic reactions and irregular cell growth, but further studies are necessary to confirm this validation.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro by Ahluwalia B1, Magnusson MK2, Isaksson S3, Larsson F4, Öhman L5.(PubMed)
(2) Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells by Tabolacci C1, Cordella M2, Turcano L3, Rossi S2, Lentini A3, Mariotti S4, Nisini R4, Sette G5, Eramo A2, Piredda L3, De Maria R5, Facchiano F6, Beninati S3.(PubMed)
(3) Immunomodulatory effects of Aloe vera and its fractions on response of macrophages against Candida albicans by Farahnejad Z1, Ghazanfari T, Yaraee R(PubMed)
(4) An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera by t'Hart LA, van den Berg AJ, Kuis L, van Dijk H, Labadie RP.(PubMed)

Food Therapy: Cruciferous Vegetables, the Best Anti- Obesity Natural Whole Food Medicine

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Obesity is a medical condition of excess body fat has accumulated overtime.

According to the Body Mass Index(BMI), a BMI over 30 is an indication of obesity. Approximately, 68% of American population are either overweight or obese.

According to the Taipei Medical University indole-3-carbinol (I3C), isolated from Cruciferous Vegetables, induced anti obesity expression by inhibited intracellular lipid accumulation of cell size increase of fat cells and pro inflammatory cytokine interleukin-6 (IL-6), the parameters related to obesity.

In Male C57BL/6 mice fed with a control diet (C group), high-fat diet (HF group) and HF+5 mg kg(-1) I3C (HFI group).than HFI group injected with I3C intraperitoneally for 12 weeks, I3C treatment group ameliorated free radicals production and increase expression of gene in regulated fatty acid storage and glucose metabolism, important parameters in related to obese onset.

Additionally, in vivo treatment with I3C reduced inflammation caused by the infiltration of macrophages, a type of white blood cell in epididymal adipose tissue and in vitro, addition of I3C decreased oxidative production and activation of inflammatory expression.

Dr. Chang HP, the lead author said, " decreased body weight and fat accumulation,....., were associated with improved glucose tolerance and with modulated expression of adipokines(secreted by adipose tissue.) and lipogenic(the process converted to fatty acids)-associated gene products"

In fact, Indole-3-carbinol (I3C) prevents diet-induced obesity by modulation of multiple genes expression involved the process of cell differentiation in production of fat cell and induced heat cause by inflammatory of fat cell underneath the skin.

By inhibiting the gene expression involved obesity and regulating the cell differentiation in fat cell and preventing fat tissues accumulation through its chemical constituents, cruciferous vegetable may have a potential benefit in preventing obesity and metabolic disorders.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes by Chang HP1, Wang ML, Hsu CY, Liu ME, Chan MH, Chen YH.(PubMed)
(2) Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice by Chang HP1, Wang ML, Chan MH, Chiu YS, Chen YH.(PubMed)
(3) Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice by Choi Y1, Kim Y, Park S, Lee KW, Park T.(PubMed)

10 Incredible Health Benefits of Herbal Alfalfa

Kyle J. Norton

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc.

Chemical constituents
Flavones, isoflavones, sterols, Bichanin, Coumestrol, Diadzein, Formonetin, Genistein, coumarin derivatives,.......

1. Herbal Alfalfa and diabetes
2. Herbal Alfalfa and cholesterol
3. Herbal Alfalfa as an Antioxidant
4. Herbal Alfalfa and Estrogenic effects
5. Herbal Alfalfa and Menopausal Symptoms
6. Herbal Alfalfa and Cancers
7. Herbal Therapy: Alfalfa, the Immunomodulatory Natural Whole Food Medicine
8. Herbal Therapy: Alfalfa, the Natural Anti microbial Whole Food Medicine
9. Herbal Therapy: Alfalfa, the Anti-inflammatory Natural Whole Food
10. Herbal Therapy: Alfalfa, the Neuroprotective Natural Whole Food

Side effects
1. High amount of vitamin K may reduce the effectiveness of anticogulation medicine
2. Alfalfa may cause additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill.
3. It may cause stomach upset and diarrhea
4. The herb may induce lupus erythematosu due to its chemical constituent L-canavanine.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca