Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Saturday, 17 August 2019

Cranberry Protects the Integrity of Bladder Cells Against Bladder Cancer

By Kyle J. Norton

The bladder formed part of the secretory system is a muscular sac in the pelvis, just above and behind the pubic bone.

The bladder has 2 main functions that store the urine made in the kidneys and control urinary secretion.

Cancer is a group of chronic diseases characterized by cell growth disorderly that starts on the surface of the inner lining tissue of a specific tissue of a gland or organ.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women, Bladder cancer usually starts from the cells on the surface of inner tissue that the lines the bladder.

Bladder cancer depending on the origination of cancer beginning can be classified into

* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder which can change shape and stretch without breaking apart. In other words, cancer in this stage is able to stretch when the bladder is full and shrink when the bladder is emptied.

More than 90 percent of bladder cancers begin in the transitional cells

* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin squamous cells.

* Adenocarcinoma
Cancer originates from the glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.

The exact causes of bladder cancer are unidentified. However, smoking has been associated with a significant factor that causes the onset of the disease.

Dr. Neal D Freedman, the lead scientist wrote, "Previous studies indicate that the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".

And, "Over the last 30 years, incidence rates have remained stable in the United States (men: 123.8/100,000 person-years to 142.2/100,000 person-years; women: 32.5/100,000 person-years to 33.2/100,000 person-years)".

On finding a potential compound for the treatment of bladder cancer, researchers examined the anti-proliferative activities of cranberry derived flavonoids on human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC).

According to the tested analysis,

* Quercetin 3-O-glucoside, isorhamnetin (3'-O-methyl quercetin), myricetin and quercetin found in cranberry showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM compared to others.

* Isorhamnetin and myricetin had very low inhibitory activity against SV-HUC even at very high concentrations (>200 μM) compared to bladder cancer cells.

These results strongly suggested that isorhamnetin and myricetin inhibited bladder cancer cells without causing harm to the nearby healthy cells.

Furthermore, according to the results of SW-780 cells incubated with the aforementioned compounds, hyperoside, a member of 3-O-galactoside of quercetin undergoes relatively less metabolic biotransformation (methylation, glucuronidation and quinone formation) compared to quercetin 3-O-glucoside.

Based on the findings, researchers said, "isorhamnetin and quercetin 3-O-glucoside may be the active forms of quercetin in the prevention of bladder cancer".

Taken altogether, cranberry processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of bladder cancer pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells by Prasain JK1, Rajbhandari R1, Keeton AB2, Piazza GA2, Barnes S. (PubMed)
(2) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)

Friday, 16 August 2019

Turmeric Protects the Liver Against the Risk of Hepatic Steatosis in Obese

By Kyle J. Norton

The liver is the largest internal organ that not only plays an essential role to cleanse the blood coming from the digestive system before passing them to other parts of the body but secrets cholesterol to aid digestive function, produce steroid hormones and vitamin D and build strong cell walls.

Steatosis is a condition caused by abnormal retention of lipids within a cell or organ. Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.

In other words, if the fat of your liver is more than 5% of liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to advanced forms of nonalcoholic fatty liver disease which have been found to induce negatively the function of the liver, particularly. in patients with obesity-associated with alcohol intoxication and/or hepatic disorders.

There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.

People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, using hepatotoxic medications total parenteral nutrition (TPN) are at the increased risk of hepatic steatosis.

Conventionally, there is no effective treatment of liver steatosis. However, treatment of liver steatosis in obese are focusing to reduce weight and symptoms and improve quality of life, totally depending on the severity of the disease.

Usually, weight loss through a combination of a healthy diet and exercise is also the first line of treatment. in patients with an advanced stage of liver fibrosis, (cirrhosis) liver transplantation may be an option.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the prevention of liver steatosis, researchers examined the alleviation effect of KBH-1, an herbal mixture of Saururus chinensis, Curcuma longa and Polygala tenuifolia in obesity-induced hepatic steatosis.

The experiment included HepG2 cells, primary neuronal cells and a high-fat diet (HFD)-induced obesity rat model in vitro and in vivo.

According to the tested assays, KBH-1 not only suppressed the lipid deposition in HepG2 cells exposed to free fatty acids (FFA) but also significantly inhibited major factors in lipogenesis associated with the formation of fat and promoted major factors in lipolysis involved in breaking down of fats.

In high fat-induced obesity model, KBH-1 improved hepatic steatosis by alleviating the effects on lipogenic genes and kinases similarly to those in vitro.

Furthermore, KBH-1 significantly improved the leptin-mediated signals that regulate food intake, energy expenditure, metabolism,.. impaired by obesity or FFA in the obesity model.

Moreover, according to the HPLC analysis, onji-saponin B and curcumin found in the formula has also potently suppressed the level of triglycerides.

In other words, KBH-1 activated the expression of AMP-activated protein kinase (AMPK) associated with the regulation of energy metabolism that stimulates glucose uptake and lipid oxidation to produce energy and suppressed the expression of PPARγ involved in hepatic steatosis... in obesity.

Based on the findings, researchers wrote, "These findings show the potential of KBH-1 as a functional food supplement or preventive agent in the treatment of obesity (.associated with hepatic steatosis)".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hepatic steatosis in obese, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Whole Food Onion Anti-Parasitic, Bacterial and Fungal Activity

By Kyle J. Norton

Microbial infection is a disease caused by microorganisms, including viruses, bacteria, fungi, or parasites.

Most healthy adults can be recovered quickly without using antibiotics.

However, if the immune system or antibiotics used cannot wipe off all the micro invader in a specific time, approximately 3 to 8 weeks, it will lead to the compromise, leading to chronic infection, such as asthma, airway inflammation, pneumonia, and other respiratory diseases.

Viruses are made up of a piece of genetic material, such as DNA or RNA enclosed in a coat of protein. Virtual infection is a result of a viral invasion that use components of invaded cells to multiply, leading to the damages or alternation of the DNA or RNA of the host cells.

Bacterias are single-cell organisms that cause infectious disease by multiplying after finding the specific tissue or organ. Pathogenic bacteria also challenges the immune system for survival.

Fungi are a class of living organism, including yeasts, molds, and mushrooms. fungal infections in most cases start in the lungs or on the skin. The disease has been found mostly in people with a weakened immune system and long-term use of antibiotics.

Parasites are living organisms that live and extract food in a host. Parasites are also completely dependent on the host for survivals, including lice, ringworms, pinworms, and scabies.

Believe it or not, over 70 percent of parasites are not visible to the human eye, such as the malarial parasite, However, some parasites such as worms can reach many meters in length.

According to the statistics provided by the CDC, infectious diseases cause over 15 million visits to physician offices and 3.7 million visits to the emergency department in the US every year.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In Anti-Parasitic activity

On finding a potential compound for the treatment of infectious diseases, researchers examined the anti-parasitic activity of garlic and onion.

According to the tested analysis, the abundance of a number of sulfur secondary metabolites in garlic and one (zwiebelane) in the onion extract killed both types of parasites (On Trypanosoma brucei brucei and Leishmania tarentolae) efficiently.

Futhermore, both extracts also inhibited the Trypanosoma brucei trypanothione reductase irreversibly.

The combinations of garlic and onion with common trypanocidal and leishmanicidal drugs exerted a synergistic effect in 50% of all tested cases.

Moreover, by additional differentiation of the chemical compound in both extracts, researchers found that the efficacy of garlic and onion against the tested parasites may be related to the amount and the profile of sulfur-containing compounds through inhibiting certain materials in the parasitic cells.

In Bacterial and Fungal Activity

Additonally, in the comparison of the antimicrobial activities of onion (Allium cepa), garlic (Allium sativum), mint (Mentha spicata), thyme (Thymus vulgaris), oak (Quercus), aloe vera (Aloe barbadensis Miller), and ginger (Zingiber officinale).

All extracts of these medicinal herbs in 80% methanol, 80% ethanol, 80% acetone, and 100% water demonstrated a significant effect against selected microbial strains, including Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pasteurella multocida, and fungal strains, Aspergillus niger, Aspergillus flavus, Rhizopus solani, and Alternaria alternata.

However, The extracts show better antimicrobial activity against bacterial strains as compared to fungal strains.

Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases caused by parasitic and microbial infection pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
-
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of Phenolic Compounds and Antioxidant and Antimicrobial Activities of Some Common Herbs by Abdul Qadir M1, Shahzadi SK1, Bashir A2, Munir A2, Shahzad S. (PubMed)
(2) Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities by Krstin S1, Sobeh M2, Braun MS3, Wink M. (PubMed)

Healthy Food Onion Reduces the Risk of Head and Neck Cancer

By Kyle J. Norton

Cancer is a class of diseases associated with cells growth disorderly and uncontrollably in the tissue of a specific organ. Over time cancer can become progressively worse and damage other healthy tissues.

Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. Patients with head and neck cancer at the very early stage are asymptomatic due to the very small size of the tumor. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organ, leading to secondary metastasis.

The exact causes of head and neck cancer are not identified. However, researchers found that excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust are prevalent factors associated with an increased risk of head and neck cancer.

Dr. Shu-Chun Chuang in the investigation of the risk of diet on head and neck cancer (HNC) wrote, "An inverse association was observed for higher frequency intake of fruit (4th vs. 1st quartile OR=0.52, 95% CI=0.43–0.62, ptrend<0.01) and vegetables (OR=0.66, 95% CI=0.49–0.90, ptrend=0.01). Intake of red meat (OR=1.40, 95% CI=1.13–1.74, ptrend=0.13) and processed meat (OR=1.37, 95% CI=1.14–1.65, ptrend<0.01) were positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR=0.90, 95% CI=0.84–0.97)". wrote, "

In other words, a diet rich with fruits and vegetable and low red meat intake reduces the risk of HNC, whereas, a diet rich with red meat and processed meat is associated with a higher risk of the disease.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In the urgency to find a potential compound for the treatment of head and neck cancer, researchers investigated the potentially favorable role of garlic and onion within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.

By analyzing the pooled individual-level data from eight case-control studies, including 4590 cases and 7082 controls, researchers found that at the 95% confidence intervals (CIs) for associations between garlic and onion intakes and HNC

* The ORs of 0.95 was associated with participants with no or low garlic use, and 0.74 for high garlic use participants.

* Increasing onion intake OR was 0.91 ( for >1 to ≤3 portions per week) and 0.83 ( for >3 portions per week) compared to <1 portion per week.

* Furthermore, higher onion intake showed a significant inverse association with laryngeal cancer risk (OR = 0.69; 95% CI 0.54-0.88).

In other words, the risk of head and neck cancer are decreased proportionally with the amount intake of onion daily and weekly, particularly in laryngeal cancer.

Based on the finding, researchers wrote, "The results of this pooled-analysis support a possible moderate inverse association between... onion intake and HNC risk".

Taken altogether, onion may be considered a remedy for the prevention and treatment of head and neck cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Relation of allium vegetables intake with head and neck cancers: evidence from the INHANCE consortium by Galeone C1, Turati F1, Zhang ZF2, Guercio V3, Tavani A1, Serraino D4, Brennan P5, Fabianova E6, Lissowska J7, Mates D8, Rudnai P9, Shangina O10, Szeszenia-Dabrowska N11, Vaughan TL12, Kelsey K13, McClean M14, Levi F15, Hayes RB16, Purdue MP17, Bosetti C1, Brenner H18,19, Pelucchi C1, Lee YC20, Hashibe M21, Boffetta P22, La Vecchia C. (PubMed)
(2) Diet and the Risk of Head and Neck Cancer: A Pooled Analysis in the INHANCE Consortium by Shu-Chun Chuang,1,2 Mazda Jenab,2 Julia E. Heck,3 Cristina Bosetti,4 Renato Talamini,5Keitaro Matsuo,6 Xavier Castellsague,7 Silvia Franceschi,2 Rolando Herrero,8Deborah M. Winn,9 Carlo La Vecchia,4,10 Hal Morgenstern,11 Zuo-Feng Zhang,3 Fabio Levi,12Luigino Dal Maso,5 Karl Kelsey,13 Michael D. McClean,14 Thomas Vaughan,15Philip Lazarus,16 Joshua Muscat,16 Heribert Ramroth,17 Chu Chen,15 Stephen M. Schwartz,15Jose Eluf-Neto,18 Richard B. Hayes,19 Mark Purdue,9 Stefania Boccia,20,21 Gabriella Cadoni,22David Zaridze,23 Sergio Koifman,24 Maria Paula Curado,2 Wolfgang Ahrens,25Simone Benhamou,26 Elena Matos,27 Pagona Lagiou,28 Neonilla Szeszenia-Dabrowska,29Andrew F. Olshan,30 Leticia Fernandez,31 Ana Menezes,32 Antonio Agudo,33Alexander W. Daudt,34 Franco Merletti,35 Gary J. Macfarlane,36 Kristina Kjaerheim,37Dana Mates,38 Ivana Holcatova,39 Stimson Schantz,40 Guo-Pei Yu,40 Lorenzo Simonato,41Hermann Brenner,42 Heiko Mueller,42 David I. Conway,43 Peter Thomson,44Eleonora Fabianova,45 Ariana Znaor,46 Peter Rudnai,47 Claire M. Healy,48 Gilles Ferro,2Paul Brennan,2 Paolo Boffetta,49,50 and Mia Hashibe. (PMC)

Bromelain Protects the Joints Against Osteoarthritis

By Kyle J. Norton

Osteoarthritis (OA), a form of arthritis, is a chronic condition found mostly in elderly caused by of wear and tear on a joint.

The University of Porto Medical School in the definition of OA advised that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip and hand joints(3).

The condition affects over 25 million people in the United States.

The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest.

Today management of osteoarthritis (OA) focuses on pain relief and improved physical function and quality of life through pharmacological, nonpharmacological, and surgical treatments.

Most common causes of OA are

* Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints often associated with senescence invertebrates. arising from long term wear and tear, heavy long-term use or specific injuries. The improper repair process of injuring joints can also result in symptoms of osteoarthritis (OA) in old age, according to TCM.

* Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA), such as vitamin D. On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to early onset of osteoarthritis (OA).

* Cartilage
Cartilage is a flexible connective tissue cushioned the ends of bones in the joints that allow the joints to move smoothly. Rough or wears down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone.

The above causes of Osteoarthritis (OA) may also be the result of injury, overuse, and Rheumatoid Arthritis,

In other words, lifelong protection of cartilage and joint damage and injury have an inverse association with the risk of OA.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural resource for the treatment of osteoarthritis, researchers compared the effect of a combination of bromelain, trypsin, and rutin (ERC) to diclofenac.

The study included103 patients with osteoarthritis of the knee randomly received either the combination of bromelain, trypsin and rutin or diclofenac including 52 patients treated with ERC and 51 patients treated with the diclofenac.

According to the tested assay,

* The mean value of the Lequesne's Algofunctional Index (LFI) decreased from 13.0 to 9.4 in the ERC group and from 12.5 to 9.4 in the diclofenac group.

* Non-inferiority of ERC was demonstrated by both primary criteria, LFI (MW = 0.5305; CI-LB = 0.4171) and complaint index (MW = 0.5434; CI-LB = 0.4296).

Where LFI is a measurement of the severity of osteoarthritis.

* ERC also showed the superior improvement of secondary efficacy criteria, compared to diclofenac

* The global judgment of efficacy by physician resulted in at least good ratings for 51.4% of the ERC patients, and for 37.2% of the diclofenac patients.

Futhermore, the majority of patients rate the tolerability in both drug groups as very good or good.

Based on the finding, researchers wrote, " ERC can be considered as an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful episodes of OA of the knee".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton

Thursday, 15 August 2019

Herbal Ashwagandha Arrests Ovarian Cancer in Vitro

By Kyle J. Norton

Cancer is the class of medical diseases characterized by irregular cell growth in the tissue or specific organ in the body due to the alternation of cell DNA.

The ovaries formed part of women reproductive system are the reproductive organs that connect to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary take a turn to release an egg every month in the mid-point of each menstrual cycle.

Furthermore, the ovaries also produce the female hormones estrogen and progesterone.

Ovarian cancer is medical a condition caused by abnormal cells growth of ovarian cells that start on the surface of the inner lining of the ovary. Over time, the oversize tumor can travel a distance away to infect the nearby organ and tissue via the fluid and blood circulation.

Ovarian cancer is one of the fifth most common cancer, accounting for more deaths than any other cancer of the female reproductive system in the US, according to the statistics. The lifetime risk of getting ovarian cancer is a woman is about 1 in 78, comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.

The causes of ovarian cancer are not cleanly defined. However, epidemiologically, family history, BRCA genetic preposition, never being pregnant or giving birth, tall adult height, hormone replacement therapy, smoking, exposure to asbestos are some prevalent factors found in patients with the disease.

Most common symptoms of ovarian cancer are abdominal bloating, pressure in the pelvis or lower back, a frequent or urgent need to urinate and/or constipation, changes in bowel movements and increased abdominal girth accompanied by general symptoms shared by other types of cancer.

The epithelial ovarian tumor is the most common form of ovarian cancer that is arisen from the cell on the surface of the ovary, accounting over 90% of ovarian cancer of all cases, including serious tumor, endometrioid tumor, and mucinous cystadenocarcinoma.

Germ cell ovarian cancer found in the a censer of the egg-producing cells within the ovary and sex cord-stromal ovarian cancer that occur in children and teens as a result of birth defects are 2 other types of ovarian cancer.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potential compound for the treatment of ovarian cancer with no side effects, researchers investigated the effects withaferin A (WFA), a bioactive compound isolated from the plant Withania somnifera, when used alone or in combination with cisplatin (CIS) on chemo-resistance of cancer stem cells (CSCs).

The study included nude mice bearing orthotopic ovarian tumors generated by injecting human ovarian epithelial cancer cell line (A2780), administration of WFA and cisplatin (WFA) alone or in combination, showed a 70 to 80% reduction in tumor growth and complete inhibition of metastasis, compared to untreated controls.

WFA (2 mg/kg) injection resulted in a highly significant elimination of cells expressing CSC markers such as genes associated with cell to cell interaction, growth and differentiation signaling, and cell proliferation.

Furthermore, genes involved in cancer promotion, metastasis, and multidrug resistance and proliferation are also inhibited by the WFA, compared to no effect of mice treated with CIS alone (6 mg/kg).

In other words, CIS alone (6 mg/kg) inhibited CSC without affecting the aforementioned genes. These may explain the recurrence of cancer in patients treated with carboplatin and paclitaxel.

Based on the findings, researchers said, "WFA alone or in combination with CIS eliminates putative CSCs, we conclude that WFA in combination with CIS may present more efficacious therapy for ovarian cancer".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of ovarian cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation of Ashwagandha (Withania somnifera, Dunal) enhances NK cell function in ovarian tumors in the laying hen model of spontaneous ovarian cancer by Barua A1, Bradaric MJ, Bitterman P, Abramowicz JS, Sharma S, Basu S, Lopez H, Bahr JM. (PubMed)
(2) Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells by Kakar SS1, Ratajczak MZ2, Powell KS3, Moghadamfalahi M4, Miller DM2, Batra SK5, Singh SK. (PubMed)

Cranberry Inhibits Neurodegenerative Diseases in Vitro

By Kyle J. Norton

Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neuron due to aging, leading to the problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.

Dementia is a general term of neurodegenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life.

About 5-8% of all people over the age of 65 have some forms of dementia, and this number doubles every five years above that age.

Most common types of dementia are
* Alzheimer's disease
Alzheimer's destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of degeneration of hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.

* Absence of acetylcholine
Absence of acetylcholine is a condition caused by damage of nerves located in front of the brain, that lead to language difficulty, memory loss, concentration problem, and reduced mobile skills due to lacking reaction in muscular activity and refection and anxiety- and depression-like behaviors.

3. Dementia due to long-term alcohol abuse
Most classic form of the condition is the Korsakoff's dementia results in extremely poor short term memory often associated with the memory losses of confabulations due to diminished processing resources and/or an encoding or retrieval deficit.

* Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.

Besides aging, geographical, hereditary and viral and toxicological exposure may also correlate to the development of the diseases on the elderly.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of neurodegenerative diseases, researchers examined the effect of purified cranberry proanthocyanidins (PAC-1A) on neuroblastoma (NB) cell lines.

On SMS-KCNR cells, PAC-1A caused a loss of proton motive force associated with the increase of generation of reactive oxygen species (ROS) that induce cytotoxicity in the tested cell line.

Furthermore, PAC-1A inhibited neuroblastoma (NB) cells proliferation by reducing the expression of the proteins associated with pro-survivals (Bcl-2, MCL-1, Bcl-xL) and increased levels of proteins associated with pro-apoptosis (Bax, Bad, Bid).

Moreover, pathways involved in apoptosis was also increased by the injection of PAC-1A compared to the inhibition of the expression of pathways involved in the promotion of cell cycle division.

More importantly, cyclophosphamide (CP), the chemo drugs used to suppress the immune system function also exhibited by the injection of PAC-1A.

In other words, PAC-1A and CP worked synergistically to increase cytotoxicity and expression of pro-apoptotic markers, reduced cellular antioxidants enzymes (glutathione (GSH) and superoxide dismutase (SOD)) levels.

Additional analysis of the anti-cancer activity of PAC-1A, researchers found that Additional features of PAC-1A also slow down the cancer cell cycle progression and induced cell death via TNF-family death receptor activity.

Based on the findings, researchers said, "PAC-1A has demonstrated the chemotherapeutic potential to treat a broad spectrum of NBs including highly malignant tumors that show resistance to standard chemotherapeutics and apoptotic stimuli".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of neurodegenerative disease, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cells by Singh AP1, Lange TS, Kim KK, Brard L, Horan T, Moore RG, Vorsa N, Singh RK. (PubMed)
(1) Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vacciniummyrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin by Cásedas G1, González-Burgos E2, Smith C3, López V4, Gómez-Serranillos MP. (PubMed)
(2) Most common diseases of 50 plus - Diseases of Central Nervous system - Dementia: The Types by Kyle J. Norton