Sunday 20 July 2014

Another Smaller salad for One

Recipes attributed to Company Coming salad by Jean Pare

A simple serving which can be easy multiplied.
Lettuce leaves ( or shredded lettuce)  1
Pear or peach half  1
Salad dressing ( or mayonnaise)
Medium Cheddar cheese, grated for sprinkling
Put lettuce leaf on plate. Placed pear or peach half side up. Spoon dollop od salad dressing in center. Sprinkle with cheese. Serve 1.

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Saturday 19 July 2014

Phytochemical Indole-3-carbinol and Lung cancer

By Kyle J. Norton

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin,  found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
In mice study, Indole-3-carbinol showed to inhibit ling cancer via modulation of the receptor tyrosine kinase/PI3K/Akt signaling pathway(1), in dose dependent manner(2), In support of the above, the study by Medical College of Soochow University, indicated that I3C reduces radiosensitivity of lung cancer cells by mediating EGFR expression, indicating that EGFR may be an important target for I3C-mediated radioresistance in lung cancer. In deed, the individual of indole-3-carbinol or silibinin, showed to inhibit 43 and 36% reductions, respectively, in the multiplicity of tumors on the surface of the lung and 83 and 50% reductions, respectively, and mixtures of I3C and silibinin are more potent than the individual compounds for the chemoprevention of lung cancer in A/J mice, according to University of Minnesota(4).


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References
(1) Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis by Qian X1, Melkamu T, Upadhyaya P, Kassie F.(PubMed)
(2) Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol by Kassie F1, Matise I, Negia M, Upadhyaya P, Hecht SS.(PubMed)
(3) [EGFR-dependent impact of indol-3-carbinol on radiosensitivity of lung cancer cells].

[Article in Chinese] by Xiao X1, Meng Q, Xu J, Jiao Y, Rosen EM, Fan S.(PubMed)
(4) Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice by Dagne A1, Melkamu T, Schutten MM, Qian X, Upadhyaya P, Luo X, Kassie F.(PubMed)

The Best of Summer Kiwi coconut lime smoothie

Recipe contributed by Raw, Quick and delicious! 5 ingredient recipes in just 15 minutes by Douglas McNish, Published by Robert Rose. You can visit them at www.robertrose.ca

A creamy blend of tart citrus, sweet kiwifruit and rich coconut. this smoothie is a satisfying midday pick-me-up for when you are feeling peckish.
Tips:
You can substitute hemp milk for nut milk.
Use kiwifruit that are soft and ripe. To extract the fresh from kiwifruit, use a paring knife to remove a small amount of the skin from the bottom. Carefully insert a small spoon ( a grapefruit spoon is ideal) between the fresh and the skin and rotate it until the skin become loose. Scoop out the fresh.
Coconut oil is solid at room temperature. It has a melting temperature of 76 degree F (24 degree C), so it is easy to liquefy. To melt it, place in a shallow glass bowl over a pot od simmering water.
1 cup Nut milk  250mL
3 whole kiwifruit, peeled  3
1 banana     1
3tbsp. freshly squeezed lime juice  45mL
3tbsp. melted coconut oil 45mL
In a blender, combine nut milk, kiwi, banana, lime juice and coconut oil. Blend at high speed until smooth. Serve immediately. Make 11/2 cups (375mL).
variation: To make this smoothies even creamier, substitute 2 tbsp. (30mL0 coconut butter for the coconut oil.
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Small salad for One

Recipes attributed to Company Coming salad by Jean Pare

Enough for one serving. Simple to increase
Lettuce leaves ( or shredded lettuce)  1
Pear or peach half  1
Cottage cheese 2-3 tbsp.  30 - 45 mL
Paprika, sprinkle
Put lettuce leaf on plate. Placed pea

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Friday 18 July 2014

Phytochemical Indole-3-carbinol and Breast cancer

By Kyle J. Norton

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin,  found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Breast cancer (malignant breast neoplasm) is a cancer started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. There is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Indole-3-carbinol may act as NAG-1 modulators involved in natural products-induced NAG-1 transcriptional signaling pathway used in prevention and treatment of cancer(1). According to the University of Urbino "Carlo Bo",, The indole-3-carbinol cyclic tetrameric derivative (CTet) inhibited breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction, AKT(2). In human breast cancer cell lines MCF-7 and MDA-MB-231, the derivative also enhances ER stress response, as the main upstream molecular mechanism through which CTet acts in both hormone-responsive and triple-negative breast cancer cells(3). In support to the above, the study of University of Urbino Carlo Bo, Urbino (PU),  showed that the derivative may also be a potential anticancer combination agent for both hormone-responsive and triple-negative breast tumors(4).
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References
(1) Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents by Yang MH1, Kim J2, Khan IA3, Walker LA4, Khan SI5.(PubMed)
(2) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(3) Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines by Galluzzi L1, De Santi M, Crinelli R, De Marco C, Zaffaroni N, Duranti A, Brandi G, Magnani M(PubMed)
(4) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).

The Best of Citrus explosion smoothie

Recipe contributed by Raw, Quick and delicious! 5 ingredient recipes in just 15 minutes by Douglas McNish, Published by Robert Rose. You can visit them at www.robertrose.ca

This tart refreshing smoothie is a perfect way to start your day. Enjoy it with Rise and Shine Bars or breakfast porridge.
Tips:
For a creamer smoothie, substitute an equal amount of fresh nut milk or hemp milk for water.
To yield the maximum juice from citrus, allow them to sit at room temperature for 30 minutes, before juicing. Once the fruit is at room temperature, use the palm of your hand to roll it on the counter to release the juices before slicing and squeezing.
Single serve blender with travel lids make it easy to take a smoothie with you on the go to pack for travel. Check your local home or kitchen supply store for these handy appliances.
1/2 cup filtered water 125mL
1 banana   1
1/4 cup freshly squeezed orange juice 60mL
3tbsp. freshly squeezed lemon juice 45mL
2tbsp. freshly squeezed lime juice 30mL
In a blender, combine water, banana and orange-lemon and lime juiced. Blend at high speed until smooth. Serve immediately. Make 11/4 cup (300mL)
Variation: Substitute 1/4 cup (60mL) fresh grapefruit segment for lime juice.


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Another way for making banana tasty - Banana salad

Recipes attributed to Company Coming salad by Jean Pare

Bring the tropical to the table. The kids love it.
Banana  3
Finely chopped walnuts or pecans lettuce leaves 1/2 cup, 125 mL
Whipped cream ( or 1/4 envelope topping) 1/4 cup, 50 mL
Salad dressing ( or mayonnaise) 1/4 cup,  50 mL
Cut banana in half crosswise, then in half lengthwise. Dip each piece in lemon juice. Roll in walnuts and arrange on lettuce leaves. This can be done on one large plate or on individual small plates.
Whip cream until stiff. Mix in salad dressing. Spoon over bananas. Serve 6.
Variation: Omit walnuts. Roll in toasted coconut.


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