Saturday, 8 July 2023

The Over Growth of #CandidaAlbicans' Complications, According to Researchers

Kyle J. Norton

Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

In many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

According to the article of Health Line, the causes of the overgrowth of candida include the use of antibiotics in the vagina, pregnancy, and uncontrolled diabetes. weak immune system,....... and lack of sleep.


Some life-threatening and chronic implications of candida overgrowth
1. Toxic shock syndrome(TSS)
Candida overgrowth can cause toxic shock syndrome (TSS)(157), a potentially fatal illness by producing toxins to suppress the immune system(158)(159), leading to infectious cause of high fever, accompanied by confusion, extreme fatigue and weakness, headache, severe diarrhea, sore throat, vomiting, widespread red rash, coma(161), and multiple organ failure(160).

2. Scalded skin syndrome (SSS)
Scalded skin syndrome is defined as a condition of skin infection inducing damage to the skin with marked shedding due to toxins(162) released by candida in suppressing the immune system(162).

Depending on the severity, it can cause bloodstream infection(163) and electrolyte imbalance, involved in regulating myocardial and neurological function(164), fluid balance(165), oxygen delivery, etc., resulting in high morbidity and mortality(166).

Chronic diseases
3. Irritable Bowel Syndrome (IBS)(167)(168)
As the condition worsens, candida takes advantage of a weakened immune system and imbalances in the digestive system, allowing the fungus to overrun the digestive tracts(169), leading to gases that irritate the intestinal and stomach linings(171) and initiating pain(170)(172).

4. Chronic Sinusitis(173)

As candida growth occurs in the sinus cavities(173), it causes fungal serious infections, with symptoms of nasal congestion, facial pain, pressure, congestion, fullness, and reduced or absent sense of smell. Both chronic and acute fungal sinusitis require immediate treatment(174).

5. Fibromyalgia
Fibromyalgia syndrome is a chronic condition that causes intense pain in various places around the body, including muscles, connective tissues, and joints, as well as a host of other symptoms, as a result of the production of mycotoxins by overgrowth candida(175), causing autoimmune diseases(143)(144)(136) by triggering inflammation in the intestinal tract(151).

Fibromyalgia syndrome affects more than 6 million people in the United States.

6. Chronic Fatigue Syndrome

Chronic fatigue syndrome (CFS) is defined as a health condition of persistent fatigue unrelated to exertion, it interferes with the patient's daily activity, causing trouble staying on top of their responsibilities at home and on the job, etc.(176) due to production of mycotoxins by overgrowth candida(177)(178), triggering inflammation(179) in the intestinal tract.

Symptoms of chronic fatigue syndrome include a headache, tender lymph nodes, fatigue, weakness, muscle, joint aches, inability to concentrate,(180) etc.

7. Thrush
Thrush is defined as a condition of infection of the mouth caused by overgrowth of candida fungus(181)(182).

8. Eczema, or Atopic Dermatitis
Eczema is a general term for many types of skin inflammation (dermatitis). The most common form of eczema is atopic dermatitis in some cases caused by an overgrowth of candida(183)(184) as a result of immune suppressive factors(185).



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Non-albicans Candida spp. causing fungemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)
(158)The lesson of the month 2: toxic shock syndrome.
Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2. (PubMed)
(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)

(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)(158)Lesson of the month 2: toxic shock syndrome. Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2. (PubMed)(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)
(160) Toxic Shock Syndrome, C health(161)Group A streptococcal toxic shock syndrome with the extremely aggressive course in the third trimester. Sugiyama T1, Kobayashi T, Nagao K, Hatada T, Wada H, Sagawa N.(PubMed).
(162) Scalded skin syndrome, the University of Maryland medical center(163)Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Kett DH1, Azoulay E, Echeverria PM, Vincent JL; Extended Prevalence of Infection in ICU Study (EPIC II) Group of Investigators. (PubMed)
(164) [Infectious and metabolic nervous system complications of systemic cancer].[Article in Spanish]Ortiz N1.(PubMed)
(165) [Voriconazole compromises renal function in an elderly CDK patient with Candida albicans infection].[Article in Italian] Anastasio P1,.(PubMed)
(166)Endogenous thrombospondin-1 regulates leukocyte rear Marcarelli F, Bilancio G, Mele AA, De Santo NGuitment and activation and accelerates death from systemic candidiasis. Martin-Manso G1, Navarathna DH, Galli S, Soto-Pantoja DR, Kuznetsova SA, Tsokos M, Roberts DD. (PubMed)
(167) [Life-threatening complications of Crohn's disease and ulcerative colitis: a systematic analysis of admissions to an ICU during 18 years]. [Article in German] Huber W1, Herrmann G, Schuster T, Phillip V, Saugel B, Schultheiss C, Hoellthaler J, Gaa J, Hartel M, Schmid RM, Reindl W.(PubMed)
(168)The role of Candida albicans in the pathogenesis of food-intolerant irritable bowel syndrome. Shepherd C.(PubMed)
(169) Yeasts in the gut: from commensals to infectious agents. Schulze J1, Sonnenborn U.(PubMed)
(170) Treatment of abdominal pain in irritable bowel syndrome. Vanuytsel T1, Tack JF, Boeckxstaens GE. (PubMed)
(171) Current gut-directed therapies for irritable bowel syndrome. Chang HY1, Kelly EC, Lembo AJ.(PubMed)
(172) Abdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanisms.Elsenbruch S1.(PubMed)
(173) [Changes of etiology of chronic sinusitis].[Article in Chinese] Deng Q1, Peng P.(PubMed)
(174)Invasive fungal sinusitis of the sphenoid sinus. Lee DH1, Yoon TM1, Lee JK1, Joo YE2, Park KH3, Lim SC1.(PubMed)
(175) Occurrence of killer yeasts in isolates of clinical origin. Robledo-Leal E1, Villarreal-Treviño L, González GM. (PubMed)
(176)Experiences of daily activity in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and their implications for rehabilitation programs. Pemberton S1, Cox DL. (PubMed)
(177) Chronic illness associated with mold and mycotoxins: is Naso-sinus fungal biofilm the culprit? Brewer JH1, Thrasher JD, Hooper D.(PubMed)
(178) Detection of mycotoxins in patients with chronic fatigue syndrome.Brewer JH1, Thrasher JD, Straus DC, Madison RA, Hooper D.(PubMed)
(179) Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression.Taranu I1, Braicu C2, Marin DE3, Pistol GC3, Motiu M3, Balacescu L2, Beridan Neagoe I2, Burlacu R4.(PubMed)
(180)Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome.
Forsyth LM1, Preuss HG, MacDowell AL, Chiazze L Jr, Birkmayer GD, Bellanti JA. (PubMed)
(181) Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Cheng S1, Clancy CJ, Checkley MA, Handfield M, Hillman JD, Progulske-Fox A, Lewin AS, Fidel PL, Nguyen MH. (PubMed)
(182) Is endometrial infection with Candida albicans a cause of recurrent vaginal thrush? Smith JR1, Wells C, Jolly M, Shah P, Savage M, Reginald P, Kitchen VS. (PubMed)
(183) Candida albicans-specific lymphoproliferative and cytokine (IL-4 and IFN-gamma) responses in atopic eczema dermatitis syndrome. Evidence of CD4/CD8 and CD3/CD16+CD56 ratio elevations in vitro. Kosonen J1, Luhtala M, Viander M, Kalimo K, Terho EO, Savolainen J.(PubMed)
(184) Candida albicans mannan- and protein-induced humoral, cellular, and cytokine responses in atopic dermatitis patients. Savolainen J1, Kosonen J, Lintu P, Viander M, Pène J, Kalimo K, Terho EO, Bousquet J.(PubMed)
(185) Guidelines for treatment of atopic eczema (atopic dermatitis) Part II.
Ring J1, Alomar A, Bieber T, Deleuran M, Fink-Wagner A, Gelmetti C, Gieler U, Lipozencic J, Luger T, Oranje AP, Schäfer T, Schwennesen T, Seidenari S, Simon D, Ständer S, Stingl G, Szalai S, Szepietowski JC, Taïeb A, Werfel T, Wollenberg A, Darsow U; European Dermatology Forum; European Academy of Dermatology and Venereology; European Task Force on Atopic Dermatitis; European Federation of Allergy; European Society of Pediatric Dermatology; Global Allergy and Asthma European Network. (PubMed)

#GreenTea's GTE and EGCG, Show a Significant Decrease in Pulmonary Fibrosis by Promoting Antioxidant and Blocking Angiogenesis Activities, Researchers Say

Kyle J. Norton

Green tea may have a potential possibility in the cure of pulmonary fibrosis induced by overexpression of free radicals.
Pulmonary fibrosis (PF) is a chronic and progressive condition of lung disease characterized by reduced numbers and increased stiffness of air sac in the lungs (alveoli), affecting the lung breathing function to provide enough oxygen into the bloodstream

Green tea is a precious drink that processed a number of health benefits known to almost everyone in Asia and the Western world.

In the evaluation of green tea extract efficacy in pulmonary fibrosis caused by direct injury due to overexpression of oxygen free radicals and inflammatory cells and fibroblasts in mice model with injection of Paraquat (0.3 mg/kg) into the right lungs of rats, after 2 weeks, then assigned the tested mice to group treated by green tea extract or nontreatment groups and a control group treated by saline, after assessment, researchers found that
* Nontreatment group exerts a significant expression of pulmonary fibrosis, observed by contents of light microscopic morphometry and hydroxyproline and over the capacity of ROS observed by the lipid peroxidation assay.

Light microscopic morphometry is a valuable technique in the analysis of precancerous lesions at the light and electron microscopic level, in this case, it is pulmonary fibrosis.

Further examination also discovered that nontreatment mice group displays a pronouncedly increased
levels of malondialdehyde (MDA), an indication of overexpression of free radicals in induction of oxidative stress caused by ROS chain reaction and endothelin (ET)-1, and prepro-ET-1 mRNA expression, a strong indication of the endothelium signals of vasoconstriction and local cellular growth and survival of air sac cells in the lungs (alveoli).

Malondialdehyde (MDA) is a marker of oxidative stress

Endothelin 1 (ET-1) is a potent vasoconstrictor

Compared to nontreatment and saline groups, green tea administered 1% GTE mixed with feed group shows a significant decrease in pulmonary fibrosis, along with decreases in MDA, ET-1, and prepro-ET-1 mRNA expression

The results suggested that green tea inhibitory oxidative activity in reduced expression of pulmonary fibrosis through the promoted production of antioxidants and antioxidants from the host to restore the ratio of antioxidant and free radicals and decreased the facilitation of proinflammatory cytokines in precipitated damage and apoptosis of lung cells and fibroblasts.

Dr. Kim HR, the lead author, after taking into account of other confounders said, "GTE inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and ET-1 expression".

Additional study of the neutrophils in the site of infection in initiated host defense and inflammation for pulmonary fibrosis development by the Medical School of Padova, revealed that application of green tea (-)epigallocatechin-3-gallate (EGCG) strongly inhibits neutrophil elastase by repressing the reactive oxygen species activity in the induction of apoptosis of activated neutrophils.

In vitro, administration of EGCG dramatically inhibited chemokine expression, and secondary pro-inflammatory mediators induced by primary pro-inflammatory in activated neutrophil chemotaxis in the migration of neutrophils of the immune system to the site of infection.

Importantly, the injection of green tea EGCG also demonstrated a significant effect by blocking neutrophil-mediated angiogenesis in vivo by the initiated growth of new blood vessels to stimulate and fuel the ongoing lung cell damage and death of the cell in the alveoli.

This differentiation constituted a substantial and protective effect in enhanced resolution in a pulmonary inflammation model and significantly reduced consequent fibrosis.

Dr. Donà M, at the end of the analysis, said, "These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential".


The above analysis of green tea effect in protect the lung against the development of pulmonary fibrosis caused by free radical chain reaction and overproduction of pro-inflammatory factors were supported by the study of "the protective effect of green tea extract (GTE), curcumin, against N-acetyl cysteine (NAC) on experimentally induced pulmonary fibrosis" by Cairo University.

According to the study, the application of curcumin (200 mg/kg b.w), GTE (150 mg/kg b.w), and NAC (490 mg/kg b.w) orally for 14 days with concomitant administration of cyclophosphamide (CP), revealed a strong activity in inhibited oxidative stress and lung myeloperoxidase activity observed in animals of the CP group.

Cyclophosphamide is a chemo drug used to suppress the immune system.

Myeloperoxidase (MPO) is a highly oxidative enzyme.

The treatment group also decreased the levels of N-acetyl-β-d-glucosaminidase, leukotriene C₄, and protein in bronchoalveolar lavage fluid (BALF) in a demonstration of overreaction of immune response in the induction of inflammation through inhibited production of proinflammatory cytokines (growth factor-β, interleukin -1β, and histamine) in initiated lung injury and induced apoptosis of lung cells.

N-acetyl-beta-D-glucosaminidase) in the analysis of kidney disease including nephrotoxicity.

Leukotriene C₄ is a leukotriene produced and secreted by eosinophils on activation.

Bronchoalveolar lavage fluid (BALF) is used to analyze interstitial lung diseases.

Protein abundance levels in BALF is a marker of lung diseases.

Taken together, green tea and its bioactive polyphenols may be considered a functional food for the prevention and treatment of pulmonary fibrosis through reducing oxidative stress and inflammatory effect in elevated risk and progression of the disease.

However, further data collection on studies performed with human consumption of green tea during the course of the disease will be necessary to complete the picture of its potential in ameliorating pulmonary fibrosis possibilities.

Intake of green tea supplements should be taken with exceptional care, as acute liver toxicity was reported in several medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis by Donà M1, Dell'Aica I, Calabrese F, Benelli R, Morini M, Albini A, Garbisa S.(PubMed)
(2) Green tea extract inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and endothelin-l expression by Kim HR1, Park BK, Oh YM, Lee YS, Lee DS, Kim HK, Kim JY, Shim TS, Lee SD(PubMed)
(3) Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine by Hamdy MA1, El-Maraghy SA, Kortam MA(PubMed)

#Antioxidant #Lycopene Shows A Protective Effect on Kidney Tissues, According to Studies

Kyle J. Norton

The kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.

Besides being accompanied by the liver and skin to form a detox system in the body, the kidneys also process significant effects that maintain the body fluid balance, regulate the production of red blood cell and high blood pressure.

Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.

Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.

CKD can cause dangerous levels of fluid, electrolytes, and wastes to build up in the body.

According to statistics, approximately 14 percent of the US general population suffers from CKD. More than 661,000 Americans are living with kidney failure, including 468,000 individuals on dialysis.

People with reduced kidney function do not experience any symptoms until the advanced stage. In other words, kidney disease in the advanced stage can lead to dangerous levels of fluid, electrolytes, and building toxins in the body.

Out of many risk factors associated with CKD, some researchers suggested high blood pressure is one most prevalent factors found in most patients.

In this advanced stage, patients also experience symptoms of gastrointestinal discomfort, weakness,
sleep problems, changes of urination, decreased mental sharpness, muscle twitches and cramps, and swelling of feet and ankles, particularly the persistent itching.


Some researchers suggested high blood pressure is one of the major causes of CKD.

The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"

And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".


Lycopene is a phytochemical found in tomatoes in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potent ingredient for the protection of kidney damage, researchers examined the effect of lycopene on the nephrotoxicity of deltamethrin.

The study included male albino rats that were divided into four groups with10 animals each: group I served as control, which received standard diet; group II received oral administration of deltamethrin (1.28 mg/kg per day) for 30 days; group III received both deltamethrin and lycopene (1 mg/kg per day); group IV received lycopene (1 mg/kg per day).

According to the results of the end of the experiment, the deltamethrin-treated group not only showed significantly increased expression of the pro-inflammatory cytokine, TNF-α but also caused mild necrotic changes of the kidney associated with localized cell death due to interruption of the blood supply.

Renal proximal tubules in the deltamethrin treated group also showed an increased number and irregular shape of mitochondria causing the reduced function of the cell in the kidney to take nutrients from the cell breaks it down and turn it into energy.

Vacuolar degeneration in the epithelial cells, increased number of lysosomes, and loss of apical microvilli associated with the reduced function of kidney cells in the absorptive and secretory function, may lead to the decrease of the detoxed function of the kidney.

Moreover, focal segmental thickening and the duplication of the glomerular basement membrane and podocyte changes are involved in kidney damage. were also found in the deltamethrin treated group.


Based on the findings, researchers said, "Histopathological and ultrastructural study showed some protective effect of lycopene on kidney tissues".

Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats by El-Gerbed MS. (PubMed)
(3) High Blood Pressure & Kidney Disease. What is high blood pressure? the Natural Kidney Foundation. (NIH)

#Greentea's Epigallocatechin-3-gallate (#EGCG) Promotes Anti-Inflammatory, Immune Regulatory, and Antioxidant Activation Against the Risk of Chronic Inflammatory Diseases

Kyle J. Norton

Good news for people with chronic inflammatory diseases, green tea polyphenols (GrTPs) is found to reduce the risk and progression of the diseases through the exhibition of potent antioxidants in regulating vital signaling pathways involved in the production of inflammatory cytokines. a renowned institute study suggested

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger in each drink will attenuate the expression.

Chronic inflammation diseases are medical conditions caused by the overreaction of the immune system in protection against microbial invasion and damage to organs due to injury, affecting the tissue healing process, which can lead to life-long debilitation and loss of tissue function and organ failure.
According to the University of Kentucky Medical Center, green tea phytochemical polyphenols protected our body against inflammation through actions in intercepted the surge of inflammatory markers like cytokines and the production of cyclooxygenase-2 in innated anti-inflammatory cytokines.

In chronic Inflammatory Bowel Disease patients, catechin isolated from green tea enhanced the antioxidant production such as such as glutathione peroxidases (GPO) and glutathione (GSH), in significantly inhibited excessive oxidative stress through direct or indirect in reducing the oxidative damages to the colon.

Dr. Fan FY, the lead author said, "Catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways( involved proinflammation specifically)".

Particularly, the study also specified the impression of antioxidant catechin in stabilizing the structure of the gastrointestinal micro-ecological environment via promoting the proliferation of beneficial intestinal bacteria and regulating the balance of intestinal flora for induction of relief in patients with IBD.

Furthermore, in psoriasis mouse model, BALB/c mice topically treated with IMQ for 6 consecutive days, displayed a significant alleviated psoriasiform dermatitis, improved the skin pathological structure by reduce the expression of epidermal PCNA(Base cells) and promoted the expression of caspase-14 involved in inflammation.


In fact, according to the study, the efficacy of Epigallocatechin-3-gallate (EGCG), for the treatment of
psoriasis-like inflammation is the result of the phytochemical functions in anti-inflammatory, immune regulatory, and antioxidant activation.

Taken together, green tea may be used as a protectively functional food in ameliorating the risk and treatment of chronic inflammatory diseases, but regular large amounts of injections should be avoided to prevent toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author: Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Phytoceuticals: the new 'physic garden' for asthma and chronic obstructive pulmonary disease by Grandhi S1, Donnelly LE, Rogers DF. (PubMed)
(2) Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study by Tabak C1, Arts IC, Smit HA, Heederik D, Kromhout D.(PubMed)
(3) Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats by Onoue S1, Matsui T, Aoki Y, Ishida H, Nukaya H, Kou K, Yamada S.(PubMed)

#Garlic Improves #Fertility by Restoring the #Testosterone-Induced Antioxidant #Enzymes and Decreased #LipidPeroxidation in Males

Kyle J. Norton

Recent studies conducted by some academic institutes suggested that garlic may have the potential in modified the levels of serum testosterone in the blood, depending on over or under-expressions.

The sex hormone testosterone plays an essential role in male reproductive physiology, including the testes, a primary productive organ in the production of spermatozoa and reproductive hormones.

Furthermore, the male steroid hormone also processes a specific function in building bone and muscle mass as well as stimulating sexual desire in both sexes.

In women, testosterone is produced by the ovaries in women in a small amount. The hormone is also produced in small quantities by the adrenal glands in both sexes.

Truly, overexpression of testosterone may cause reduced production of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) by natural antioxidant enzymes and increased presence of free radicals in the body, which can lead to cytotoxicity and weaken the function of the immune system.

In other words, abnormally high levels of testosterone in the blood can alter the balance of the ratio of antioxidants and free radicals in the body, leading to free radicals in the induction of oxidative stress, a primary cause of chronic ailments.

Some researchers suggested that the overproduction of testosterone may associate with an increase in the risk of prostate cancer, caused by oxidative stress effects in the prostate gland.

On the other hand, underexpression of testosterone may induce symptoms of erectile dysfunction, reduced sperm count and sperm quality, decreased libido or sexual activity, infertility, reduced muscle mass...... and increased body fat.

According to the Catholic University of The Sacred Heart, hypogonadism in men also reduced the production of natural antioxidants that also lead to oxidative stress, related to augmented cardiovascular risk(8).

In immune response, low levels of testosterone may increase the immune production of white blood cells that protect the body against infection. However, a prolonged period of low levels of testosterone can also lead to long-term overproduction of white blood cells, a leading cause of autoimmune diseases.

Garlic may be the next generation of natural testosterone reducers or inducers. Garlic increases the production of the hormone when it is low and inhibits excessive testosterone when it is high.

Garlic (Allium sativum) is a species in the onion genus, belongings to the family Amaryllidaceae, native to central Asia.

The herb or food has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure, cholesterol, natural antibiotic, etc.

Dr. Prasad S led the research at the Industrial Toxicology Research Centre, diallyl sulfide (DAS), a constituent of garlic, exerted antioxidant activities against testosterone-induced oxidative stress in male Swiss albino mice, by significantly restoring the testosterone-induced antioxidant enzymes and decreased lipid peroxidation.

The effects of garlic supplementation on protein metabolism also suggested that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high-protein diet.

In the concerns of conventional medicine adriamycin (ADR), a potent cytotoxic drug that causes many adverse effects on different body organs, researchers at the Faculty of Medicine, Zagazig University conducted an experience to evaluate the effect of aged garlic extract (AGE) when it is used combination with adriamycin (ADR).


At the end of the study, the researcher found that aged garlic extract (AGE), a garlic preparation, AGE can be used as an adjuvant therapy to resume male infertility and weak spermatogenesis induced by cytotoxic drugs or other environmental toxins through its cytoprotective and antioxidant properties.

In fact, like all-natural phytochemicals, garlic is both a testosterone booster and testosterone reducer, depending on the levels of testosterone in the body and the amount of garlic intake.

However, the use of garlic extracts and supplements should be taken with care, as overdoses may induce liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis by El-Akabawy G1, El-Sherif NM2.(PubMed)
(2) Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action by Hammami I1, Amara S, Benahmed M, El May MV, Mauduit C.(PubMed)
(3) The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding by Hammami I1, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV.(PubMed)
(4) Modulatory effects of diallyl sulfide against testosterone-induced oxidative stress in Swiss albino mice by Prasad S1, Kalra N, Shukla Y.(PubMed)
(5) Testosterone and oxidative stress: the oxidation handicap hypothesis by Carlos Alonso-Alvarez,1,* Sophie Bertrand,1 Bruno Faivre,2 Olivier Chastel, 3 and Gabriele Sorci1,2(The Royal Society Publicizing)
(6) https://www.stronghealthtips.com/garlic
(7) Effects of testosterone on antioxidant systems in male secondary hypogonadism by Mancini A1, Leone E, Festa R, Grande G, Silvestrini A, de Marinis L, Pontecorvi A, Maira G, Littarru GP, Meucci E(PubMed)
(8) The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats by Nasr AY(PubMed)

#Chafuroside A (CFA) Isolated from #OlongTea Attenuates the #InflammatorySymptoms in Patients with #Asthma/#ChronicObstructivePulmonaryDisease (#COPD)

Kyle J. Norton

Green tea may be considered as a potential pharmacotherapy for asthma and chronic obstructive pulmonary disease (COPD), a renowned institute study suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will resolved the problem.

Chronic obstructive pulmonary disease (COPD) is a condition of lung disease caused by obstruction of air flow in normal breathing.

In a total of 13,651 adults from three Dutch cities examined from 1994 to 1997. observation of dietary intake estimated using a food frequency questionnaire, and flavonoid intake calculated using specific food composition tables, showed a significant effect of flavonoid intake regularly in reduced risk COPD.

According to the returned questionnaire, total catechin, flavonol, and flavone intake was positively associated with FEV1 in air flow of a deep breath and inversely associated with chronic cough and breathlessness, common symptoms of chronic obstructive pulmonary disease (COPD).

More specifically, Dr. Tabak C, the lead author said, "Flavonol and flavone intake was independently associated with chronic cough only"

Furthermore, Chafuroside A (CFA), a water-soluble flavone C-glycoside, isolated from oolong tea, in oral administration exhibited at 0.5mg/kg or higher exhibited a profound effect in attenuated inflammatory symptoms in a dose-dependent manner, in experimental asthma/chronic obstructive pulmonary disease (COPD)-like model.

In fact, Biomarker profiling revealed that the CFA/SAM at 0.1mg CFA/kg equipotent to CFA at 1.0mg/kg testing result also expressed protective activity against antigen-induced airway inflammation.

Taking together, there is no doubt that green tea may be used as a therapeutic and functional food for reduced risk and treatment of chronic obstructive pulmonary disease (COPD) through expression of plant phytochemicals, but large amount intake regularly should be taken with care in prevented toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Author: Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phytoceuticals: the new 'physic garden' for asthma and chronic obstructive pulmonary disease by Grandhi S1, Donnelly LE, Rogers DF. (PubMed)
(2) Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study by Tabak C1, Arts IC, Smit HA, Heederik D, Kromhout D.(PubMed)
(3) Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats by Onoue S1, Matsui T, Aoki Y, Ishida H, Nukaya H, Kou K, Yamada S.(PubMed)

#AloeVera Exerts Protective Effects Against Polycystic Ovarian Syndrome (PCOs) through Several Mechanisms, Researchers Say

Kyle J. Norton

Scientists from some respectable institutes suggested that aloe vera may have a potential and profound effect in reduced symptoms, risk, and treatment of polycystic ovarian syndrome(PCOs).

Polycystic Ovarian Syndrome is a condition characterized by endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for the metabolic disorder(1) resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19), weight gain and obesity(15)(16)(17). The syndrome affects over 5% of the women population or 1 in 20 women[1].


According to studies, women with PCOs after reproductive age, are associated with a continuously increased risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD, and hypertension(21)[1].


Women with PCOs may experience some of the symptoms of irregular, oligomenorrhea or absent menstrual periods, male pattern hair growth, acne, weight gain, obstructive sleep apnea, closure of the upper airway, causing stop breathing while sleeping, difficulty conceiving, anxiety, emotional disturbance, poor quality of life, menstrual cycle disturbances, depression, autonomic dysfunction, problematic eating, and general psychosocial dysfunction.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The herb is most commercially cultivated due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes,...... and elevated of cholesterol, The herb also is one of many popular herbs studied in scientific ways with some conflicting results.

According to the study by Desai BN, Maharjan RH, Nampoothiri LP. 70% of PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

Several classes of pharmacological agents have been used to manage dyslipidemia with serious adverse effects.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharides, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

Application aloe vera in Charles Foster female rats induced PCOs by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days) exerts significant reductions of plasma triglyceride and LDL cholesterol levels and an increase of HDL cholesterol by restoring the ovarian steroid status.

The Aloe vera gel treatment also caused a reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities.

Another study also indicated that Aloe vera gel formulation exerts a protective effect against the PCOS phenotype by altering key steroidogenic activity. These results are attributed to phyto-components in the gel.


Dr.Pérez YY and the research team in the study of the Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice, said, "The polyphenol-rich extract from Aloe vera. decrease significantly both body weight (p < 0.008) and blood glucose levels, calculated using the homeostasis model assessment for insulin resistance (HOMA-IR)".

Also in the confirmation of the above result, the study of Aloe vera leaves on blood glucose levels in type I and type II diabetic rat models, vera leaf pulp extract suggested hypoglycemic activity on IDDM and NIDDM rats, the effect being enhanced for type II diabetes in comparison with glibenclamide.

Taken together, aloe vera can be used as a secondary and therapeutic treatment in ameliorating all aspects of symptoms, progression, and treatment of polycystic ovarian syndrome.

However, further data collection performed with human consumption during the course of the investigation is necessary to complete the picture of Aloe Vera, protective effect against polycystic ovarian syndrome (PCO) possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
[1]. The Holistic Prevention, management and Treatment of Polycystic Ovarian Syndrome: The Symptoms(Revised edition with Citations) by Kyle J. Norton
[2] Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP. (PubMed)
[3] Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
[4]. Drug-induced lupus: an update by Vasoo S.(PubMed)