Tocopherols Kills Liver Cancer Cells in Vitro

By Kyle J. Norton

The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage dose does not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. 

However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.

In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effects of Tocopherols on liver cancer.

According to the analysis of the developed poly(lactide-co-glycolide)/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles to accomplish the simultaneous delivery of an optimized ratio of doxorubicin (DOX) and elacridar (ELC) that targets both LCSCs and liver cancer cells,

* DOX/ELC molar ratio of 1:1 was synergistic in HepG2 cells and HepG2-TS.

* The optimized ratio (NDEs )showed that the combination exhibits significantly increased cytotoxic effects against both HepG2 and HepG2-TS, compared to DOX-loaded nanoparticles (NDs) or ELC-loaded nanoparticles (NEs) in vitro.

* Most importantly, the nanoparticles exhibited better tumor targeting, with NDE showing the strongest antitumor activity with lower systemic toxicity.

After talking about other factors into account, researchers said, "These results suggested that NDE represented a promising combination therapy against liver cancer by targeting both liver cancer cells and CSCs.".

Taken altogether, tocopherols used alone or combined with doxorubicin may be considered adjunct therapies in the treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles by Chen D1,2,3, Pan X4, Xie F5, Lu Y2, Zou H2, Yin C6, Zhang Y7, Gao J. (PubMed)

Angelica Sinensis Inhibits the Abnormally Proliferative Cardiac Fibroblasts

By Kyle J. Norton

The heart formed part of the circulatory system pumps blood through the blood vessels. The blood provided not only nutrients to cell metabolism but also remove waste during the process.

Heart disease is a class of diseases associated with blood vessels and the heart.

According to the statistics, heart disease is the leading cause of death for both men and women. Approximately, over 600,000 Americans die from heart disease each year or 1 in every 4 deaths are from heart disease.

A fibroblast associated with wound healing is a type of biological cell that produces collagen, and the structural framework (stroma) for body tissues.

Cardiac fibroblasts accompanied by myocytes, endothelial cells, and vascular smooth muscle cells are the permanent cellular constituents of the heart.

Cardiac fibroblasts play a critical role in the structure and function of the heart tissues involved in blood circulation to provide nutrients and fluids to the body daily functioning.

Normally, cardiac fibroblasts are activated by the immune system following injury with the function to repair and remodeling tissues of the heart.

Activation of cardiac fibroblasts for heart tissue healing during the post-infarction has been found to involve several processes in the transition to the proliferative phase of infarct healing, including the stimulation of inflammatory reaction, followed by rapid suppression of proinflammatory cytokines and subsequent resolution of the leukocytic infiltrate.

Any disruption of the process may cause forming heart scars and reduce the function of the heart tissue to perform its normal function, leading to many cardiac pathologic conditions, including hypertensive heart disease and aortic stenosis.

On finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of XueFuZhuYu Decoction (XFZYD) on collagen synthesis and proliferation of cardiac fibroblasts and provide academic bases of remedying kinds of heart disease aroused by the proliferation of cardiac fibroblasts.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of the analysis,
* Compared with the control group, 1 g/ml XFZYD(dilution 1:80) and 10 percent serum of rat contained XFZYD could significantly inhibit the collagen synthesis and the proliferation of cardiac fibroblasts.

* Moreover, 1 g/ml XFZYD(dilution 1:80) could significantly affect collagen secretion of cardiac fibroblasts (P < 0.05), up to 17.9%.

In other words, XFZYD protects the heart connective tissue and muscles against the formation of fibroblasts induced by collagen secretion.

Based on the results, researchers suggest, "XFZYD could inhibit both proliferation and collagen secretion of cardiac fibroblasts. It could resist cardiac muscle fibrosis".

Taken altogether, angelica sinensis may be considered a remedy for the protection of the heart against cardiac fibroblasts, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Effects of xuefuzhuyu decoction on collagen synthesis and proliferation of cardiac fibroblasts].[Article in Chinese] by Ding Z1, Gao C, Ji R, Wo X. (PubMed)

Green Peas, the Potential Anticancer Functional Foods

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Exposure to toxic chemicals has been a major cause of cancer initiation.

Believe it or not, the California judge ruled that some coffee sellers were required to brand the beverage with cancer warning labels due to containing acrylamide, a chemical compound in the list of chemicals in the facilitated cause of cancer or reproductive harm.

According to the national cancer institute, acrylamide to be reasonably anticipated to be a human carcinogen, based on studies in laboratory animals given acrylamide in drinking water.

Acrylamide, a chemical substance used primarily to make polyacrylamide and acrylamide copolymers. has been included in that list since 1990.

Acrylamide (AA) is classified as a Group 2A carcinogen according to the International Agency for Research on Cancer, but coffee only contains a small amount of AA.

Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalaya Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.

On finding a potent ingredient for the treatment of malignant tumors, researchers investigated green pea anticancer property.

Pisum sativum (Family: Fabaceae), as known as green pea processed nutritional content of fiber, protein, starch, trace elements, and many phytochemical substances have been found to protect the cell DNA integrity through a number of mechanisms, including
* Antixodant against the onset of oxidative stress in the induction of cell DNA damage.

* Anti-inflammatory against overexpression of pro-inflammatory cytokines to induce cell damage.

* Other health benefits of green peas include antibacterial, antidiabetic, antifungal, anti-inflammatory, anti-hypercholesterolemia,

According to chemical analysis, rich in apigenin, hydroxybenzoic, hydroxycinnamic, luteolin, and quercetin, were contributed to anti-carcinogenesis property.

Taken altogether, green peas may be considered a functional food for the prevention of cancers,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)
Pea, Pisum sativum, and Its Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (Research Gate)

Oleanolic Acid Cures Diarrhea in Vivo

By Kyle J. Norton

Diarrhea is a condition of frequent bowel movements with three loose or liquid each day. A prolonged period of diarrhea may result in dehydration due to fluid loss.

Acute diarrhea, healed on its own is a common problem caused by viruses that may last in a few days. The most common causes of acute diarrhea are rotavirus in children and norovirus in adults.

Persistent diarrhea lasts more than 4 weeks is considered chronic diarrhea.

Chronic diarrhea is a medical condition caused by impaired digestion of fats due to low production of the pancreatic enzymes and impaired absorption of fats due to small intestinal disease, including lactose, sorbitol, and fructose intolerance and irritable bowel syndrome (IBS).

Certain medications such as antibiotics, dietary changes, infected by bacteria or viruses are some of the most common factors associated with an increased risk of diarrhea.

Infections by bacteria such as Salmonella or Escherichia coli are the most common causes of acute diarrhea. Patients with acute diarrhea usually are recovered within a week or 2 with or without medication.

However, patients with some bowel diseases such as irritable bowel syndrome or inflammatory bowel disease also frequently experience chronic conditions, which can not be cured unless the diseases are treated.

In some cases, chronic frequent and severe diarrhea can be a sign of intestinal disease or a functional bowel disorder.

The most common symptoms of diarrhea include loose, watery stools. abdominal pain and gastrointestinal discomforts. In the severe case, patients may also experience symptoms of fever and blood in the stool.

Some researchers suggested that symptoms of diarrhea accompanied by blood in the stool is also a sign of colon cancer.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that improves the digestive functioning, researchers examined the effect of oleanolic acid (OA) on Salmonella typhimurium (S.T), a common cause of acute, self-limiting food-borne diarrhea with severe intestinal inflammation and intestinal barrier damage.

The study included a total of eighty BALB/c mice (4-week-old) that were randomly divided into the control group (no S.T, no OA), the S.T group (S.T only), the S.T + OA group (S.T plus 100 mg kg-1 OA) and the OA group (100 mg kg-1 OA only).

According to the results of the analysis,
* Compared with the S.T group, OA administration significantly reduced clinical symptoms and weight loss, and the severity of diarrhea and intestinal structural damage was significantly alleviated observed by a decrease in the diarrhea index (DI) and jejunal histological damage.

* In the infected jejunum, OA maintained the expression and localization of occludin, claudin-1, and ZO-1 to protect the jejunal barrier.

* OA treatment not only reduced the levels of COX-2 and iNOS but also inhibited the secretion of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α.

* A treatment significantly inhibited IκB phosphorylation and degradation against the intestinal tissues.


* OA also decreased the level of TLR4 associated with inflammatory cytokine and the activation of the MAPK pathway in the production of anti-inflammatory cytokines.

Collectively, researchers said, "OA can maintain the intestinal tight junction barrier and prevent diarrhea caused by S.T.".

Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of liver diarrhea, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway by Dong N1, Xue C1, Zhang L1, Zhang T1, Wang C1, Bi C1, Shan A. (PubMed).

Dandelion(Taraxacum officinale) inhibits the Onset of Liver Toxicity in Vivo

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

Liver disease is a class of medical conditions characterized by the reducing partly or completely the function of the liver, including liver failure.

Liver toxicity is a condition caused by the accumulation of toxin in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long term use of certain medicines.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linking to the increased mortality, and extending to those with chronic liver disease.

The most common signs and symptoms of liver toxicity may include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the promotion of liver functioning, scientists examined the hepatic toxic effects of prenatal exposure to lead in rats by adding the dandelion (Taraxacum officinale) to the diet.

Selected female rats induced liver toxicity by lead acetate was administered to half of the rats through drinking water from the 5th day of gestation until the 14th day postpartum accompanied by a normal diet (control) or a diet enriched with dandelion (treated) throughout the study for 14 days.

Control female rats fed with lead acetate showed a lead deposition in the blood and stomach of their pups as well as hepatic tissue damages.

Moreover, female tested rats fed with lead acetate also significant decreases in liver weight and protein content

Additionally, the lead treatment caused an increase in the levels of oxidative stress and stress markers by reducing the activity of antioxidant enzymes.

However, rats co-treated with lead and dandelion showed no damages or biochemical changes in puppies and mothers.

In other words, the dandelion extract inhibited the poisoning activity in the induction of liver oxidative stress and liver toxicity.

Collectively, researchers wrote, "supplementation of pregnant and lactating rats with dandelion protects their offspring against lead poisoning, likely through reduction of oxidative stress and liver damages".

Taken altogether, Dandelion may be considered a remedy for the protection of liver against chemical toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dandelion-enriched diet of mothers alleviates lead-induced damages in liver of newborn rats by Gargouri M1, Magné C2, Ben Amara I3, Ben Saad H4, El Feki A. (PubMed)

Cruciferous Vegetables Reduces the Risk of Ischemic Strokes

By Kyle J. Norton

Stroke is a medical condition caused by reduced blood flow to the brain resulting in cell death due to blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagic, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

Sadly, stroke is one of the most common causes of death worldwide.

In the US, according to statistics, approximately 800,000 people suffer a stroke in which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

There is a general belief that stroke is an accumulation over a long period of the unhealthy diet with red meat and processed meats in the induction of artery-clogging.

Atherosclerosisassociated with hardening of the arteries caused by the buildup of fatty substances in the arteries can lead to stroke. 

In other words, if the blood vessel that feeds the brain is blocked, a stroke occurs.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow and decreased the chance of blood clots.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential remedy for reducing the mortality rate of cardiovascular diseases, researchers examined the therapeutic potential and protective effect of D3T found in cruciferous vegetables for the treatment of ischemic stroke.

The study included selected mice subjected to transient middle cerebral artery occlusion/reperfusion (tMCAO/R) were administered with vehicle or D3T to evaluate the effect of D3T in cerebral brain injury.

Based on the results of the experiment,

* D3T reduced infarct size, decreased brain edema, lessened blood-brain barrier disruption, and ameliorated neurological deficits.

* D3T suppressed microglia (MG) activation induced by stroke and inhibited peripheral inflammatory immune cell infiltration of CNS in the ischemic brain.

* D3T also exerted a protective effect on ischemic stroke against the induction of oxidative stress by mediating the improved expression of antioxidant enzyme Nrf2.

Based on the results, researchers said, "D3T confers protection against ischemic stroke, which is mediated through suppression of MG activation and inhibition of CNS peripheral cell infiltration, and that the protective effect of D3T in ischemic stroke is dependent on the activation of Nrf2".

Taken altogether, cruciferous vegetables may be considered functional remedies for the protection in ischemic strokes, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway by Kuo PC1, Yu IC2, Scofield BA1, Brown DA3, Curfman ET2, Paraiso HC4, Chang FL5, Yen JH. (PubMed)

Moronic acid, The Potential Anti-inflammatory Antioxidant

By Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the insult from the foreign invasion.

In other words, inflammation is a process of the immune system that responds to harmful pathogens.

In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

In some cases, the overproduction of proinflammatory cytokines may damage nearby healthy cells and tissues, causing the formation of scars.

In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.

On finding a potential phytochemical for the treatment of inflammatory diseases, researchers examined the FS-3 fraction, obtained from the dichloromethane extract isolated from B. cuneata, comprised triterpenes β-sitosterol (1), α-amyrin (2), moronic acid (3), and ursolic acid (4) on inflammation.

Comparison to indomethacin (41.5 ± 0.6%) treatment at 0.1 mg/mouse ear, moronic acid displayed the highest inhibitory effect (68.1 ± 1.3%).

In HPLC treated tissues. moronic acid was the most active (73.3 ± 1.1%, indomethacin 33.8 ± 0.8%) in the inhibition of levels of histamine involved in the inflammatory response.

* Moronic acid was the principal anti-inflammatory and antihistaminic compound present in B. cuneata.

Most importantly, moronic acid showed a strong activity on the activation of RAW 264.7 cell stimulated with LPS, at 30 and 15 mg/mL and a significant reduction of ON (36% and 28% respectively) but had no significant effect on TNFα production.

Taken altogether, moronic acid may be considered supplements for the treatment of diseases associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of moronic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory and antihistaminic activity of triterpenoids isolated from Bursera cuneata (Schldl.) Engl by Figueroa-Suárez MZ1, González Christen J2, Cardoso-Taketa AT3, Gutiérrez Villafuerte MDC4, Rodríguez-López V. (PubMed)