Lycopene Prevents the Onset of Metabolic Syndrome

By Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

Epidemiological studies suggested if you have 3 of the above syndrome you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

Most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Common complications of untreated metabolic syndrome epidemiologically have been found by experts to complicate chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Symptoms of signs of metabolic syndrome depending types of affected conditions and complications.

Some researchers suggested that in the US, metabolic syndrome may be correlated with the promotion of a high-fat diet over the past few decades.


Dr. Silvia Moreno-Fernández wrote, "The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast".

And, "High-fat/high-glucose fed rats showed an increased bodyweight, abdominal circumference, and fat deposition, combined with oxidative stress, impaired glucose tolerance, dyslipidemia, and mechanical allodynia. Altogether, our results showed an early-stage MetS which, in addition, could lead to T2DM and cardiovascular disease development over time in HFG animals. ".

The results strongly suggested that both metabolic syndrome and obesity in the US population are attributed to the Western diet pattern.

In other words, by changing to a healthy diet such as traditional diet, the risk of obesity and metabolic syndrome can be decreased substantially.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a potent compound for reducing risk cardiovascular disease and diabetes, researchers examined the effects of lycopene on metabolic syndrome.

In a total of 13 196 participants, aged 20 years and older, divided into three groups according to serum concentrations of lycopene, researchers found that prevalence of the metabolic syndrome associated with levels of antioxidant was significantly higher in the normal and overweight group compared to the obese group.

In other words, the risk of metabolic syndrome depending on the levels of lycopene in the body only affects people with normal weight or overweight.

Additionally, the study included A total of 2499 participants 20 years and older with metabolic syndrome that were divided into 3 groups based on their serum concentration of lycopene suggested that levels of lycopene also showed significant effects on HRs of mortality.

In other words, people with higher levels, compared to those of lower serum lycopene concentration.have a lower mortality rate and hazard ratios (HR).

Taken altogether, lycopene found in tomato may have a strong effect on the initiation of metabolic syndrome, particularly in normal weight and overweight individuals, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Higher levels of serum lycopene are associated with reduced mortality in individuals with metabolic syndrome by Han GM1, Meza JL2, Soliman GA3, Islam KM1, Watanabe-Galloway S. (PubMed)
(2) The influence of BMI on the association between serum lycopene and the metabolic syndrome by Han GM1, Soliman GA2, Meza JL3, Islam KM1, Watanabe-Galloway S. (PubMed)
(3) High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model by Silvia Moreno-Fernández,1,2 Marta Garcés-Rimón,3 Gema Vera,2,4 Julien Astier,5Jean François Landrier,5 and Marta Miguel. (PMC)

Healthy Food Kale Promotes Bile Acid Binding Naturally Against High Blood Cholesterol

By Kyle J. Norton

Bile acids synthesized from by oxidation from cholesterol in the liver, flowing to the gallbladder to aid digestion.

Bile acids binding is a process to interfere with normal fat digestion and absorption including the prevention of absorption of fat-soluble vitamins such as A, D, E, and K.

In other words, binding of bile acids (BAs) may have a strong effect to lower blood cholesterol levels by increasing the excretion of bile acids in the stool and reducing the amount of bile acid returning to the liver.

By inhibiting the levels of bile acid caused by a certain type of liver/bile duct disease such as partial biliary obstruction, levels of cholesterol can be controlled.

Conventionally, the effects of bile acid sequestrant are limited. Low doses of 8 gram/day of Cholestyramine, a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption can lower LDL cholesterol by 10%-15% comapred to high doses of 24 gram/day of only 25%.

In other words, bile acid-binding medicine such as Cholestyramine, used alone are less effective, comapred to statins in lowering LDL cholesterol.

Most common symptoms associated with the intake of Cholestyramine are constipation, diarrhea, stomach/abdominal pain, bloating, nausea, vomiting, and loss of appetite.

Bile acid sequestrants such as lovastatin combined with niacin may be used to lower aggressively lower LDL cholesterol levels.

Dr. Gordon Schectman and colleagues in the study published at the American Journals of Cardiology wrote, " Niacin and lovastatin are effective drugs for hypercholesterolemia management in the Veterans Administration Medical Center setting. However, in elderly veterans, bile acid sequestrants were associated with a higher rate of adverse effects limiting compliance, and psyllium was ineffective".

Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe.

The Kale's leave is highly nutritious cultivated as foods in most part of Europe.

On finding a potent compound for the prevention and treatment of hypercholesterolemia, researchers examined the effects of kale bile acid-binding capacity.

The study included the testing of three different compositions of bile acids to establish the optimal dose for bile acid-binding.

Compared to other cruciferous vegetables such as red leaf lettuce, red cabbage, red kale, green kale, and Brussels sprouts, kale showed significantly higher bile acid-binding capacity at 1.5 g sample and remained constant up to 2.5 g.

In kale Comparision, minimally processed (microwaved 3 min or steamed 8 min) green kale showed significantly higher bile acid-binding capacity (91.1 ± 0.3 and 90.2 ± 0.7%, respectively) compared to lyophilized kale (85.5 ± 0.24%).

Furthermore, kale also prevented cholesterol reabsorption into the blood by binding to hydrophobic bile acids, chenodeoxycholic acid, and deoxycholic acid preferably.

These results suggested that kale processes the highest anti hypercholesterolemic activity by binding to bile acids compared to other veggies in the same family.

Based on the findings, researchers said, " regular consumption of kale, especially minimally processed kale, can help excrete more bile acids and, thus, may lower the risk of hypercholesterolemia".

Taken altogether, kale may be considered a functional food for the promotion of bile acid-binding, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In Vitro Bile Acid Binding Capacities of Red Leaf Lettuce and Cruciferous Vegetables by Yang IF1, Jayaprakasha GK1, Patil BS. (PubMed)
(2) Evaluation of the effectiveness of lipid-lowering therapy (bile acid sequestrants, niacin, psyllium and lovastatin) for treating hypercholesterolemia in veterans by Gordon Schectman, Schectmana, Jan Hiatt, Pharm D. Arthur Hartz, MD. (the American Journals of Cardiology)

Phytochemical Alliin Suppresses the Onset of Hyperlipidemia in Vivo

By Kyle J. Norton

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

High blood cholesterol is the most common causes of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL.  and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 millions of American and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, produces vitamin D and steroid hormones.

The healthy ratio of low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is ant numbers that are less than 4.

People with hyperlipidemia are asymptomatic. However, if untreated, the condition can cause cholesterol build-up on the arterial wall, leading to narrowing the arteries inducing blockage that causes heart disease and stroke.

Although there are many factors that can induce the expression of hyperlipidemia, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a significant implication on the onset of hyperlipidemia in the population in the US.

An article cited from the study by Tufts University wrote, "In two studies published online in the American Journal of Transplantation, researchers determined that hyperlipidemia accelerates heart-transplant rejection in mice. By using models that mimic the health conditions found in human transplant recipients, the researchers from Tufts determined that transplant rejection was accelerated whether the hyperlipidemia (high cholesterol and high triglycerides in the blood) was caused by genetics or solely by a high-fat diet".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a potential compound for the treatment of hyperlipidemia, researchers examined the bioactive compound alliin (S-allyl cysteine sulfoxide) derived from garlic in an animal model.

The study included C57BL/6J DIO mice randomly assigned to drinking water with or without alliin (0.1 mg/ml) for 8 weeks.

Based on the tested results, alliin exerted antihyperlipidemic activity with no significant effect on the body weight, adiposity or energy balance.

However, alliin treatment enhanced glucose homeostasis and increased insulin sensitivity.

The efficacy of alliin antihyperlipidemic effects was attributed to alliin induced balance of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.

Collectively, researchers concluded," alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders".

In other to find out more information about alliin hypolipidemic activity, researchers examined the effects of alliin on the lipid profile in a rabbit model. 

The study included 19 New Zealand White rabbits were fed a cholesterol-rich diet (0.25% cholesterol) for 18 weeks with 10 rabbits received freshly produced allicin (3 mg/kg orally) starting at 8 weeks, and nine received a placebo.

According to the results from tested assays, allicin produced by reacting alliin showed a significant effect on serum cholesterol and low-density lipoprotein concentrations compared to control in days dependent manner.

Additionally, levels of serum high-density lipoprotein levels were also improved between groups.

Dr. Eilat S, the lead scientist wrote, in the final report, "allicin has a beneficial effect on the serum lipid profile in hyperlipidemic rabbits, and should be further tested clinically".

Taken altogether, alliin may be considered supplements for the prevention and treatment of hyperlipidemia with no side effect, responding to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) (1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice.
Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)

(2) Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic by Eilat S1, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z.(PubMed)
(3) Hyperlipidemia, caused by a high-fat diet, aggressively accelerates organ rejection by Tufts University (Science News)

Betaxanthins, the Potential Anti Cancer Phytochemical

By Kyle J. Norton


Cancer is a class of chronic diseases caused by cells growth and multiplies disorderedly and uncontrollably in the body.

Every day millions of cell grow to replace millions of dead cells to keep our body in balance and healthy. Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again.

Under normal circumstance, cell growth is limit to a number of cycles before dying and replacing by new cells. However, in cancer, the invasive cell can grow indefinitely. In other words, the cancer cell ignores the cell growth inhibitor.

According to the statistics provided by the American Cancer Society, in 2019, 1,762,450 new cancer cases will be diagnosed in the US. The disease will also cause the death of 606,880 Americans in the same year.

Believe it or not, the study continued, "Over the past decade of data, the cancer incidence rate (2006-2015) was stable in women and declined by approximately 2% per year in men, whereas the cancer death rate (2007-2016) declined annually by 1.4% and 1.8%, respectively".

Depending on the types and grade of cancer, some cancers can be progressively worse and damage other healthy tissues. Sometimes cancers can spread to other tissues and organs in the body via lymph or blood.

The most common prevalent factors that induce cancer risk are
* Aging is a prevalent risk factor of cancer developing as most patients with cancer are found in older adults. Some researchers suspected that free radicals may be one of the contributors.

*  Tobacco use is asscoaited with an increased risk of lung cancer, due to chemicals induced cells alternation

* Sunlight is the major cause of skin cancer,

*ionizing radiation: Any types of hazard chemicals cause of gene mutation

* Virus and bacteria infection

* Hormones: Abnormal production of certain hormones can increase the risk of sex-related cancers

* Family history.


Carcinoma cancer is a most common type of malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands, accounting to 90% of all cancer cases.

Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

With an aim to find a potential compound for the treatment of inflammatory disease, researchers examined the anti-inflammatory effects of red beetroot betaxanthins.

Vitexin-2-O-xyloside found in beetroot, in combination with betaxanthins and betacyanins, exerted antiproliferative activity in breast, liver, colon, and bladder cancer cell lines.

This efficacy was attributed to the synergistic activity in the inhibition of genes associated with pro-survivals, angiogenesis, and promotion of apoptosis.

Hypoxia-inducible factor 1A that responses to the decreases in available oxygen in the cancer cellular environment were also inhibited by the combination.

These results strongly suggested that these phytochemicals enhance their anticancer activity through The multi-target action.

Based on the findings, researchers said, "Vitexin-2-O-xyloside, betaxanthins, and betacyanins can be used in combination with conventional anticancer drugs to reduce their toxicity and overcome the multidrug resistance of cancer cells".

Taken altogether, betaxanthins combined with other phytochemicals may be considered a remedy for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Cancer statistics, 2019 by Siegel RL1, Miller KD2, Jemal A. (PubMed)

Onion, the Natural Vasorelaxant Remedy

By Kyle J. Norton

Vasorelaxant is a term that refers to the reduction of vascular tension.

Vascular disease is a disease associated with an abnormal condition of the blood vessels, affecting the blood flow to the body.

There are many types of vascular disease associated with vascular constriction, including stroke, peripheral artery disease (PAD), a disease is caused by reduced blood flow to the limbs, abdominal aortic aneurysm (AAA), carotid artery disease (CAD),  arteriovenous malformation (AVM), pulmonary embolism (blood clots) and  deep vein thrombosis (DVT).

According to the statistics, approximately 8.5 million people in the US are living with Peripheral artery disease (PAD), one of the most common types of vascular disease.

There are no single causes of vascular disease. However, diabetes, hyperlipidemia (high levels of fats in the blood, such as cholesterol and triglycerides), smoking, high blood pressure, obesity, physical inactivity are some of most prevalent factors found in patients with the condition.

Some researchers suggested that the rise of aging patients with vascular disease may be correlated to the promotion of high-fat diet over the past few decades in inducing a large population with obesity and Type II diabetes in the US.

Dr. Morteza Mowlaie, the lead scientist wrote, " Significant positive association between left ventricular hypertrophy and plaque score and also a significant positive association between left ventricular hypertrophy with the presence of chest pain was found (p<0.05)"

And, "Association of diabetes mellitus with the presence of chest pain was positive. A positive correlation between hypertension with plaque score was demonstrated too (p<0.05). Also, an inverse association of plaque score with left ventricular ejection fraction was detected too (p<0.05)".

In other words, patients with diabetes are associated with vascular disease, that induces similar symptoms of atherosclerosis such as left ventricular hypertrophy, chest pain, and hypertension in plaque score

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient which processes cardioprotection researchers examined the investigate the effect of onion (Allium cepa) peel hydroalcoholic extract (OPE) on rat hypertension induced by high-fructose diet and aorta contractility.

Three groups of rats were given fructose (10% WN/V) in drinking water for 6 weeks but the control group received tap water and hypertensive groups received saline or OPE at 200, 400 and 800 mg kg(-1) daily for last 3 weeks by gavage.

OPE reduces aorta contractions induced by KCl or Phe in a concentration-dependent manner through its vasorelaxant effects.

L-NAME (100 microM), methylene blue (10 microM) and indomethacin (10 microM) Inhibited nitric oxide, cGMP and prostaglandin synthesis associated with a decrease of vasodilation also inhibited by the administration of OPE.

Furthermore, OPE did not change heart rate but reduced hypertension induced by fructose after 3 weeks of the experimental period.

The efficacy of OPE vasorelaxant activity was attributed to the inhibition of hypertension by extract quercetin content, antioxidant activity and inhibiting vascular smooth muscle cells Ca2+ influx associated with the change of vascular diameter.

Taken altogether, onion may be considered a remedy for the promotion of vasorelaxant activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat by Naseri MK1, Arabian M, Badavi M, Ahangarpour A. (PubMed)
(2) Close association of arterial plaques with left ventricular hypertrophy and ejection fraction in hemodialysis patients by Morteza Mowlaie 1 and Hamid Nasri. (PMC)

Bromelain, the Natural Prevention and Treatment of Chronic Rhinosinusitis (RS) With No Side Effects

By Kyle J. Norton

Rhinosinusitis (RS) is a condition associated with the inflammation of the sinuses and nasal cavity.

Chronic Rhinosinusitis (CRS) is an inflammation of  the sinuses and nasal cavity that last more than 12 weeks.

According to statistics, the prevalence of CRS in Korea, Europe, and the US is approximately 7%, 10%, and 12%, respectively.

The exact causes of CRS are not identified. However, some researches suggested that infection that does not heal itself due to the inability of the immune system to destroy all the infectious pathogens in the acute phase of infection may play a critical role to the onset of the condition.

Symptoms of CRS are totally depending on the state of severity. Some patients may experience symptoms of facial pressure or pain, post-nasal drainage, nasal blockage, anosmia or hyposmia, or fatigue.

Conventionally, medications used for the treatment of CRS are focusing on reducing symptoms and improved quality of life, inclduing prescribed antibiotics in case of bacterial infection.

If all medicines fail, surgery may be necessary. 

Out of many risk factors associated with the onset of CRS, some researchers suggested that cigarette smoking may have a strong and negative impact on the syndrome.

Dr. Douglas D. Reh, the lead scientist wrote, " Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS)".

And, "There is clear evidence in the literature that cigarette smoke, either through active smoking or passive exposure to SHS, contributes to CRS".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to discover a potential ingredient for the treatment of chronic rhinosinusitis, researchers investigated the penetration of bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS), compared to the control group.

40 participants with CRS were divided into 2 groups equally either treated by bromelain derived from pineapple (Ananas comosus) or control.

Bromelain 500 mg tablet twice daily administered for 30 days in the treatment group displayed a significant effect in reduced inflammation in patients with CRS compared to control.

In other words, bromelain has an excellent distribution from blood to rhinosinusal mucosa in exhibition anti-inflammatory activity.

Based on the findings, researchers said, "Its (bromelain) diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies".

In a pilot study, researchers evaluated the efficacy, tolerability, and impact on the quality of life (QoL) of bromelain tablets (500 FIP) in patients with chronic rhinosinusitis (CRS).

According to the results from 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery,  treatment with bromelain tablets (500 FIP) for 3 months, exerted a strong effect in symptom scores (Total Symptom Scores: TSS); a Total Rhinoscopy Score (TRS) and the Sinonasal Outcome Test 20 (SNOT-20 GAV) with no side effects.

Dr. Büttner L, the lead scientist wrote in the final report, "Preliminary results indicate good tolerability, symptom control, and improvement in QoL for the treatment of CRS using bromelain tablets (500 FIP)".

Taken altogether, bromelain may be considered supplements for the treatment of chronic rhinosinusitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis by Passali D1, Passali GC2, Bellussi LM1, Sarafoleanu C3, Loglisci M1, Manea C3, Iosif C4, Passali FM. (PubMed)
(2) Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study by Büttner L1, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. (PubMed)
(3) Impact of Tobacco Smoke on Chronic Rhinosinusitis – A Review of the Literature by Douglas D. Reh, MD,1 Thomas S. Higgins, MD,1 and Timothy L. Smith, MD, MPH. (PMC)

Herbal Turmeric Reduces the Risk of Multiple Sclerosis

By Kyle J. Norton

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) casued by the immune system attacks the protective sheath (myelin) that covers nerve fibers.

MS causes communication problems between the brain and the rest of the body.

SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".

The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".

In other words, people having certain genes inherited from the parent are at the substantial risk of MS developing comapred to people who do not.

According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world. 

Conventionally, MS treatments are focusing on controlling inflammation that injures nerve fibers, reduces the frequency and severity of relapses, and preventing the accumulation of further nerve damage and improving symptoms and quality of life.

Most common symptoms of MS are numbness or weakness in one or more limbs, electric-shock sensations associated with certain neck movements, tremor, and lack of coordination physically.

In the vision, MS also induces symptoms of partial or complete loss of vision, prolonged double vision and blurry vision.

Additionally, patients with MS may also experience symptoms of slurred speech, fatigue, headache, dizziness, and reduced sexual, bowel and bladder function.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of multiple sclerosis (MS), researchers examined the efficacy of curcumin on a cascade of inflammation in the progression of different stages in MS patients.

Based on the tested analysis, curcumin inhibited the migration Th17cell into the central nervous system across the blood-brain barrier (BBB) in the induction of the tissue inflammation and tissue destruction by decoupling the production of pro-inflammatory cytokines (interleukin (IL)-17 and IL-22).

Where Th17 has been found to associated with hallmarks of many immune-inflammatory diseases.

In other words, curcumin blocked the axon degeneration and the various manifestations of nerve-muscle disorders associated with the onset of MS.

Furthermore, by searching the publication involved in curcumin treatment of MS, researchers found that the efficacy of curcumin for the treament of MS was attributed to numerous properties such as anti-inflammation and inhibition of secretion of proinflammatory cytokines.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of MS, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets by Ghanaatian N1, Lashgari NA1, Abdolghaffari AH2,3,4,5, Rajaee SM5, Panahi Y6, Barreto GE7,8, Butler AE9, Sahebkar A. (PubMed)
(2) Therapeutic potential of curcumin for multiple sclerosis by Qureshi M1, Al-Suhaimi EA2, Wahid F3, Shehzad O4, Shehzad A. (PubMed)
(3) Discovery of multiple sclerosis gene could inspire new therapies — if it’s right by SHARON BEGLEY. (Stat)