#Herbal #Andrographis Process Anti-inflammation and Infection Properties By Regulating the Functions of the Innate Immune Response

Kyle J. Norton

Scientists may have found a herbal plant for the treatment of inflammatory diseases with no side effects, according to the studies.
Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, and pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage to the body by activating the protein associated with the production of pro-inflammatory cytokines.

The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.

The immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness, and fever.

Chronic inflammation is a serious condition caused by the immune system's to adapt to the new change due to its inability to kill all the invasions within a set of times.

Some researchers in the observation of the history of immune evolution suggested that the immune system also try to adapt to a new environment such as chronic inflammation if, for whatever reason, it can not fill all invasive pathogens within 3 to weeks, leading to the development of several diseases and conditions, including some cancers and rheumatoid arthritis.

Furthermore, chronic inflammation can also be caused by the autoimmune disorder, which involves your immune system mistakenly attacking healthy tissue, and long-term exposure to irritants, such as industrial chemicals or polluted air.

Dr. Anne M. Minihane, the lead scientist in the study "Low-grade inflammation, diet composition, and health: current research evidence and its translation" wrote, "An unresolved inflammatory response is likely to be involved from the early stages of disease development" and " The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation–health/disease associations".

And. " Such approaches are likely to provide a more discriminating means of quantifying inflammation–health/disease associations, and the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".

The results clearly suggested that adding certain amounts of anti-inflammatory foods into your diet may be the best way to prevent chronic inflammatory diseases.

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

With an aim to reaffirm the traditional use of Andrographis paniculata for the treatment of infection and inflammation, researchers examined the effects of Andrograpanin, one of the diterpene lactones in A. paniculata in vivo and in vitro.

Application of Andrograpanin inhibited the NO and other 3 pro-inflammatory cytokines in a range from 5-90 microM in a dose-dependent manner.

The efficacy of the anti-inflammatory activity of Andrograpanin was associated with the reduction of the expression of iNOS, enzymes in catalyzing the production of NO, and pro-inflammatory cytokines gene (proteins) expression.

Furthermore, the anti-inflammatory effects were contributed by inhibiting the protein (p38) and (mitogen-activated protein kinase (MAPKs)) which are responsive to stress stimuli, p38, and stress response.

Dr. Liu J, after taking into account co and confounders wrote, "Andrograpanin might be useful as a potential anti-inflammatory leading compound for inflammatory drug development".

In an additional analysis of other major compounds isolated from herbal Andrographis, researchers looked into Human β-defensin-2 (hBD-2), an inducible antimicrobial peptide that plays an important role in innate immunity.

As a prediction, according to the PCR and Western blot assays, injection of Andro (1.0-10 µmol/L) exhibits the expression of hBD-2 in a dose-dependent manner.

However, under the expression of SB203580 (an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK)), MG-132 (an inhibitor of nuclear factor κB (NF-κB)), and an NF-κB activator inhibitor, but not by an inhibitor of ERK (PD98059) or by an inhibitor of JNK(SP600125), the effects of hBD-2 mRNA and protein expression in responsive to andro were attenuated.

These results clearly suggested andro exerts its antimicrobial effects by exhibiting the expression of hBD-2 by regulating the functions of the innate immune response against stress and stimuli.

Taken together, herbal Andrographis processed with high levels of bioactive compounds may be considered a functional remedy against inflammation and infection.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(2) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells BY He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD. (PubMed)
(3) Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells by Shao ZJ, Zheng XW, Feng T, Huang J, Chen J, Wu YY, Zhou LM, Tu WW, Li H.(PubMed).
(4) Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory properties in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPK signaling pathways by Liu J, Wang ZT, Ge BX. (PubMed)
(5) Low-grade inflammation, diet composition, and health: current research evidence and its translation by Anne M. Minihane, 1,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)

#CaffeinatedCoffee Protects the Liver Cell Integrity Against the Onset of #LiverDiseases, According to Studies

Kyle J. Norton

Habitual caffeinated coffee intake may have the potential of curing Non-Alcoholic Liver Disease, some scientists found.

Non-alcohol fatty liver disease (NAFLD) is a chronic medical condition of the fatty liver caused by excessive fat deposited (steatosis) in the liver other than over-consumption of alcohol.

The disease is a common liver disorder found in most developed countries, probably due to over-consumption of carbohydrates which are considered a major stimulus for hepatic de novo lipogenesis (DNL), the esterification of plasma-free fatty acids, such as the American diet.

According to a clinical assessment conducted by the joint study led by Global Clinical Research, " Hepatic de novo lipogenesis(DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD"(4).

Compared to lipids that were defined as soluble substances in organic solvents, including the various types of fatty acids, eicosanoids, fatty alcohols, fatty aldehydes, ...... and hydrocarbons, fatty acids from non-lipid sources are men made substances that do not rely on organic solvents, but use other chemicals to separate the lipids from the rest of the food, including buttermilk fat, beef fat (tallow, suet), chicken fat cream pork fat, (lard),... and stick margarine

Dr. Paglialunga S. the lead author suggested as of today, there is no NAFLD-specific therapeutic agent available. However, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease(4).

Some researchers also said a chronic metabolic derangement referred to steatosis are directly associated with patients with obesity and type 2 diabetes(4).

According to the statistic, approximately, 80 million of US adults suffer from Non-alcoholic fatty liver disease (NAFLD) in which 30% to 40% of those patients show no visible signs and symptoms.

However, most patients with Non-Alcoholic Liver Disease may experience signs and symptoms of abdominal swelling, enlarged blood vessels just beneath the skin's surface, spleen, red palms,.... and jaundice as a result of liver advanced scarring (steatohepatitis and cirrhosis).

If you have some of the above symptoms, please see your doctor right way to rule out the possibility.

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significantly reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.

Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, researchers suggested coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.

In fact, the effect of coffee on attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.

Dr. Chen S, the lead researcher suggested said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".

Interestingly, the review of literature published in the database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protecting the liver against complications of fibrosis incidence.

Information collected indicated that coffee and coffee caffeine intake have an enormous demonstration in ameliorated risk and symptoms of Nonalcoholic liver disease, but some researchers suggested that other components may also play an important role in the enhancement of these results.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10. (PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC. (PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)
(4) Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease by Sabina Paglialunga1 and Clayton A. Dehn(PubMed)

#Herbal #Chamomile Improves Insomnia Through its Anxiolytic or Sedative Properties, Researchers Say

Kyle J. Norton

Intake of chamomile may have a strong and positive effect in preventing and treating insomnia, some scientists suggested.

Insomnia is a chronic sleep disorder characterized by difficulty of falling asleep and/or staying asleep. The condition affects most of the population of older adults due to hormones change that is associated with aging.

Most adults have experienced insomnia sometimes in their life. According to statistics, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime and women suffer from insomnia more often than men.

Some researchers suggested that psychiatric and medical conditions, unhealthy sleep habits, and in a healthy diet and lifestyle, particularly in the use of substances, and/or certain biological factors are major causes of insomnia onset.

Some women in certain stages of the menstrual cycle also suffer from this type of sleep disorder, due to the body's inability to cope with the sudden change of hormone production. Needless to say, insomnia is caused by menstrual pain. According to the National Sleep Foundation poll, 33% of women said, their sleep is disturbed during their menstrual cycles.

In Australia, according to statistics produced by Virtual Medical Center, "Almost 90% of Australians suffer from a sleeping disorder, with 30% experiencing a severe sleeping disorder" and "There are over 70 different defined sleep disorders which result in reduced sleep quantity or reduced sleep quality"(4).

Poor sleep quality in patients who suffer from insomnia may induce symptoms of fatigue, irritability, decreased memory and concentration,..... and malaise.

These results truly have a strongly negative impact on quality of life and work life, resulting in decreased productivity and increased absenteeism.

The use of sleep pills to treat insomnia may be effective, however, according to the Additive Center, "The dangerous effects of sleep medications range from seizures to depressed breathing. Some people also experience allergic reactions from sleeping pills that can cause difficulty breathing, chest pain, nausea, and swelling" "Though rare, people who use sleeping pills may even develop parasomnias. Parasomnias are defined as sleep disorders that include behaviors like sleep-walking, sleep-eating, sleep-sex, sleep-driving, and other potentially dangerous sleep-related activities"(5).

Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae.

The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, and relieve excessive gas,..... and bloating in the intestine.

Chamomile is one of the most popular herbs used for sleep disorders in herbal medicine.


According to Dr. Srivastava JK and the research team at the Case Western Reserve University, in the investigation of The dried flowers of chamomile containing many terpenoids and flavonoids that may contribute to its medicinal properties, found that injection in the form of herbal tea consumed more than one million cups per day worldwide may have a significant impact in the treatment of insomnia(1).

In the concerns of chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia, scientists at the University of Michigan conducted an experiment of 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6 months, showed that application of 270 mg of chamomile twice daily or placebo for 28-days exerts modest benefits of daytime functioning and mixed benefits on sleep diary(2).

Dr. Zick SM, the lead author at the end of the evaluation, said, "Chamomile did show a modest advantage on daytime functioning, although these did not reach statistical significance. Effect sizes were generally small to moderate (Cohen's d ≤ 0.20 to < 0.60) with sleep latency, nighttime awakenings, and Fatigue Severity Scale (FSS), having moderate effect sizes in favor of chamomile"(2).


The efficacy of chamomile in the treatment of insomnia may also be attributed to the anxiolytic or sedative properties in the improvement of sleep, according to the study of traditionally endowed with anxiolytic or sedative properties,(3).

However, Dr. Wheatley D suggested, "its slow onset of effect (2-3 weeks) renders it unsuitable for short-term use (i.e. 'jet-lag'), but it does have profound beneficial effects on sleep architecture (augments deep sleep) that may make it particularly suitable for long-term use and for the elderly"(3).

The findings suggested that chamomile may be used as a functional food to improve insomnia due to the procession of anxiolytic or sedative properties.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA. (PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) Chamomile: A herbal medicine of the past with a bright future by Srivastava JK1, Shankar E, Gupta S.(PubMed)
(2) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT. (PubMed)
(3) Medicinal plants for insomnia: a review of their pharmacology, efficacy, and tolerability. by Wheatley D.(PubMed)
(4) Insomnia by Virtual Medical Center

#Vegetables' #Phenethyl-isothiocyanate (PEITC) Inhibits #ChemicalToxins through Its Antioxdant Activities, Researchers Say

Kyle J. Norton

Phenethyl isothiocyanate (PEITC), a natural product formed from gluconasturtiin in cruciferous vegetables may be the next generation of detoxified natural food against benzene, acrolein, and crotonaldehyde in cigarette smokers.
Detoxification is the process of removing toxic or harmful substances from our bodies.

According to statistics, thousands of new chemicals are registered for use in foods, medications, household products, and lawn-care products, these types of environment toxins also add to the risk of chronic illness in long-term exposure.

Particularly, these chemical substances induced by developmental toxins and neurotoxins exposed to pre- or post-natal babies have never been studied.

The EWG | Environmental Working Group in the article of " A BENCHMARK INVESTIGATION OF INDUSTRIAL CHEMICALS, POLLUTANTS AND PESTICIDES IN UMBILICAL CORD BLOOD" published on July 14, 2005, wrote, “an average of 200 industrial chemicals and pollutants in umbilical cord blood from 10 babies born in August and September of 2004 in U.S. hospitals”(4)

And, "Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests".

Some researchers suggested that detoxification also include balancing the levels of antioxidants and free radicals.

Overexpression of ROS species caused by toxins accumulation may precipitate the elevation of oxidative stress and cytotoxicity that can lead to healthy cell's DNA alternation

In other words, increased antioxidant enzymes in the production of host antioxidants such as superoxide dismutase, and superoxide dismutases (SODs),..... that break down the superoxide anion into oxygen and hydrogen peroxide may decrease oxidative stress by restoring the ratio of free radicals and antioxidants in the body.

Other common symptoms of toxin accumulation in the body include chronic fatigue, body odor, insomnia, food or chemical sensitivities and headaches.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok-choy, broccoli etc.

According to the University of Pittsburgh, the phytochemical phenethyl isothiocyanate (PEITC) reduced the level of benzene by 24.6% (P = 0.002), and acrolein by 15.1%, but had no effect on crotonaldehyde, in the study of 82 cigarette smokers.

A randomized phase II clinical trial with a crossover design conducted to evaluate the effect of 2-phenethyl isothiocyanate (PEITC), against toxins in cigarette smokers, suggested that 2-Phenethyl isothiocyanate (PEITC) treated mice show reduced metabolic activation of NNK by 7.7%.
NNK is a tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is associated increased risk of lung cancer.

In support of the detoxified effect of cruciferous vegetables against body toxins, isothiocyanates from cruciferous vegetables showed to promote Nrf2, a protein in regulated the expression of antioxidant proteins in protected cells against oxidative damage, induced production of cytoprotection by detoxification mechanisms, and excretion of both harmful substances and toxic metals.

Furthermore, in Hepa1c1c7 murine hepatoma cells study of the induction of detoxification enzymes by benzyl isothiocyanate (BITC) and its synthetic N-acetyl-L-cysteine (NAC) conjugate (NAC-BITC), Dr. Hwang ES said, "BITC and NAC-BITC inhibited Hepa1c1c7 cell growth in a dose-dependent manner. Cell growth was 4.5~57.2% lower in Hepa1c1c7 cells treated with 0.1~10 μM BITC than in control-treated Hepa1c1c7 cells."


Taking together, there is no doubt that cruciferous vegetables have a strong effect in reducing the accumulation of toxic chemicals in the body, particularly in cigarette smokers.

But a further larger sample size and multiple studies are necessary to confirm its viability.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke by Yuan JM1, Murphy SE2, Stepanov I3, Wang R4, Carmella SG3, Nelson HH5, Hatsukami D3, Hecht SS3.(PubMed)
(2) Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers by Yuan JM1, Stepanov I2, Murphy SE3, Wang R4, Allen S2, Jensen J2, Strayer L2, Adams-Haduch J4, Upadhyaya P2, Le C2, Kurzer MS5, Nelson HH6, Yu MC7, Hatsukami D2, Hecht SS8(PubMed)
(3) Nrf2, a master regulator of detoxification and also an antioxidant, anti-inflammatory, and other cytoprotective mechanisms, is raised by health-promoting factors by Pall ML1, Levine S2. (PubMed)
(4) The EWG | Environmental Working Group in the article " A BENCHMARK INVESTIGATION OF INDUSTRIAL CHEMICALS, POLLUTANTS AND PESTICIDES IN UMBILICAL CORD BLOOD" published on July 14, 2005,

Excessive #Coffee Intake Daily and Regularly Is Associated with The Risk of #BladderCancer, Researchers Say

Kyle J. Norton

Coffee consumption may have a strong association with the potential risk of bladder cancer development, some scientists suggested.

Bladder cancer is a medical condition of cell growth irregularly and disorderly in the bladder. Cancer may spread to distant tissues and organs in the later stage.

Depending on the originated and infected tissue, bladder cancer can be classified into 3 types(4), including
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.

* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation

* Adenocarcinoma
Cancer begins originates in the glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation.

Deepening to the stage, patients with bladder can experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in the lower back and/or abdomen, reduced bladder capacity, difficulty in urination,.... and common symptoms of loss of appetite and weight.

If you experience some of the symptoms above, please check with your doctor right way.

Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, a diet high in fried meats and fat, aging are substantial risk factors in the development of bladder cancer.

According to statistic
* Bladder cancer is the ninth most common cancer in the world.

* Every year over 430,000 new cases are diagnosed in 2012. And

* Men are 4 times more likely to develop bladder cancer compared to women.

Coffee, a popular and social beverage worldwide, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

According to Shandong University, in the review literature published online satisfied the criteria and guidelines to investigate the risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day, and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01

The findings in both case-control and cohort studies showed a positive association between coffee intake and the risk of bladder cancer.

In nonsmokers, according to the pooled dataset comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy, and Spain. risk of bladder cancer did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk of bladder cancer increases substantially.

Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".

Others, in analyzed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
 compared to nondrinkers (RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1. RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more

Taken together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in the exhibited incidence of bladder cancer regardless of numbers of cups intake daily and regularly.

However, Due to the small size of the studies, some researchers suggested that a sample size of a clinical trial with multi-centers involved are necessary to rule out or reconfirm the side effect of coffee intake possibility.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, and Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton

#Herbal #Calendula and Its Extacts Processed Cytotoxic Activity By Inducing Tumor Cell Apoptosis by Blocking Cancer in Facilitated Growth, Invasion, and Metastasis

Kyle J. Norton

Herbal calendula may process a profound and sustainable effect in inhibiting the key step in tumor angiogenesis, some scientists suggested.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells' growth and proliferation.

Cancers are a class of diseases caused by the alternation of DNA that initiates healthy cells to grow disorderly and uncontrollably.

At the later stage, the cancerous cells may travel a distance away from the original site to infect healthy cells of other tissue and organs.

Cancers are the second leading cause of death worldwide besides heart diseases.

According to a statistic from the Canada Government, approximately 1 in 2 Canadians will be diagnosed with cancer during their lifetime, and 1 in 4 will die from the disease.

Most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers account for half of all cancers diagnosed in Canada.

Believe it or not, 1/4 of cancers death are due to lung cancer.

Depending on the type of cancer, people with cancers may experience general and specific symptoms.

The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer. For example, some cancers of the pancreas can release substances that cause blood clots in veins of the legs".
DNA alteration is the major cause of the disease.

Some researchers suggested smoking, radiation, viruses, carcinogens, obesity, hormones, chronic inflammation,.... and physical inactivity are associated with an increased risk of cancers.


Calendula is also known as pot marigold, annual or perennial herbaceous plant of about 12–20 species of the genus Calendula, belongings to the family Asteraceae, native to Southern Europe.

The herb has been used in traditional medicine as a spasmolytic, spasmogenic, and inflammatory agent and to treat abdominal cramps, wound healing, skin diseases, colitis,.... and constipation.

Chemicals Compounds
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin,.... and n-paraffins.

The study of Calendula against the Angiogenesis of most solid tumors suggested that calendula consists of a strong and positive effect in suppressed tumor growth through its anti-infectious endothelial cells proliferation(1).

The application of calendula extract also displayed antiangiogenic activity through a direct inhibitory activity against the key step in tumor angiogenesis(1).

Furthermore, according to Universidad de Granada, the extract exhibited cytotoxic tumor cell activity, induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells, and prolonged the survival days of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).

Caspase 3 is one of a member of caspases that acts as a crucial mediator in programmed cell death (apoptosis).

In lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, calendula officinalis flower extract reduced the lung tumor nodules by 74% with a 43.3% increase in lifespan, probably through the inhibition of key enzymes involved in processes of metastasis(3).

These results suggested that herbal calendula officinalis and its extracts processed cytotoxic activity in the induction of tumor cells apoptosis by blocking cancer in facilitated growth, invasion, and metastasis.

However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of herbal calendula anti-cancer possibilities.


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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)

#Herbal #Alfalfaseed Extract and Alfalfa Process Strong Anti Microbial Activities, Researchers Suggest

Kyle J. Norton

Alfalfa may be a potential antimicrobial agent used for the treatment of infection or infectious-related diseases.
The microorganism, first observed by Anton van Leeuwenhoek in 1675 is a class of microscopic organisms, including a bacterium, virus, or fungus.

Believe it or not, single-celled bacteria, algae, protozoa, or multicellular, such as algae and fungi can survive under all types of extreme environments.

And less than 1% of bacteria, can invade and cause infection and diseases.

Although the discovery of human antibiotics is medicines that kill or slow the growth of bacteria, however, overuses of antibiotics has been found to induce microbial resistance to certain drugs.

Dr. Jose M. Munita, the lead author in the study of " Mechanisms of Antibiotic Resistance" said, "Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide" and " The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice"(4).

Some researchers the concerns of antibiotics' serious side effects in the treatment of diseases suggested that clinicians should eliminate the use of drugs associated with chronic or fatal because multiple therapeutic alternatives exist for virtually every potential infection(5).

Truly, herbal teas have been used popularly as natural alternatives for the treatment of infectious diseases. Dr. Mayram Hacioglu has found 31 herbal teas that may be alone and in combination with antibiotics or antifungals against some standard and clinical isolate's antimicrobial activities(6).

Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.

North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.

According to the Via Orabona 4, Università, chemical compound saponins found in the alfalfa family exhibited antimicrobial activities in a selection of medically important yeasts, Gram-positive and negative bacteria.

Dr. Avato P, the lead author said, "(The antimicrobial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus, and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".

Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, the alfalfa fed group showed a decline in fecal E. coli numbers marginally.

The study also suggested the result of the decline of anti-E. coli number is due to the presence of phytochemical phenolics in alfalfa.

In fact, Karunya University in the investigation of the Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strains showed a positive effect of alfalfa seed extract in inhibition of five
bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depends on the concentration of extract with the maximum inhibition seen in 300µg/ml concentration of extract.

There is no doubt that the intake of alfalfa regularly may be beneficiary in reducing the risk and treatment of microbial infection and diseases. But further human trials are necessary.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech. student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)
(4) Mechanisms of Antibiotic Resistance by Jose M. Munita1,2,4 and Cesar A. Arias(PubMed)
(5) Antibiotic side effects by Cunha BA(PubMed)
(6) Antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study by Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, and Gulten Otuk(PMC)