Kyle J. Norton
Green tea is found to consist of an anti-obesity function, a recent study by a popular institute suggested.
Green tea, considered a functional food, has a number of health benefits and has been reported by several renowned research and studies. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will do the trick.
Obesity is a medical condition of excess body fat accumulated over time. A person is considered obese if excess body weight relative to height is over 30 in the BMI index.
According to the University of the Punjab, Epigallocatechin gallate, a polyphenol found in tea plants exhibited anti obesity effect through modulation of thePPAR[gamma] pathway in metabolism involved fat cells/adipose tissues.
In an animal study, the chemical constituent stopped the adipogenic cell differentiation through different proteins and transcription factors in the expression of adipocyte formation which is considered as fat cell development in contribution to obesity.
Dr. Javaid MS, the lead author in the study said, "Docking analysis of PPAR gamma and epigallocatechin gallate demonstrated that epigallocatechin gallate binds with PPAR gamma at its active site and blocks its activity".
Also, in animals induced by a high-fat diet, green tea Epigallocatechin 3-gallate (EGCG), exerted anti-obesity effects through reduced plasma glucose and alleviated complications of diabetes by attenuating advanced glycation end products (AGEs) formation involved proteins or lipids expression.
Dietary EGCG tested in C57BL/6 mice induced by a high-fat diet with or without ECGC for 17 weeks and compared to a control group placed on a low-fat diet for the same period, also showed a significantly reduced weight gain, plasma glucose, insulin level, liver and kidney weight, which can be seen in obesity in compared control mice.
Importantly, green tea Epigallocatechin 3-gallate (EGCG fed mice ovally decreased the levels of AGEs(advanced glycation end product) in both plasma and liver while inhibiting the receptor for AGE (RAGE) expression of activating Nrf2, antioxidant response, and enhanced anti-oxidative stress ratio of GSH/GSSG.
Other searchers opinionated the effect of green tea in reduced fat/adipose tissue accumulation in obese subjects is a result of the pro-oxidant action of EGCG, in the de-activated cellular production of reactive oxygen species, through the indication of adenosine monophosphate-activated protein kinase in suppressed gene and protein expression of enzymes and transcription factors involved in adipogenesis and lipogenesis(fat and disposed metabolism).
Taken together, green tea with all the phytochemicals may be used as an anti-obesity functional food to help control hyperglycemia, reduce weight, and alleviate diabetes complications.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Epigallocatechin Gallate as an anti-obesity therapeutic compound: an in silico approach for structure-based drug designing by Javaid MS1, Latief N1, Ijaz B1, Ashfaq UA2(PubMed).
(2) Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3(PubMed)
(3) Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity by Suzuki T1, Pervin M2, Goto S3, Isemura M4, Nakamura Y5.(PubMed)
Wednesday, 13 September 2023
#Fennel Shows a Significant Effect on Primary Dysmenorrhea, Scientists Find
Kyle J. Norton
Fennel may have a potential and positive effect in reducing pain through its anti-antispasmodic property, some scientists suggested.
Anti-antispasmodic activity is an action that relieves, prevents, or lowers the incidence of muscle spasms, especially those of adnominal muscle in the uterus and smooth muscle such as in the bowel wall.
Certain hormones that have the function of controlling muscle contraction and relaxation are found to be associated with the intensity of muscle spasms, if overexpressed.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the findings, the natural antispasmodic ingredients with little or no side effects, Dr. Shamkant B. Badgujar, and colleagues launched an investigation to compare doses of 2.5 and 10.0 mL/L of an alcoholic extract with other Germanic medicinal plants, including Melissa officinalis, Rosmarinus officinalis, Mentha piperita, Matricaria chamomilla, Carum carvi, and Citrus aurantium.
The experiment was carried out on guinea pig ileum by using acetylcholine and histamine as spasmogens.
After taking into all account co and confounders, researchers found that application-tested doses of alcoholic extract of the fruits of Foeniculum vulgare exert a significant anti-antispasmodic activity by inhibiting the acetylcholine and histamine-induced guinea pig ileal contractions.
Further analysis of the effects of n essential oil obtained from the fruits of Foeniculum vulgare at the doses of 25 μg/ and 10 μg/mL, researchers discovered that the injections also demonstrated a similar as of the extract but through the inhibition of the hormone oxytocin and prostaglandin activities.
Oxytocin and prostaglandin are hormones with a function that causes contraction of the muscles of the uterus. Overcontraction of the muscles of the uterus is a major cause of abdominal pain in women.
Additionally, the comparison of the antispasmodic property of 4 different herbal medicine that has been used in traditional medicine for the treatment of abdominal pain in Swiss mice, including fennel according to the guidelines of the Organization for Economic Co-operation and Development (OECD) also found that all herbs used in the testing display a substantial reduction of abdominal pain without inducing any adverse effects.
In the experiment carried out in the guinea pig, the application of fennel also showed significant relaxation in different agonists like histamine and acetylcholine-induced contractions in guinea pig ileum.
Interestingly, in the study to investigate whether oral fennel drop has any effects on primary dysmenorrhea, the occurrence of painful menstrual cramps of the uterus, researchers conducted an experiment on sixty college students who suffer from primary dysmenorrhea.
The participants were randomly assigned to two groups and followed up for two cycles. The treatment group was given fennel drop and the control group was given non-steroidal anti-inflammatory drugs (NSAIDs) or oral contraceptive pills.
After assessing the final report, researchers suggested that both groups exert a clinically significant effect in reducing pain. However, the comparison of bleeding severity in the study group before and after the intervention on the first day, second day, third day, fourth day, and fifth day was 0.948, 0.330, 0.508, 0.583, and 0.890, respectively.
Taken together, fennel may be considered a secondary and therapeutical form of treatment in reducing pain caused by overexpression of hormones that control muscle contraction through its antispasmodic activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Spasmolytic effect of traditional herbal formulation on guinea pig ileum by Kumar D1, Ganguly K1, Hegde HV1, Patil PA2, Kholkute SD1(PubMed)
(3) Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug by Bokaie M1, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M(PubMed)
Fennel may have a potential and positive effect in reducing pain through its anti-antispasmodic property, some scientists suggested.
Anti-antispasmodic activity is an action that relieves, prevents, or lowers the incidence of muscle spasms, especially those of adnominal muscle in the uterus and smooth muscle such as in the bowel wall.
Certain hormones that have the function of controlling muscle contraction and relaxation are found to be associated with the intensity of muscle spasms, if overexpressed.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the findings, the natural antispasmodic ingredients with little or no side effects, Dr. Shamkant B. Badgujar, and colleagues launched an investigation to compare doses of 2.5 and 10.0 mL/L of an alcoholic extract with other Germanic medicinal plants, including Melissa officinalis, Rosmarinus officinalis, Mentha piperita, Matricaria chamomilla, Carum carvi, and Citrus aurantium.
The experiment was carried out on guinea pig ileum by using acetylcholine and histamine as spasmogens.
After taking into all account co and confounders, researchers found that application-tested doses of alcoholic extract of the fruits of Foeniculum vulgare exert a significant anti-antispasmodic activity by inhibiting the acetylcholine and histamine-induced guinea pig ileal contractions.
Further analysis of the effects of n essential oil obtained from the fruits of Foeniculum vulgare at the doses of 25 μg/ and 10 μg/mL, researchers discovered that the injections also demonstrated a similar as of the extract but through the inhibition of the hormone oxytocin and prostaglandin activities.
Oxytocin and prostaglandin are hormones with a function that causes contraction of the muscles of the uterus. Overcontraction of the muscles of the uterus is a major cause of abdominal pain in women.
Additionally, the comparison of the antispasmodic property of 4 different herbal medicine that has been used in traditional medicine for the treatment of abdominal pain in Swiss mice, including fennel according to the guidelines of the Organization for Economic Co-operation and Development (OECD) also found that all herbs used in the testing display a substantial reduction of abdominal pain without inducing any adverse effects.
In the experiment carried out in the guinea pig, the application of fennel also showed significant relaxation in different agonists like histamine and acetylcholine-induced contractions in guinea pig ileum.
Interestingly, in the study to investigate whether oral fennel drop has any effects on primary dysmenorrhea, the occurrence of painful menstrual cramps of the uterus, researchers conducted an experiment on sixty college students who suffer from primary dysmenorrhea.
The participants were randomly assigned to two groups and followed up for two cycles. The treatment group was given fennel drop and the control group was given non-steroidal anti-inflammatory drugs (NSAIDs) or oral contraceptive pills.
After assessing the final report, researchers suggested that both groups exert a clinically significant effect in reducing pain. However, the comparison of bleeding severity in the study group before and after the intervention on the first day, second day, third day, fourth day, and fifth day was 0.948, 0.330, 0.508, 0.583, and 0.890, respectively.
Taken together, fennel may be considered a secondary and therapeutical form of treatment in reducing pain caused by overexpression of hormones that control muscle contraction through its antispasmodic activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Spasmolytic effect of traditional herbal formulation on guinea pig ileum by Kumar D1, Ganguly K1, Hegde HV1, Patil PA2, Kholkute SD1(PubMed)
(3) Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug by Bokaie M1, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M(PubMed)
#Freeze-dried Instant #Coffee Promotes Antioxidants and Induces Weight Loss, Researchers Say
Kyle J. Norton
Compared to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.
Coffee, a popular drink may be an excellent beverage for induced weight loss and weight management, a reviewed study by a respectable university revealed.
Coffee, emerging as a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
Weight loss is an intentional reduction of the total body mass, according to the definition stated by medicine, health, or physical fitness experts.
According to the University of Exeter, in the reviewed data from human clinical trials, differentiated 8 eligible trials, green coffee extract (GCE) have moderated or significant effect in reduced weight loss in compared to placebo.
In the rat model, 48t rats were fed with either a control diet with water (C) or a control diet with a coffee solution (CF). At the end of week 4, animals in each dietary group were subdivided into three exercise groups: before exercise (BE), during exercise (DE), and after exercise (AE), The group fed with coffee solution showed a significantly reduced total weight compared diet with water group.
The efficacy of dietary coffee in decreased total weight loss may be attributed to the extract function in stimulating the production of antioxidants in suppressed free radical expression. as well as increasing total cholesterol.
Dr. Choi EY the lead author said, "Freeze-dried instant coffee can promote activities of antioxidant enzymes and induce weight loss but also aggravate the plasma cholesterol profile in rats".
Additionally, in the comparison of the daily consumption of coffee and caffeinated beverages between 494 weight loss maintainers and 2129 individuals from the general population, significantly more cups of coffee are found in the weight loss maintainers than in the general population group.
Other researchers insisted that the efficacy of coffee in induced weight loss, probably due to activities of caffeine and other chemical constituents of coffee, such as chlorogenic acid and quinides.
Collective findings suggested that coffee may have a potentially therapeutic property in weight deduction. However, some reviewed trials were associated with a high risk of bias. poor methodological quality, therefore, more studies are necessary to confirm the promising validity, some researchers suggested.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) The use of green coffee extract as a weight-loss supplement: a systematic review and meta-analysis of randomized clinical trials by Onakpoya I1, Terry R, Ernst E.(PubMed)
(2) Caffeine intake is related to successful weight loss maintenance by Icken D1, Feller S2, Engeli S3, Mayr A4, Müller A1, Hilbert A5, de Zwaan M1.(PubMed)
(3) Freeze-dried instant coffee can promote the activities of antioxidant enzymes and induce weight loss but also aggravate the plasma cholesterol profile in rats by Choi EY1, Park SY, Cho YO.(PubMed)
(4) Coffee, diabetes, and weight control by Greenberg JA1, Boozer CN, Geliebter A.(PubMed)
------------------------------------------------------------------------------------------------------------
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Compared to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.
Coffee, a popular drink may be an excellent beverage for induced weight loss and weight management, a reviewed study by a respectable university revealed.
Coffee, emerging as a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
Weight loss is an intentional reduction of the total body mass, according to the definition stated by medicine, health, or physical fitness experts.
According to the University of Exeter, in the reviewed data from human clinical trials, differentiated 8 eligible trials, green coffee extract (GCE) have moderated or significant effect in reduced weight loss in compared to placebo.
In the rat model, 48t rats were fed with either a control diet with water (C) or a control diet with a coffee solution (CF). At the end of week 4, animals in each dietary group were subdivided into three exercise groups: before exercise (BE), during exercise (DE), and after exercise (AE), The group fed with coffee solution showed a significantly reduced total weight compared diet with water group.
The efficacy of dietary coffee in decreased total weight loss may be attributed to the extract function in stimulating the production of antioxidants in suppressed free radical expression. as well as increasing total cholesterol.
Dr. Choi EY the lead author said, "Freeze-dried instant coffee can promote activities of antioxidant enzymes and induce weight loss but also aggravate the plasma cholesterol profile in rats".
Additionally, in the comparison of the daily consumption of coffee and caffeinated beverages between 494 weight loss maintainers and 2129 individuals from the general population, significantly more cups of coffee are found in the weight loss maintainers than in the general population group.
Other researchers insisted that the efficacy of coffee in induced weight loss, probably due to activities of caffeine and other chemical constituents of coffee, such as chlorogenic acid and quinides.
Collective findings suggested that coffee may have a potentially therapeutic property in weight deduction. However, some reviewed trials were associated with a high risk of bias. poor methodological quality, therefore, more studies are necessary to confirm the promising validity, some researchers suggested.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) The use of green coffee extract as a weight-loss supplement: a systematic review and meta-analysis of randomized clinical trials by Onakpoya I1, Terry R, Ernst E.(PubMed)
(2) Caffeine intake is related to successful weight loss maintenance by Icken D1, Feller S2, Engeli S3, Mayr A4, Müller A1, Hilbert A5, de Zwaan M1.(PubMed)
(3) Freeze-dried instant coffee can promote the activities of antioxidant enzymes and induce weight loss but also aggravate the plasma cholesterol profile in rats by Choi EY1, Park SY, Cho YO.(PubMed)
(4) Coffee, diabetes, and weight control by Greenberg JA1, Boozer CN, Geliebter A.(PubMed)
------------------------------------------------------------------------------------------------------------
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
#GreenTea #Catechin #Extract Reduces the Risk of #ProstateCancer, According to Studies
Kyle J. Norton
Prostate cancer is a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth with the possibility of spreading to distant parts of the body. Most prostate cancers are slow-growing and prostate cancer may be detected during physical (rectum) exams.
Green tea may be used as a functional food in the prevention and treatment of prostate cancer, a renowned institute study suggested
Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.
According to the Fu Jen Catholic University, New Taipei City, catechin nanoemulsion preparation showed the highest inhibition of growth of PC-3 tumor cells, with concentration being 15.4 μg/mL and 8.5 μg/mL
The inhibition of prostate cancer cell line is observed in cell cycle arrest by regulated proteins involved in cell cycle division, namely cyclin A, cyclin B, cyclin-dependent kinase 2, and cyclin-dependent kinase 1 expression, and activated cell apoptosis and survival.
Dr. Tsai YJ, the lead author said, "Catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (BCL-2) expression and increase in cytochrome c expression( in the induction of apoptosis) for activation of caspase-3, caspase-8, and caspase-9 (involved cell death)".
Furthermore, in the recruited 404 PCA cases and 395 controls from the same hospital who completed data on habitual tea consumption, including green, oolong, black, and pu'er tea regular green drinkers have a significantly reduced risk of prostate cancer development.
The review of the inverse relation of tea drinkers and risk of prostate cancer has shown explicitly:
1. A total of 32 cases and 50 controls reported habitual green tea drinking, showing an adjusted OR of 0.60 (95% confidence interval (CI): 0.37, 0.98).
2. A moderate excess risk was observed among the habitual pu'er tea drinkers (OR=1.44, 95% CI: 1.02, 1.91).
3. A significantly lower intake of EGCG was observed among cases (54.4 mg) than the controls (72.5 mg).
Additionally, the differentiation of 7 observational studies and 3 randomized controlled trials was retrieved from Cochrane Library, PubMed, ScienceDirect Online, and hand searching. the database, also reveals an interest correlated incidence of PCa decreases with each 1 cup/day increase of green tea.
According to the study, "higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa".
Collectively, green tea consumption is associated inversely with the risk of PCA but the injection of a large amount of green tea supplement should be taken with care to prevent toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3 by Tsai YJ1, Chen BH1.(PubMed)
(2)Reduced prostate cancer risk with green tea and epigallocatechin 3-gallate intake among Hong Kong Chinese men by Lee PMY1, Ng CF2, Liu ZM3, Ho WM4, Lee MK5, Wang F1, Kan HD6, He YH7, Ng SSM2, Wong SYS1, Tse LA1.(PubMed)
(3) Green tea and the risk of prostate cancer: A systematic review and meta-analysis by Guo Y1, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X.(PubMed)
Prostate cancer is a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth with the possibility of spreading to distant parts of the body. Most prostate cancers are slow-growing and prostate cancer may be detected during physical (rectum) exams.
Green tea may be used as a functional food in the prevention and treatment of prostate cancer, a renowned institute study suggested
Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.
According to the Fu Jen Catholic University, New Taipei City, catechin nanoemulsion preparation showed the highest inhibition of growth of PC-3 tumor cells, with concentration being 15.4 μg/mL and 8.5 μg/mL
The inhibition of prostate cancer cell line is observed in cell cycle arrest by regulated proteins involved in cell cycle division, namely cyclin A, cyclin B, cyclin-dependent kinase 2, and cyclin-dependent kinase 1 expression, and activated cell apoptosis and survival.
Dr. Tsai YJ, the lead author said, "Catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (BCL-2) expression and increase in cytochrome c expression( in the induction of apoptosis) for activation of caspase-3, caspase-8, and caspase-9 (involved cell death)".
Furthermore, in the recruited 404 PCA cases and 395 controls from the same hospital who completed data on habitual tea consumption, including green, oolong, black, and pu'er tea regular green drinkers have a significantly reduced risk of prostate cancer development.
The review of the inverse relation of tea drinkers and risk of prostate cancer has shown explicitly:
1. A total of 32 cases and 50 controls reported habitual green tea drinking, showing an adjusted OR of 0.60 (95% confidence interval (CI): 0.37, 0.98).
2. A moderate excess risk was observed among the habitual pu'er tea drinkers (OR=1.44, 95% CI: 1.02, 1.91).
3. A significantly lower intake of EGCG was observed among cases (54.4 mg) than the controls (72.5 mg).
Additionally, the differentiation of 7 observational studies and 3 randomized controlled trials was retrieved from Cochrane Library, PubMed, ScienceDirect Online, and hand searching. the database, also reveals an interest correlated incidence of PCa decreases with each 1 cup/day increase of green tea.
According to the study, "higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa".
Collectively, green tea consumption is associated inversely with the risk of PCA but the injection of a large amount of green tea supplement should be taken with care to prevent toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3 by Tsai YJ1, Chen BH1.(PubMed)
(2)Reduced prostate cancer risk with green tea and epigallocatechin 3-gallate intake among Hong Kong Chinese men by Lee PMY1, Ng CF2, Liu ZM3, Ho WM4, Lee MK5, Wang F1, Kan HD6, He YH7, Ng SSM2, Wong SYS1, Tse LA1.(PubMed)
(3) Green tea and the risk of prostate cancer: A systematic review and meta-analysis by Guo Y1, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X.(PubMed)
#Healthyfood #Tomato Inhibits Liver Stress Markers Against the Onset of #HepaticSteatosis, Researchers Show
Kyle J. Norton
Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of your liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.
Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication, and/or hepatic disorders.
There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.
People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, and use hepatotoxic medications total parenteral nutrition (TPN) are at an increased risk of hepatic steatosis.
Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.
Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".
And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings continue to outline the early stages of NAFLD development prior to overt liver inflammation and advanced liver disease".
The results strongly suggested the risk of the Western diet on hepatic steatosis developing.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.
The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).
According to the tested assays, before treatment of tomato, the HA group fed a high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.
Tomato treated group showed a significant increase in levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in the NL group, apparently due to higher absorption (63.07 vs. 44.45%).
Furthermore, tomato treated group protected the liver by alleviating oxidative stress through the reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.
Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.
Interestingly, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.
In other words, tomatoes inhibited the onset and progression of hepatic steatosis in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.
Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very-low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".
Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of hepatic steatosis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on the liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins, Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)
Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of your liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.
Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication, and/or hepatic disorders.
There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.
People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, and use hepatotoxic medications total parenteral nutrition (TPN) are at an increased risk of hepatic steatosis.
Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.
Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".
And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings continue to outline the early stages of NAFLD development prior to overt liver inflammation and advanced liver disease".
The results strongly suggested the risk of the Western diet on hepatic steatosis developing.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.
The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).
According to the tested assays, before treatment of tomato, the HA group fed a high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.
Tomato treated group showed a significant increase in levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in the NL group, apparently due to higher absorption (63.07 vs. 44.45%).
Furthermore, tomato treated group protected the liver by alleviating oxidative stress through the reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.
Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.
Interestingly, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.
In other words, tomatoes inhibited the onset and progression of hepatic steatosis in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.
Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very-low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".
Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of hepatic steatosis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on the liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins, Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)
#Herbal #Angelica Protects the Cell DNA integrity, Enhances Cytototicity Against the Omset of #Glioblastoma, Researchers Find
Kyle J. Norton
Cancers are a class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissues and organs through blood and fluid circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originating from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients have survived longer than five years.
If you are male you are at 1.5 higher risk of glioblastoma, compared to your female counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, and a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change in body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
In finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effects".
Taken together, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
Cancers are a class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissues and organs through blood and fluid circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originating from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients have survived longer than five years.
If you are male you are at 1.5 higher risk of glioblastoma, compared to your female counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, and a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change in body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
In finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effects".
Taken together, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
#Bromelain Combined with Cytotoxic Drugs Enhance the Efficacy of Chemo Drug and Reduce Adverse Effects, Researchers Say
Kyle J. Norton
Bromelain may have a strong effect in enhancing the chemodrug effect for the treatment of cancer, according to studies.
Chemo drugs are a group of medications used for the treatment of cancers that have been spread to other healthy tissues and organs or reduce the size of the tumor before removing it by surgery.
Cancer is a class of diseases caused by irregular cell growth in the organ tissues. The originated site where the cancer starts is considered primary cancer.
Most cancers at the advanced stage can induce secondary metastasis, by traveling a distance away from the primary site to infect other healthy tissues and organs.
Conventionally, the use of chemo drugs may be effective in controlling cancer, however, the medicines also have been found to cause significant side effects, including hair loss, easy bruising and bleeding, infection, anemia, and gastrointestinal discomforts such as nausea and vomiting and constipation, leading to reduce the quality of life of patients at the time of treatment.
According to the American Cancer Society, in the US, nearly 14.5 million children and adults with a history of cancer were alive on January 1, 2014.
Believe it or not, prostate (43%), colon and rectum (9%), and melanoma (8%) are the three most common cancers among male cancer survivors, and breast (41%), uterine corpus (8%), and colon and rectum (8%) are the most common among female survivors.
Most cases of cancer can be treated successfully if diagnosed in the early stage. Some cancers such as breast cancer have a 5-year survival rate closed to 100% if diagnosed at the local stage.
As of today, due to unbearable side effects in some cancer patients, the scientific community is urgency to discover plant compounds that can improve the chemo drugs' efficacy accompanied by reducing the adverse effect through dose reduction.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to discover a natural compound that enhances the chemo drug penetration for the treatment of cancer, researchers examined the antitumor properties of bromelain on hydrolyzing glycosidic linkages in faulty glycoprotein associated with cancer.
Injection of bromelain has been found to inhibit the MUC1, a glycoprotein involved in tumor cell invasion, metastasis, and chemo-resistant properties.
Additionally, bromelain enhanced the efficacy of cisplatin and 5-FU in cancer treatment by affecting the barrier function of MUC1.
Furthermore, bromelain protected the integrity and the viability of skin cells against the onset of malignant peritoneal mesothelioma (MPM) induced by the expression of MUC1.
Based on the results, researchers said, "current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Moreover, in malignant peritoneal mesothelioma (MPM), treatment with various concentrations of bromelain after 4 and 72 h showed an adverse effect on the tested cancer cell through its antitumor activity in inducing cell death by apoptosis and autophagy.
Interestingly, the combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) assessed at 72 h showed a significant effect in inducing cytotoxicity compared to the bromelain treatment group.
These results suggested that bromelain may be combined with conventional chemo drugs to enhance the anti-cancer effect and reduce the adverse effect of chemotherapy in cancer patients.
Taken together, bromelain may be considered a supplement for the enhancement of chemotherapy, and reduction of side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Estimated Numbers of Cancer Survivors by State as of January 1, 2014
Bromelain may have a strong effect in enhancing the chemodrug effect for the treatment of cancer, according to studies.
Chemo drugs are a group of medications used for the treatment of cancers that have been spread to other healthy tissues and organs or reduce the size of the tumor before removing it by surgery.
Cancer is a class of diseases caused by irregular cell growth in the organ tissues. The originated site where the cancer starts is considered primary cancer.
Most cancers at the advanced stage can induce secondary metastasis, by traveling a distance away from the primary site to infect other healthy tissues and organs.
Conventionally, the use of chemo drugs may be effective in controlling cancer, however, the medicines also have been found to cause significant side effects, including hair loss, easy bruising and bleeding, infection, anemia, and gastrointestinal discomforts such as nausea and vomiting and constipation, leading to reduce the quality of life of patients at the time of treatment.
According to the American Cancer Society, in the US, nearly 14.5 million children and adults with a history of cancer were alive on January 1, 2014.
Believe it or not, prostate (43%), colon and rectum (9%), and melanoma (8%) are the three most common cancers among male cancer survivors, and breast (41%), uterine corpus (8%), and colon and rectum (8%) are the most common among female survivors.
Most cases of cancer can be treated successfully if diagnosed in the early stage. Some cancers such as breast cancer have a 5-year survival rate closed to 100% if diagnosed at the local stage.
As of today, due to unbearable side effects in some cancer patients, the scientific community is urgency to discover plant compounds that can improve the chemo drugs' efficacy accompanied by reducing the adverse effect through dose reduction.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to discover a natural compound that enhances the chemo drug penetration for the treatment of cancer, researchers examined the antitumor properties of bromelain on hydrolyzing glycosidic linkages in faulty glycoprotein associated with cancer.
Injection of bromelain has been found to inhibit the MUC1, a glycoprotein involved in tumor cell invasion, metastasis, and chemo-resistant properties.
Additionally, bromelain enhanced the efficacy of cisplatin and 5-FU in cancer treatment by affecting the barrier function of MUC1.
Furthermore, bromelain protected the integrity and the viability of skin cells against the onset of malignant peritoneal mesothelioma (MPM) induced by the expression of MUC1.
Based on the results, researchers said, "current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Moreover, in malignant peritoneal mesothelioma (MPM), treatment with various concentrations of bromelain after 4 and 72 h showed an adverse effect on the tested cancer cell through its antitumor activity in inducing cell death by apoptosis and autophagy.
Interestingly, the combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) assessed at 72 h showed a significant effect in inducing cytotoxicity compared to the bromelain treatment group.
These results suggested that bromelain may be combined with conventional chemo drugs to enhance the anti-cancer effect and reduce the adverse effect of chemotherapy in cancer patients.
Taken together, bromelain may be considered a supplement for the enhancement of chemotherapy, and reduction of side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Estimated Numbers of Cancer Survivors by State as of January 1, 2014
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