Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday 13 August 2017

Food Therapy: Kidney Bean, The Anti Obesity Complications Natural functional Food

Intake of kidney bean regularly may reduced risk of complication in obese patients, a study conducted by renowned institute insisted.

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, genus Phaseolus, belonging to the family Fabaceae. The bean is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

Obesity is a medical condition of excess body fat has accumulated overtime. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity. Unfortunately, 68% of American population are either overweight or obese.

According to the Instituto Tecnológico de Durango,, kidney bean may have potential effects as natural alternative treatments of some metabolic alterations associated with obesity.

The efficacy may involve the regulation of many aspects, including lipid profile, and lipid and carbohydrates metabolisms, in addition to anti-inflammatory and antioxidant activities.

The study also found that kidney beans exerted a similar anti obese effect of that of green tea and its active principles, in both in vitro (cell cultures) and in vivo (animal models).

In fact, the test of different levels of lectin of kidney bean (Phaseolus vulgaris) content (27 g/kg meal) in a high-quality (lactalbumin) control diet in obese Zucker (fafa) rats and their lean littermates, phytochemical compound, bean lectin as a dietary adjunct or therapeutic agent expressed a stimulated gut function and ameliorated obesity, in doses depended manner.The result also indicated that a safe and effective dose-range of bean lectin can be established for human subjects.

Furthermore, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), in a randomised, double-blind, placebo-controlled of 12 volunteers, exerted a significant on glycometabolic and appetite control affecting satiety sensations and lower desire to eat.

But further studies are needed to prove the concept of Kidney Bean as a supplement used as functional food in balanced meals in obese, glucose-intolerant and diabetic subjects.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Plants with potential use on obesity and its complications by Gamboa-Gómez CI1, Rocha-Guzmán NE1, Gallegos-Infante JA1, Moreno-Jiménez MR1, Vázquez-Cabral BD1, González-Laredo RF1.(PubMed)
(1) Lipid accumulation in obese Zucker rats is reduced by inclusion of raw kidney bean (Phaseolus vulgaris) in the diet by Pusztai A1, Grant G, Buchan WC, Bardocz S, de Carvalho AF, Ewen SW.(PubMed)
(3) Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects by Spadafranca A1, Rinelli S, Riva A, Morazzoni P, Magni P, Bertoli S, Battezzati A.(PubMed)

Alternative Therapy: Yoga, the Ancient Technique in Alleviated and Complications of Stress

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Yoga participants is found to benefit from decrease levels of all kinds of physical, emotional, vocational, or academic stress, a renowned institute study suggested.

Yoga is a ancient practical technique of India, included breath control, meditation, bodily movement and gesture,..... with an aim to achieve harmonization of the body, mind, and spirit.

Stress is a normal reaction when a person comes under pressure or threat, as expression of sudden surge of hormone adrenaline.

In a feasibility study explored engagement and effectiveness of a systematic 10-week yoga program aimed at university faculty, staff, and students, individual, attended yoga class displayed a significant improvement in cope with perceived stress and psychological, behavioral, and physical symptoms of stress, after 10 weeks.

Dr. Brems C, the researcher said, " The study demonstrates feasibility of a yoga intervention in an academic setting and provides preliminary evidence for efficacy in stress reduction."

Furthermore, according to the Johns Hopkins Hospital and Health System, yoga learners not only benefits from stress reduction but also experience the decreased anxiety and improved sleep and improved quality of life.

In a pilot study, nine nurses participated in 6 weekly sessions of yoga nidra to measure of sleep, stress, and muscle fatigue in psychiatric nurses, researchers found that 6 weekly sessions of yoga nidra results in positive perception of stress level and muscle fatigue.

Additionally, yoga also demonstrated a positive effect in alleviated stress during pregnancy, according to the The University of Tokyo study.

In recruited 60 healthy primiparas without complications, attended yoga classes twice a month and to practice yoga at their homes using DVD 3 times a week from 20 gestational weeks until childbirth, measurement of hormone and alpha-amylase concentrations related to stress showed to decrease significantly with increased scores of vigor for a positive dimension of mood.

Therefore, participated in yoga class may be a potential source in reduced risk of mental disorders in pregnant women and enhanced fetal growth, as well as promoted stress alleviation in healthy adults

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) A Yoga Stress Reduction Intervention for University Faculty, Staff, and Graduate Students by Brems C1.(PubMed)
(2) Using Yoga Nidra to Improve Stress in Psychiatric Nurses in a Pilot Study by Anderson R1, Mammen K1, Paul P1, Pletch A1, Pulia K1.(PubMed)

Saturday 12 August 2017

Herbal Therapy: Aloe Vera, the Neuroprotective Natural Whole Food Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Study from renowned institute suggested that Aloe arborescens may be a potentially neuroprotective
agent against copper induced neurobehavioral features of Parkinson's disease.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

According to the joint study lead by the Cadi Ayyad University, Neurosciences, Pharmacology and Environment Unit, Aloe Vera expressed altered dopaminergic innervations associated to neurological disorders, Parkinson's disease following Cu intoxication.

Dr. Abbaoui A, the lead researcher said, " (Aloe arborescens gel )AEAAG administration to Cu intoxicated rats showed a noticeable beneficial effect; this potential was featured by a complete recovery of the (tyrosine hydroxylase)TH expression (in regulation of dopamine Synthesis)
and locomotor behavior deficiencies in the intoxicated rats".

Aloe emodin, an active compound found in Aloe Vera leaf, also exhibited neuroprotective effects by attenuated scopolamine(a medication used to treat motion sickness and postoperative nausea and vomiting)-induced cognitive deficits via inhibiting acetylcholinesterase (AChE) activity involved breaking down of neurotransmitter and modulating oxidative stress.

The study also insisted, the antioxidants activities inhibited significantly extracellular intracellular reactive oxygen species (ROS) production to prevent cytotoxicity in patients with Alzheimer's disease(AD).

In fact, The neuro protective expression of Aloe Vera polysaccharide is found to downregulate(caspase-3 expression) the process of apoptotic cell death in the brain during injure.

Taking together, Aloe Vera exerted neuroprotective effect in reduced risk of dementia through many aspects, including free radical inhibition, anti cytotoxicity, chemical toxicity..... but human trials are necessary to confirm its validity.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Neuroprotective potential of Aloe arborescens against copper induced neurobehavioral features of Parkinson's disease in rat by Abbaoui A1, Hiba OE2, Gamrani H3.(PubMed)
(2) Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells by Tao L, Xie J, Wang Y, Wang S, Wu S, Wang Q, Ding H.(PubMed)
(3) Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats by Lu ZQ1, Deng YJ, Lu JX.(PubMed)

Herbal Therapy: Chaste Tree Berry Normalizes Menstrual Cycle and Enhanced Pregnancy in Women with Oligomenorrhea

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

If you expect that herbal medicine will ease the symptoms of your illness, you will be disappointed. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly address to the cause of the disease.

A renowned study suggested that Chaste tree berry have a potential effect in enhancing pregnancy in women with abnormal menstrual cycle.

Fertility is a natural process to insure the survival of human species. Through natural selection, we produce many offspring when the reproductive system works at it's peak in the suitable environment with plenty of food around. On the other hand, the reproductive system may completely shut down or work at it's minimum state and we produce less offspring, when the environment is hostile including less foods around, war, epidemic.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In a total of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L, a preparation from Chaste tree berry or placebo 3 times a day over 3 months or 3 cycles, the preparation not only normalized the menstrual cycke of women with oligomenorrhea, but also significantly improved the chance of pregnancy in compared placebo group.

Dr. Bergmann J, the lead author said, " The baby take-home rate during the therapy and 6 months after the end of the therapy showed a ratio of 18.7 /6.4%)".

The effectiveness of the preparation in enhanced rate of pregnancy with remarkable outcome may be
due to the increase of progesterone during the luteal phase compared to the oligomenorrhea placebo group, with only very few undesirable side effects.

In other study with the same group of women, researchers found that treatment of preparation to women with sterility and oligomenorrhea, can induce pregnancy over a period of 3-6 months with a attractive rate.

Promisingly, in a randomized double blind study to test the effect of Vitex agnus castus preparation (Strotan capsules) vs. placebo, involved 52 women with luteal phase defects due to latent hyperprolactinaemia, women who are taking the daily dose of one capsule (20 mg) Vitexagnus castus preparation reserved the elevated pituitary prolactin and normalized deficits in luteal phase length and increased luteal phase progesterone synthesis. comparable to placebo, after three month of therapy.

Dr. Milewicz A, the lead researcher said, "Side effects were not seen, two women treated with the Vitex agnus castus preparation got pregnant. The tested preparation is thought to be an efficient medication in the treatment of luteal phase defects due to latent hyperprolactinaemia".

Taking together, Chaste tree berry may have a pharmaceutical value in promoting pregnancy in women with sterility and oligomenorrhea, but large doses should be taken with care against toxicity.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women by Westphal LM1, Polan ML, Trant AS.(PubMed)
(2) [Vitex agnus castus extract in the treatment of luteal phase defects due to latenthyperprolactinemia. Results of a randomized placebo-controlled double-blind study].
[Article in German]by Milewicz A1, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, Schmitz H.(PubMed)
(3) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German]by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)

Friday 11 August 2017

The Best Diet Suggestions to Healthy Life and Longevity for A Serve Chronic Ill Patient

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The diet contains 80% of vegetables, Fruits, and Beverage, and 10% of While meat and 10% Others
Intakes of vegetables, and fruits and vegetables combined, but not fruits alone, significantly reduce risk of NHL.( https://www.ncbi.nlm.nih.gov/pubmed/23238796)

Vegetables suggestion
(Green leafy vegetables such as spinach and Swiss chard, green leaf lecture and cruciferous vegetables, bell pepper of all colors, whole grain, celery, tomato, onion) (https://www.ncbi.nlm.nih.gov/pubmed/19423521)
1. A higher intake of green leafy vegetables and cruciferous vegetables is associated with a lower risk of NHL overall, particularly follicular lymphoma and DLBCL.
(https://www.ncbi.nlm.nih.gov/pubmed/21695384)

2. High vegetable and fruit intake may reduce the risk of non-Hodgkin lymphoma (NHL) as vegetables and fruit are rich in antioxidants to target the immune system and lymphoma
(https://www.ncbi.nlm.nih.gov/pubmed/19423521)

3. The risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR=0.49, 95% CI 0.23-1.02).
(https://www.ncbi.nlm.nih.gov/pubmed/17443415)

Fruits suggestions
1. Avocado( check the health benefits ( https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-avocado.html)

2. Blue or black berry
(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-blueberries.html)

3. Strawberries(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-aarden-strawberries.html)

4 Orange(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-oranges-citrus.html)

5. Pineapple(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-pineapple-ananas.html)

6. Apricot(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-apricot-prunus.html)

7. Apple(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-apple-malus.html)

Beverages suggestion
1, Black Tea, Tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-α- and NF-κB-mediated regulation of MAPK signaling pathway(https://www.ncbi.nlm.nih.gov/pubmed/24754510)(https://www.ncbi.nlm.nih.gov/pubmed/10942245)

2. Coffee with dairy only
A minor influence of coffee on the frequency of apoptotic cells induced by the test compounds, rendering an increase in sensitivity for apoptosis as a reason for the reduced genomic damage an unlikely or at least incomplete explanation.( https://www.ncbi.nlm.nih.gov/pubmed/15242187)

3. Water

White meats suggestion
1. Turkey
For a source of CLAs are the only natural fatty acids accepted by the National Academy of Sciences of USA as exhibiting consistent antitumor properties (https://www.ncbi.nlm.nih.gov/pubmed/14498991) and tryptophan for better sleep (http://www.ncbi.nlm.nih.gov/pubmed/3090582)

2. Chicken breast
Source of nutrient 14% of total dietary energy, 37% of protein, 13% to 32% of selected B vitamins and iron, 20% of fat, and 34% of cholesterol) https://www.ncbi.nlm.nih.gov/pubmed/1552132)

3. Deep sea fish
With same source of nutrients with plenty of omega-3 fatty acids with a lot of health benefit (https://kylejnorton.blogspot.ca/2013/11/phytochemicals-in-foods-19-health.html)

10% Others
1. Potatoes (https://kylejnorton.blogspot.ca/2013/11/healthy-foods-potatoes-solanum.html)

2. Yam(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-yams-dioscorea.html)

3. Brown Rice(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-whole-grain-brown-rice-or.html)

4. Whole Gain Cereal(https://www.ncbi.nlm.nih.gov/pubmed/27301975) and (https://www.ncbi.nlm.nih.gov/pubmed/26062574)

5. Nuts and seeds
Almonds (Prunus Dulcis)(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-nuts-seeds-almonds-prunus.html)

Walnuts (Juglans).(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-nuts-seeds-walnuts-juglans.html)

You can also substitute these, excepted nuts and seeds with whole gain breads.

Moderate exercise suggestion
Regular walking about 20-40 minutes daily at your own pace to improved blood circulation, digestive absorption and immune system(https://kylejnorton.blogspot.ca/p/blog-page_31.html)

Cooking methods:
Steam and boiling vegetables over raw, boiling may reduce nutrients but does not cause problem to long term intakers.
Prefer steam or boiling in meat to reduced risk of harmful chemical and increased free radical induced risk of cancer and weakened immune expression
Topical black pepper and virgin olive oil right after steam and boiling with a little salt for taste.

Other cooking methods may induce production of cancerous chemicals and free radical expression in domino’s effects(reduced antioxidant levels and promoted chronic diseases, including cancers

Not canned foods, please
(Most of them contain some kinds of harmful chemicals for preservation).

Please make sure you talk to a dietitian before implementing. Hope you well and good luck.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Food Therapy: Cruciferous Vegetable- The Best Whole Food Medicine in Anti Inflammatory Effects

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Intake of cruciferous vegetable may be inversely correlated with circulating of proinflammatory levels of in women.

In a total of 1,005 middle-aged Chinese women study, consumption of cruciferous vegetable regularly is associated to lower circulating concentrations of proinflammatory cytokins.

Proinflammatory cytokines, also known as Interleukin (IL) and tumor necrosis factor (TNF), secreted by immune system to protect out body in inducing fever, inflammation, tissue destruction, etc.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, b roccoli etc.

Further to the study, Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells exhibited the induction of apoptosis in the cancer cell line, through involvement of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin.

Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through a induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.

Other phytochemical found the vegetables, such as 3,3'-diindolylmethane (DIM) , a derivative of indole-3-carbinol, also expressed anti proinflammayroy effect through interleukin (IL)-1beta, IL-6 and tumor necrosis factor.

In fact, chemical compounds found in the vegetable, not only inhibited the pro infammatory cytokins in expression of chronic diseases and caners, but also involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH.(PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)

Herbal Therapy: Alfalfa, the Neuroprotective Natural Whole Food

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.

Neuroprotection is the action to preserve neuronal structure and/or function of the brain, particular in delay of neurodegenatve diseases and enhanced integrity of neurons.

According to the L.R. Institute of Pharmacy, methanol extract of Medicago sativa (MS) induced neuroprotective effect through antioxidant and anti-inflammatory activities against ischemia and reperfusion-induced cerebral injury in mice as free radicals expression are elevated with deletion of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD) and total tissue sulfhydryl (T-SH) groups.

Indeed, mice treated with Medicago sativa (MS) exhibited significantly scavenged free radicals activity against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O(•-) (2) and also inhibited XD/XO conversion and resultant O(•-) (2) production.

Dr. Bora KS, the lead researchers said, " treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity".

Further more, in the review of 117 references compiled from major databases as Chemical Abstracts, Science Direct, SciFinder, PubMed, Dr. Dukes Phytochemical and Ethnobotany, CIMER, and InteliHealth, M. sativa seems to hold great potential for various biological activities, including heat disease and neuro protective effects, attributed to some major classes of phytoconstituents, including
saponins, flavonoids, phytoestrogens, coumarins, alkaloids, amino acids, phytosterols, vitamins, digestive enzymes and terpenes.

With all the available scientific literature indicated above, alfalfa may attract the attention of natural product researchers to focus on the unexplored therapeutic potential of M. sativa, particular in neuro protective area.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult by Bora KS1, Sharma A.(PubMed)
(2) Phytochemical and pharmacological potential of Medicago sativa: a review by Bora KS1, Sharma A.(PubMed)