Kyle J. Norton
Herbal Butterbur may have a potential and positive effect on reducing the levels of blood cholesterol with no side effects, some scientists suggested.
Cholesterol is a waxy substance needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat.
However, too much cholesterol can be dangerous because cholesterol cannot dissolve in your blood.
The special particle called lipoprotein moves this waxy, soft substance from place to place, leading to cholesterol accumulation in the arterial wall that disrupts the risk of oxygenic blood transportation to the heart, a major cause of cardiovascular disease.
There are 2 types of cholesterol. The high-density lipoprotein which returns the blood cholesterol to the liver for future use and the low-density lipoprotein which processes a number of aforementioned functions.
The healthy ratio that maximizes the body's functions is 4 (low-density lipoprotein or bad cholesterol) to 1 (high-density lipoprotein or good cholesterol. Any numbers less than 4 are considered healthy.
Some researchers suggested although there are many risk factors associated with the onset of high blood cholesterol, an unhealthy diet is one major and accumulated risk of the syndrome.
Dr. Robert L. Rosenthal in the study "Effectiveness of altering serum cholesterol levels without drugs" wrote, "Drug therapy with statins and other agents can result in dramatic lipid-lowering effects. Despite the wealth of data supporting the beneficial effects of pharmacologic therapy on cardiovascular risk, patients often express a desire to accomplish similar goals with diet alone".
And, "... a variety of dietary strategies designed to lower lipid levels, including the American Heart Association diet, the Ornish diet, the Mediterranean diet, exercise, phytosterols, fiber, soy products, and fish oil".
These results strongly suggest you can lower your blood cholesterol by following a healthy diet and moderate exercise without using drugs.
Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts,, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
In finding a natural ingredient for the treatment of high blood cholesterol, researchers at the Chungnam National University, Gyeongsan examined the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profile and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG).
The study included ICR mice (6-8 weeks old, male) fed with BMP (0.1% or 0.3%) for 1 week, and on day 7, MSG (4 mg/g) was administered intraperitoneally.
Before application of BMP, administration of MSG showed a significant decrease of antioxidant biomarkers such as total glutathione level and antioxidant enzyme activities such as glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and quinone reductase (NQO1) and increase of the levels of reactive oxygen species (ROS).
After the injection of BMP supplementation, treated mice markedly enhanced the hepatic antioxidant enzyme activities.
Furthermore, BMP supplementation decreased total cholesterol, atherogenic index, and low-density lipoprotein-cholesterol, compared to the MSG-treated group.
Dr. Park CH the lead author in the heart team wrote, "Based on these results, it was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with MSG.".
Additionally, in the review of the anti-obesity effect of an extract of Petasites japonicus (a culinary vegetable from Eastern Asia) (PJET) on a murine adipocyte cell line (3T3-L1) and on diet-induced obesity-prone mice, researchers showed PJET lowered the body weight gain and visceral fat tissue accumulation and ameliorated the plasma cholesterol concentration.
Furthermore, PJET significantly attenuated three adipogenic transcription factors, which play a crucial role in adipogenic induction associated with adipocyte differentiation and cholesterol homeostasis, and genes involved in higher levels of total cholesterol.
These results indicated herbal Butterbur inhibited levels of bad cholesterol through many mechanisms, including gene expression, transcription factors, and levels of antioxidants
Taken together, herbal Butterbur processed a number of bioactive compounds that may be considered a functioning remedy for the prevention and treatment of high blood cholesterol with no side effect, pending the large sample size and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer, and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice by Park CH, Kim MY, Sok DE, Kim JH, Lee JH, Kim MR.(PubMed)
(2) Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet by Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N, Itoh H.(PubMed)
Tuesday, 31 October 2023
#Herbal #Bilberry Induces Apoptotic Cell Bodies and Nucleosomal DNA Fragmentation Against #Cancer, Researchers say
Kyle J. Norton
Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At an early, most people with cancer are asymptomatic, however, later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. As of today, researchers do not know why one person develops cancer and another doesn’t, even though they share some common risk factors for the disease.
However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Searching the list of natural compounds with a strong potential for the treatment of cancer with no side effects, scientists investigated the secondary metabolites including flavonoids (1-8), caffeic (9) and chlorogenic (10) acids from the extract of Sakhalin bilberry Vaccinium smallii leaves in vitro.
All 10 metabolites included in the study displayed a significant effect in the inhibition of EGF-induced neoplastic transformation in the conversion of normal cells into tumor cells of mouse JB6 Cl 41 P+ cells.
Furthermore, none of the compounds isolated from bilberry extract showed non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.
The results suggested that bilberry secondary metabolites protect the normal against the alternation of the cell's DNA without causing harm to the nearby healthy normal cells.
In HL60 cells, injection of bilberry extract induced apoptotic cell bodies and nucleosomal DNA fragmentation.
However, bilberry did not exert similar effects against the HCT116. The proportion of apoptotic cells induced in HCT116 was much lower than that in HL60 cells, without the presence of DNA fragmentation.
According to the extracted analysis, the efficacy of bilberry against cancer cell lines was attributed to the bioactive phenolic compounds, including anthocyanins in initiating the free radical scavenging property.
Dr. Katsube N, the lead scientist after taking into account co and confounders wrote in the final report, "These results indicate that the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis".
Taken altogether, bilberry processed significant bioactive secondary metabolites may be considered a functional remedy for the prevention and treatment of cancer, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cancer-preventive activities of secondary metabolites from leaves of the bilberryVaccinium smallii A. Gray by Mechikova GY1, Kuzmich AS, Ponomarenko LP, Kalinovsky AI, Stepanova TA, Fedorov SN, Stonik VA. (PubMed)
(2) Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins by Katsube N1, Iwashita K, Tsushida T, Yamaki K, Kobori M. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At an early, most people with cancer are asymptomatic, however, later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. As of today, researchers do not know why one person develops cancer and another doesn’t, even though they share some common risk factors for the disease.
However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Searching the list of natural compounds with a strong potential for the treatment of cancer with no side effects, scientists investigated the secondary metabolites including flavonoids (1-8), caffeic (9) and chlorogenic (10) acids from the extract of Sakhalin bilberry Vaccinium smallii leaves in vitro.
All 10 metabolites included in the study displayed a significant effect in the inhibition of EGF-induced neoplastic transformation in the conversion of normal cells into tumor cells of mouse JB6 Cl 41 P+ cells.
Furthermore, none of the compounds isolated from bilberry extract showed non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.
The results suggested that bilberry secondary metabolites protect the normal against the alternation of the cell's DNA without causing harm to the nearby healthy normal cells.
In HL60 cells, injection of bilberry extract induced apoptotic cell bodies and nucleosomal DNA fragmentation.
However, bilberry did not exert similar effects against the HCT116. The proportion of apoptotic cells induced in HCT116 was much lower than that in HL60 cells, without the presence of DNA fragmentation.
According to the extracted analysis, the efficacy of bilberry against cancer cell lines was attributed to the bioactive phenolic compounds, including anthocyanins in initiating the free radical scavenging property.
Dr. Katsube N, the lead scientist after taking into account co and confounders wrote in the final report, "These results indicate that the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis".
Taken altogether, bilberry processed significant bioactive secondary metabolites may be considered a functional remedy for the prevention and treatment of cancer, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cancer-preventive activities of secondary metabolites from leaves of the bilberryVaccinium smallii A. Gray by Mechikova GY1, Kuzmich AS, Ponomarenko LP, Kalinovsky AI, Stepanova TA, Fedorov SN, Stonik VA. (PubMed)
(2) Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins by Katsube N1, Iwashita K, Tsushida T, Yamaki K, Kobori M. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
#Herbal #Artichoke Extract or and/or Its #Cynaropicrin Show Strong Inhibition of the Delay or Overcome the Resistance of CML to Chemotherapy., According to Studies
Kyle J. Norton
Artichoke may be the next target to extract the ingredients needed for the treatment of chronic myeloid leukemia (CML), according to studies.
Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved in cell cycle division and tumor suppression.
Epidemiologically, most people with CML are associated with risk factors of aging, male gender, and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.
According to the statistics provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also caused the death of 1,090 people, including 620 men and 470 women.
The most common symptoms of CML include easy bleeding and tired, unintended weight loss, pain or fullness below the ribs on the left side, and pale skin.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent and for the treatment of digestive disorders, abdominal pain gas bloating, etc.
Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin and showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.
In other words, the study was carried out to examine the effect of CCL extract on human K562 CML and K562 imatinib-resistant (IMAR) cell proliferation and on p210BCR/ABL expression.
Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.
Injection of CCL extract was shown to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.
In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.
In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.
In the depth differentiation, researchers also found that CCL extract showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.
Taken together, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)
Artichoke may be the next target to extract the ingredients needed for the treatment of chronic myeloid leukemia (CML), according to studies.
Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.
The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved in cell cycle division and tumor suppression.
Epidemiologically, most people with CML are associated with risk factors of aging, male gender, and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.
According to the statistics provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also caused the death of 1,090 people, including 620 men and 470 women.
The most common symptoms of CML include easy bleeding and tired, unintended weight loss, pain or fullness below the ribs on the left side, and pale skin.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent and for the treatment of digestive disorders, abdominal pain gas bloating, etc.
Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin and showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.
In other words, the study was carried out to examine the effect of CCL extract on human K562 CML and K562 imatinib-resistant (IMAR) cell proliferation and on p210BCR/ABL expression.
Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.
Injection of CCL extract was shown to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.
In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.
In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.
In the depth differentiation, researchers also found that CCL extract showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.
Taken together, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)
#Healthyfood #Onion and Garlic Extracts Inhibit the Incidences of LiverToxicity, According to Studies
Kyle J. Norton
The liver is the largest internal organ and the only organ in the human body that can regenerate itself.
The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building a strong cell wall, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizes drugs.
The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, inclduing cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in many recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound that processes liver protective activity, researchers examined the effects of onion and garlic extracts on cadmium (Cd)-induced liver oxidative damage in rats.
The study included
* The Cd group was challenged with 3CdSO(4).8H(2)O (as Cd; 1.5 mg/kg bw per day per oral) alone, and
* The extract-treated groups were pretreated with varying doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and after that co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks.
Based on the tested differentiation, the Cd group showed a significant increase in the levels of lipid peroxidation and glutathione S-transferase. In contrast, antioxidant enzymes such as glutathione, superoxide dismutase, and catalase levels were decreased in the liver.
Furthermore, liver oxidative stress markers such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase were also found to increase in the Cd group.
In other words, Cd showed induced oxidative damage in rat liver.
Injection of garlic and onion extract not only inhibited all parameters in the Cd group but also exerted a liver protective effect in a dose-dependent manner.
Based on the findings, researchers wrote, "high dose of onion and a moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity".
Taken together, onion may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of quercetin: From chemistry to medicine by Miltonprabu S1, Tomczyk M2, Skalicka-Woźniak K3, Rastrelli L4, Daglia M5, Nabavi SF6, Alavian SM7, Nabavi SM. (PubMed)
(2) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats by Obioha UE1, Suru SM, Ola-Mudathir KF, Faremi TY. (PubMed)
The liver is the largest internal organ and the only organ in the human body that can regenerate itself.
The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building a strong cell wall, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizes drugs.
The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, inclduing cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in many recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound that processes liver protective activity, researchers examined the effects of onion and garlic extracts on cadmium (Cd)-induced liver oxidative damage in rats.
The study included
* The Cd group was challenged with 3CdSO(4).8H(2)O (as Cd; 1.5 mg/kg bw per day per oral) alone, and
* The extract-treated groups were pretreated with varying doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and after that co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks.
Based on the tested differentiation, the Cd group showed a significant increase in the levels of lipid peroxidation and glutathione S-transferase. In contrast, antioxidant enzymes such as glutathione, superoxide dismutase, and catalase levels were decreased in the liver.
Furthermore, liver oxidative stress markers such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase were also found to increase in the Cd group.
In other words, Cd showed induced oxidative damage in rat liver.
Injection of garlic and onion extract not only inhibited all parameters in the Cd group but also exerted a liver protective effect in a dose-dependent manner.
Based on the findings, researchers wrote, "high dose of onion and a moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity".
Taken together, onion may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of quercetin: From chemistry to medicine by Miltonprabu S1, Tomczyk M2, Skalicka-Woźniak K3, Rastrelli L4, Daglia M5, Nabavi SF6, Alavian SM7, Nabavi SM. (PubMed)
(2) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats by Obioha UE1, Suru SM, Ola-Mudathir KF, Faremi TY. (PubMed)
Monday, 30 October 2023
Ingredients Found in #Cucumber Work Synergistically Against the Risk of #Diabetes, Researchers Say
Kyle J. Norton
Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.
In other words, diabetes is a condition associated with the inability of the body to use insulin properly.
Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged up by fat and cholesterol.
Hallmarks of diabetes are hyperglycemia and insulin resistance.
According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes
The most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.
* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.
* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.
* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin
* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.
* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, and an increase in urine specific gravity.
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a natural compound that processes anti-diabetes properties, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.
The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,
Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.
* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.
* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better-reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL
* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.
In other words, all ingredients in cucumbers work synergistically to exhibit anti-diabetes activity compared to a single compound.
Taken together, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton
Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.
In other words, diabetes is a condition associated with the inability of the body to use insulin properly.
Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged up by fat and cholesterol.
Hallmarks of diabetes are hyperglycemia and insulin resistance.
According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes
The most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.
* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.
* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.
* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin
* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.
* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, and an increase in urine specific gravity.
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a natural compound that processes anti-diabetes properties, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.
The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,
Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.
* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.
* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better-reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL
* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.
In other words, all ingredients in cucumbers work synergistically to exhibit anti-diabetes activity compared to a single compound.
Taken together, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton
#Onion Promotes Antiproliferative and Anti-Inflammatory Effects. Against the Risk of #Endometriosis, According to Studies
Kyle J. Norton
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.
More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, and some of the endometriosis tissues grow somewhere else in the body.
Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.
According to the statistics, 20% of reproductive-age women with endometriosis present without symptoms, and 55% of women have developed the new onset of severe menstrual cramps.
Additionally, endometriosis also induces sub-fertility (less fertile than a normal couple) in 25% of women.
Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.
* Hormone therapy may be accompanied by pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.
In a surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.
* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.
In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells),
* Quercetin inhibited the proliferation and induced the cell cycle arrest.
* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, and loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.
* Quercetin also suppressed the expression of signaling pathways associated with endometrial cell survival and growth.
On endometriosis auto-implanted mouse models,
* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.
* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis.
In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.
Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".
Taken together, onion processed with an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits the proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.
More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, and some of the endometriosis tissues grow somewhere else in the body.
Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.
According to the statistics, 20% of reproductive-age women with endometriosis present without symptoms, and 55% of women have developed the new onset of severe menstrual cramps.
Additionally, endometriosis also induces sub-fertility (less fertile than a normal couple) in 25% of women.
Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.
* Hormone therapy may be accompanied by pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.
In a surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.
* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.
In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells),
* Quercetin inhibited the proliferation and induced the cell cycle arrest.
* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, and loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.
* Quercetin also suppressed the expression of signaling pathways associated with endometrial cell survival and growth.
On endometriosis auto-implanted mouse models,
* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.
* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis.
In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.
Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".
Taken together, onion processed with an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits the proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)
#Ginger Bioactive Compounds and Extract Process Anti Lung Cancer Activity, Researchers Show
Kyle J. Norton
Scientists may have found a pungent spice which processes the potential to treat lung cancer, according to studies.
Lung cancer is a medical condition characterized by irregular cell growth in the lung tissue.
In Canada, according to the statistics, lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.
The 5-year survival rate for people with stage IB NSCLC is about 68%.
At the advanced stage, the lung cancer cell may suppress the nearby blood vessels and nerves leading to vomiting blood and localized severe pain accompanied by other general symptoms of cancer such as weight loss, reduced appetite.
In this stage, lung cancer also can travel a distance away to infect other healthy cells of tissue and organs, leading to secondary metastasis.
The most common glands and organs of lung cancer metastases are the adrenal gland, bones, brain, and liver.
Although there are many factors associated with the onset of lung cancer, some researchers suggested that current and past smoking accounts for most of the cases. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.
Dr. Ozlü T, the lead scientist in examining the risk of lung cancer from smoking, wrote, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers. In recent decades, there has been a shift from squamous and small cell lung cancer types to adenocarcinoma, due to increasing rates of smoking among the female population and rising light cigarette usage".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of lung cancer with no side effects compared to chemo medication examined the anti-lung cancer of bioactive compounds isolated from ginger.
[6]-shogaol, [6]-paradol and [6]-gingerol, potentiate the anti-NSCLC activity, however, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth.
[6]-Shogaol also induced cell cycle arrest (G1 or G2/M) and apoptosis as well as the cascades associated with the programming cell deaths.
Furthermore, [6]-shogaol inhibited protein (Akt kinase activity), associated with cancer proliferation and survival In NCI-H1650 lung cancer cells by inhibiting the regulator involved in cell cycle progression.
Dr. Myoung Ok Kim and colleagues in the final report said, "The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC".
In order to reveal more information about ginger anti-lung cancer activity, researchers examined the [6]-gingerol and [6]-shogaol and a ginger extract with a high level of shogaols (GEHS) against lung cancer cells.
[6]- shogaol has greater growth inhibitory activity (about 10-fold) on lung and colon cancer cell lines than [6]- gingerol.
Shogaols of ginger preparations and GEHS has a stronger cancer-preventive effect, compared to other ginger extracts.
The inhibitory activities of GEHS and extract from fresh ginger, as well as [6]-shogaol and [6]-gingerol inhibited an NNK-induced lung carcinogenesis model in A/J mice.
These results provide the basic information on key active cancer preventive constituents in ginger extracts. The development of a standardized and more active ginger extract preparation will facilitate future pre-clinical and clinical studies on the health benefits of ginger extracts, according to the author.
Taken together, ginger processed with a high amount of bioactive compounds may be considered a function alternative for prevention and combined primary therapy for the treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 by Myoung Ok Kim, 1 , 2 , † Mee-Hyun Lee, 1 , 3 , † Naomi Oi, 1 , † Sung-Hyun Kim, 1 , 2 , †Ki Beom Bae, 1 Zunnan Huang, 1 , 4 Dong Joon Kim, 1 , 5 Kanamata Reddy, 1 Sung-Young Lee,1 , 6 Si Jun Park, 2 Jae Young Kim, 2 Hua Xie, 1 , 7 Joydeb Kumar Kundu, 8 Zae Young Ryoo, 2Ann M. Bode, 1 Young-Joon Surh, 3 and Zigang Dong. (PMC)
(2) Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect by Sang, Shengmin. (NIH)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Scientists may have found a pungent spice which processes the potential to treat lung cancer, according to studies.
Lung cancer is a medical condition characterized by irregular cell growth in the lung tissue.
In Canada, according to the statistics, lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.
The 5-year survival rate for people with stage IB NSCLC is about 68%.
At the advanced stage, the lung cancer cell may suppress the nearby blood vessels and nerves leading to vomiting blood and localized severe pain accompanied by other general symptoms of cancer such as weight loss, reduced appetite.
In this stage, lung cancer also can travel a distance away to infect other healthy cells of tissue and organs, leading to secondary metastasis.
The most common glands and organs of lung cancer metastases are the adrenal gland, bones, brain, and liver.
Although there are many factors associated with the onset of lung cancer, some researchers suggested that current and past smoking accounts for most of the cases. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.
Dr. Ozlü T, the lead scientist in examining the risk of lung cancer from smoking, wrote, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers. In recent decades, there has been a shift from squamous and small cell lung cancer types to adenocarcinoma, due to increasing rates of smoking among the female population and rising light cigarette usage".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of lung cancer with no side effects compared to chemo medication examined the anti-lung cancer of bioactive compounds isolated from ginger.
[6]-shogaol, [6]-paradol and [6]-gingerol, potentiate the anti-NSCLC activity, however, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth.
[6]-Shogaol also induced cell cycle arrest (G1 or G2/M) and apoptosis as well as the cascades associated with the programming cell deaths.
Furthermore, [6]-shogaol inhibited protein (Akt kinase activity), associated with cancer proliferation and survival In NCI-H1650 lung cancer cells by inhibiting the regulator involved in cell cycle progression.
Dr. Myoung Ok Kim and colleagues in the final report said, "The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC".
In order to reveal more information about ginger anti-lung cancer activity, researchers examined the [6]-gingerol and [6]-shogaol and a ginger extract with a high level of shogaols (GEHS) against lung cancer cells.
[6]- shogaol has greater growth inhibitory activity (about 10-fold) on lung and colon cancer cell lines than [6]- gingerol.
Shogaols of ginger preparations and GEHS has a stronger cancer-preventive effect, compared to other ginger extracts.
The inhibitory activities of GEHS and extract from fresh ginger, as well as [6]-shogaol and [6]-gingerol inhibited an NNK-induced lung carcinogenesis model in A/J mice.
These results provide the basic information on key active cancer preventive constituents in ginger extracts. The development of a standardized and more active ginger extract preparation will facilitate future pre-clinical and clinical studies on the health benefits of ginger extracts, according to the author.
Taken together, ginger processed with a high amount of bioactive compounds may be considered a function alternative for prevention and combined primary therapy for the treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 by Myoung Ok Kim, 1 , 2 , † Mee-Hyun Lee, 1 , 3 , † Naomi Oi, 1 , † Sung-Hyun Kim, 1 , 2 , †Ki Beom Bae, 1 Zunnan Huang, 1 , 4 Dong Joon Kim, 1 , 5 Kanamata Reddy, 1 Sung-Young Lee,1 , 6 Si Jun Park, 2 Jae Young Kim, 2 Hua Xie, 1 , 7 Joydeb Kumar Kundu, 8 Zae Young Ryoo, 2Ann M. Bode, 1 Young-Joon Surh, 3 and Zigang Dong. (PMC)
(2) Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect by Sang, Shengmin. (NIH)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Subscribe to:
Posts (Atom)