Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 31 May 2019

Tomato Inhibits the Onset of Non-alcoholic Steatohepatitis

By Kyle J. Norton

Nonalcoholic steatohepatitis (NASH), is a type of inflammatory non-alcoholic fatty liver disease caused by a buildup of fat in the liver.

Most cases of NASH if untreated can lead to liver scars or building up of scar over time, a condition of liver cirrhosis and one of the most common causes of liver cancer.

Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.

Most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.

If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, you may have some forms of liver disease. Please check with your doctor to rule out the possibility.

Out of many prevalent factors associated with increased risk of non-alcoholic steatohepatitis, some researchers suggested the rise of the condition in the US population may be correlated to the promotion of the Western diet over the past few decades.

Dr. H. Cortez-Pinto, the lead scientist said, " Comparison of their diet history with control data (C) revealed that carbohydrate consumption was lower in patients (P): P—243.6±5.7g vs. C—261.5±1.6g, P<0.05, and most patients had very low fiber intake. Conversely, total fat consumption was higher in patients: P—79.7±1.7g vs. 73.0±0.4, P<0.01. A significantly higher intake of n-6 fatty acids (P=0.003) and the then-6/n-3 ratio was found in patients, P<0.001".

And, "Our results suggest that the quality and combination of carbohydrates and fat intake may be more relevant than their isolated amount; an increased fat intake with an excessive amount of n-6 fatty acids can be implicated in promoting necro-inflammation, and provides further grounds for individualized dietary therapy".

Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of liver disease, researchers examined the effect of lycopene, a non-provitamin A carotenoid and the pigment principally responsible for the characteristic deep-red color of ripe tomato and tomato products on subjects with non-alcoholic steatohepatitis.

According to the review of the epidemiological study, tomato extract supplementation showed a significant protective effect against HFD-induced hepatic inflammation compared supplementation of lycopene.

In patients with NASH, increased levels of plasma lycopene may have a strong impact on the progression of NASH as patients have been shown to have significantly reduced plasma lycopene.

In vivo, dietary lycopene inhibits liver carcinogen-induced preneoplastic lesions in the rat liver that was effective in reducing NASH-promotion in rats.

The efficacy of lycopene in the inhibition of NASH and another chronic disease may be associated with the body in lycopene metabolism involved in both the chemical and enzymatic modifications.

Futhermore, in vivo synthesis of ACR from lycopene showed to attenuate hepatic steatosis, by decreasing the macrophage conditioned medium induced and TNFα-mediated induction of pro-inflammatory cytokine and chemokines.

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the prevention and treatment of NASH, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention by Ip BC1, Wang XD. (PubMed)
(2) How different is the dietary pattern in non-alcoholic steatohepatitis patients? by H. Cortez-Pintoa, L. Jesusa, H. Barrosc, C. Lopesc, M.C. Mourab, and M.E. Camiloa. (Clinical Nutrition)

Bromelain Suppresses Osteoarthritis (OA) Similar to Those of Diclofenac with No Side Effects

By Kyle J. Norton

Osteoarthritis (OA), a form of arthritis, is a condition associated with aging-induced wear and tear on a joint or joints.

Tne condition is very common in older adults, affecting over 25 million people in the US with no sign of stopping.

According to the University of Porto Medical School, the differences in prevalence and incidence estimates of osteoarthritis (OA), according to the case definition, are in the knee, hip and hand joints(3).

The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in a change of weather, at night.

In the advanced diseases, the pain can occur even at rest(8).

Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).

Some researchers suggested that OA is not simply a disease related to aging or mechanical stress of joints but rather a “metabolic disorder(70)(71)” interrelated to lipid, metabolic, and humoral mediators(70).

Indeed, OA has been linked not only to obesity(46)(47) but also to other cardiovascular risk factors(72)(73), namely, diabetes(74), dyslipidemia, hypertension, and insulin resistance(75).

More precisely, the majority of patients with OA also suffer from one or more of below conditions

* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).

* Cardiovascular disease
According to Erasmus University Medical Centre, there is an association of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).

*Peripheral vascular disease
According to Himchan Hospital, patient with due to osteoarthritis are associated with risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).

* Congestive heart failure
Hypertension, diabetes, and older age have shown to increased risk of Congestive heart failure modestly(81).

* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83).

6. Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).

* Respiratory disease
People with respiratory disease are also at a higher risk to develop osteoarthritis (OA), including chronic cough and bilateral infiltrates on chest roentgenogram(86).

* High serum of cholesterol
There is an association between high serum cholesterol level and both knee and generalized OA, according to the study of 113 females and 133 males with average ages 46 14.2 and 51.54 16.0 years by King Khalid University Hospital(87).

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a natural compound from healthy food for the treatment of inflammatory diseases, researchers examined the effects of bromelain on patients with osteoarthritis of the knee.

The randomized, double-blind placebo-controlled trial included 47 patients with a confirmed diagnosis of moderate to severe knee OA randomized to 12 weeks of bromelain 800 mg/day or placebo, with a 4-week follow-up.

According to the results from 31 patients completed the trial, including 14 in the bromelain group and 17 in the placebo group, both treatment groups showed clinically relevant improvement in the WOMAC disability subscale only with a mild adverse outcome.

In order to reveal and confirm the effects of bromelain on OA, a joint a randomized, single-blind, active-controlled pilot study. led by the Mahidol University was conducted in patients with OA for 16 weeks.

40 knee OA patients enrolled in the study were randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).

According to the tested assays,

* At week 4, the improvement of total WOMAC and pain subscales from baseline was observed in both groups, however, two patients in the diclofenac treatment group showed adverse effects that lead to discontinuation of diclofenac.

* At week 16, bromelain treatment group showed a significant improvement of all aspects, including total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4), compared to baseline values.

* Also compared to the based line, the bromelain-treated group also showed a decrease of plasma MDA and LPS-stimulated PGE2 production,

* Bromelain exerted a similar effect to those of diclofenac after 4 weeks.

Taken altogether, bromelain used alone may be considered supplements for the prevention and treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study by Brien S1, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. (PubMed)
(2) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: Diseases associated with Osteoarthritis by Kyle J. Norton

Phytochemical Alliin, the Best for Myocardial Ischemia-Reperfusion Injury

By Kyle J. Norton

Myocardial ischemia injury is a medical condition caused by severe impairment of coronary blood supply induced damage or dysfunction of the cardiac tissue.

Myocardial reperfusion is the process to restore the coronary blood flow after a period of coronary blockage that leads to severely reduced or no oxygen .blood flow to the heart.

The condition severity is totally dependent on the intensity and duration of the coronary occlusion.

According to the statistics from the WHO, in 2008, 12% of all death or approximately 7,254,000 deaths worldwide have directly or indirectly caused by myocardial ischemia injury.

In other words, coronary heart disease causes 1/4 total death in the worldwide population and 50% of the death associated with other forms of heart disease.

Most common symptoms of myocardial ischemia injury are neck or jaw pain, shoulder or arm pain, a fast heartbeat, shortness of breath, and fatigue accompanied by nausea and vomiting.

Most common causes of myocardial ischemia injury are a result of the plaque built-up on the coronary arterial wall due to long-term unhealthy diet with higher amount of fat and trans fat, red meat, processed food and fewer in fruits and vegetables.

Most patients with CHD also are found to have a sedentary lifestyle.

In other words, the promotion of a high-fat diet over the past few decades induced obesity is the major culprit that celebrates the risk of myocardial ischemic injury.

Dr. Meng F, the lead scientist wrote, "Obese patients are more sensitive to myocardial ischemia, which has been linked with high mortality rates".

And "(High fat diet-induced)An impaired MIF/AMPK activation response (cellular stress response) and consequent reduced membrane Glut4 expression (in the heart muscle) may play an important role in increasing myocardial susceptibility to I/R in obesity".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the prevention of the tissue damage caused by blood supply returns to tissue, researchers examined the role of alliin in myocardial ischemia-reperfusion (I/R) injury.

In a mouse model of I/R injury, injection alliin showed a significant effect in reducing the area at risk and the infarct area.

Compared with I/R group, alliin also improved the cardiac function in the mice I/R + alliin group. The expression of hypoxia/reoxygenation (H/R) induced apoptosis of cardiomyocytes due to I/R was also attenuated by the administration of alliin.

Confirmed by the tested assays, alliin also exerted the myocardial protection by increasing the heart's ability to withstand the ischaemic insult.

In vivo, alliin decreased cells apoptosis and increased the autophagy activity against the initiation of tissues damage after I/R injury in the tested animal.

Moreover, injection of 3-Methyladenine autophagy inhibitor commonly used to selectively block autophagy was found to reduce the function of alliin observed in the tested animal.

Based on the findings, researchers said, "all the results indicated that alliin alleviates myocardial ischemia-reperfusion injury by promoting autophagy".

Taken altogether, alliin may be considered supplements for the protection against myocardial ischemia-reperfusion injury, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin alleviates myocardial ischemia-reperfusion injury by promoting autophagy by Zhao R1, Xie E1, Yang X2, Gong B. (PubMed)
(2) Impaired myocardial MIF/AMPK activation aggravates myocardial ischemia reperfusion injury in high-fat diet-induced obesity by Meng F1, Li D2, Song B3, Li L. (PubMed)

Phytochemical Lycopene Protects the Kidneys Against Renal/Kidney Cancer

By Kyle J. Norton

Kidney cancer or renal cancer is primary cancer caused by irregular cell growth in the kidney tissue.

Kidneys are to bean-shaped organs located below the rib cage, one on each side of your spine with a function to filter out blood and remove waste through urinary secretion.

The kidney also plays a critical in maintaining the levels of fluids in the body, by removing extra fluids to make urine.

Furthermore, the kidney also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.

There are 2 most common types of kidney cancer including

* Renal cell carcinoma is the most common type of adult kidney cancer, originated in the lining of the proximal convoluted tubule that transport primary urine, accounting for over 85% of all kidney cancer diagnosed.

* Urothelial carcinoma is also called transitional cell carcinoma accounting for 10% to 15% of the kidney cancers diagnosed in adults.

The stages of renal cell carcinoma are
1. Stage 0
Kidney (renal cells) cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but in the surface of the kidney lining.
2. Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep kidney lining, but still completely inside the kidney.
a. Stage IA1
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
b. Stage IB: cancer in this stage have invaded the connective tissue, & less than 5mm (1/5 inch).
b.1. Stage IB1: Cancer is 4 cm large (1 3/4 inches).
b.2. Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)
3. Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the kidney.
4. Stage III
In this stage, cancerous cells have spread to the tissues immediately surrounding the kidney.
5. Stage IV
In the stage, IV is the most advanced stage of renal cell carcinoma as cancerous cells have spread to the distant parts of the body

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a potential compound for the treatment of kidney cancer, researchers examined the role of a lycopene-rich diet in the development of RCC in the TSC2 mutant Eker rat model.

Selected 10-week old female Eker rats (n=90) in the study were assigned in equal numbers to receive 0, 100 or 200mg/kg of lycopene as part of their daily diet sacrificed at the 18 months.

According to the tested assays, tumor size was decreased from 94% in control animals to 65% in the lycopene group.

Furthermore, the mean numbers of renal carcinomas and tumor length were statistically significantly decreased in the lycopene group compared to untreated controls. More precisely, tumor numbers decreased (P<0.002) in the lycopene group were linearly (P<0.003) to the increased lycopene injection from 0 to 200.

Compared to lycopene treated group, the control rats fed only the basal diet had a greater length of tumors.

Additional differentiation of lycopene efficacy, researchers found that lycopene inhibited the kidney cancer cell by blocking the protein in signaling cell proliferation, and in promoting the cancer cell invasive response.

Based on the findings, researchers wrote, "dietary supplementation with lycopene attenuates the development of renal cell cancers in the predisposed TSC2 mutant Eker rat model".

Taken altogether, lycopene may be considered supplements for the prevention and treatment of kidney cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model by Sahin K1, Cross B2, Sahin N1, Ciccone K2, Suleiman S2, Osunkoya AO2, Master V2, Harris W2, Carthon B2, Mohammad R3, Bilir B2, Wertz K4, Moreno CS2, Walker CL5, Kucuk O. (PubMed)
(2) A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression by Dogukan A1, Tuzcu M, Agca CA, Gencoglu H, Sahin N, Onderci M, Ozercan IH, Ilhan N, Kucuk O, Sahin K. (PubMed)
(3) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton

Thursday, 30 May 2019

Herbal Bilberry Normalizes the Angiogenesis In the Body

By Kyle J. Norton

Angiogenesis refers to the formation of new blood vessels from the existing vasculature.

Angiogenesis, on one hand, plays a critical role in repairing the tissue damages including arteriosclerosis, myocardial infarction. On another hand, the expression of angiogenesis has been found to cause diseases and induce progression of retinopathies, benign tumor, and cancer.

In other words, abnormal blood vessel growth that cause either excessive or insufficient has been linked to underlying many deadly and debilitating conditions.

Under normal condition, the development of angiogenesis totally depends on the functional demands of the body. For example, exercise stimulates angiogenesis in skeletal muscle and heart and a lack of exercise can lead to capillary regression.

Clearly, these results demonstrated the needs of angiogenesis for the body to function better and the formation of new blood vessels occurs throughout human life.

However, in the cancer perspective, new blood vessel growth is important for cancer proliferation and metastatic spread. The survival of tumor cells totally depends on an adequate supply of oxygen and nutrients.

Dr. the lead scientist said, "Levels of expression of angiogenic factors reflect the aggressiveness of tumor cells. The discovery of angiogenic inhibitors should help to reduce both morbidity and mortality from carcinomas".

In other words, if we can stop the tumor in stimulating the production of new blood vessels to supply energy for them to grow, we may cure cancer.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find potential treatment for diseases associated with angiogenesis,with no side effects, researchers examined the antiangiogenic properties and antioxidant activities (a) of the main anthocyanidins (delphinidin, cyanidin, and malvidin) found as constituents in Vaccinium myrtillus (bilberry) anthocyanosides (VMA) and (b) of N-acetyl-L-cysteine (NAC).

Anthocyanidins exerted a significant inhibition of vascular endothelial growth factor (VEGF) associated with the grow od new blood vessel in a concentration-dependent manner.

Anthocyanidin at 3 and/or 10 microM are the most effective compared to those of NAC at 1 microM (the only concentration tested).

Moreover, both anthocyanidin (0.3-10 microM) and NAC (1-1000 microM) concentration-dependently also exerted a significantly scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.

The findings suggested that VMA processes an anti-angiogenic activity depending on the main constituent anthocyanidins (delphinidin, cyanidin, and malvidin), presumably via antioxidant effects.

Additionally, in vitro and in vivo, Vaccinium myrtillus (Bilberry) extracts (VME) showed an anti-angiogenic effect on 0.3-30 µg ml(-1)) compared to those of GM6001 (0.1-100 µM; a matrix metalloproteinase inhibitor).

In human umbilical vein endothelial cells (HUVECs), VME inhibited VEGF-A-induced proliferation of HUVECs.

According to the vivo assay, intravitreal administration of VME inhibited the formation of neovascular tufts during oxygen-induced retinopathy in mice.

The results suggested that VME may be effective against retinal diseases involving angiogenesis.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of diseases involved angiogenesis, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inhibitory actions of bilberry anthocyanidins on angiogenesis by Matsunaga N1, Tsuruma K, Shimazawa M, Yokota S, Hara H. (PubMed)
(2) Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo by Matsunaga N1, Chikaraishi Y, Shimazawa M, Yokota S, Hara H. (PubMed)
(3) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)

Herbal Turmeric Protects the Skin Against Radiodermatitis

By Kyle J. Norton

Radiodermatitis is a skin condition caused by exposure to ionizing radiation, particularly in patients with radiotherapy during cancer treatment.

Most common symptoms of RD are red patches accompanied by blistering.

Radiodermatitis can be classified

* Acute radiodermatitis develops in a few hours or weeks after the first exposure to radiation. The condition is healed itself in a short period of time

* Chronic RD is a condition of radiodermatitis that develops months, years or even decades after radiation.

The persistent reaction of RD can lead to complication of telangiectasia, a condition of widened venules (tiny blood vessels) that cause threadlike red lines or patterns on the skin, leading to
reduced quality of life and cosmetic outcome.

Dr. Sophie Seité, the lead scientist in the differentiation of the prevention and treatment of acute and chronic radiodermatitis wrote, "Today, treatment of radiodermatitis reactions is in its infancy. Although there is insufficient evidence available to form recommendations that would prevent or reduce radiodermatitis, some advances have been made using low-level light therapy (LLLT) or vascular lasers to control the symptoms".

And, "Some recent preclinical and clinical research suggests that LLLT has biostimulating properties which allow the tissues to regenerate and heal faster, reduce inflammation, and prevent fibrosis. Also, in late-onset radiodermatitis pulsed dye laser treatment has been shown to be beneficial in clearing radiation-induced telangiectasia. In the absence of evidence-based recommendations, the objective of this paper is to review how to prevent or manage the symptoms of radiodermatitis reactions".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to discover a natural compound for the treatment of radiodermatitis, a condition found in occurs in 95% of patients receiving radiation therapy (RT) for cancer, researchers examined the efficacy of oral curcumin, one of the biologically active components in turmeric, at reducing radiation dermatitis severity (RDS) at the end of RT, using the RDS scale, compared to placebo.

The multisite, randomized, double-blinded, placebo-controlled trial involved in 686 breast cancer patients who received either four 500-mg capsules of placebo or curcumin three times daily throughout their prescribed course of RT until 1-week post-RT.

More than 3% of the curcumin-treated group showed a reduction of radiation dermatitis severity compared to placebo.

The treatment group also report a change in pain, symptoms, and quality of life however, they were not statistically significant between arms.

In other words, oral curcumin reduced radiation dermatitis severity compared to placebo but not significantly.

In order to clarify the effect of curcumin on reducing radiation dermatitis severity (RDS) researchers assessed the ability of curcumin in 30 breast cancer patients.

The study involved 30 adult females with noninflammatory breast cancer or carcinoma in situ prescribed RT (receiving radiotherapy) without concurrent chemotherapy, received 2.0 grams of curcumin or placebo orally three times per day (i.e., 6.0 grams daily) throughout their course of RT.

According to the weekly assessments and the Standard pooled variances t-test, curcumin reduced RDS compared to placebo at end of treatment.

Furthermore, 28.6% of curcumin-treated patients had moist desquamation, compared to placebo of 87.5%, according to Fisher's exact test.

Demographics, compliance, radiation skin dose, redness, pain or symptoms are not significant differences in both groups.

Based on the findings, researchers wrote in the final report, "oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of radiodermatitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients by Ryan Wolf J1,2,3, Heckler CE4,5, Guido JJ4,5, Peoples AR4, Gewandter JS6, Ling M7, Vinciguerra VP8, Anderson T9, Evans L10, Wade J11, Pentland AP12, Morrow GR. (PubMed)
(2) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients by Ryan JL1, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. (PubMed)
(3) Prevention and treatment of acute and chronic radiodermatitis by Sophie Seité,1 René-Jean Bensadoun,2 and Jean-Michel Mazer. (PMC)

Phytochemical Quercetin Isolated from Onion Inhibits Parameters Involved in Oral cancer Developing

By Kyle J. Norton

Oral cancer is a medical condition of malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Most common types of oral cancer are

* Squamous cell carcinoma

Squamous cell carcinoma is one of the most common types of oral cancer accounting over 90% of all cases and arisen from the squamous cell layer in the lining of the oral cavity and oropharynx.

* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. The cancer can spread deeply into the surrounding tissue.

* Minor salivary gland cancers
The cancer is originated from the salivary gland accounted for less than 1% of all cases.

According to the statistics, approximately, 53,000 Americans will be diagnosed with oral or oropharyngeal cancer in 2019.

The disease also causes the death of over 9,750 patients, roughly 1 person per hour, 24 hours per day.

The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The 5-year survival rate of the localized stage of oral cancer is 84%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the overall 5-year survival rate is 65%.

The survival rate is even lower (39%) If cancer has spread to a distant part of the body,

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In the urgency to find a potential compound for the treatment of oral cancer, researchers investigated the potential effects of quercetin, a principal flavonoid compound in onions anti-oral cancer activities.

On SAS human oral cancer cells, quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments.

Quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 that promotes cancer cell growth and proliferation and (MMP)-9 involved in cancer cells angiogenesis and metastasis.

Additionally, quercetin also inhibited the proteins associated with the promotion of forming new blood vessel in SAS human oral cancer cells.

Furthermore, quercetin also blocked the expression of enzymes associated with the pathogenesis of many solid tumors through its inflammatory activation.

Moreover, proteins involved in cellular interactions with the extracellular matrix that cause tumor initiation, progression, and metastasis were also inhibited by the injection of quercetin.

More importantly, quercetin also exhibited the gene expression of tumor suppression such as P53 and apoptosis.

In other words, quercetin protects the oral cells by blocking the proteins involved in the signaling expression of tumor initiation, progression, and metastasis such as Ras homolog gene family, member A (RhoA) and protein kinase C (PKC).

Taken altogether, onion may be considered a remedy for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)
(2) Mouth ( Oral Cancer) Cancer by Kyle J. Norton