Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Tuesday, 6 August 2019

Betaxanthins, the Natural Free Radical Scavenger

By Kyle J. Norton

Free radical scavengers are types of antioxidants that inhibit free radicals before they can induce oxidation.

Antioxidants are stable atoms which inhibit oxidation caused by free radicals.

Oxidative stress associated with chronic disease is caused by long-term imbalanced ratio of free radicals and antioxidants. Over time, oxidative stress epidemiologically can cause proteins, lipid, and cellular damage, major causes of heart disease, stroke, and diabetes.

Antioxidants besides produced by the body, they can also come into the body from the dietary sources.

Not all free radicals are bad, in a moderate amount, free radicals are necessary for the body functioning, including the promotion of heart function in blood circulation.

Dr. Anu Rahal and colleagues in the examination of the interplay of oxidative stress, prooxidants, and antioxidants wrote, "Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme systems participating in the in vivo redox homeostasis".

And, "the importance of oxidative stress in the body growth and development as well as proteomic and genomic evidences of its relationship with disease development, incidence of malignancies and autoimmune disorders, increased susceptibility to bacterial, viral, and parasitic diseases, and an interplay with prooxidants and antioxidants for maintaining a sound health, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue".

Most common types of free radical scavengers produced by the human
* Catalases are antioxidants that protect the cell from oxidative damage by decomposed hydrogen peroxide to water and oxygen.

*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.

*Superoxide dismutase (SOD) dissolves superoxide radical into either ordinary molecular oxygen or hydrogen peroxide.

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effects of proline-betaxanthin generated by betalamic acid, the chromophore of betaxanthins.

According to the results of 24 betaxanthin species synthesized by the condensation reaction of purified betalamic acid and amino acids or amines, researchers found that all compound exerted a significant inhibition of free radicals.

γ-aminobutyric acid (GABA)-betaxanthins, compared to Proline-, dopamine-, under large-scale conditions, and their 1,1-diphenyl-2-picrylhydrazyl showed comparatively low activity,

Furthermore, the free radical scavenging activity of dopamine-betaxanthin was similar to that of red pigment betanin and the anthocyanin cyanidin 3-glucoside.

Moreover, proline-betaxanthin demonstrated the highest antioxidant activity compared to those of dopamine-, 1,1-diphenyl-2-picrylhydrazyl, similar to those of flavonoid quercetin.

Taken altogether, betaxanthins may be considered a free radical scavenging antioxidant remedy, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) In vitro synthesis of betaxanthins using recombinant DOPA 4,5-dioxygenase and evaluation of their radical-scavenging activities by Sekiguchi H1, Ozeki Y, Sasaki N. (PubMed)
(2) Oxidative Stress, Prooxidants, and Antioxidants: The Interplay by Anu Rahal, Amit Kumar, Vivek Singh, and Brijesh Yadav. (Research Gate)

Antioxidants Betanin Protect the Digestive Tract Against the Onset of Inflammatory Bowel Disease

By Kyle J. Norton

Inflammatory bowel disease (IBD) is a class of chronic conditions associated with the inflammation of the gastrointestinal tract, including

* Ulcerative colitis is a chronic inflammation and ulcers found in the innermost lining of the colon and rectum.

* Crohn's disease. is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.

Most common symptoms of IBD are severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.

If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.

The causes of IBD are unknown. However, some researchers suggested that the promotion of a high-fat diet over the past few decades that cause the alternation of the ration of gut microbiota may be the major culprit in facilitating the onset of IBD.

The research of Case Western Reserve University, wrote, "A high-fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation -- a major discovery for patients suffering from Crohn's disease, research indicates. Crohn's disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea".

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a treatment of inflammatory bowel disease (IBS), researchers examined the effect of beetroot (Beta vulgaris var. Rubra) products and their major component betanin on the reactive oxygen species (ROS) production and DNA damage in vitro.

In neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), injection of betanin at 100 μM for 24 h increased DNA damage, according to the comet assay.

However, in Caco-2 cells.injection of betanin at 100 μM for 24 h showed a lesser pronounced stimulation of DNA damage.

Treatment of Caco-2 cells with H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

In other words, betanin exerted a cytotoxic effect against the DNA alternated cells but inhibited the free radical expression in the induction of DNA damage of normal cells.

More precisely, betanin led to the release of ROS and apoptotic cell death.

Based on the findings, researchers wrote, " betanin may exert anti-inflammatory and potentially cancer preventive activity".

Taken altogether, betanin may be considered supplements for the prevention and treatment of inflammatory bowel disease, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High fat diet reduces gut bacteria, Crohn's disease symptoms by Case Western Reserve University. (Science Daily)

Healthy Food Cranberry Protects the Heart Against Cardiovascular Toxicity

By Kyle J. Norton

Cardiac toxicity is a condition in which the heart has been damage to some extents caused by harmful chemicals, including toxins induced by the treatment of chemotherapy, leading to reduced heart muscles function to pump blood and heart failure.

Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.

Dr. Polonsky TS, the lead scientist wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".

And, "Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".

Additionally, human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.

Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.

* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.

* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.

* Acute coronary syndromes that affect the blood flow due to blood vessel damage.

* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.

Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.

Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of cardiovascular diseases, researchers examined the protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in an animal model.

According to the results of rats were given CRAN orally (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) for 7 days, CRAN protected the heart function against DOX-induced increased mortality and ECG changes.

The reduced levels of antioxidants enzymes and increased oxidative stress in the cardiac tissues induced by DOX such as glutathione (GSH) depletion and oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls were significantly inhibited by the administration of CRAN.

Furthermore, the reduced cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) induced by DOX were also inhibited by CRAN.

Moreover, CRAN also improved the cardiac myeloperoxidase (MPO) activity against infection compared to untreated rats.

Most important, CRAN also normalized the levels of enzymes associated with cardio muscle damage and injury casued by DOX such as troponin I, creatine phosphokinase (CK), and creatine kinase-MB.

Based on the findings, researchers said, "CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats".

Taken altogether, cranberry may be considered a remedy for the protection of cardiovascular toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats by Elberry AA1, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour OM. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)

Healthy Food Onion Inhibits Invasive Osteosarcoma in Vitro

By Kyle J. Norton

Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.

Dr. James J. Morrow wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life".

And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)".

The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.

According to the statistic, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are diagnosed each year. Children and teens are younger than 20 accounts for half of the numbers.

The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% comapred to localized cancer between 60% to 80%.

Conventionally, Most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.

In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient for the treatment of osteosarcoma researchers examined the effects of quercetin on proliferation, migration, and invasion in U2OS and Saos-2 cells.

According to the tested analysis, quercetin (20, 40, 60, 80, or 100 μM) for 48 h, incubation with U2OS and Saos-2 cells showed a significant reduction of cancer cell viability, in a dose-dependent manner.

Cell adhesion, invasion, and migration of the tested cell lines were also significantly inhibited by the application of quercetin only at higher concentration.

Furthermore, the expressions of pro-apoptotic matrixes were increased accompanied by the decrease of anti-apoptotic proteins.

Moreover, gene PTHR1 associated with tumor proliferation was also decreased by quercetin.

More precisely, PTHR1 expression in U2OS cells was reduced by 0.18-, and 0.41-fold at 80, and 100 μM, respectively, whereas 0.15 and 0.38 folds in Saos-2 cells.

In other words, by inhibiting the expression of PTHR, quercetin inhibited proliferation and invasion of the tested cell lines.

Based on the results, researchers said, "quercetin reduced human metastatic osteosarcoma cell invasion, adhesion, proliferation, and migration by inhibiting PTHR1."

Taken altogether, onion may be considered a remedy for the prevention and treatment of metastatic osteosarcoma, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1 by Li S1, Pei Y1, Wang W1, Liu F1, Zheng K2, Zhang X.
(PubMed)
(2) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)

Monday, 5 August 2019

Healthy Food Broccoli, Processes Depressant-Like Property

By Kyle J. Norton

Depression is a common and serious psychological illness, affecting physical and mental functions of patients, including the patients feeling, thinking and acting.

Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.

There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.

Most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.

In severe case, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming his or herself.

According to the statistics provided by the Anxiety and Depression of Association of American, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.

Conventionally, selective serotonin reuptake inhibitors (SSRIs) is the primary medication for the treatment of depression due to its relatively lower side effects comapred to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants and monoamine oxidase inhibitors (MAOIs).

Dr. Steven S. Clevenger and colleagues in examining the role of selective serotonin reuptake inhibitors in the relapse risk of major depressive disorder wrote, "According to the included studies, the relapse risk in adults was lower when SSRIs were combined with psychotherapy".

And, " the combination of SSRIs and cognitive behavioral therapy may effectively reduce relapse. Escitalopram appeared to yield better results and fewer side effects than did other SSRIs or SNRIs".
On finding a potent compound which process depressant-like activity, researchers examined the effects of Sulforaphane (SFN), an isothiocyanate compound derived from broccoli on inflammation-related depressive symptoms.

On lipopolysaccharide (LPS, 0.5 mg/kg) induced depression-like behavior in mice, pretreatment SFN showed a significant effect in the blockage of the increase in the production of pro-inflammatory cytokine (tumor necrosis factor-α (TNF-α)) level and an increase in microglial activation of the brain associated with the inflammatory response by increasing the expression anti-inflammatory cytokine IL-10.

Activation of microglia is a hallmark of brain diseases.

In the tail suspension test and forced swimming test, immotility caused by LPS of the tested mice was also attenuated by the injection of SFN.

Degeneration of the cognition in the brain caused by the alternation of the density of the proteins associated with the brain functioning due to the LPS was also restored by the SFN.

More importantly, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food in the juvenile and adolescence has been found to prevent the risk of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions at adulthood.

In other words, SFN isolated from the rich broccoli sprout exhibited depressant-like activity was attributed to the anti-inflammatory property.

Based on the findings, researchers said, "supplementation of SFN-rich broccoli sprout could be a prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients".

Taken altogether, broccoli sprout with rich of SFN may be considered a functional food for the treatment of depression, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation by Zhang JC1, Yao W1, Dong C1, Yang C1, Ren Q1, Ma M1, Han M1, Wu J1, Ushida Y2, Suganuma H2, Hashimoto K. (PubMed)
(2) The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder by Steven S. Clevenger, Devvrat Malhotra, Jonathan Dang, Brigitte Vanle, andWaguih William IsHak. (PMC)

Herbal Turmeric and Supplemental Copper Suppress the Oral Cancer Progression

By Kyle J. Norton

Oral cancer is a medical condition caused by any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Oral cancer can be classified depending on the types of cells that cause the onset including

* Squamous cell carcinoma

Squamous cell carcinoma is one of the most common types of oral cancer, accounting for over 90% of all cases and arise from the squamous cell layer in the lining of the oral cavity and oropharynx.

* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is uncommon cancer, accounting only to an approximate 5% of all cases, but it can spread deeply into the surrounding tissue.

* Minor salivary gland cancers
The cancer is originated from the salivary gland accounting for less than 1% of all cases.

The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

Most prevalent factors associated with a higher risk of oral cancer are tobacco use including cigarettes, cigars, pipes, chewing tobacco, and snuff, among others.

Some researchers suggested that heavy alcohol use also in one of the most common risks of oral cancer.

Dr. Binh Y. Goldstein the lead scientist wrote, "The evidence for the human carcinogenic effects of alcohol drinking on the risk of cancers of the oral cavity and pharynx has been considered sufficient in the IARC Monograph 44 on alcohol and cancer in 1988".

And, "Generally, the dominant type of alcohol consumption in each population is associated with the greatest increases in risk. A large number of studies on joint exposure of alcohol and tobacco consumption demonstrate a more than multiplicative synergistic effect".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of cancer, researchers examined the effect of curcumin found abundantly in turmeric on intracellular copper levels that affect the sensitivity of oral cancer cells.

According to the differentiation of intracellular copper levels and response to curcumin treatment in a panel of OSCC cell lines derived from oral cancer patients, the concentrations that inhibited 50% OSCC cell viability (IC50) of curcumin was reduced up to 5 times in the presence of 250 µM copper.

Furthermore, increased copper level in curcumin-treated OSCC cells exerted a significant effect in increased levels of intracellular ROS and Nrf2 which regulates oxidative stress responses in the cancer cells.

Moreover, supplemental copper also inhibited migration of curcumin-treated cells by suppressing epithelial-mesenchymal transition in the promotion of cancer cells metastasis.

Interestingly, early apoptosis in combined treatment is not found in treatment with curcumin or copper alone.

In other words, copper and curcumin work synergistically to induce cancer cell death, compared to no effect in either alone treatment.

Based on the findings, researchers wrote, "Supplement of copper significantly enhanced the inhibitory effect of curcumin treatment on migration and viability of oral cancer cells".

Taken altogether, curcumin found abundantly turmeric may be combined with the copper supplement for the prevention and treatment of oral cancer pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Usage of Curcumin as Chemopreventive Agent for Oral Squamous Cell Carcinoma: An Experimental Study on Sprague-Dawley Rat by Maulina T1, Widayanti R1, Hardianto A1, Sjamsudin E1, Pontjo B2, Yusuf HY. (PubMed)
(2) Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells by Lee HM1, Patel V1, Shyur LF2, Lee WL. (PubMed)
(3) Alcohol Consumption and Cancer of the Oral Cavity and Pharynx from 1988 to 2009: An Update by Binh Y. Goldstein,1 Shen-Chih Chang,1 Mia Hashibe,2 Carlo La Vecchia,3,4 andZuo-Feng Zhang. (PMC)

Herbal Ashwagandha Destroys Liver Cancer Cells In Vitro

By Kyle J. Norton

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood coming from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, steroid hormones, and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some forms of liver disease. 95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

Compared to cancer caused by irregular cell growth in specific tissues of an organ, liver cancer precisely is caused by uncontrolled cell growth in the liver tissue that starts in the cells on the surface of the inner lining tissue of the liver.

At the advanced stage, the cancerous cell in the primary liver cancer can travel a distance away to infect other nearby healthy tissue or organ, via blood and fluid circulation, leading to secondary metastasis.

Liver cancer is caused by the alternation of liver cell DNA. Because of lower nerve tissue, most patients in the very early stage of liver cancer are assymptomatic. However, at the advanced stage, patients may experience symptoms upper abdominal pain, general weakness, abdominal swelling, jaundice and white, chalky stools accompanied by general symptoms shared by other types of cancer.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The 5-year survival rate of 44% of people diagnosed in the early stage of liver cancer only is 31%., comapred to 90% and 100% of colon and breast cancer, respectively.

Some researchers suggested long-term excessive alcohol use has been linked to an increased risk of liver cancer and worse prognosis comapred to other forms of liver cancer

"Liver cancer is the second leading cause of cancer-related deaths worldwide, with hepatitis B and C infections being the main causes".

"Alcohol abuse and non-alcoholic fatty liver disease are other dominant risk factors. Due to improvements in the treatment of hepatitis infections and increased alcohol consumption in some regions, it is likely that alcohol will become a leading cause of liver cancer".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On the finding a potent ingredient for the treatment of liver cancer, researchers investigated the antioxidant and apoptotic inductive effects of Withania somnifera (Ashwagandha) leaf extract ((ASH-WX; 6.25 mg/ml-100 mg/ml)) against a hepatocellular carcinoma cell line (HepG2cells).

According to the tested differentiation, ASH-WX injection demonstrated increased cytotoxicity in HepG2 cells compared to untreated control with IC50 of 5% (approximately 5.0 mg/ml).

ASH-WX also exerted strong antioxidant activities by increasing the levels of Fas-ligand associated with cell death programming and matrixes involved regulating of cancer cell migration, invasion, and metastasis and decreasing the production of pro-inflammatory induced systemic inflammation.

Furthermore, the extracts were also found to interact with cyclin D1, an important regulator of cell cycle progression.

More precisely, ASH-WX induced cell death in HepG2cells was found to increase significant accumulation in the G0/G1 and G2/M phases compared to the control and untreated cells.

In other words, ASH-WX blocked the proliferation through cell cycle arrest.

Based on the results, researchers said, "Ashwagandha could be a powerful antioxidant and a promising anticancer agent against HCC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of liver cancer, pending to larger sample size and multicenter study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant activity and apoptotic induction as mechanisms of action of Withaniasomnifera (Ashwagandha) against a hepatocellular carcinoma cell line by Ahmed W1, Mofed D1, Zekri AR2, El-Sayed N3, Rahouma M4, Sabet S. (PubMed)
(2) Liver cancer caused by alcohol consumption may have a worse prognosis than other forms by Wiley. (Medical Express)