Tuesday 19 August 2014

Obesity Complication of Stroke

By Kyle J. Norton

Obesity is defined as a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

How to calculate your BMI index
BMI= weight (kg)/ height (m2)

Stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications. Stroke is caused by uncontrolled diet that is high in saturated and trans fats resulting in cholesterol build up in the arteries and high blood pressure. In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, resulting in some cells in the brain to die off and are unable reproduce, then we have stroke. Other strokes happen when a blood vessel in the brain ruptures causing the cells in your brain to be deprived of oxygen in your blood, they die and never come back.

How Obesity associates with Stroke
1. In a study of "Evaluation of the Obesity Genes FTO and MC4R and the Type 2 Diabetes Mellitus Gene TCF7L2 for Contribution to Stroke Risk: The Mannheim-Heidelberg Stroke Study" by Winter Y, Back T, Scherag A, Linseisen J, Rohrmann S, Lanczik O, Hinney A, Scherag S, Neumaier M, Ringleb PA, Dodel R, Hebebrand J., posted in PubMed, researchers found that the observed trends of obesity risk alleles for risk of stroke/TIA as well as the possible sex-specific differences in clinical outcomes found for the TCF7L2 (rs7903146) require replication in future studies. Our study demonstrates that candidate gene studies for common stroke may benefit from focusing on polymorphisms that predispose to vascular risk.

2. According to the study of "Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008" by George MG, Tong X, Kuklina EV, Labarthe DR., posted in PubMed, researchers wrote that During the period of study, the prevalence of hospitalizations of acute ischemic stroke increased among all age and gender groups except females aged 5 to 14 years. Females aged 15 to 34 years and males and females aged 35 to 44 years showed a decrease in the prevalence of hospitalizations for subarachnoid hemorrhage, whereas females aged 5 to 14 years showed increases for subarachnoid hemorrhage. Hypertension, diabetes, obesity, lipid disorders, and tobacco use were among the most common coexisting conditions, and their prevalence increased from 1995 to 2008 among adolescents and young adults (aged 15-44 years) hospitalized with acute ischemic stroke.

3. In the study of "Weight of the obesity epidemic: rising stroke rates among middle-aged women in the United States" by Towfighi A, Zheng L, Ovbiagele B., posted in PubMed, researchers found that Stroke prevalence among women aged 35 to 54 years has tripled over the past 2 decades, at the same time remaining stable among men. Prevalence of obesity and 3 metabolic syndrome components increased; they may be key factors in the increase in women's stroke prevalence.

4. According to the study of "Health and economic burden of the projected obesity trends in the USA and the UK" by Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M., posted in PubMed, researchers wrote that These trends project 65 million more obese adults in the USA and 11 million more obese adults in the UK by 2030, consequently accruing an additional 6-8·5 million cases of diabetes, 5·7-7·3 million cases of heart disease and stroke, 492,000-669,000 additional cases of cancer, and 26-55 million quality-adjusted life years forgone for USA and UK combined.

5. In a study of "Prevalence of overweight and obesity in the United States, 1999-2004" by Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM., posted in PubMed, researchers found that The prevalence of overweight among children and adolescents and obesity among men increased significantly during the 6-year period from 1999 to 2004; among women, no overall increases in the prevalence of obesity were observed. These estimates were based on a 6-year period and suggest that the increases in body weight are continuing in men and in children and adolescents while they may be leveling off in women.

6. Etc.

Treatments of Obesity and Stroke
1. Accoesing to the abstract of the study of `Targeting the melanocortin receptor system for anti-stroke therapy` by Holloway PM, Smith HK, Renshaw D, Flower RJ, Getting SJ, Gavins FN., posted in PubMed, researchers indicated that Stroke continues to be a leading cause of death worldwide, with risk factors including smoking, diabetes, hypertension and obesity. The pathophysiology of stroke is highly complex: reintroduction of blood flow to the infarcted brain region is paramount in limiting ischaemic damage caused by stroke, yet a concomitant inflammatory response can compound tissue damage. The possibilities of pro-resolving treatments that target this inflammatory response have only recently begun to be explored. This review discusses the endogenous roles of the melanocortin system in reducing characterized aspects of inflammation, and how these, together with potent neuroprotective actions, suggest its potential as a therapeutic target in stroke.

2. In a study of `Preventing increased blood pressure in the obese Zucker rat improves severity of stroke`by Osmond JM, Mintz JD, Stepp DW., posted in PubMed, researchers wrote that Cerebral ischemia was induced for 60 min using an intralumenal suture technique, followed by 24 h of reperfusion. HCT treatment effectively prevented the increase in blood pressure in obese rats; however, the LS diet did not lower pressure. Importantly, infarct size was normalized by HCT after ischemia-reperfusion injury. Additionally, HCT improved the changes in MCA structure observed in untreated OZRs. There were no benefits of the LS diet on stroke injury or vessel structure. These results indicate that increased pressure is essential for driving the changes in infarct size in OZRs.

3. According to the study of `Three-month exercise and weight loss program improves heart rate recovery in obese persons along with cardiopulmonary function`by Nagashima J, Musha H, Takada H, Takagi K, Mita T, Mochida T, Yoshihisa T, Imagawa Y, Matsumoto N, Ishige N, Fujimaki R, Nakajima H, Murayama M., posted in PubMed, researchers found that Our data demonstrated that HRR can be improved in obese subjects by a 3-month exercise and weight loss program. Improvement in cardiopulmonary function by exercise seems to be the main contributor to the increment of HRR.

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The Best snack dip: Simple tune spread

Diabetic recipe
Contributed by diabetic cooking "Great tasting recipe for the entire Family" by Jean Pare, published by Company coming.

Serve with variety of low fat crackers. Or take for lunch along with crackers, bread or fresh vegetables. For more flavour, add a little more teriyaki sauce.
Finely chopped red onion   2tbsp.  30ml
Can of white tuna, packed in water, drained and broken into chunk's  6 oz.  170 g
Teriyaki sauce  4 - 6 tsp.  20 - 30 ml
Combined all 3 ingredients in small bowl. Chill for 1 - 2 hours to blend flavours.
Make 1 cup (250ml)
 1 tbsp (15ml); 17 calories; .4 g total fat (.1g sat., 5.0 mg cholesterol); 70 mg sodium; 3g protein; trace carbohydrate; trace dietary fiber.
Choice: 1/2 meat and alternatives
Variation: Omit teriyaki sauce and add 2 tbsp. (20ml) non fat herb and garlic-flavoured cream cheese and 2 tsp. (10ml) low sodium soy sauce.
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The Best of snack: Italian eggplant Sticks

Recipe contributed by Quick and easy family favorites by Vickie and JoAnn
By Karen Pitcher
Burleson, TX

Served with marinara sauce or even salsa, this Italian-season veggies will get a big thumbs up from family and friends

3 eggplant peeled
1. cup Italian favored dry bread crumbs
1 tsp. salt
1 tsp. pepper
3 eggs
1/4 cup milk
oil for deep frying
Cue eggplant into3''x1/2' stick; place in ice water for 30 minutes. drain and set aside.
Combined bread crumbs, salt and pepper; set a side. Blend together eggs and milk in a shallow bowl, dip eggplant sticks into egg mixture and dredge in bread crumbs mixture. Arrange eggplant on an ungreased baking sheet. Cover and chill for 20 minutes.
Pour oil to a depth of one inch in a deep skillet; heat oil to 275 degrees. Add eggplant and cook 2 minutes on each side or until golden. Drain on paper towels. Serve 6


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Monday 18 August 2014

Obesity Complication of Depression

By Kyle J.Norton

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

How to calculate your BMI index
BMI= weight (kg)/ height (m2)

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself. The mild case of depression can be defeated by a variety of self-care techniques. Others require the treatment of medication, such as antidepressant medications and psychotherapy that help to reduce and sometimes eliminate the symptoms of depression.

How Obesity associates with depression
1. According to the study of "Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies" by Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. (Source from Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. f.s.lent-luppino@lumc.nl.), posted in PubMed, researchers concluded that This meta-analysis confirms a reciprocal link between depression and obesity. Obesity was found to increase the risk of depression, most pronounced among Americans and for clinically diagnosed depression. In addition, depression was found to be predictive of developing obesity.

2. In a study of "
Parental depression, family functioning, and obesity among African American children" by Davis M, Young L, Davis SP, Moll G. (Source from Department of Psychology, Jackson State University in Jackson, MS 39217-0350, USA. melvin.davis@jsums.edu), posted in PubMed, Researchers found that several models emerged for predicting childhood and parental body mass index, parental depression, and child behavioral problems. Findings indicated a role for parental depression in childhood obesity. These findings are discussed in light of Bandura 's Social Cognitive Theory, and the family's role in childhood obesity

3. In n abstract of the study of "
Association between obesity and depression: Evidence from a longitudinal sample of the elderly in Taiwan" from Chang HH, Yen ST. (Source from a Department of Agricultural Economics , National Taiwan University , Taipei , Taiwan), posted in PubMed, researchers indicated that : In contrast to most findings for the Western countries, a negative association between obesity and depression of the elderly is evident in Taiwan. The different findings between Western and Asian countries may be due to the cultural differences. Unlike the Western countries that stigmata are attached to excessive overweight, being overweight is not a symbol of unhealthiness because only the wealthy can afford to eat more and put on more weight in the Chinese society

4. According tithe study of "Association between Body Mass Index and depression: the "fat and jolly" hypothesis for adolescents girls" by Revah-Levy A, Speranza M, Barry C, Hassler C, Gasquet I, Moro MR, Falissard B, posted in PubMed, researchers found that there is evidence for a gender difference in the association between BMI and depression in adolescents, supporting the need to study boys and girls separately. Overweight adolescent girls are more likely to be depressed than obese adolescent girls, giving support for "fat and jolly" hypothesis not only among older women but also among adolescent girls.

5. In a study of "Obesity and onset of significant depressive symptoms: results from a prospective community-based cohort study of older men and women" byVogelzangs N, Kritchevsky SB, Beekman AT, Brenes GA, Newman AB, Satterfield S, Yaffe K, Harris TB, Penninx BW; Health ABC Study., (Source from Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernststraat 887, 1081 HL Amsterdam, Netherlands. n.vogelzangs@ggzingeest.nl) posted in PubMed, researchers concluded that This study shows that obesity, in particular visceral fat, increases the risk of onset of significant depressive symptoms in men. These results suggest that specific mechanisms might relate visceral fat to the onset of depression.

6. etc.

E. Treatments of Obesity and Depression
1. According to the abstract of the study of "Treatment of Comorbid Obesity and Major Depressive Disorder: A Prospective Pilot Study for their Combined Treatment" by Faulconbridge LF, Wadden TA, Berkowitz RI, Pulcini ME, Treadwell T. (Source from Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA), posted in PubMed, researchers found that Obese individuals suffering from major depressive disorder can lose weight and achieve improvements in symptoms of depression and CVD risk factors with 16 weeks of combined treatment. A larger randomized controlled trial is needed to establish the efficacy of this treatment.

2. In a study of "Depression and suicidality in obese patients" by Lester D, Iliceto P, Pompili M, Girardi P. (Source from The Richard Stockton College of New Jersey, USA), posted in PubMed, researchers indicated that A study of 70 obese patients indicated the presence of severe depression in 32% of the sample and some suicidal risk in 23%. Given this high prevalence, health professionals should always explore the presence of depression and suicidality in obese patients.

3.. In a study of " The Role of Adipokines in Understanding the Associations between Obesity and Depression" by Taylor VH, Macqueen GM. (Source from Mood Disorders Program, Centre for Mountain Health Services, McMaster University, D150-A, 100 West 5th Street, St. Joseph's Healthcare, Hamilton, ON, Canada L8N 3K7), posted in PubMed, researchers found that This paper is one of the first to examine the association between adipokines and depression. It provides an overview of the physiological role of adipokines and summarizes the data suggesting that they may be dysregulated in major depression. This area of research may become increasingly important as new treatment strategies are developed.

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A Mayonnaise-like dressing for Diabetics

Diabetic recipe
Attributed to Delicious Dish for diabetics by Robin Ellis, Published by Skyhorse Publishing Inc. New York. You can view its website at www.skyhorsepublishing.com.

Not as soft and unctuous  of course, but good with salmon, for instance and asparagus, and does not involve the irksome though rewarding business of making mayonnaise! Heresy, I know.....
1 tbsp. cider vinegar
1 tsp. Dijon mustard
juice of 1/4 of a lemon
4 - 5 tbsp. extra-virgin canola/colza oil.

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The Best 4 tomato salsa - Spicy Mexi-Bean Dip

Contributed by diabetic cooking "Great tasting recipe for the entire Family" by Jean Pare, published by Company coming.

Make this recipe in accompany fresh tomato salsa. Serve both with Crispy barbecue Chips

Cooked (or 1 can 19oz., 540ml) black bean, drained and rinse  1/12 cups  375ml
Dice jalapeno pepper and seed removed  1tbsp.  15 ml
Salsa   1/4 cup  60ml
Light sour cream   1/4 cup  60ml
Grated light Monterery jack cheese 1/12 cups   375ml
Mash beans with fork or masher in medium bowl until broken up. Add next 3 ingredients and 1/2 of cheese. Spoon into shallow1 quart (1L) casserole. Sprinkle remaining 1/2 cheese on top. Bake, uncovered in 350 degree F (175 degree C) oven for 20 minutes or until bubbly. Make 2 cups (500ml)
2 tbsp. (30ml); 67 calories; 3.6 g total fat (2.4g sat., 10.3 mg cholesterol); 118 mg sodium; 4g protein; 5g carbohydrate; 1g dietary fiber.
Choice; None

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Sunday 17 August 2014

Obesity Complication of Asthma

By Kyle J. Norton

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

B. How to calculate your BMI index
BMI= weight (kg)/ height (m2)

C. How Obesity associates with Asthma
1. In an abstract of study of "Overweight is not a comorbidity factor during childhood asthma (GrowthOb study)?" by Mahut B, Beydon N, Delclaux C. (Source from Hôpital européen Georges-Pompidou, Service de Physiologie - Clinique de la Dyspnée, F-75015 Paris, France), posted in PubMed, researchers indicated that Compared to normal weight children, overweight plus obese children had reduced lung volume ratios (FRC/TLC and RV/TLC), no evidence of airflow limitation and similar symptoms.In conclusion, the observed functional relationships with BMI are not specific of asthma, and, being overweight is not associated with significant clinical impacts on asthma during childhood.

2. According to a study of "Urban-rural differences in asthma prevalence among young people in Canada: the roles of health behaviors and obesity" by Lawson JA, Janssen I, Bruner MW, Madani K, Pickett W. (Source from Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, SK, Canada, and the Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada), posted in PubMed, researchers found that Although asthma prevalence among youth was lower in rural areas, this association was not mediated by health behaviors or obesity. Other exposures, likely environmental, are the logical mechanisms through which rural geographic status is related to lower asthma prevalence.

3. In a study of "The association of obesity and asthma severity and control in children" by
Quinto KB, Zuraw BL, Poon KY, Chen W, Schatz M, Christiansen SC. (Source from Department of Allergy and Immunology, University of California, San Diego, La Jolla, Calif), posted in PubMed, researchers found that Even after adjusting for demographics, parental education level, asthma controller use, and gastroesophageal reflux disease and diabetes mellitus diagnoses, overweight (BMI percentile for age, 85% to 94%) and obese (BMI percentile for age, ≥95%) children were more likely to have increased β-agonists dispensed (odds ratio of 1.15 [95% CI, 1.02-1.27] and odds ratio of 1.17 [95% CI, 1.06-1.29], respectively) and increased risk for oral corticosteroids dispensed (odds ratio of 1.21 [95% CI, 1.13-1.29] and odds ratio of 1.28 [95% CI, 1.21-1.36], respectively) compared with normal-weight (BMI percentile for age, 16% to 84%) children.

4. According to the study of "The relationship between obesity and asthma severity and control in adults" by Mosen DM, Schatz M, Magid DJ, Camargo CA Jr. (Source from Center for Health Research, Kaiser Permanente, Portland, OR 92111, USA. david.m.mosen@kpchr.org), posted in PubMed, researchers found that Even after adjusting for demographics, smoking status, oral corticosteroid use, evidence of gastroesophageal reflux disease, and inhaled corticosteroid use, obese adults were more likely than those with normal BMIs (<25 kg/m(2)) to report poor asthma-specific quality of life (odds ratio [OR], 2.8; 95% CI, 1.6-4.9), poor asthma control (OR, 2.7; 95% CI, 1.7-4.3), and a history of asthma-related hospitalizations (OR, 4.6; 95% CI, 1.4-14.4).

5. In a study of "Measures of obesity associated with asthma diagnosis in ethnic minority children" by Vangeepuram N, Teitelbaum SL, Galvez MP, Brenner B, Doucette J, Wolff MS. (Source from
Department of Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1512, New York, NY 10029, USA),posted in PubMed, researchers found that When comparing the highest quintile of each body fat measure to the combined lowest two quintiles, higher body mass index percentile, percent body fat, and waist circumference all were associated with a higher likelihood of physician-diagnosed asthma (PR = 1.63 (95% CI 1.12-2.39), 1.50 (95% CI 1.02-2.21), and 1.56 (95% CI 1.04-2.34), resp.). Conclusions. This study found a significant association between increased body size and asthma diagnosis, regardless of the measurement examined.

6. In an abstract of the study of "Body mass index and the risk of asthma in adults" by Luder E, Ehrlich RI, Lou WY, Melnik TA, Kattan M. (Source from Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1202B, New York, NY 10029, USA. elisabeth.luder@mssm.edu), posted in PubMed, researchers indicated that this cross-sectional study showed that men and women differ significantly in the association between BMI and asthma prevalence only with respect to the lowest weight category. While women had a monotonic association, men showed a U-shaped relationship, indicating that both extremes of weight are associated with a higher prevalence of asthma.

7. Etc

D. Treatments of Obesity and Asthma

1. According to the study of "Influence of obesity on control in asthmatic Japanese patients defined by the Japanese definition of obesity" by Youkou A, Hasegawa T, Suzuki K, Koya T, Sakagami T, Toyabe S, Arakawa M, Gejyo F, Narita I, Suzuki E. (Source from Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan.), posted in PubMed, researchers found that This study investigated influences of JASSO-defined obesity on asthma severity and management in a clinical setting in Japan. It is possible that there are strong interactions between asthma and obesity, such as obesity causing decreased ICS therapy efficacy and leukotriene (LT)-related inflammation, although further investigation is necessary.

2. According to a study of "Impact of bariatric surgery on pulmonary function and nitric oxide in asthmatic and non-asthmatic obese patients" by Lombardi C, Gargioni S, Gardinazzi A, Canonica GW, Passalacqua G. (Source from Allergy Unit, Department of Internal Medicine, Sant'Orsola-Poliambulanza Hospital, Brescia, Italy), posted in PubMed, researchers stated that Bariatric surgery significantly reduces the intake of inhaled corticosteroids and the levels of exhaled nitric oxide, thus bronchial inflammation, in asthmatics.

3. According to the study of "Weight loss and asthma control in severely obese asthmatic females" by Maniscalco M, Zedda A, Faraone S, Cerbone MR, Cristiano S, Giardiello C, Sofia M. (Source from Section of Respiratory Medicine, Hospital S. Maria della Pietà Casoria, Naples, Italy. mauromaniscalco@hotmail.com), posted in PubMed, researchers found that Consistent weight loss in severely obese patients with asthma is associated to improvement in respiratory symptoms and lung function. However, the mechanisms underlying the effect of large body mass changes on asthma would require further studies.
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