Omega -3 Fatty Acids Lowers the Risk of Oral Cancer in Vivo

By Kyle J. Norton


Oral cancer is a medical condition characterized by irregular cell growth in the oral cavity, due to the alternation of cell DNA.

In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.

Early diagnosed oral cancer may have a close to 100% recovery.

According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration the stage of cancer.

According to the Oral Cancer Foundation in the article "Oral Cancer Fact", in the US, approximately, 50000 Americans will be diagnosed with oral pharyngeal cancer this year. It will cause about 10,000 deaths.

Family history, smoking, alcohol drinking, infected by HPV virus, poor hygiene and genetic preposition are some of the risk factors associated with the disease.

Most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting for over 90% of all cases and arises from the squamous cell layer in the lining of the oral cavity and oropharynx.

* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. Cancer can spread deeply into the surrounding tissue.

* Minor salivary gland cancers
The cancer is originated from the salivary gland accounted for less than 1% of all cases.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of chronic diseases, researchers investigated the chemopreventive effects of various dietary n-6 and n-3 fatty acids in a 9,10-dimethyl-1,2-benz[a]-anthracene (DMBA)- and betel quid extract (BQE) -induced hamster oral cancer model.

The selected thirty 6-week-old adult male hamsters included in the study were divided into normal, low, and high dietary n-6 and n-3 fatty acid groups under DMBA + BQE treatment for 16 weeks.

According to the tested analysis,
* The low dietary n-6/n-3 fatty acid group exhibited a significantly lower tumor number, volume, and burden than those of the other groups.

In other words, high levels of n-3 fatty acids compared to low levels of n-6 fatty acids induced a strong inhibition of the initiation and progression of oral cancer cells.

In the right buccal pouch tissue, the low dietary n-6/n-3 fatty acid group had significantly lower nuclear factor-κB associated with pro-inflammatory expression, proliferating cell nuclear antigen, and cyclin D1 expression in cell cycle division.

More precisely, high levels of n-3 fatty acids compared to low levels of n-6 fatty acids inhibited the parameters involved in oral cancer proliferation.

Collectively, researchers concluded, " the lower dietary n-6/n-3 fatty acid ratio exerted chemopreventive effects in the DMBA- and BQE-induced hamster oral cancer model".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Low dietary n-6/n-3 polyunsaturated fatty acid ratio prevents induced oral carcinoma in a hamster pouch model by Lee HC1, Liang A1, Lin YH2, Guo YR1, Huang SY. (PubMed)

Herbal Dandelion(Taraxacum officinale) in the Promotion of Anti-inflammatory Activity

By Kyle J. Norton

The immune system formed part of the body's defense plays a critical role in the protection of the body against infectious organisms.

The immune system executes the defense strategy through a series of the immune response by attacking foreign substances that invade body systems to cause disease.

A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.

Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

Acute inflammation is a natural and systematic immune response to protect our body against the invasion of foreign bacteria and viruses by the initiated production of inflammatory cytokines to the site of infection.

However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby tissues.

These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs functioning, such as liver scars caused by hepatitis virus infection.

Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.

Furthermore, chronic inflammation occurred that lasts for months or years when the immune system response to the site of infection failure to eliminate agents that cause acute inflammation.

An autoimmune disorder that attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.

Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the promotion of immune functioning, scientists examined inflammatory effects and the mechanism of taraxasterol in LPS-stimulated BV2 microglial cells.

According to the tested differentiation of BV2 microglia cells that were treated with taraxasterol 12 h before LPS stimulation, taraxasterol showed an inhibition activity on LPS-induced TNF-α and IL-1β production of pro-inflammatory cytokines.

The western blot analysis suggested that taraxasterol also demonstrated an inhibitory effect in the activation of proteins associated with the initiation of the innate immune response induced by the LPS stimulation.

More precisely, taraxasterol dose-dependently inhibited LPS-induced TNF-α and IL-1β production and NF-κB activation.

Furthermore, the injection of taraxasterol also disrupted the formation of lipid rafts, the subdomains of the plasma membrane that contain high concentrations of cholesterol and glycosphingolipids, and inhibited the translocation of TLR4associated with activation of pro-inflammatory cytokines in the lipid rafts.

Moreover, taraxasterol was found to activate the signaling pathway involved in cholesterol efflux from cells.

Collectively, researchers said, " the anti-inflammatory effect of taraxasterol was attenuated by transfection with LXRα siRNA. In conclusion, these results suggested that taraxasterol inhibits LPS-induced inflammatory response in BV2 microglia cells by activating the LXRα-ABCA1 signaling pathway".

Taken altogether, Dandelion may be considered a remedy for modulation of the immune response, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol Inhibits LPS-Induced Inflammatory Response in BV2 Microglia Cells by Activating LXRα by Liu B1, He Z2, Wang J2, Xin Z3, Wang J2, Li F3, Fu Y. (PubMed)

Herbal Angelica Protects The Stomach Cells Against the Onset of Gastric Cancer

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract. The pyloric sphincter is a muscular valve that opens to allow food to pass from the stomach to the small intestine.

The stomach secretes acid and enzymes to digest food.  The stomach muscles contract periodically, churning food to aid digestion.

Gastric/Stomach cancer is a chronic condition characterized by irregular cell growth in the tissues of the stomach. Adenocarcinoma is the most common type of gastric cancer.

Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.

More precisely, common site metastasises from primary gastric cancer is the secondary liver (48%), peritoneum (32%), lung (15%), and bone (12%).

Most cases of gastric cancer start in the cells on the surface of the inner lining of stomach tissue.
Due to the small size at the early stage, gastric cancer is asymptomatic.

However, at the later stage, after penetrating into the deeper layers of the stomach, the cancer cell may travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

At this stage, most patients with gastric cancer may experience symptoms of severe abdominal pain caused by the suppressing of the oversize tumor on the nerve cells, or vague discomfort in the abdomen, usually above the navel, particularly heartburn and indigestion, accompanied by general symptoms shared with other types of cancer.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

In Canada, Gastric cancer affects 2.1% of male cancer patients and 1.3% of female cancer patients.

The most common causative risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis,.

On finding a natural ingredient for the prevention and treatment of digestive diseases, scientists examined the effects of danggui (Chinese angelica) isolated compound N-butylidenephthalide (BP) on gastric cancer.

Angelica or danggui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to results that angelica used for the treatment in patients with gastric cancer, using data from Taiwan's National Health Insurance Research Database (NHIRD),
* Danggui users showed an increased survival rate, compared with non-danggui users.

* Treatment of danggui are highly associated with decreased mortality.

* Furthermore, in vitro results BP inhibited gastric cancer cell proliferation, and induced cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.

* Moreover, BP caused an increase of REDD1 expression associated with the regulation of cell damage that inhibits mTOR signaling involved in tumor formation and angiogenesis.

Additionally, BP also suppressed the growth of AGS xenografts tumor in vivo.

Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BPDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells. BP inhibited the in vivo growth of AGS xenograft tumors".

Taken altogether, Danggui processed abundantly bioactive compound N-butylidenephthalide (BP)  may be considered an herbal medicine for the treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)

Healthy Veggie Broccoli Inhibits the Onset of Stomach Cancer in Vitro

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Gastric/Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric/stomach cancer.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

The causes of gastric cancer are debatable, but some researchers suggested that people with chronic
gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease(4).

Other diseases associated with the early onset of gastric cancer are obesity and smoking(4).

According to the Universidad de Salamanca, bacteria and viruses, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development(5).

Most patients with stomach cancer in the early stage are asymptomatic.

However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On findings a natural wholefood for the prevention of chronic disease, researchers examined the inhibitory effect of SFN, a bioactive compound found in broccoli on gastric cancer.

According to the results of differentiation, SFN treatment significantly decreases the tumorsphere formation and the expression levels of gastric cancer stem cells (CSCs) markers.

Furthermore, SFN exerted inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs.

Moreover, Intriguingly, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs.

Based on the results, researchers wrote, "Collectively, these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of the Sonic Hh pathway, which might be a promising agent for gastric cancer intervention".

Taken altogether, broccoli may process anti stomach cancer activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway by Ge M1, Zhang L1, Cao L1, Xie C2, Li X2, Li Y2, Meng Y2, Chen Y2, Wang X2, Chen J2, Zhang Q2, Shao J1, Zhong C. (PubMed)
(2) Stomach cancer by Mayo Clinic
(3) [Microorganisms and cancer: scientific evidence and new hypotheses].[Article in Spanish] by Velázquez E1, Peix A, Gómez-Alonso A(PubMed)
(4) Stomach cancer statistics (Canadian cancer society)

Antioxidant Moronic Acid, a Natural and Potential Anti-HIV Agents

By Kyle J. Norton

Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).

According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, infected mother to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches and joint pain similar to those of influenza in the early stage of the viral attacks.

People in the early stage infected by the virus may experience some acute symptoms caused by the immune response, including fever sore throat, rash, muscle and joint aches and pains, headache,...

If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, swollen lymph nodes,...

In the late stage, HIV-1 may severely damage the immune system, making the infected host vulnerable to a variety of life-threatening diseases and cancers. If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.

According to the statistic, AIDS is the fifth leading cause of death in the US.

People between ages 25 and 44 in the United States are at substantially higher risk compared to other age groups.

According to statistics, approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.

Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found in extracted from Rhus javanica, Mistletoe, etc.

On finding a potential phytochemical for the prevention of viral infection, researchers compared the anti-HIV activity of seven new triterpene derivatives.

According to the results of differentiation,

* Moronic acid derivatives 19, 20, and 21 showed significant activity in HIV-1 infected H9 lymphocytes.

* Furthermore, in the MT-4 cell line, compounds 19 and 20 showed strong effects against HIV-1 NL4-3 and drug-resistant strains in the MT-4 cell line compared to the betulinic acid analog 8 (PA-457), which has successfully completed a Phase IIa clinical trial.

* Moreover, the compound 20 showed potent anti-HIV activity with EC50 values of 0.0085 microM against NL4-3, 0.021 microM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 microM against FHR-2 (an HIV strain resistant to 8).

Based on the findings, researchers said, "Promising compound 20 has become a new lead for modification, and further development of 20-related compounds as clinical trial candidates is warranted".

Taken altogether, moronic acid may be considered a promising anti-HIV agent,  pending to the confirmation of the larger sample size and multicenter human study.

Intake of moronic acid in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents by Yu D1, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH. (PubMed)

Herbal Ashwagandha Protects the Heart Against Damage in Post Myocardial Injury

By Kyle J. Norton

The circulatory system consists of the heart, blood vessels, and blood with the function to transport of nutrients, oxygen, and hormones to cells throughout the body and removal of metabolic wastes (carbon dioxide, nitrogenous wastes).

Cardiovascular disease is a class of chronic conditions associated with the heart and blood vessels.

According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.

Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease risk for them, according to the Jean Hailes for Women Health in the article cardiovascular health.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.

Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.

The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.

In other words, high blood pressure, high blood cholesterol, smoking, diabetes, weight, depression and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.

The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled

* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.


In the urgency to discover a natural ingredient for the promotion of cardio-functioning, researchers examined the efficacy of Withania somnifera (Ws) to limit myocardial injury after ischemia and reperfusion compared to that of Vit E,

The study included Wistar rats (150-200 g) that were divided into six groups and received orally saline (sham, control group), Ws-50/kg (Ws control and treated group) and Vit E-100 mg/kg (Vit E control and treated group) respectively for 1 month.

According to the results of the experiment of Vit E and Ws treated groups that were anesthetized subjected to 45 min occlusion of the LAD coronary artery followed by 60 min reperfusion on the 31st day,

* Postischemic reperfusion rats showed significant cardiac necrosis, depression of left ventricular functions (MAP, LVEDP, (+) and (-)LVdP/dt) and a significant fall in GSH (p < 0.01), SOD, CAT (p < 0.05).

* Postischemic reperfusion rats also demonstrated a fail in LDH and increased cardio stress markers and levels of  MDA, compared to the sham group. 

* In comparison tested, Ws and Vit E favorably modulated most of the hemodynamic, biochemical and histopathological parameters though no significant restoration in GSH, mean arterial pressure VAP.

* More importantly, chronic administration of Ws on markedly augmented antioxidants (GSH, GSHPx, SOD, CAT) compared to Vit E that does not stimulate the synthesis of endogenous antioxidants compared to sham.

Based on the evidence, researchers said, "Ws significantly reduced myocardial injury and emphasize the beneficial action of Ws as a cardioprotective agent".

Taken altogether, Ashwagandha may be considered supplements for the treatment of myocardial injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment by Gupta SK1, Mohanty I, Talwar KK, Dinda A, Joshi S, Bansal P, Saxena A, Arya DS. (PubMed)

Broccoli Modulates the Immune Response

By Kyle J. Norton

Immunomodulators are agents that modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.

In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending on the body's needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.

The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.

Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in inducing apoptosis and reducing the proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.


Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On findings a natural wholefood for the prevention of infectious disease, researchers examined the effects of Quercetin, a great representative of polyphenols, flavonoids subgroup, flavonols found in broccoli on the immune response.

Quercetin exhibited antioxidant activity in radical scavenging and anti-allergic properties by stimulation of the immune system against the antiviral activity, histamine release,

Furthermore, quercetin also modulated the immune response by decreasing the pro-inflammatory cytokines, leukotrienes creation, and suppressing interleukin IL-4 production.

The antioxidant improved the Th1/Th2 balance, and restrain antigen-specific IgE antibody formation.

Moreover, quercetin was also effective in the inhibition of enzymes such as lipoxygenase, eosinophil, and peroxidase by suppressing inflammatory mediators.

Based on the results, researchers wrote, " All mentioned mechanisms of action contribute to the anti-inflammatory and immunomodulating properties of quercetin that can be effectively utilized in the treatment of late-phase, and late-late-phase bronchial asthma responses, allergic rhinitis, and restricted peanut-induced anaphylactic reactions".

And "Plant extract of quercetin is the main ingredient of many potential anti-allergic drugs, supplements and enriched products".

Taken altogether, broccoli containing high amounts of quercetin may be considered a functional food for the improvement of the immune response,  pending to the confirmation of the larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin and Its Anti-Allergic Immune Response by Mlcek J1, Jurikova T2, Skrovankova S3, Sochor J. (PubMed)