Tocopherols Suppresses the Onset of Oxidative Stress

By Kyle J. Norton

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.

In other words, oxidative stress is either caused by overexpression of free radical or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress presented in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

Tocopherols are phytochemicals with antioxidative stress activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of osteoporosis, researchers examined the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats.

The study included ACI rats induced mammary carcinogenesis following by the implanted with 9 mg of 17β-estradiol (E2) in silastic tubings and fed with control or 0.3% γ-TmT diet for 1, 3, 7, and 14 days.

According to the results of the analysis, 

* γ-TmT treatment rats showed an increase in the levels of tocopherols and their metabolites in the serum and mammary glands.

* γ-TmT decreased the levels of E2-induced nitrosative and oxidative stress markers, nitrotyrosine, 8-Isoprostane, and 8-oxo-dG in the serum in the hyperplastic mammary tissues by stimulating the expression of the protein (Nrf2) associated with the production of the antioxidant enzyme, including superoxide dismutase, catalase, and glutathione peroxidase in the host.

* More precisely, the inhibition of nitrosative/oxidative stress through induction of antioxidant response is the primary effect of γ-TmT in the early stages of E2-induced mammary hyperplasia.

* More importantly, γ-TmT also exerted cytoprotective activity against estrogen-induced breast cancer, without causing the death of healthy cells.

Taken altogether, tocopherols may be considered a supplement for the treatment of diseases involved in the expression of oxidative stress, including cancers, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats by Das Gupta S1, So JY1, Wall B1, Wahler J1, Smolarek AK1, Sae-Tan S1, Soewono KY1, Yu H1, Lee MJ1, Thomas PE1, Yang CS1,2, Suh N. (PubMed)

Broccoli Eradicates the Risk of Oxidative Stress

By Kyle J. Norton

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In other words, xidative stress is a result of the overexpression of free radicals and reduced levels of antioxidants produced by the host.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Other factors that increase the production of free radicals are cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

Antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donating an electron to or accept an electron from other molecules to exhibit chain and domino's effects.

The most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, including hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radicals.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes antioxidative stress property, researchers examined the effects sulforaphane (SF), antioxidant activity against alcohol-induced hepatic injury.

Male C57BL/6 mice selected to the study were orally administrated with broccoli sprout extract (BSE) containing sulforaphane [7.6, 25.2, and 50.4 mg/kg of body weight (bw)] once a day for 14 days. However, on the 13th day, mice were challenged with alcohol (5 g/kg of bw) every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44 ± 1.24 nmol/mg of protein, p < 0.01) in the liver.

According to the results of the study, the administration of low-, medium-, and high-dose BSE markedly reversed the decrease of antioxidant capacity by increasing the liver antioxidant enzymes.

More precisely, low-, medium-, and high-dose BSE increased the levels of glutathione (GSH) (2.07 ± 0.31 mg/g of protein, p < 0.05; 2.31 ± 0.32 mg/g of protein, p < 0.01; and 2.46 ± 0.21 mg/g of protein, p < 0.01), superoxide dismutase (SOD) (483.20 ± 62.76 units/mg of protein; 500.81 ± 49.82 units/mg of protein, p < 0.05; and 605.00 ± < 64.32 units/mg of protein, p < 0.01), glutathione peroxidase (GSH-Px) (318 ± 60.74 units/mg of protein; 400.67 ± 72.47 units/mg of protein, p < 0.01; and 394.72 ± 62.97 units/mg of protein, p < 0.01), and glutathione S-transferase (GST) (31.84 ± 6.34 units/mg of protein, p < 0.05; 30.34 ± 6.40 units/mg of protein, p < 0.05; and 38.08 ± 7.05 units/mg of protein, p < 0.01) in the liver.

These results were associated with reduced liver stress markers malondialdehyde (MDA) and increased phase 2 enzymes via nuclear erythroid-2-related factor 2 (Nrf2), the antioxidant enzymes enhancer.

Furthermore, the low-, medium-, and high-dose BSE also promoted the levels of the endoplasmic reticulum (ER)-stress-specific proteins in response to stress.

Based on the evidence, researchers said, "These results indicate that BSE protects the liver against alcohol challenge via upregulating antioxidant capacity and downregulating ER stress".

Taken altogether, the consequences of these results suggest that the broccoli process a higher amount of SFN may be considered a remedy for the prevention and treatment of diseases associated oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli Sprout Extract Alleviates Alcohol-Induced Oxidative Stress and Endoplasmic Reticulum Stress in C57BL/6 Mice by Lei P1, Zhao W1, Pang B1, Yang X1, Li BL2,3, Ren M4, Shan YJ. (PubMed)

Tocopherols Kills Liver Cancer Cells in Vitro

By Kyle J. Norton

The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage dose does not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. 

However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.

In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effects of Tocopherols on liver cancer.

According to the analysis of the developed poly(lactide-co-glycolide)/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles to accomplish the simultaneous delivery of an optimized ratio of doxorubicin (DOX) and elacridar (ELC) that targets both LCSCs and liver cancer cells,

* DOX/ELC molar ratio of 1:1 was synergistic in HepG2 cells and HepG2-TS.

* The optimized ratio (NDEs )showed that the combination exhibits significantly increased cytotoxic effects against both HepG2 and HepG2-TS, compared to DOX-loaded nanoparticles (NDs) or ELC-loaded nanoparticles (NEs) in vitro.

* Most importantly, the nanoparticles exhibited better tumor targeting, with NDE showing the strongest antitumor activity with lower systemic toxicity.

After talking about other factors into account, researchers said, "These results suggested that NDE represented a promising combination therapy against liver cancer by targeting both liver cancer cells and CSCs.".

Taken altogether, tocopherols used alone or combined with doxorubicin may be considered adjunct therapies in the treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles by Chen D1,2,3, Pan X4, Xie F5, Lu Y2, Zou H2, Yin C6, Zhang Y7, Gao J. (PubMed)

Angelica Sinensis Inhibits the Abnormally Proliferative Cardiac Fibroblasts

By Kyle J. Norton

The heart formed part of the circulatory system pumps blood through the blood vessels. The blood provided not only nutrients to cell metabolism but also remove waste during the process.

Heart disease is a class of diseases associated with blood vessels and the heart.

According to the statistics, heart disease is the leading cause of death for both men and women. Approximately, over 600,000 Americans die from heart disease each year or 1 in every 4 deaths are from heart disease.

A fibroblast associated with wound healing is a type of biological cell that produces collagen, and the structural framework (stroma) for body tissues.

Cardiac fibroblasts accompanied by myocytes, endothelial cells, and vascular smooth muscle cells are the permanent cellular constituents of the heart.

Cardiac fibroblasts play a critical role in the structure and function of the heart tissues involved in blood circulation to provide nutrients and fluids to the body daily functioning.

Normally, cardiac fibroblasts are activated by the immune system following injury with the function to repair and remodeling tissues of the heart.

Activation of cardiac fibroblasts for heart tissue healing during the post-infarction has been found to involve several processes in the transition to the proliferative phase of infarct healing, including the stimulation of inflammatory reaction, followed by rapid suppression of proinflammatory cytokines and subsequent resolution of the leukocytic infiltrate.

Any disruption of the process may cause forming heart scars and reduce the function of the heart tissue to perform its normal function, leading to many cardiac pathologic conditions, including hypertensive heart disease and aortic stenosis.

On finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of XueFuZhuYu Decoction (XFZYD) on collagen synthesis and proliferation of cardiac fibroblasts and provide academic bases of remedying kinds of heart disease aroused by the proliferation of cardiac fibroblasts.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of the analysis,
* Compared with the control group, 1 g/ml XFZYD(dilution 1:80) and 10 percent serum of rat contained XFZYD could significantly inhibit the collagen synthesis and the proliferation of cardiac fibroblasts.

* Moreover, 1 g/ml XFZYD(dilution 1:80) could significantly affect collagen secretion of cardiac fibroblasts (P < 0.05), up to 17.9%.

In other words, XFZYD protects the heart connective tissue and muscles against the formation of fibroblasts induced by collagen secretion.

Based on the results, researchers suggest, "XFZYD could inhibit both proliferation and collagen secretion of cardiac fibroblasts. It could resist cardiac muscle fibrosis".

Taken altogether, angelica sinensis may be considered a remedy for the protection of the heart against cardiac fibroblasts, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Effects of xuefuzhuyu decoction on collagen synthesis and proliferation of cardiac fibroblasts].[Article in Chinese] by Ding Z1, Gao C, Ji R, Wo X. (PubMed)

Green Peas, the Potential Anticancer Functional Foods

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Exposure to toxic chemicals has been a major cause of cancer initiation.

Believe it or not, the California judge ruled that some coffee sellers were required to brand the beverage with cancer warning labels due to containing acrylamide, a chemical compound in the list of chemicals in the facilitated cause of cancer or reproductive harm.

According to the national cancer institute, acrylamide to be reasonably anticipated to be a human carcinogen, based on studies in laboratory animals given acrylamide in drinking water.

Acrylamide, a chemical substance used primarily to make polyacrylamide and acrylamide copolymers. has been included in that list since 1990.

Acrylamide (AA) is classified as a Group 2A carcinogen according to the International Agency for Research on Cancer, but coffee only contains a small amount of AA.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of malignant tumors, researchers investigated green pea anticancer property.

Pisum sativum (Family: Fabaceae), as known as green pea processed nutritional content of fiber, protein, starch, trace elements, and many phytochemical substances have been found to protect the cell DNA integrity through a number of mechanisms, including
* Antixodant against the onset of oxidative stress in the induction of cell DNA damage.

* Anti-inflammatory against overexpression of pro-inflammatory cytokines to induce cell damage.

* Other health benefits of green peas include antibacterial, antidiabetic, antifungal, anti-inflammatory, anti-hypercholesterolemia,

According to chemical analysis, rich in apigenin, hydroxybenzoic, hydroxycinnamic, luteolin, and quercetin, were contributed to anti-carcinogenesis property.

Taken altogether, green peas may be considered a functional food for the prevention of cancers,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)
Pea, Pisum sativum, and Its Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (Research Gate)

Oleanolic Acid Cures Diarrhea in Vivo

By Kyle J. Norton

Diarrhea is a condition of frequent bowel movements with three loose or liquid each day. A prolonged period of diarrhea may result in dehydration due to fluid loss.

Acute diarrhea, healed on its own is a common problem caused by viruses that may last in a few days. The most common causes of acute diarrhea are rotavirus in children and norovirus in adults.

Persistent diarrhea lasts more than 4 weeks is considered chronic diarrhea.

Chronic diarrhea is a medical condition caused by impaired digestion of fats due to low production of the pancreatic enzymes and impaired absorption of fats due to small intestinal disease, including lactose, sorbitol, and fructose intolerance and irritable bowel syndrome (IBS).

Certain medications such as antibiotics, dietary changes, infected by bacteria or viruses are some of the most common factors associated with an increased risk of diarrhea.

Infections by bacteria such as Salmonella or Escherichia coli are the most common causes of acute diarrhea. Patients with acute diarrhea usually are recovered within a week or 2 with or without medication.

However, patients with some bowel diseases such as irritable bowel syndrome or inflammatory bowel disease also frequently experience chronic conditions, which can not be cured unless the diseases are treated.

In some cases, chronic frequent and severe diarrhea can be a sign of intestinal disease or a functional bowel disorder.

The most common symptoms of diarrhea include loose, watery stools. abdominal pain and gastrointestinal discomforts. In the severe case, patients may also experience symptoms of fever and blood in the stool.

Some researchers suggested that symptoms of diarrhea accompanied by blood in the stool is also a sign of colon cancer.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that improves the digestive functioning, researchers examined the effect of oleanolic acid (OA) on Salmonella typhimurium (S.T), a common cause of acute, self-limiting food-borne diarrhea with severe intestinal inflammation and intestinal barrier damage.

The study included a total of eighty BALB/c mice (4-week-old) that were randomly divided into the control group (no S.T, no OA), the S.T group (S.T only), the S.T + OA group (S.T plus 100 mg kg-1 OA) and the OA group (100 mg kg-1 OA only).

According to the results of the analysis,
* Compared with the S.T group, OA administration significantly reduced clinical symptoms and weight loss, and the severity of diarrhea and intestinal structural damage was significantly alleviated observed by a decrease in the diarrhea index (DI) and jejunal histological damage.

* In the infected jejunum, OA maintained the expression and localization of occludin, claudin-1, and ZO-1 to protect the jejunal barrier.

* OA treatment not only reduced the levels of COX-2 and iNOS but also inhibited the secretion of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α.

* A treatment significantly inhibited IκB phosphorylation and degradation against the intestinal tissues.


* OA also decreased the level of TLR4 associated with inflammatory cytokine and the activation of the MAPK pathway in the production of anti-inflammatory cytokines.

Collectively, researchers said, "OA can maintain the intestinal tight junction barrier and prevent diarrhea caused by S.T.".

Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of liver diarrhea, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway by Dong N1, Xue C1, Zhang L1, Zhang T1, Wang C1, Bi C1, Shan A. (PubMed).

Dandelion(Taraxacum officinale) inhibits the Onset of Liver Toxicity in Vivo

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

Liver disease is a class of medical conditions characterized by the reducing partly or completely the function of the liver, including liver failure.

Liver toxicity is a condition caused by the accumulation of toxin in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long term use of certain medicines.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linking to the increased mortality, and extending to those with chronic liver disease.

The most common signs and symptoms of liver toxicity may include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the promotion of liver functioning, scientists examined the hepatic toxic effects of prenatal exposure to lead in rats by adding the dandelion (Taraxacum officinale) to the diet.

Selected female rats induced liver toxicity by lead acetate was administered to half of the rats through drinking water from the 5th day of gestation until the 14th day postpartum accompanied by a normal diet (control) or a diet enriched with dandelion (treated) throughout the study for 14 days.

Control female rats fed with lead acetate showed a lead deposition in the blood and stomach of their pups as well as hepatic tissue damages.

Moreover, female tested rats fed with lead acetate also significant decreases in liver weight and protein content

Additionally, the lead treatment caused an increase in the levels of oxidative stress and stress markers by reducing the activity of antioxidant enzymes.

However, rats co-treated with lead and dandelion showed no damages or biochemical changes in puppies and mothers.

In other words, the dandelion extract inhibited the poisoning activity in the induction of liver oxidative stress and liver toxicity.

Collectively, researchers wrote, "supplementation of pregnant and lactating rats with dandelion protects their offspring against lead poisoning, likely through reduction of oxidative stress and liver damages".

Taken altogether, Dandelion may be considered a remedy for the protection of liver against chemical toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dandelion-enriched diet of mothers alleviates lead-induced damages in liver of newborn rats by Gargouri M1, Magné C2, Ben Amara I3, Ben Saad H4, El Feki A. (PubMed)