Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Medication
A.3. Medication
The aim of the treatment is to relieve symptoms of the disease
1. Acetaminophen
a. Acetaminophen such as Tylenol can help to relive the pain of Osteoarthritis. In the study to Tramadol/APAP add-on significantly improved knee OA pain which had been inadequately controlled by NSAIDs. Both tramadol/APAP and NSAIDs were effective at maintaining the pain-reduced state(238)(239).
b. According to RX(241) list side effects are not limit to
b.1. Nausea(239) and vomiting(240)
b.2. Appetite loss(241)
b.3. Itching(241)
b.4. Diarrhea
b.5. Dark urine(241)
b.6. Abdominal pain(241)
b.7. Constipation(239)
b.8. Others may include sedation, urinary retention, pruritus and/or respiratory depression(240).
2. Nonsteroidal anti-inflammatory drugs (NSAIDs).
a. The use of the medicine should be taken into account of in cost effectiveness, adverse event data and individual cardiovascular and gastrointestinal risks(242).
b. Side effects are not limit to
According to King’s College School of Medicine and Dentistry, nonsteroidal anti-inflammatory drugs may cause(243)
b.1. A nonspecific colitis (in particular, fenemates), and many patients with collagenous colitis are taking NSAIDs.
b.2. Large intestinal ulcers, bleeding, and perforation
b.3. Relapse of classic inflammatory bowel disease
b.4. Serious complications of diverticular disease (fistula and perforation)
b.5. Small intestinal perforation, ulcers, and strictures requiring surgery
b.6. Specific biochemical and subcellular organelle damage(243).
The University of Sydney insisted that the drug may also cause enteropathy(244).
3. Narcotics
Narcotics are natural opioid drugs derived from the Asian poppy may provide relief from more severe osteoarthritis pain(245), with additive effect(246).
b. According to NIH, the side effects(247) are not limit to
b.1. Risk of dependence
b.2. Dizziness and drowsiness
b.3. Nausea and vomiting
b.4. Headache and fatigue
b.5. Others include
Yawning, insomnia, restlessness, mood swings, diarrhea(247)
A.4.. Non medication therapy
Non medication therapies such as
1. Physical therapy or physiotherapy
Physical therapy is the form of medical rehabilitation for develop, maintain and restore maximum movement and functional ability for patients caused by injure, aging and other external factors such as diseases(250). In knee osteoarthritis, according to The University of Melbourne, more research may be needed to support the claim, physiotherapy interventions has shown to reduce pain and improve function in those with knee OA(249). But according to the joint study by the University of Melbourne, University of Otago and Monash University, physical therapy dose not result in greater improvement in pain or function than other treatment such as sham treatment in patients with hip osteoarthritis(248).
2. Occupational Therapy
According to the Canadian Association of Occupation Therapists, Occupational therapy is the form of treatment involved evaluating and improving a persons functional abilities of a specific age group or disability such as arthritis, developmental coordination disorder, mental illness, or spinal cord injury, etc...(251). But some research suggested that patient should be encouraged to change of lifestyle to achieve a optimal self-managing the effects and symptoms of OA(252).
Unfortunately, according to the University of Alberta, the implication for Rehabilitation Pain gasp has not been focused in training programs in occupational therapy education even it is a prevalent condition in all age groups(253). Some research in regarded to occupation therapy in treatment of hand exercise in osteoarthritis, insisted that high-quality studies are necessary to establish a strong and sound of evidences in concerning functional assessment and the effect of hand exercises in hand osteoarthritis(254).
In need, depending to the individual needs, including patients education and self-management programs. Weight loss may be necessary if the osteoarthritic patient is overweight(255); physical therapy may also be needed for muscle strengthening with aerobic conditioning(256)(257) and tai chi exercise(258) with improving pain and function in people with OA, depending to the disease severities(258), etc.
Exercise therapy may be beneficiary for treatment of pain in patients with OA(259), but when it is used in conjunctions with other forms of therapies such as strength training and exercise with additional passive manual mobilisation, the combination has found to achieve better pain relief in patients with knee osteoarthritis(260), according to the study by Maastricht University
Manual therapy on the other hand, is more effective than exercise for those with hip OA in the short and long-term(261). Unfortunately, in the investigate the addition of manual therapy to exercise therapy for the reduction of pain and increase of physical function in people with knee osteoarthritis (OA), researchers at the showed that combined strategy of exercise therapy plus manual therapy with booster sessions was not superior to exercise therapy alone in patients with knee osteoarthritis(262).
A.5. Surgery
Surgery only necessary if symptoms persist, depending on several factors, including the location and severity of OA damage, patient characteristics and risk factors.(265).
1. Arthrocentesis plus corticosteroid
Arthrocentesis is a medical procedure to remove joint fluid with a sterile needle for analysis through injection of corticosteroids into the joints to relieve pain, swelling, and inflammation. According to Regions Hospital, there is a reluctance of surgeon to perform such operation in patient who are receiving anticoagulation at therapeutic levels(263).
According to the Mayo clinic, cortisone shots overdoses can cause joint damage(264).
2. Arthroscopy
Arthroscopy is a minimally invasive surgical procedure to examine and treat the abnormalities of and damage to the cartilage and ligaments through the arthroscope. It is considered as one of the standard interventions with low potential for complications for patient with knee osteoarthritis(265) and ankles, shoulders, elbows, wrists and hips osteoarthritis(266).
3. Lubrication injections
Injections of hyaluronic acid derivatives (Hyalgan, Synvisc) are recommended only to patients who have not found adequate pain relief in conservative treatment(268).
Platelet-rich plasma (PRP) contains high concentrations of autologous growth factors that originate from platelets influences the production of SZP from human joint-derived cells, has shown effectively in treatment of osteoarthritis or damage in the knee joint. or damage in the knee joint, according to the study by University of California(267).
4. Realigning bones
Osteotomy is a surgical procedure used to realign bones, cartilage and reposition the joint to reduce knee pain by shifting your body weight away from the damaged cartilage(269). Osteotomies about the hip may be used for the prevention and treatment of osteoarthrosis(270), only if the mechanical causes of the potential or established osteoarthritis is clear and the operation succeeds in reducing the pathologically excessive joint loads(271).
5. Joint replacement
Joint replacement is a surgical procedure of orthopedic surgery to relief pain and to place the damaged joint surfaces(272). Over 1 million surgical procedure have been perform in elective total knee and hip replacements annually in the United States alone(273). According to study, over 70 % of patients who received rapid mobilization of total joint replacement patients recover safely and reduced the overall length of hospital stay(274).
Joint replacement is considered as a treatment only for patients with severe joint pain or dysfunction that can not be alleviated by non invasive treatments. But, according to Odense University Hospital, hip replacement can be postponed in patients with severe hip osteoarthritis if patients participate in a education and supervised exercise program(275).
6. Etc.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
(236) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(237) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial by Ferreira de Meneses SR1,2, Hunter DJ3, Young Docko E4, Pasqual Marques A5.(PubMed)
(238) The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). by Park KS1, Choi JJ, Kim WU, Min JK, Park SH, Cho CS.(PubMed)
(239) Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial by Emkey R1, Rosenthal N, Wu SC, Jordan D, Kamin M; CAPSS-114 Study Group.(PubMed)
(240) Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials by Remy C1, Marret E, Bonnet F.(PubMed)
(241) Tylenol Side Effects Center(RXlist)
(242) Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis(The BMJ)
(243) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(244) Detection and prevention of NSAID-induced enteropathy by Davies NM1, Saleh JY, Skjodt NM.(PubMed)
(245) Patient preference and willingness to pay for knee osteoarthritis treatments. by Posnett J1, Dixit S2, Oppenheimer B2, Kili S3, Mehin N4.(PubMed)
(246) A model of additive effects of mixtures of narcotic chemicals by Shirazi MA1, Linder G.(PubMed)
(247) Pain medications - narcotics(NIH)
Monday 13 March 2017
Sunday 12 March 2017
The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis Treatment in Conventional Medicine - The Weight management
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Weight management
A.2. Weight management
Over weight and obesity are found to be associated to increased risk of osteoarthritis to elder. According to studies, Over weight and obesity can lead to more severe cartilage degeneration(121)(123) as assessed by both morphological and quantitative MRI measurements(122).According to the study by University of California San Francisco, in the study of 127 individuals with risk factors for knee OA, 62 subjects with a body mass index (BMI) decrease≥10% found to associate to a slower progression of T2 values in individuals with risk factors for OA,(235).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Weight management
A.2. Weight management
Over weight and obesity are found to be associated to increased risk of osteoarthritis to elder. According to studies, Over weight and obesity can lead to more severe cartilage degeneration(121)(123) as assessed by both morphological and quantitative MRI measurements(122).According to the study by University of California San Francisco, in the study of 127 individuals with risk factors for knee OA, 62 subjects with a body mass index (BMI) decrease≥10% found to associate to a slower progression of T2 values in individuals with risk factors for OA,(235).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
Saturday 11 March 2017
The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis Treatment in Conventional Medicine - Physical Activity
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Physical Activity
A.1. Physical Activity
According to the center for diseases control and prevention recommends that everyone, including those with arthritis, get 150 minutes of moderate exercise per week, including daily flexibility exercises to maintain proper joint range of motion and do balance exercises in patient with osteoarthritis(231). According to the study by University of Manitoba, 12 week lower body positive pressure-support low-load treadmill walking program in patients aged between 55 and 75 years, improved knee joint pain, function, and thigh muscle strength in overweight patients with knee osteoarthritis (OA) and consider as a safe user-friendly mode of exercise used in management of day-to-day joint symptoms associated with knee OA(232)(233). Other studies insisted that the same program showed a significant improvements in knee joint pain and function and demonstrated significant increases in thigh muscle strength about the degenerative knee(234). Stretching gently on joints may improve flexibility, lessen stiffness and reduced pain. In a study of Low-level laser therapy (LLLT) and stretching exercises, researchers found that LLLT can be used as resource to increase the effects of physical therapy(237).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
(236) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(237) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial by Ferreira de Meneses SR1,2, Hunter DJ3, Young Docko E4, Pasqual Marques A5.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Physical Activity
A.1. Physical Activity
According to the center for diseases control and prevention recommends that everyone, including those with arthritis, get 150 minutes of moderate exercise per week, including daily flexibility exercises to maintain proper joint range of motion and do balance exercises in patient with osteoarthritis(231). According to the study by University of Manitoba, 12 week lower body positive pressure-support low-load treadmill walking program in patients aged between 55 and 75 years, improved knee joint pain, function, and thigh muscle strength in overweight patients with knee osteoarthritis (OA) and consider as a safe user-friendly mode of exercise used in management of day-to-day joint symptoms associated with knee OA(232)(233). Other studies insisted that the same program showed a significant improvements in knee joint pain and function and demonstrated significant increases in thigh muscle strength about the degenerative knee(234). Stretching gently on joints may improve flexibility, lessen stiffness and reduced pain. In a study of Low-level laser therapy (LLLT) and stretching exercises, researchers found that LLLT can be used as resource to increase the effects of physical therapy(237).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
(236) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(237) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial by Ferreira de Meneses SR1,2, Hunter DJ3, Young Docko E4, Pasqual Marques A5.(PubMed)
Friday 10 March 2017
The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis- Non medication therapy - Physical therapy or physiotherapy
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Physical therapy or physiotherapy
A.4.. Non medication therapy
Non medication therapies such as
1. Physical therapy or physiotherapy
Physical therapy is the form of medical rehabilitation for develop, maintain and restore maximum movement and functional ability for patients caused by injure, aging and other external factors such as diseases(250). In knee osteoarthritis, according to The University of Melbourne, more research may be needed to support the claim, physiotherapy interventions has shown to reduce pain and improve function in those with knee OA(249). But according to the joint study by the University of Melbourne, University of Otago and Monash University, physical therapy dose not result in greater improvement in pain or function than other treatment such as sham treatment in patients with hip osteoarthritis(248).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
(236) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(237) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial by Ferreira de Meneses SR1,2, Hunter DJ3, Young Docko E4, Pasqual Marques A5.(PubMed)
(238) The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). by Park KS1, Choi JJ, Kim WU, Min JK, Park SH, Cho CS.(PubMed)
(239) Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial by Emkey R1, Rosenthal N, Wu SC, Jordan D, Kamin M; CAPSS-114 Study Group.(PubMed)
(240) Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials by Remy C1, Marret E, Bonnet F.(PubMed)
(241) Tylenol Side Effects Center(RXlist)
(242) Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis(The BMJ)
(243) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(244) Detection and prevention of NSAID-induced enteropathy by Davies NM1, Saleh JY, Skjodt NM.(PubMed)
(245) Patient preference and willingness to pay for knee osteoarthritis treatments. by Posnett J1, Dixit S2, Oppenheimer B2, Kili S3, Mehin N4.(PubMed)
(246) A model of additive effects of mixtures of narcotic chemicals by Shirazi MA1, Linder G.(PubMed)
(247) Pain medications - narcotics(NIH)
(248) Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized clinical trial by Bennell KL1, Egerton T1, Martin J1, Abbott JH2, Metcalf B1, McManus F1, Sims K3, Pua YH4, Wrigley TV1, Forbes A5, Smith C5, Harris A6, Buchbinder R7.(PubMed)
(249) Physiotherapy management of knee osteoarthritis by Page CJ1, Hinman RS, Bennell KL.(PubMed)
(250) Policy statement: Description of physical therapy(World federation of physical therapy)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The Physical therapy or physiotherapy
A.4.. Non medication therapy
Non medication therapies such as
1. Physical therapy or physiotherapy
Physical therapy is the form of medical rehabilitation for develop, maintain and restore maximum movement and functional ability for patients caused by injure, aging and other external factors such as diseases(250). In knee osteoarthritis, according to The University of Melbourne, more research may be needed to support the claim, physiotherapy interventions has shown to reduce pain and improve function in those with knee OA(249). But according to the joint study by the University of Melbourne, University of Otago and Monash University, physical therapy dose not result in greater improvement in pain or function than other treatment such as sham treatment in patients with hip osteoarthritis(248).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.htmlReferences
(231) Physical Activity and Arthritis Overview(CDC)
(232) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(233) Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? by Takacs J1, Anderson JE, Leiter JR, MacDonald PB, Peeler JD.(PubMed)
(234) Managing Knee Osteoarthritis: The Effects of Body Weight Supported Physical Activity on Joint Pain, Function, and Thigh Muscle Strength by Peeler J1, Christian M, Cooper J, Leiter J, MacDonald P.(PubMed)
(235) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative by Serebrakian AT1, Poulos T, Liebl H, Joseph GB, Lai A, Nevitt MC, Lynch JA, McCulloch CE, Link TM.(PubMed)
(236) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(237) Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial by Ferreira de Meneses SR1,2, Hunter DJ3, Young Docko E4, Pasqual Marques A5.(PubMed)
(238) The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID). by Park KS1, Choi JJ, Kim WU, Min JK, Park SH, Cho CS.(PubMed)
(239) Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial by Emkey R1, Rosenthal N, Wu SC, Jordan D, Kamin M; CAPSS-114 Study Group.(PubMed)
(240) Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials by Remy C1, Marret E, Bonnet F.(PubMed)
(241) Tylenol Side Effects Center(RXlist)
(242) Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis(The BMJ)
(243) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(244) Detection and prevention of NSAID-induced enteropathy by Davies NM1, Saleh JY, Skjodt NM.(PubMed)
(245) Patient preference and willingness to pay for knee osteoarthritis treatments. by Posnett J1, Dixit S2, Oppenheimer B2, Kili S3, Mehin N4.(PubMed)
(246) A model of additive effects of mixtures of narcotic chemicals by Shirazi MA1, Linder G.(PubMed)
(247) Pain medications - narcotics(NIH)
(248) Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized clinical trial by Bennell KL1, Egerton T1, Martin J1, Abbott JH2, Metcalf B1, McManus F1, Sims K3, Pua YH4, Wrigley TV1, Forbes A5, Smith C5, Harris A6, Buchbinder R7.(PubMed)
(249) Physiotherapy management of knee osteoarthritis by Page CJ1, Hinman RS, Bennell KL.(PubMed)
(250) Policy statement: Description of physical therapy(World federation of physical therapy)
Thursday 9 March 2017
The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis preventive Phytochemicals
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The preventive Phytochemicals
1. Epigallocatechin including catechins, found abundantly in green tea, St John wort, black Tea, carob flour, Fuji apples, etc. is a phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols)
EGCG has shown to slow the progression of OA and relieve OA-associated pain in a mouse model study of research team lead by Dr. Daniel J Leong(201).
a. Inflammatory effects
Catechins might be useful therapeutically as an anti-inflammatory modulator of dental pulpal inflammation(203), through up-regulated expressions of IL-8 in fighting against infection or PGE(2) in response to infection or inflammation(202).
b. Antiviral activities
(-)-epigallocatechin (EGC) and green tea extract (GTE) inhibited the cytopathic effect of coxsackie B3 virus, but did not inhibit the cytopathic effects of HSV-1, HSV-2, influenza A or influenza B viruses(203(204).
c. Antioxidants
Polyphenolic components extracted from green tea leaves, exhibit antioxidative effects against free radical initiated and peroxidation of human low density lipoprotein(205)(206).
2. Catechin is phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in white tea, green tea, black tea, grapes, wine, apple juice, cocoa, lentils, etc.
a. Body-weight regulation
Green tea-caffeine showed to exert its hypolipidemic and antiobesogenic effects through regulate peroxisome proliferator-activated receptors (PPARs) in the effect on lipid metabolism and obesity(207). The Ewha Womans University study also support the above result in weight reduction but through genes expression(208). It mixture improves weight maintenance, through thermogenesis, fat oxidation, and sparing fat free mass(209).
b. Antioxidant activity(210)(211)
Polyphenolic compounds (included catechins) in the berries of edible honeysuckle, including proanthocyanidins, catechins, exhibit the beneficial anti-adherence and chemo-protective activities in against a number of chronic conditions, e.g., cancer, diabetes mellitus, tumour growth or cardiovascular and neurodegenerative diseases, according to the study by Constantine the Philosopher University in Nitra(212).
c. Anti-inflammatory effect
Polymeric tannins and monomeric flavonoids, such as catechin and epicatechin found in green tea showed to exhibit anti inflammatory effects(213) through interfere with immunobiochemical pathways that are highly relevant for immunosurveillance and competing virus infections(213).
3. Theaflavin is phytochemicals of Flavan-3-ols, in the group of Flavonoids (polyphenols) found abundantly in black tea.
a. Antioxidant capacities
Theaflavin-3′-gallate (TF(2)B), a derivative of theaflavin exhibits positive antioxidant capacities on singlet oxygen(214), hydrogen peroxide(215), hydroxyl radical(216), and the hydroxyl radical induced DNA damage in vitro(214).
b. Antimicrobial activities
Plant polyphenols, including Theaflavins have exhibited anti microbial activity against several food-borne pathogenic bacteria(217) and growed in Mueller-Hinton medium(218).In the evaluation of the antimicrobial activities of seven green tea catechins and four black tea theaflavins, including (-)-gallocatechin-3-gallate, (-)-epigallocatechin-3-gallate, (-)-catechin-3-gallate, (-)-epicatechin-3-gallate, theaflavin-3, 3′-digallate, theaflavin-3′-gallate, and theaflavin-3-gallate exhibit antimicrobial activities, better than medicinal antibiotics, such as tetracycline or vancomycin, at comparable concentrations(218).
c. Anti inflammation
The major polyphenolic compounds in black tea leaves are theaflavins strongly inhibited TPA-induced edema of mouse ears, through its anti inflammatory activity(219).
4. Myricetin is a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. It has been used as antioxidant to lower cholesterol, treat certain types of cancer, etc.
a. Antioxidant and cytotoxic activity
Extracted from plants containing phenolic compound, including flavonoid-galloyl glycoside [myricetin 3-O-(2',3'4'-tri-O-galloyl)-α-l-rhamnopyranoside] exhibited high antioxidant activity(220)(221) and cytotoxic activity(222) against Hep G2 and hepatocellular carcinoma(220).
b. Antitumour and anti-inflammatory activities
On mammary tumour cells LM2, myricetin may be a promising agent in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities due to its inhibitory activity to the release of NO(223). According to the study by East China Normal University, the phytochemical Myricetin also consist anti obesity and anti anti inflammatory activity(224)
5. Cyanidin is an anthocyanins (flavonals), in the group of Flavonoids (polyphenols), found abundantly in red apple and pear, bilberry, blackberry, blueberry, cherry, cranberry, peach, plum, hawthorn, etc.
a. Antioxidants
In menopausal women, intake antioxidants has shown to reduce the level of OS. Blackberries (BBs) containing mainly cyanidin 3-O-β-d-glucoside (C3G) exhibit its antioxidant effect in preventing bone loss in rat model(225). According to the joint study by Wonkwang University, Cyanidin-3-glucoside (C3G) is one of the major components of anthocyanin, a water-soluble phytochemical, may be a potential antioxidant for prevention of bone-related diseases, such as osteoporosis, rheumatoid arthritis, and periodontitis(226)
b. Anti-inflammatory Effects
According to Kyung Hee University, cyanidin-3-O-beta-D-glycoside express potent anti-inflammatory effects by regulating NF-kappaB pathway(228). Its polyphenolic-enriched red raspberry extract, containing Cyanidin-3-glucoside (C3G) one of the major component of anthocyanin decreases in the rate of degradation of both proteoglycan and type II collagen as well as inhibition of inflammation, pannus formation, cartilage damage, and bone resorption(227).
c. Obesity
Cyanidin-3-O-β-glucoside (Cy-3-g)-rich foods inhibited the onset of obesity, partly related to the activation of skeletal muscle lipoprotein lipase(LPL), and inhibition of LPL in adipose tissue(229)(230).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html
References
(201) Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model by Daniel J Leong, Marwa Choudhury, Regina Hanstein, David M Hirsh, Sun Jin Kim, Robert J Majeska, Mitchell B Schaffler, John A Hardin, David C Spray, Mary B Goldring, Neil J Cobelli, and Hui B Sun(PMC)
(202) Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells by Hirao K1, Yumoto H, Nakanishi T, Mukai K, Takahashi K, Takegawa D, Matsuo T.(PubMed)
(203) Green Tea Catechins and Cardiovascular Health: An Update by Pon Velayutham, Anandh Babu, and Dongmin Liu(PubMed)
(203) [The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases].[Article in Chinese] by Tao P1.(PubMed)
(204) Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. by Nakane H1, Ono K.(PubMed)
(205) Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein. by Liu Z1, Ma LP, Zhou B, Yang L, Liu ZL.(PubMed)
(206) Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. byCai YJ1, Ma LP, Hou LF, Zhou B, Yang L, Liu ZL.(PubMed)
(207) The effect of bioactive compounds in tea on lipid metabolism and obesity through regulation of peroxisome proliferator-activated receptors by Lee SJ1, Jia Y.(PubMed)
(208) Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. by Lee MS1, Kim CT, Kim Y.(PubMed)
(209) Green tea catechins, caffeine and body-weight regulation by Westerterp-Plantenga MS1.(PubMed)
(210) Total polyphenols, catechin profiles and antioxidant activity of tea products from purple leaf coloured tea cultivars. byKerio LC1, Wachira FN, Wanyoko JK, Rotich MK.(PubMed)
(211) Effects of quercetin and catechin on hepatic glutathione-S transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats. by Wiegand H1, Boesch-Saadatmandi C, Regos I, Treutter D, Wolffram S, Rimbach G.(PubMed)
(212) Phenolic profile of edible honeysuckle berries (genus lonicera) and their biological effects by Jurikova T1, Rop O, Mlcek J, Sochor J, Balla S, Szekeres L, Hegedusova A, Hubalek J, Adam V, Kizek R.(PubMed)
(213) Bioactivites of two common polyphenolic compounds: Verbascoside and catechin by Sipahi H1,2, Gostner JM3, Becker K2, Charehsaz M1, Kirmizibekmez H4, Schennach H5, Aydin A1, Fuchs D2.(PubMed)
(214) Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses by Yuan-yuan Wu,1,2 Wei Li,1,3 Yi Xu,1,2 En-hui Jin,1,2 and You-ying Tu(PMC)
(215) Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties by Babich H1, Gottesman RT, Liebling EJ, Schuck AG.(PubMed)
(216) Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells by Yang Z1, Jie G, Dong F, Xu Y, Watanabe N, Tu Y.(PubMed)
(217) Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease by Taguri T1, Tanaka T, Kouno I.(PubMed)
(218) Antibacterial spectrum of plant polyphenols and extracts depending upon hydroxyphenyl structure by Taguri T1, Tanaka T, Kouno I.(PubMed)
(219) Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus by Friedman M1, Henika PR, Levin CE, Mandrell RE, Kozukue N.(PubMed)
(220) Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala by Haggag EG1, Kamal AM, Abdelhady MI, El-Sayed MM, El-Wakil EA, Abd-El-Hamed SS.(PubMed)
(221) Preformulation studies of myricetin: a natural antioxidant flavonoid by Yao Y1, Lin G1, Xie Y1, Ma P2, Li G3, Meng Q4, Wu T3.(PubMed)
(222) Chemical components from the leaves of Ardisia insularis and their cytotoxic activity by Van NT1, Vien TA, Van Kiem P, Van Minh C, Nhiem NX, Long PQ, Anh LT, Kim N, Park S, Kim SH.(PubMed)
(223) Isolated flavonoids against mammary tumour cells LM2 by Carli CB1, de Matos DC, Lopes FC, Maia DC, Dias MB, Sannomiya M, Rodrigues CM, Andreo MA, Vilegas W, Colombo LL, Carlos IZ.(PubMed)
(224) Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes. by Wang Q1, Wang ST1, Yang X1, You PP1, Zhang W2.(PubMed)
(225) Cyanidin 3-O-β-D-Glucoside Improves Bone Indices by Kaume L1, Gilbert W1, Smith BJ2, Devareddy L1.(PubMed)
(226) Dual Role of Cyanidin-3-glucoside on the Differentiation of Bone Cells. by Park KH1, Gu DR2, So HS3, Kim KJ1, Lee SH4.(PubMed)
(227) Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model by Jean-Gilles D1, Li L, Ma H, Yuan T, Chichester CO 3rd, Seeram NP.(PubMed)
(228) Anti-inflammatory effects of black rice, cyanidin-3-O-beta-D-glycoside, and its metabolites, cyanidin and protocatechuic acid by Min SW1, Ryu SN, Kim DH.(PubMed)
(229) Lipoprotein lipase activity of adipose tissue, skeletal muscle and post-heparin plasma in primary endogenous hypertriglyceridaemia: relation to lipoprotein pattern and to obesity by Taskinen MR, Nikkilä EA, Kuusi T.(PubMed)
(230) Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity by Wei X1, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y, Xiao Y, Ling W.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The preventive Phytochemicals
1. Epigallocatechin including catechins, found abundantly in green tea, St John wort, black Tea, carob flour, Fuji apples, etc. is a phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols)
EGCG has shown to slow the progression of OA and relieve OA-associated pain in a mouse model study of research team lead by Dr. Daniel J Leong(201).
a. Inflammatory effects
Catechins might be useful therapeutically as an anti-inflammatory modulator of dental pulpal inflammation(203), through up-regulated expressions of IL-8 in fighting against infection or PGE(2) in response to infection or inflammation(202).
b. Antiviral activities
(-)-epigallocatechin (EGC) and green tea extract (GTE) inhibited the cytopathic effect of coxsackie B3 virus, but did not inhibit the cytopathic effects of HSV-1, HSV-2, influenza A or influenza B viruses(203(204).
c. Antioxidants
Polyphenolic components extracted from green tea leaves, exhibit antioxidative effects against free radical initiated and peroxidation of human low density lipoprotein(205)(206).
2. Catechin is phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in white tea, green tea, black tea, grapes, wine, apple juice, cocoa, lentils, etc.
a. Body-weight regulation
Green tea-caffeine showed to exert its hypolipidemic and antiobesogenic effects through regulate peroxisome proliferator-activated receptors (PPARs) in the effect on lipid metabolism and obesity(207). The Ewha Womans University study also support the above result in weight reduction but through genes expression(208). It mixture improves weight maintenance, through thermogenesis, fat oxidation, and sparing fat free mass(209).
b. Antioxidant activity(210)(211)
Polyphenolic compounds (included catechins) in the berries of edible honeysuckle, including proanthocyanidins, catechins, exhibit the beneficial anti-adherence and chemo-protective activities in against a number of chronic conditions, e.g., cancer, diabetes mellitus, tumour growth or cardiovascular and neurodegenerative diseases, according to the study by Constantine the Philosopher University in Nitra(212).
c. Anti-inflammatory effect
Polymeric tannins and monomeric flavonoids, such as catechin and epicatechin found in green tea showed to exhibit anti inflammatory effects(213) through interfere with immunobiochemical pathways that are highly relevant for immunosurveillance and competing virus infections(213).
3. Theaflavin is phytochemicals of Flavan-3-ols, in the group of Flavonoids (polyphenols) found abundantly in black tea.
a. Antioxidant capacities
Theaflavin-3′-gallate (TF(2)B), a derivative of theaflavin exhibits positive antioxidant capacities on singlet oxygen(214), hydrogen peroxide(215), hydroxyl radical(216), and the hydroxyl radical induced DNA damage in vitro(214).
b. Antimicrobial activities
Plant polyphenols, including Theaflavins have exhibited anti microbial activity against several food-borne pathogenic bacteria(217) and growed in Mueller-Hinton medium(218).In the evaluation of the antimicrobial activities of seven green tea catechins and four black tea theaflavins, including (-)-gallocatechin-3-gallate, (-)-epigallocatechin-3-gallate, (-)-catechin-3-gallate, (-)-epicatechin-3-gallate, theaflavin-3, 3′-digallate, theaflavin-3′-gallate, and theaflavin-3-gallate exhibit antimicrobial activities, better than medicinal antibiotics, such as tetracycline or vancomycin, at comparable concentrations(218).
c. Anti inflammation
The major polyphenolic compounds in black tea leaves are theaflavins strongly inhibited TPA-induced edema of mouse ears, through its anti inflammatory activity(219).
4. Myricetin is a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. It has been used as antioxidant to lower cholesterol, treat certain types of cancer, etc.
a. Antioxidant and cytotoxic activity
Extracted from plants containing phenolic compound, including flavonoid-galloyl glycoside [myricetin 3-O-(2',3'4'-tri-O-galloyl)-α-l-rhamnopyranoside] exhibited high antioxidant activity(220)(221) and cytotoxic activity(222) against Hep G2 and hepatocellular carcinoma(220).
b. Antitumour and anti-inflammatory activities
On mammary tumour cells LM2, myricetin may be a promising agent in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities due to its inhibitory activity to the release of NO(223). According to the study by East China Normal University, the phytochemical Myricetin also consist anti obesity and anti anti inflammatory activity(224)
5. Cyanidin is an anthocyanins (flavonals), in the group of Flavonoids (polyphenols), found abundantly in red apple and pear, bilberry, blackberry, blueberry, cherry, cranberry, peach, plum, hawthorn, etc.
a. Antioxidants
In menopausal women, intake antioxidants has shown to reduce the level of OS. Blackberries (BBs) containing mainly cyanidin 3-O-β-d-glucoside (C3G) exhibit its antioxidant effect in preventing bone loss in rat model(225). According to the joint study by Wonkwang University, Cyanidin-3-glucoside (C3G) is one of the major components of anthocyanin, a water-soluble phytochemical, may be a potential antioxidant for prevention of bone-related diseases, such as osteoporosis, rheumatoid arthritis, and periodontitis(226)
b. Anti-inflammatory Effects
According to Kyung Hee University, cyanidin-3-O-beta-D-glycoside express potent anti-inflammatory effects by regulating NF-kappaB pathway(228). Its polyphenolic-enriched red raspberry extract, containing Cyanidin-3-glucoside (C3G) one of the major component of anthocyanin decreases in the rate of degradation of both proteoglycan and type II collagen as well as inhibition of inflammation, pannus formation, cartilage damage, and bone resorption(227).
c. Obesity
Cyanidin-3-O-β-glucoside (Cy-3-g)-rich foods inhibited the onset of obesity, partly related to the activation of skeletal muscle lipoprotein lipase(LPL), and inhibition of LPL in adipose tissue(229)(230).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html
References
(201) Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model by Daniel J Leong, Marwa Choudhury, Regina Hanstein, David M Hirsh, Sun Jin Kim, Robert J Majeska, Mitchell B Schaffler, John A Hardin, David C Spray, Mary B Goldring, Neil J Cobelli, and Hui B Sun(PMC)
(202) Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells by Hirao K1, Yumoto H, Nakanishi T, Mukai K, Takahashi K, Takegawa D, Matsuo T.(PubMed)
(203) Green Tea Catechins and Cardiovascular Health: An Update by Pon Velayutham, Anandh Babu, and Dongmin Liu(PubMed)
(203) [The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases].[Article in Chinese] by Tao P1.(PubMed)
(204) Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. by Nakane H1, Ono K.(PubMed)
(205) Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein. by Liu Z1, Ma LP, Zhou B, Yang L, Liu ZL.(PubMed)
(206) Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. byCai YJ1, Ma LP, Hou LF, Zhou B, Yang L, Liu ZL.(PubMed)
(207) The effect of bioactive compounds in tea on lipid metabolism and obesity through regulation of peroxisome proliferator-activated receptors by Lee SJ1, Jia Y.(PubMed)
(208) Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. by Lee MS1, Kim CT, Kim Y.(PubMed)
(209) Green tea catechins, caffeine and body-weight regulation by Westerterp-Plantenga MS1.(PubMed)
(210) Total polyphenols, catechin profiles and antioxidant activity of tea products from purple leaf coloured tea cultivars. byKerio LC1, Wachira FN, Wanyoko JK, Rotich MK.(PubMed)
(211) Effects of quercetin and catechin on hepatic glutathione-S transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats. by Wiegand H1, Boesch-Saadatmandi C, Regos I, Treutter D, Wolffram S, Rimbach G.(PubMed)
(212) Phenolic profile of edible honeysuckle berries (genus lonicera) and their biological effects by Jurikova T1, Rop O, Mlcek J, Sochor J, Balla S, Szekeres L, Hegedusova A, Hubalek J, Adam V, Kizek R.(PubMed)
(213) Bioactivites of two common polyphenolic compounds: Verbascoside and catechin by Sipahi H1,2, Gostner JM3, Becker K2, Charehsaz M1, Kirmizibekmez H4, Schennach H5, Aydin A1, Fuchs D2.(PubMed)
(214) Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses by Yuan-yuan Wu,1,2 Wei Li,1,3 Yi Xu,1,2 En-hui Jin,1,2 and You-ying Tu(PMC)
(215) Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties by Babich H1, Gottesman RT, Liebling EJ, Schuck AG.(PubMed)
(216) Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells by Yang Z1, Jie G, Dong F, Xu Y, Watanabe N, Tu Y.(PubMed)
(217) Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease by Taguri T1, Tanaka T, Kouno I.(PubMed)
(218) Antibacterial spectrum of plant polyphenols and extracts depending upon hydroxyphenyl structure by Taguri T1, Tanaka T, Kouno I.(PubMed)
(219) Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus by Friedman M1, Henika PR, Levin CE, Mandrell RE, Kozukue N.(PubMed)
(220) Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala by Haggag EG1, Kamal AM, Abdelhady MI, El-Sayed MM, El-Wakil EA, Abd-El-Hamed SS.(PubMed)
(221) Preformulation studies of myricetin: a natural antioxidant flavonoid by Yao Y1, Lin G1, Xie Y1, Ma P2, Li G3, Meng Q4, Wu T3.(PubMed)
(222) Chemical components from the leaves of Ardisia insularis and their cytotoxic activity by Van NT1, Vien TA, Van Kiem P, Van Minh C, Nhiem NX, Long PQ, Anh LT, Kim N, Park S, Kim SH.(PubMed)
(223) Isolated flavonoids against mammary tumour cells LM2 by Carli CB1, de Matos DC, Lopes FC, Maia DC, Dias MB, Sannomiya M, Rodrigues CM, Andreo MA, Vilegas W, Colombo LL, Carlos IZ.(PubMed)
(224) Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes. by Wang Q1, Wang ST1, Yang X1, You PP1, Zhang W2.(PubMed)
(225) Cyanidin 3-O-β-D-Glucoside Improves Bone Indices by Kaume L1, Gilbert W1, Smith BJ2, Devareddy L1.(PubMed)
(226) Dual Role of Cyanidin-3-glucoside on the Differentiation of Bone Cells. by Park KH1, Gu DR2, So HS3, Kim KJ1, Lee SH4.(PubMed)
(227) Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model by Jean-Gilles D1, Li L, Ma H, Yuan T, Chichester CO 3rd, Seeram NP.(PubMed)
(228) Anti-inflammatory effects of black rice, cyanidin-3-O-beta-D-glycoside, and its metabolites, cyanidin and protocatechuic acid by Min SW1, Ryu SN, Kim DH.(PubMed)
(229) Lipoprotein lipase activity of adipose tissue, skeletal muscle and post-heparin plasma in primary endogenous hypertriglyceridaemia: relation to lipoprotein pattern and to obesity by Taskinen MR, Nikkilä EA, Kuusi T.(PubMed)
(230) Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity by Wei X1, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y, Xiao Y, Ling W.(PubMed)
Wednesday 8 March 2017
The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis preventive Antioxidants
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The preventive Antioxidants
1. Immune system and functioning (Free radical scavengers)
Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(176)(177), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(178)(179). The domino effects have shown to induce many chronic illness, such as cancers(179)
a. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including white blood cells activation and proliferation(180)(181)of T-helper-cell differentiation, the production of specific antibody in regulation of the immune response(182).
b. Vitamin C
Researchers found that vitamin C raised the concentration in the blood of total immunoglobulin(183) in promotion of the ability of antibodies and phagocytic cells to clear pathogens(184).
c. Vitamin E
Vitamin E not only increased both cell-dividing and IL-producing capacities of naive T cells(185) but also enhanced the immune functions(186) in association with significant improvement in resistance to influenza infection(187).
d. Zinc
Zinc, having a regulatory role in the immune system,(189) as a antioxidant is essential mineral improved immune system by enhancing the proper function of T and B cells(188) which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals(190).
2. Antioxidants and osteoarthritis
Diet included vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(193). According to the study of "Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis", vitamins A, C, and E in combination; ginger; turmeric; or Zyflamend (New Chapter, Brattleboro, Vermont) have found to be effective for the treatment of OA(191). According to Dr. Christensen R, and DR. Bliddal H. food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) may also have a very large clinical effect, for treatment of OA(192)
b. Glucosamine
Glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans(194), a major component of joint cartilage(195). Treatment of glucosamine sulfate, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, or nutrients, such as antioxidants and omega-3 fatty acids showed to prevent cartilage degeneration and treat arthritis, according to study(195).
c. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid(196). showed effectively in treatment for OA (197) as well as reducing arthritis pain(198) and joint inflammation(198) in many patients.
d. Methylsulfonylmethane, also known DMSO2 is an organosulfur compound with the formula (CH3)2SO2
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age with knee OA pain enrolled in an outpatient medical center. MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(199)(200)
3. Etc.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html
References
(176) Free Radicals, Antioxidants in Disease and Health by Lien Ai Pham-Huy,1 Hua He,2 and Chuong Pham-Huy3(PMC)
(177) Superoxide Anion and Its Functions(Beta Forces)
(178) Free radicals and antioxidants in normal physiological functions and human disease by Valko M1, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J.(PubMed)
(179) Free radicals, metals and antioxidants in oxidative stress-induced cancer by Valko M1, Rhodes CJ, Moncol J, Izakovic M, Mazur M.(PubMed)
(180) Vitamin A, immunity, and infection by Semba RD1.(PubMed)
(181) Vitamin A as an immunomodulating agent by Rumore MM1.(PubMed)
(182) The effect of newborn vitamin A supplementation on infant immune functions: trial design, interventions, and baseline data by Ahmad SM1, Raqib R2, Qadri F3, Stephensen CB4(PubMed)
(183) Effect of dietary vitamin C on the growth performance and innate immunity of juvenile cobia (Rachycentron canadum) by Zhou Q1, Wang L, Wang H, Xie F, Wang T.(PubMed)
(184) The treatment of poliomyelitis and other virus diseases with vitamin C by KLENNER FR.(PubMed)
(185) Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity by Adolfsson O1, Huber BT, Meydani SN.(PubMed)
(186) Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. by Meydani SN1, Han SN, Wu D.(PubMed)
(187) Vitamin E and infectious diseases in the aged by Han SN1, Meydani SN.(PubMed)
(188) Zinc and its role in immunity and inflammation by Bonaventura P1, Benedetti G1, Albarède F2, Miossec P3.(PubMed)
(189) Zinc homeostasis and immunosenescence by Maywald M1, Rink L2.(PubMed)
(190) Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats by Yousef MI1, El-Hendy HA, El-Demerdash FM, Elagamy EI.(PubMed)
(191) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(192) Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment by Christensen R, Bliddal H.(PubMed)
(193) Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid–induced ulcerative colitis in rat by Gulgun Tahan, MD,*† Erman Aytac, MD,* Huseyin Aytekin, MD,‡ Feyza Gunduz, MD,† Gulen Dogusoy, MD,§ Seval Aydin, MD,¶ Veysel Tahan, MD,** and Hafize Uzun, MD(PMC)
(194) Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP by Little PJ1, Drennon KD, Tannock LR.(PubMed)
(195) Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acid by Jörg Jerosch(PubMed)
(196) NON-PHYSIOLOGICAL AMINO ACID (NPAA) THERAPY TARGETING BRAIN PHENYLALANINE REDUCTION: PILOT STUDIES IN PAHENU2 MIC by Kara R. Vogel,1 Erland Arning,2 Brandi L. Wasek,2 Teodoro Bottiglieri,2 and K. Michael Gibson1,(PubMed)
(197) DLPA (D, L Phenylalanine)(Whole health Chicago)
(198) PHENYLALANINE(WebMD)
(199) Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. by Kim LS1, Axelrod LJ, Howard P, Buratovich N, Waters RF.(PubMed)
(200) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study by Debbi EM1, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The preventive Antioxidants
1. Immune system and functioning (Free radical scavengers)
Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(176)(177), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(178)(179). The domino effects have shown to induce many chronic illness, such as cancers(179)
a. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including white blood cells activation and proliferation(180)(181)of T-helper-cell differentiation, the production of specific antibody in regulation of the immune response(182).
b. Vitamin C
Researchers found that vitamin C raised the concentration in the blood of total immunoglobulin(183) in promotion of the ability of antibodies and phagocytic cells to clear pathogens(184).
c. Vitamin E
Vitamin E not only increased both cell-dividing and IL-producing capacities of naive T cells(185) but also enhanced the immune functions(186) in association with significant improvement in resistance to influenza infection(187).
d. Zinc
Zinc, having a regulatory role in the immune system,(189) as a antioxidant is essential mineral improved immune system by enhancing the proper function of T and B cells(188) which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals(190).
2. Antioxidants and osteoarthritis
Diet included vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(193). According to the study of "Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis", vitamins A, C, and E in combination; ginger; turmeric; or Zyflamend (New Chapter, Brattleboro, Vermont) have found to be effective for the treatment of OA(191). According to Dr. Christensen R, and DR. Bliddal H. food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) may also have a very large clinical effect, for treatment of OA(192)
b. Glucosamine
Glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans(194), a major component of joint cartilage(195). Treatment of glucosamine sulfate, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, or nutrients, such as antioxidants and omega-3 fatty acids showed to prevent cartilage degeneration and treat arthritis, according to study(195).
c. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid(196). showed effectively in treatment for OA (197) as well as reducing arthritis pain(198) and joint inflammation(198) in many patients.
d. Methylsulfonylmethane, also known DMSO2 is an organosulfur compound with the formula (CH3)2SO2
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age with knee OA pain enrolled in an outpatient medical center. MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(199)(200)
3. Etc.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html
References
(176) Free Radicals, Antioxidants in Disease and Health by Lien Ai Pham-Huy,1 Hua He,2 and Chuong Pham-Huy3(PMC)
(177) Superoxide Anion and Its Functions(Beta Forces)
(178) Free radicals and antioxidants in normal physiological functions and human disease by Valko M1, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J.(PubMed)
(179) Free radicals, metals and antioxidants in oxidative stress-induced cancer by Valko M1, Rhodes CJ, Moncol J, Izakovic M, Mazur M.(PubMed)
(180) Vitamin A, immunity, and infection by Semba RD1.(PubMed)
(181) Vitamin A as an immunomodulating agent by Rumore MM1.(PubMed)
(182) The effect of newborn vitamin A supplementation on infant immune functions: trial design, interventions, and baseline data by Ahmad SM1, Raqib R2, Qadri F3, Stephensen CB4(PubMed)
(183) Effect of dietary vitamin C on the growth performance and innate immunity of juvenile cobia (Rachycentron canadum) by Zhou Q1, Wang L, Wang H, Xie F, Wang T.(PubMed)
(184) The treatment of poliomyelitis and other virus diseases with vitamin C by KLENNER FR.(PubMed)
(185) Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity by Adolfsson O1, Huber BT, Meydani SN.(PubMed)
(186) Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. by Meydani SN1, Han SN, Wu D.(PubMed)
(187) Vitamin E and infectious diseases in the aged by Han SN1, Meydani SN.(PubMed)
(188) Zinc and its role in immunity and inflammation by Bonaventura P1, Benedetti G1, Albarède F2, Miossec P3.(PubMed)
(189) Zinc homeostasis and immunosenescence by Maywald M1, Rink L2.(PubMed)
(190) Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats by Yousef MI1, El-Hendy HA, El-Demerdash FM, Elagamy EI.(PubMed)
(191) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(192) Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment by Christensen R, Bliddal H.(PubMed)
(193) Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid–induced ulcerative colitis in rat by Gulgun Tahan, MD,*† Erman Aytac, MD,* Huseyin Aytekin, MD,‡ Feyza Gunduz, MD,† Gulen Dogusoy, MD,§ Seval Aydin, MD,¶ Veysel Tahan, MD,** and Hafize Uzun, MD(PMC)
(194) Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP by Little PJ1, Drennon KD, Tannock LR.(PubMed)
(195) Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acid by Jörg Jerosch(PubMed)
(196) NON-PHYSIOLOGICAL AMINO ACID (NPAA) THERAPY TARGETING BRAIN PHENYLALANINE REDUCTION: PILOT STUDIES IN PAHENU2 MIC by Kara R. Vogel,1 Erland Arning,2 Brandi L. Wasek,2 Teodoro Bottiglieri,2 and K. Michael Gibson1,(PubMed)
(197) DLPA (D, L Phenylalanine)(Whole health Chicago)
(198) PHENYLALANINE(WebMD)
(199) Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. by Kim LS1, Axelrod LJ, Howard P, Buratovich N, Waters RF.(PubMed)
(200) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study by Debbi EM1, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.(PubMed)
Tuesday 7 March 2017
The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis preventive Diet
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The preventive Diet
The aims of the diet is to provide protection to avoid elevation of the inflammatory effects(139) in induced-degeneration causes of osteoarthritis(133)(134)
1. Green tea
Epigallocatechin 3-gallate (EGCG), according to the College of Pharmacy, found abundantly in green tea showed to exhibit its anti anti-rheumatic activity in patients with joint diseases(140) through its antioxidant property(141).
2. Salmon
Salmon is the common name for Salmonidae, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within five years returning to the exacted location where they were born to reproduce and die.
a. Weight loss
Intake of salmon oil has shown to induce body weight loss in mice, according to the study by University of Washington(142). N3 long-chain polyunsaturated fatty acids (n3-LCPUFA) enhanced body weight loss, at the end of the 1-month period in 16 children through deduction of insulin resistance(143).
b. Antioxidants
Megadoses of vitamin E, found in salmon oil exhibited pro-oxidative activity, through increased the anti-oxidative capacity of the liver(144).
c. Omega 3 fatty acids
Omega 3 fatty acids is necessary to maintain the ratio of good and bad cholesterol(145), thus reducing the risk of cholesterol inflammation(146)(148) cause of heart diseases (147) and osteoarthritis(133)(134).
d. Anti inflammation
Omega 3 fatty acids not only reduces the risk of inflammatory effects on our joints and improved blood flow(149), by regulating the migration of inflammatory cells(139), but also reduce the elevation of the proinflammatory leukotriene LTB(4) causes of autoimmune diseases(150).
3. Walnut tree
Walnut tree, cultivated for its nut and kernel and for commercial purpose all over the world, is one of the Genus plant belong to the family Juglandaceae about 30–130 ft).
a. Antioxidant effects(151)(152)
Even-though walnuts consumption did not only significantly change the plasma antioxidant capacity of healthy, well-nourished older adults through its polyphenols in inhibitiobn plasma and LDL oxidation(151) but chronic consumption, it improved postprandial serum antioxidants and biomarkers of oxidative status(152) through its antioxidant linoleic acid and pyridoxal phosphate in enhancing total plasma thiols(151).
b. Inflammation defense(153)
Intake of walnuts is shown to promote manganese superoxide dismutase (MnSOD), an enzyme located in mitochondria(154), is the key enzyme in protection of the energy-generating mitochondria from oxidative damage caused by free radicals(155).
c. Diabetes riskAdiponectin found abundantly in walnut-enriched meal plays an important causal role in insulin resistance and metabolic syndrome(156). Diabetes in older adult is shown to associate increased risk of osteoarthritis(157).
4. Dulse
Dulse, commonly used in Ireland and Atlantic Canada both as foods and medicines, is a red seaweed of genus Palmaria, belong to Family Palmariaceae grown attached to rocks by a “holdfast” in the North Atlantic and Northwest Pacific. Dulse is found in many health food stores or fish markets or can be ordered directly from local distributors.
a. Health benefits
Seaweeds, including dulse, showed to consist a important functional activities, such as antioxidant(158)(160)(161), antimutagenic(159)(162) and anticoagulant effect(160), antitumor activity(160), and modification of lipid metabolism(161).
b. Antioxidants
Dulse extracts showed to inhibit certain lipid peroxidations(162).
c. Weigh loss
As a rich source of fiber, dulse enhances the process of digestion, for making the stomach feeling fullness, thus reducing the risk of insulin cause of food craving(163).
5. Lime (Lemon)
Lime, a around shape with green to yellow in color and 3–6 cm in diameter, is a species of Citrus Aurantifolia, belongs to the family Rutaceae, native to Southeast Asia.
a. Antioxidant
Lime flower extract may contain high levels of antioxidant(164)(165) but lesser than the ethanol extract of cinnamon(166).
b. Vitamin C
Besides preventing the breaking off small vein cause of hardening of the vessel wall(167), vitamin C also improves the digestive system in maximum absorption of vital nutrients and plays an important role in enhancing immune system fighting against the forming of free radicals that cause muscle damage(168). According to the University of Limerick, prior supplementation with dietary antioxidants, such as vitamin C and E may ameliorate muscle functional decrements subsequent to eccentric muscle contraction(169).
6. Dairy Products
Dairy products contain high amount of nutrients, it also has measure amount of vitamin D of which is necessary for the body in calcium absorption(170). Intake of dairy products per day, according to joint study including Université Libre de Bruxelles appears to be safe and may confer a favourable benefit with regard to bone health, such as osteoarthritis(172), rheumatoid arthritis(170).
In elderly Fracture risk, according to the Geneva University Hospitals and Faculty of Medicine, improved bone growth is influenced by dietary intake, particularly of calcium and protein such as Dairy products, yogurts are essential to achieve optimal peak bone mass during skeletal growth and to prevent bone loss(171). Recommendation of consuming 3 servings of dairy products per day during childhood and adolescence, has shown to improve bone health and reduce the risk of fractures in later life(171).
In the observation of a significant dose-response relationship between baseline milk intake and adjusted mean decrease of JSW in women, researcher at the Brigham and Women's Hospital and Harvard Medical School, Boston, showed that frequent milk consumption may be associated with reduced OA progression in women and delay in knee OA progression(173).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html
References
(134) Studies on free radicals, antioxidants, and co-factors by Khalid Rahman(PMC)
(135) New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate by Hae-Suk Kim,a Michael J. Quon,c and Jeong-a Kima,b(PMC)
(136) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Singh BN1, Shankar S, Srivastava RK.(PubMed)
(137) Dietary polyphenols and mechanisms of osteoarthritis by Shen CL1, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS.(PubMed)
(138) Green tea: a new option for the prevention or control of osteoarthritis by Katiyar SK, Raman C.(PubMed)
(139) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress by K Esposito, F Nappo, R Marfella, G Giugliano, F Giugliano, M Ciotola(Circulation)
(140) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(141) Preparation and antioxidant activity of green tea extract enriched in epigallocatechin (EGC) and epigallocatechin gallate (EGCG) by Hu J1, Zhou D, Chen Y.(PubMed)
(142) Genetically determined body weight loss in mice fed diets containing salmon oil by LeBoeuf RC1, Veldee MS.(PubMed)
(143) Supplementation of n3 long-chain polyunsaturated fatty acid synergistically decreases insulin resistance withweight loss of obese prepubertal and pubertal children by López-Alarcón M1, MartÃnez-Coronado A, Velarde-Castro O, Rendón-MacÃas E, Fernández J.(PubMed)
(144) Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil by Flader D1, Brandsch C, Hirche F, Eder K.(PubMed)
(145) Omega 3 fatty acids promote macrophage reverse cholesterol transport in hamster fed high fat diet by Kasbi Chadli F1, Nazih H, Krempf M, Nguyen P, Ouguerram K.(PubMed)
(146) Cholesterol, inflammation and innate immunity by Tall AR1, Yvan-Charvet L2.(PubMed)
(147) In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation by Wang S1, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH.(PubMed)
(148) Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2. byXu H1, Hertzel AV1, Steen KA1, Wang Q2, Suttles J3, Bernlohr DA4.(PubMed)
(149) Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion by Lazzarin N1, Vaquero E, Exacoustos C, Bertonotti E, Romanini ME, Arduini D.(PubMed)
(150) Omega-3 fatty acids in inflammation and autoimmune diseases. by Simopoulos AP1.(PubMed)
(151) Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study by McKay DL1, Chen CY, Yeum KJ, Matthan NR, Lichtenstein AH, Blumberg JB.(PubMed)
(152) Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals by Haddad EH1, Gaban-Chong N, Oda K, Sabaté J.(PubMed)
(153) Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men by Jiménez-Gómez Y1, López-Miranda J, Blanco-Colio LM, MarÃn C, Pérez-MartÃnez P, Ruano J, Paniagua JA, RodrÃguez F, Egido J, Pérez-Jiménez F.(PubMed)
(154) manganese(The world healthier foods)
(155) The role of manganese superoxide dismutase in inflammation defense by Li C1, Zhou HM(PubMed)
(156) An acute intake of a walnut-enriched meal improves postprandial adiponectin response in healthy young adults by Lozano A1, Perez-Martinez P, Marin C, Tinahones FJ, Delgado-Lista J, Cruz-Teno C, Gomez-Luna P, Rodriguez-Cantalejo F, Perez-Jimenez F, Lopez-Miranda(PubMed)
(157) Links between osteoarthritis and diabetes: implications for management from a physical activity perspective by Piva SR1, Susko AM2, Khoja SS2, Josbeno DA2, Fitzgerald GK2, Toledo FG3.(PubMed)
(158) Antioxidant and cytotoxic activities of three species of tropical seaweeds by Chia YY1, Kanthimathi MS2,3, Khoo KS4, Rajarajeswaran J5, Cheng HM6, Yap WS7.(PubMed)
(159) Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer by Senthilkumar K1, Manivasagan P, Venkatesan J, Kim SK.(PubMed)
(160) Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatul by Kaline Dantas Magalhaes,1,2,† Leandro Silva Costa,1,3,† Gabriel Pereira Fidelis,1 Ruth Medeiros Oliveira,1 Leonardo Thiago Duarte Barreto Nobre,1 Nednaldo Dantas-Santos,1,2 Rafael Barros Gomes Camara,1 Ivan Rui Lopes Albuquerque,1,2 Sara Lima Cordeiro,1 Diego Araujo Sabry,1 Mariana Santana Santos Pereira Costa,1 Luciana Guimaraes Alves,1 and Hugo Alexandre Oliveira Rocha1,2(PMC)
(161) [Nutritional evaluation and physiological effects of edible seaweeds].[Article in Spanish] by Jiménez-Escrig A1, Goñi Cambrodón I.(PubMed)
(162) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(163) THE WORLD HEALTHIEST FOODS - PART II - VEGETABLES by Kyle J. Norton
(164) Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat by Nag N1, Halder S, Chaudhuri R, Adhikary S, Mazumder S.(PubMed)
(165) Phytochemicals and antioxidant capacity of tortillas obtained after lime-cooking extrusion process of whole pigmented mexican maize by Aguayo-Rojas J1, Mora-RochÃn S, Cuevas-RodrÃguez EO, Serna-Saldivar SO, Gutierrez-Uribe JA, Reyes-Moreno C, Milán-Carril(PubMed)
(166) Antioxidant and anticholinesterase activities of eleven edible plants by Boğa M1, Hacıbekiroğlu I, Kolak U.(PubMed)
(167) Aging Hearts and Arteries: A Scientific Quest, Chapter 4: Blood Vessels and Aging: The Rest of the Journey(NIH)
(168) Does antioxidant vitamin supplementation protect against muscle damage? by McGinley C1, Shafat A, Donnelly AE(PubMed)
(169) Effects of dietary supplementation with vitamins C and E on muscle function during and after eccentric contractions in humans by Shafat A1, Butler P, Jensen RL, Donnelly AE.(PubMed)
(170) Effects of Dairy Products Consumption on Health: Benefits and Beliefs-A Commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases by Rozenberg S1, Body JJ2, Bruyère O3, Bergmann P4, Brandi ML5, Cooper C6,7, Devogelaer JP8, Gielen E9, Goemaere S10, Kaufman JM11, Rizzoli R12,Reginster JY13(PubMed)
(171) Dairy products, yogurts, and bone health by Rizzoli R1.(PubMed)
(172) Got osteoarthritis? Maybe milk can help by Sahni S1, McLean RR.(PubMed)
(173) Milk consumption and progression of medial tibiofemoral knee osteoarthritis: data from the Osteoarthritis Initiative by Lu B1, Driban JB, Duryea J, McAlindon T, Lapane KL, Eaton CB(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, non pharmacological, and surgical treatments(4).
The preventive Diet
The aims of the diet is to provide protection to avoid elevation of the inflammatory effects(139) in induced-degeneration causes of osteoarthritis(133)(134)
1. Green tea
Epigallocatechin 3-gallate (EGCG), according to the College of Pharmacy, found abundantly in green tea showed to exhibit its anti anti-rheumatic activity in patients with joint diseases(140) through its antioxidant property(141).
2. Salmon
Salmon is the common name for Salmonidae, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within five years returning to the exacted location where they were born to reproduce and die.
a. Weight loss
Intake of salmon oil has shown to induce body weight loss in mice, according to the study by University of Washington(142). N3 long-chain polyunsaturated fatty acids (n3-LCPUFA) enhanced body weight loss, at the end of the 1-month period in 16 children through deduction of insulin resistance(143).
b. Antioxidants
Megadoses of vitamin E, found in salmon oil exhibited pro-oxidative activity, through increased the anti-oxidative capacity of the liver(144).
c. Omega 3 fatty acids
Omega 3 fatty acids is necessary to maintain the ratio of good and bad cholesterol(145), thus reducing the risk of cholesterol inflammation(146)(148) cause of heart diseases (147) and osteoarthritis(133)(134).
d. Anti inflammation
Omega 3 fatty acids not only reduces the risk of inflammatory effects on our joints and improved blood flow(149), by regulating the migration of inflammatory cells(139), but also reduce the elevation of the proinflammatory leukotriene LTB(4) causes of autoimmune diseases(150).
3. Walnut tree
Walnut tree, cultivated for its nut and kernel and for commercial purpose all over the world, is one of the Genus plant belong to the family Juglandaceae about 30–130 ft).
a. Antioxidant effects(151)(152)
Even-though walnuts consumption did not only significantly change the plasma antioxidant capacity of healthy, well-nourished older adults through its polyphenols in inhibitiobn plasma and LDL oxidation(151) but chronic consumption, it improved postprandial serum antioxidants and biomarkers of oxidative status(152) through its antioxidant linoleic acid and pyridoxal phosphate in enhancing total plasma thiols(151).
b. Inflammation defense(153)
Intake of walnuts is shown to promote manganese superoxide dismutase (MnSOD), an enzyme located in mitochondria(154), is the key enzyme in protection of the energy-generating mitochondria from oxidative damage caused by free radicals(155).
c. Diabetes riskAdiponectin found abundantly in walnut-enriched meal plays an important causal role in insulin resistance and metabolic syndrome(156). Diabetes in older adult is shown to associate increased risk of osteoarthritis(157).
4. Dulse
Dulse, commonly used in Ireland and Atlantic Canada both as foods and medicines, is a red seaweed of genus Palmaria, belong to Family Palmariaceae grown attached to rocks by a “holdfast” in the North Atlantic and Northwest Pacific. Dulse is found in many health food stores or fish markets or can be ordered directly from local distributors.
a. Health benefits
Seaweeds, including dulse, showed to consist a important functional activities, such as antioxidant(158)(160)(161), antimutagenic(159)(162) and anticoagulant effect(160), antitumor activity(160), and modification of lipid metabolism(161).
b. Antioxidants
Dulse extracts showed to inhibit certain lipid peroxidations(162).
c. Weigh loss
As a rich source of fiber, dulse enhances the process of digestion, for making the stomach feeling fullness, thus reducing the risk of insulin cause of food craving(163).
5. Lime (Lemon)
Lime, a around shape with green to yellow in color and 3–6 cm in diameter, is a species of Citrus Aurantifolia, belongs to the family Rutaceae, native to Southeast Asia.
a. Antioxidant
Lime flower extract may contain high levels of antioxidant(164)(165) but lesser than the ethanol extract of cinnamon(166).
b. Vitamin C
Besides preventing the breaking off small vein cause of hardening of the vessel wall(167), vitamin C also improves the digestive system in maximum absorption of vital nutrients and plays an important role in enhancing immune system fighting against the forming of free radicals that cause muscle damage(168). According to the University of Limerick, prior supplementation with dietary antioxidants, such as vitamin C and E may ameliorate muscle functional decrements subsequent to eccentric muscle contraction(169).
6. Dairy Products
Dairy products contain high amount of nutrients, it also has measure amount of vitamin D of which is necessary for the body in calcium absorption(170). Intake of dairy products per day, according to joint study including Université Libre de Bruxelles appears to be safe and may confer a favourable benefit with regard to bone health, such as osteoarthritis(172), rheumatoid arthritis(170).
In elderly Fracture risk, according to the Geneva University Hospitals and Faculty of Medicine, improved bone growth is influenced by dietary intake, particularly of calcium and protein such as Dairy products, yogurts are essential to achieve optimal peak bone mass during skeletal growth and to prevent bone loss(171). Recommendation of consuming 3 servings of dairy products per day during childhood and adolescence, has shown to improve bone health and reduce the risk of fractures in later life(171).
In the observation of a significant dose-response relationship between baseline milk intake and adjusted mean decrease of JSW in women, researcher at the Brigham and Women's Hospital and Harvard Medical School, Boston, showed that frequent milk consumption may be associated with reduced OA progression in women and delay in knee OA progression(173).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html
References
(134) Studies on free radicals, antioxidants, and co-factors by Khalid Rahman(PMC)
(135) New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate by Hae-Suk Kim,a Michael J. Quon,c and Jeong-a Kima,b(PMC)
(136) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Singh BN1, Shankar S, Srivastava RK.(PubMed)
(137) Dietary polyphenols and mechanisms of osteoarthritis by Shen CL1, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS.(PubMed)
(138) Green tea: a new option for the prevention or control of osteoarthritis by Katiyar SK, Raman C.(PubMed)
(139) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress by K Esposito, F Nappo, R Marfella, G Giugliano, F Giugliano, M Ciotola(Circulation)
(140) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(141) Preparation and antioxidant activity of green tea extract enriched in epigallocatechin (EGC) and epigallocatechin gallate (EGCG) by Hu J1, Zhou D, Chen Y.(PubMed)
(142) Genetically determined body weight loss in mice fed diets containing salmon oil by LeBoeuf RC1, Veldee MS.(PubMed)
(143) Supplementation of n3 long-chain polyunsaturated fatty acid synergistically decreases insulin resistance withweight loss of obese prepubertal and pubertal children by López-Alarcón M1, MartÃnez-Coronado A, Velarde-Castro O, Rendón-MacÃas E, Fernández J.(PubMed)
(144) Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil by Flader D1, Brandsch C, Hirche F, Eder K.(PubMed)
(145) Omega 3 fatty acids promote macrophage reverse cholesterol transport in hamster fed high fat diet by Kasbi Chadli F1, Nazih H, Krempf M, Nguyen P, Ouguerram K.(PubMed)
(146) Cholesterol, inflammation and innate immunity by Tall AR1, Yvan-Charvet L2.(PubMed)
(147) In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation by Wang S1, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH.(PubMed)
(148) Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2. byXu H1, Hertzel AV1, Steen KA1, Wang Q2, Suttles J3, Bernlohr DA4.(PubMed)
(149) Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion by Lazzarin N1, Vaquero E, Exacoustos C, Bertonotti E, Romanini ME, Arduini D.(PubMed)
(150) Omega-3 fatty acids in inflammation and autoimmune diseases. by Simopoulos AP1.(PubMed)
(151) Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study by McKay DL1, Chen CY, Yeum KJ, Matthan NR, Lichtenstein AH, Blumberg JB.(PubMed)
(152) Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals by Haddad EH1, Gaban-Chong N, Oda K, Sabaté J.(PubMed)
(153) Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men by Jiménez-Gómez Y1, López-Miranda J, Blanco-Colio LM, MarÃn C, Pérez-MartÃnez P, Ruano J, Paniagua JA, RodrÃguez F, Egido J, Pérez-Jiménez F.(PubMed)
(154) manganese(The world healthier foods)
(155) The role of manganese superoxide dismutase in inflammation defense by Li C1, Zhou HM(PubMed)
(156) An acute intake of a walnut-enriched meal improves postprandial adiponectin response in healthy young adults by Lozano A1, Perez-Martinez P, Marin C, Tinahones FJ, Delgado-Lista J, Cruz-Teno C, Gomez-Luna P, Rodriguez-Cantalejo F, Perez-Jimenez F, Lopez-Miranda(PubMed)
(157) Links between osteoarthritis and diabetes: implications for management from a physical activity perspective by Piva SR1, Susko AM2, Khoja SS2, Josbeno DA2, Fitzgerald GK2, Toledo FG3.(PubMed)
(158) Antioxidant and cytotoxic activities of three species of tropical seaweeds by Chia YY1, Kanthimathi MS2,3, Khoo KS4, Rajarajeswaran J5, Cheng HM6, Yap WS7.(PubMed)
(159) Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer by Senthilkumar K1, Manivasagan P, Venkatesan J, Kim SK.(PubMed)
(160) Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatul by Kaline Dantas Magalhaes,1,2,† Leandro Silva Costa,1,3,† Gabriel Pereira Fidelis,1 Ruth Medeiros Oliveira,1 Leonardo Thiago Duarte Barreto Nobre,1 Nednaldo Dantas-Santos,1,2 Rafael Barros Gomes Camara,1 Ivan Rui Lopes Albuquerque,1,2 Sara Lima Cordeiro,1 Diego Araujo Sabry,1 Mariana Santana Santos Pereira Costa,1 Luciana Guimaraes Alves,1 and Hugo Alexandre Oliveira Rocha1,2(PMC)
(161) [Nutritional evaluation and physiological effects of edible seaweeds].[Article in Spanish] by Jiménez-Escrig A1, Goñi Cambrodón I.(PubMed)
(162) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(163) THE WORLD HEALTHIEST FOODS - PART II - VEGETABLES by Kyle J. Norton
(164) Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat by Nag N1, Halder S, Chaudhuri R, Adhikary S, Mazumder S.(PubMed)
(165) Phytochemicals and antioxidant capacity of tortillas obtained after lime-cooking extrusion process of whole pigmented mexican maize by Aguayo-Rojas J1, Mora-RochÃn S, Cuevas-RodrÃguez EO, Serna-Saldivar SO, Gutierrez-Uribe JA, Reyes-Moreno C, Milán-Carril(PubMed)
(166) Antioxidant and anticholinesterase activities of eleven edible plants by Boğa M1, Hacıbekiroğlu I, Kolak U.(PubMed)
(167) Aging Hearts and Arteries: A Scientific Quest, Chapter 4: Blood Vessels and Aging: The Rest of the Journey(NIH)
(168) Does antioxidant vitamin supplementation protect against muscle damage? by McGinley C1, Shafat A, Donnelly AE(PubMed)
(169) Effects of dietary supplementation with vitamins C and E on muscle function during and after eccentric contractions in humans by Shafat A1, Butler P, Jensen RL, Donnelly AE.(PubMed)
(170) Effects of Dairy Products Consumption on Health: Benefits and Beliefs-A Commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases by Rozenberg S1, Body JJ2, Bruyère O3, Bergmann P4, Brandi ML5, Cooper C6,7, Devogelaer JP8, Gielen E9, Goemaere S10, Kaufman JM11, Rizzoli R12,Reginster JY13(PubMed)
(171) Dairy products, yogurts, and bone health by Rizzoli R1.(PubMed)
(172) Got osteoarthritis? Maybe milk can help by Sahni S1, McLean RR.(PubMed)
(173) Milk consumption and progression of medial tibiofemoral knee osteoarthritis: data from the Osteoarthritis Initiative by Lu B1, Driban JB, Duryea J, McAlindon T, Lapane KL, Eaton CB(PubMed)
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