#Bromelain Decreases Interleukins Involved in the Production of Pro-Inflammatory Cytokines Associated with the Onset of Allergic Airway Disease (AAD)

Kyle J. Norton

Chronic allergic airway disease (AAD) is a group of the diseases characterized by airway inflammation and airway hyperresponsiveness (AHR).

Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by the persistent production of proinflammatory cytokines by the immune system in the airway.


On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.

The most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airway conditions.

Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improve quality of life through avoidance of irritants.

If the cause of reactive airway disease is found, most cases of the condition may be cured by medication.


Dr. Jill R. Johnson, the lead scientist in the examination of Allergic Airway Disease: More than Meets the IgE? wrote, "After exposure, allergens crosslink with IgE on mast cells and induce histamine and leukotriene release (6), thereby initiating the allergic response and leading to the classic symptoms of allergy, i.e., sneezing and wheezing".

And, ". Omalizumab binds to the Ce3 domain of free IgE with high affinity (7), thereby inhibiting early- and late-phase asthmatic reactions (8) and decreasing the frequency of exacerbations in severe asthmatics (9). Omalizumab binding also prevents IgE from interacting with Fc«RI and Fc«RII1 on effector cells (mast cells, B cells, eosinophils, dendritic cells, and monocytes), thus impairing their activation and making them less sensitive to allergens, and disabling signaling cascades (10), with the end result of a reduction in symptoms".

In other words, allergic airway disease (AAD) is a result of an immune response upon exposure to the allergens, Therefore, by making the immune system less sensitive to allergens, symptoms of allergic airway disease (AAD) may be reduced.


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to discover a potential compound for the treatment of diseases associated with chronic inflammation, researchers examined the ability of bromelain to reduce the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

The study included female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days.


On day 4, phosphate-buffered saline (PBS) was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS was administrated to the bromelain (intervention) group (n = 10).

According to the tested assays, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity indicated by reduced BAL total leukocytes, eosinophils, and cellular infiltrates via lung pathology compared to the control group.

Furthermore, bromelain also significantly reduced bronchoalveolar lavage (BAL) CD4+ associated and CD8+ T cells d with the T helper 2 (TH2) cells in the promotion of allergic inflammation process without affecting cell numbers in the spleen or hilar lymph node.

The efficacy of bromelain in the inhibition was attributed to the decreased interleukins involved in the production of pro-inflammatory cytokines.

In other words, bromelain protects asthma patients against allergic airway inflammation through its strong anti-inflammatory properties.

Based on the results, researchers said, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".

In order to find more information about bromelain anti-ADD activity, researchers investigated the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

Selected mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols to induce ADD followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.


According to the findings, bromelain showed a similar effect as the aforementioned results in reduced total BAL leukocytes, eosinophils, CD4+, and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.

Taken altogether, bromelain may be considered a supplement for the prevention and treatment of allergic airway disease ADD, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
(3) Allergic Airway Disease: More than Meets the IgE? by Jill R. Johnson, Ph.D. and James A. Harker, Ph.D

#Healthyfood #CruciferousVegetables Protect Cell Integrity Against DNA Damage Caused by Genotoxicity, Researchers Reveal

Kyle J. Norton

Genotoxicity is a process of destruction o a cell's genetic material (DNA, RNA), leading to gene mutation.
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.

Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.

Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.

The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.

The antigenotoxic activity is a process to inhibit the property of chemical agents that induce damages to the genetic information, leading to mutation,anti-antimutagens

Cancer is a class of diseases associated with alternation of cell DNA or genetic change of cell.

Not all Genotoxicity is mutagenicity, but all mutagens are genotoxic.

Dr. Shareen H, the lead scientist in the study of "Chapter 18 - Genotoxicity and Cancer" wrote, "Genetic toxicology is the study of chemical and physical perturbations to DNA following exposure to endogenous or exogenous agents. Hazard assessment of engineered nanomaterials involves establishing the ability of these novel materials to induce DNA damage (genotoxicity) and to subsequently initiate tumor formation (carcinogenesis)".

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

Iand n finding a potential compound for the protection of cell DNA against damage, researchers examined the effects of cruciferous vegetables (CF) in protecting humans against cancer caused by chemically induced tumor formation.


According to the dietary information,* CF and their constituents showed the effect on enzymes involved in the metabolism of DNA-reactive carcinogens.

* In vitro models, sulforaphane, a bioactive compound found in CF exerted antigenotoxic effects on metabolically competent cell lines.

* Furthermore, Brassica juices induced the production of glutathione-S-transferases (GST) and cytochrome P-450 1A2 in human hepatoma cells (HepG2) against the genotoxic effects of B(a)P and other carcinogens.
* Moreover, brussels sprouts- and garden cress juices attenuated IQ-induced DNA damage and preneoplastic lesions in the colon and liver of rats.

* Most importantly, CF affects drug metabolism in humans and consumption of red cabbage led to changes in the pattern of meat-derived urinary mutagenicity.


Taken together, cruciferous vegetables may be considered functional foods for the protection of the cells against genotoxicity, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of cruciferous vegetables and their constituents on drug-metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens by Steinkellner H1, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmüller S, Kassie F. (PubMed)
b(2) Chapter 18 - Genotoxicity and Cancer by Shareen H.Doak, Ying Liu, and ChunyingChen. (Science Direct)

#Honey Enhances the Immune Function in Speeding Up Wound Healing, Researchers Say

Kyle J. Norton

Honey may have a strong effect in speeding up wound healing, some scientists suggested.
Wound healing is the natural process of covering up the damage and injury of the body,

The process involves 4 phases
* The first phase of wound healing is to cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block drainage.

* In phase 2, the white blood cells activate the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.

* In phase 3, new blood vessels and tissues are formed in the damage and injury area.

* The recovery phase.

However, the healing process is easier said than done, the complex process in many cases are interrupted by local and systemic factors, including moisture, infection, age, and nutritional status.

Some researchers also indicated that in phase 2, due to overexpression of inflammatory cytokine, some patients may experience symptoms of localized redness, swelling, and fever.


And, the overexpression of inflammatory cytokines can also cause damage to the nearby healthy cells, leading to improper healing with the formation of large and irreversible scars.

However, people with a weakened immune system may compromise acute wound repair that promotes nonhealing wounds.


Dr. Amanda S. MacLeod, the lead author in the concerns of the immune responses to acute and chronic wounds said, "The innate immune system comprises a network of interacting mechanisms that provide a rapid response to clear microbial contamination upon skin injury" and "In the development of chronic wounds, this process stalls in the late inflammatory stage. The major defect in nonhealing wounds occurs at the phenotypic switch from inflammatory macrophages to an anti-inflammatory phenotype".

These results clearly, suggested, that the failure to switch from the phase of proinflammatory cytokines to the phase of anti-inflammatory cytokines due to the weakened immune system in the activation of p38, can lead to delayed wound healing and abnormalities in chronic wounds.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.

In the traditional use of honey for wound healing and an alternative natural antibiotic due to the advent of antibiotic resistance in microbial pathogens, researchers reviewed articles outlined in publications regarding honey and wound healing that were published between June 2010 and August 2016.
The findings suggested that multiple types of honey demonstrate their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators.

In the evaluation to examine the healing effects of honey dressings compared to silver dressings for acute or chronic wounds, researchers launched a systematic review with meta-analysis consisting of six randomized controlled trial studies.

All studies showed that honey was more efficacious for wound healing than silver, as measured in the number of days needed for wounds to heal.

Honey turned out to have more antibacterial qualities than silver in-depth analysis.

Dr. Lindberg T, the lead scientist after taking into account co and confounders, said, "All the included studies based on burns showed the unequivocal result that honey had an even more positive effect than silver on wound healing".

The results pointed out that honey may have a potential effect in speeding up wound healing and protecting the wound against microorganism infection.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Honey and Wound Healing: An Update by Saikaly SK1, Khachemoune A2. (PubMed)
(2) A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns by Lindberg T1, Andersson O1, Palm M1, Fagerström C, (PubMed)
(3) Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis by Oryan A1, Alemzadeh E2, Moshiri A3. (PubMed)
(4) The Innate Immune System in Acute and Chronic Wounds by Amanda S. MacLeod1, and Jonathan N. Mansbridge. (PMC)

#Coffee Processes Anti Edema Activity through its Effects on Lipid Peroxidation (LPO) and Antioxidant Expression , According to Researchers

Kyle J. Norton

Good news for coffee drinkers, coffee may have a potential effect in reducing the risk and treatment of edema, a recent study suggested.
Edema is a condition characterized by excess fluid retained in the body's tissues, inducing swelling.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the joint study led by Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.

The protective effect in reduced ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA, formed in the metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.

In a rat model of transient middle cerebral artery occlusion, CGA directly showed significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.

The study also addressed that the attenuation of brain edema may also be affected by the chemical compound's anti-lipid peroxidation (LPO) activity through increased antioxidant expression.

In another study in the investigation of anti-inflammatory activity against carrageenan, PGE(2), and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), researchers at the Gazi University postulated.


The findings suggested that coffee may be used as a functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwideKarate health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)

#Greentea Inhibits Parameter Associated with the Risk of Hypertension, Reserachers Suggest

Kyle J. Norton

Regular drinking of green tea may have a potential effect on maintaining normal blood pressure and reducing the risk of hypertension, a recent study suggested.
Hypertension is an abnormal high of blood pressure, one of the major risk factors in the contributed early onset of cardiovascular disease.

Green tea, considered a functional food, has a number of health benefits and has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding one slice of ginger will do the trick of neutralization.

Hypertension of male Wistar rats induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks], fed with green tea extract exhibited a strong effect in reduced hypertension (119 ± 1 mmHg) and higher renal sympathetic nerve activity (161 ± 12 spikes/s) than the control group (97 ± 2 spikes/s).
Green tea oral administration also showed a significant decrease in hypertensive parameters by amelioration. arterial baroreceptor function and vascular and systemic oxidative stress.

Furthermore, a total of 20 Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 13 weeks old with metabolic syndrome were randomized into a saline-treated group (OLETF; n = 10) and a group treated with decaffeinated-GTE (25 mg/kg/day) (GTE-OLETF; n = 10), group fed with decaffeinated-GTE significantly reduced BP (OLETF vs. GTE-OLETF; 130 ± 7 vs. 121 ± 3 mmHg, p = 0.01) in compared control fed with saline.

The study also suggested that fed mice with green tea also showed an antihypertensive effect in reduced vascular reactive oxygen species (ROS) formation and NADPH in the generation of ROS, as well as improving endothelium (cell lines the interior surface of blood vessels and lymphatic vessels)and lymphatic vessels dependent relaxation.

Dr. Ihm SH, the lead author said," (green tea extract) improved endothelial dysfunction and IR, and eventually lowered BP".

Taken together, there is no doubt that green tea processes a significant effect in reduced risk and treatment of hypertension through reduced oxidative stress and improved vascular relaxation as well as decreased metabolic syndrome in exaggerated hypertension.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) The antioxidant effects of green tea reduce blood pressure and sympathoexcitation in an experimental model of hypertension by Garcia ML1, Pontes RB, Nishi EE, Ibuki FK, Oliveira V, Sawaya AC, Carvalho PO, Nogueira FN Franco MD, Campos RR, Oyama LM, Bergamaschi CT.(PubMed)
(2) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)

#Ginger Exerts Anti-#Arteriosclerosis Activity By Inhibiting Pathways Associated with Cholesterol Synthesis and Lipid Accumulation

Kyle J. Norton

Scientists may have found a natural remedy that has the potential to treat chronic mild stress, according to studies.
Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.

Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.

Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.


Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.


There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.

The American Institute of Stress in examining the chronic stress in American adults wrote, "Numerous studies show that job stress is far and away from the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".

According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding natural ingredients or whole food for the treatment of chronic mild stress (CMS), a major contribution to atherosclerosis in the previous study examined the effects of 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale) anti-chronic stress activity.

6-gingerol (6-Gin) has long been found to process numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects, according to epidemiological studies.

CMS ApoE-/- mice used in the study were given a high-fat diet (HFD) to induce the development of atherosclerosis in-fed before administrating 6-Gin.



Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.

CMS before application of a high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.


Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed increased plaque formation, the elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.

However, the injection of 6-Gin not only reduced the expression induced by a high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol, and other isoprenoids, particularly the lipid synthesis in the liver tissues.

These results suggested the role of ginger in alleviating atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.

Dr. Wang S, the lead scientist wrote, "The antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".


Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.

Additionally, CMS also showed an improvement in several aspects of chronic stress on the injection of 6-Gin.

The finding clearly suggested that 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.


Taken altogether, ginger-processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS

#ManukaHoney Eye Drops (Optimel, Melcare, Australia) in the Treatment of #OcularDemodex and #DryEye, Reserachers Say

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of Ocular Demodex and Dry-Eye, according to studies.

Believe it or not, the Demodex in eyelashes that cause the severity of ocular discomfort is quite common in the US. According to US Federal Science, over 70% of Americans suffer from the presence of Demodex without even noticing.

The increase in age, and patients with conjunctival papillary hypertrophy, are some most common Demodex risk factors.

Furthermore, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex.


The finding strongly suggested that Demodex plays a pathogenic role in the ocular discomfort linked with aging.

Dry eye happens mostly in older adults is a condition in which a person doesn't have enough quality tears to clean and nourish the eye, leading to a chronic vision problem.

Dry eye, in most cases, is caused by the inadequate amount of tears due to lower than normal amount of tear production or tears evaporating too quickly from the eyes and poor quality of tears.

People with dry eyes may experience symptoms of irritation, gritty, scratchy or burning eyes; a feeling of something in their eyes; excess watering; and blurred vision.

Honey is a miraculous product made by bees using nectar from flowers.,

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

Researchers with an aim to find a natural source for the treatment of vision problem compared the Manuka honey and tea tree oil against ocular Demodex.

The study included 53 viable Demodex mites acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Then, the viable mites were randomized to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment.

Compared to the results of four treatments, researchers found that the survival probabilities are lowest with 100% tea tree oil, and highest with cyclodextrin-complexed and uncomplexed Manuka Honey.

The finding clearly suggested that the efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex.

In order to reveal more information about honey anti-dry eye effects, researchers evaluated
the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia).

The study included 24 participants aged 20 to 55 years with contact lens-related dry eye randomized to two treatment groups with 20 completing the study.


One group received Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks while the other group completed the treatments in the reverse order.

The Optimal treatment exerted an improvement in Dry eye symptoms significantly and patients with more severe symptoms at baseline showed a greater improvement in symptoms.

Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.

However, due to the short duration of treatment, there were no significant differences observed in the objective signs of a dry eye.

Researchers at the experiment wrote in the final report, "Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use".

Taken together, honey, particularly Tualang honey may be considered a functional remedy for the prevention and treatment of ocular Demodex and dry eye, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocularDemodex viability by Frame K1, Cheung IMY2, Wang MTM2, Turnbull PR1, Watters GA2, Craig JP. (PubMed)
(2) Treatment of contact lens related dry eye with antibacterial honey by Wong D1, Albietz JM1, Tran H1, Du Toit C1, Li AH1, Yun T1, Han J1, Schmid KL. (PubMed)