Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Monday, 25 March 2019

Honey, The Functional and Natural Depressant

By Kyle J. Norton

Depression is a psychological illness which affects a patient mentally, including thinking and feeling and physically such as loss of interest in physical activity.

The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.

There are some types of depression which can be classified as follow

1. Seasonal affective disorder (SAD) is caused by the change of weather. The mood of patients is affected by the weather and time of the year.

2. Postpartum depression is associated with the mother who can not cope with change following the birth of a child.

3. Depression with psychosis is the most severe case of depression as patients have lived in the illusion and loss of touch with reality.

4. Dysthymia, a persistent depressive disorder, also called dysthymia (dis-THIE-me-uh), is considered a chronic form of mild depression.

Most cases of depression in conventional medicine are treated with medication such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants, accompanied by psychotherapy.

If you take any aforementioned medicine, please make sure that you know all the side effects for preventive measure.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).

The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine.

Before treatment of chrysin, CUMS applied for 28days induced a decrease in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels as well as in the Na(+), K(+)-ATPase activity.

Where brain-derived neurotrophic factor (BDNF ) as a neurotransmitter modulator, plays an important role in neuronal survival and growth as well as in learning and memory.

Nerve growth factor (NGF) is a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. Reduced levels of nerve growth factor (NGF) has been found in patients with depression.

Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.

Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.

Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.

Injection of chrysin and fluoxetine treatments also exerted an antidepressant effect by protecting the CUMS rats against all alterations of the decreased production of antioxidant enzymes and increased oxidative stress.

Based on the findings, Dr. Filho CB, the lead scientists, "the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice".

Furthermore, in order to reveal more information about the honey antidepressant property, researchers examined investigated the effect of chrysin in mice exposed to unpredictable chronic stress (UCS).

In UCS applied for 28 days induced depressive-like rats, oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control) inhibited the decrease in the time of grooming in the splash test and increase in the immobility time.

Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment was also found to inhibit the production of pro-inflammatory cytokines and elevated corticotropin-releasing hormone and adrenocorticotropic hormone in the UCS-induced depressive-like rats.

Where elevated corticotropin-releasing hormone and adrenocorticotropic hormone was associated with patients with depression.

Moreover, Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment also attenuated the hormone deficiency such as 5-HT levels in the HP and elevated enzyme and matrixes such as indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP associated with depression-like symptoms, induced by UCS.

Taken altogether, honey processed bioactive compound chrysin may be considered a functional remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)

Cucumbers (Cucumis sativus) Bioactive Compound Cucurbitacin B (CuB) Kills Melanoma in Vitro

By Kyle J. Norton

Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.

The melanin is a pigment that gives skin, hair, and eyes their color.

Malignant melanin cells (melanocytes) lead to the formation of moles on the skin with usually brown or pink color.

Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver fail.

Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light color skin, personal and family history of skin cancer are associated with the onset melanoma.

However, most people with some of the aforementioned risk factors have not developed melanoma.

Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.

Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".

And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".

Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cell.

According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration and invasion potential of the melanoma cells.

In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to control.

Furthermore, injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.

Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved the formation of microfilaments.

Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".

Additonally, CuB inhibited the proliferation of the cell line was found to be in a dose-dependent manner, involving the induction of autophagy and exhibited the function of a protein associated with anti-apoptosis.

Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitive to the tested melanoma cells.

In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine side effects.

Taken altogether, cucumber processed a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending to the confirmation of larger sample size and multicenter human study

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)

Bromelain Found in Pineapple Suppresses the Symptoms and Onset of Osteoarthritis (OA)

By Kyle J. Norton

Osteoarthritis is an inflammation of joints caused by the depletion of the cartilage on the ends of the bones due to the wear and tear over time.

The disease is one most common form of arthritis that affects millions of people worldwide.

According to the statistics, in the US, approximately 10% of men and 13% in women aged 60 years or older have osteoarthritis (OA).

Most common risk factors found in patients with OA are older adults, female gender, overweight and obesity, knee injury, repetitive use of joints, low bone density.

Besides pain on the joints, other most common symptoms of OA include tenderness, stiff, low flexibility, grating sensation.

Conventionally, treatment of OA is focused on managing symptoms, by reducing pain, stiffness and swelling through the use of pain killers, improving joint mobility and flexibility and maintaining a healthy weight by exercise.

Some researchers suggested that the high prevalence of OA in the US has become a burden to the health care cost and economic burden.

Dr.Bitton R, the lead scientist at the Health Plan of Nevada wrote, "approximately one-third of direct OA expenditures are allocated for medications, much of which goes toward pain-related agents. Hospitalization costs comprise nearly half of direct costs, although these expenditures are consumed by only 5% of OA patients who undergo knee or hip replacement surgery".

And, "Indirect costs for OA are also high, largely a result of work-related losses and home-care costs".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the effects of bromelain in mild-to-moderate knee OA patients.

The randomized, single-blind, active-controlled pilot study included 40 knee OA patients randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).

At week 4, both bromelain and diclofenac treated groups showed an improvement of total the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and pain subscales compared to the baseline.

According to the tested assays, bromelain and diclofenac groups exerted similar effects after 4 weeks.

At week 16 of bromelain treatment, patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values.

In other words, bromelain reduced symptoms and improved quality of life in OA patients by inhibiting the levels of oxidative stress and overexpression of pro-inflammatory cytokines at week 16.

Based on the results, researchers after taking other factors into account wrote, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of osteoarthritis (OA), pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(2) The economic burden of osteoarthritis by Bitton R. (PubMed)

Plant-Based Bioactive Compound 3,3'-Diindolylmethane Kills Lung Cancer Cells in Vivo

By Kyle J. Norton

Lung cancer is a medical and chronic condition associated with the alternation of the cells in the lung tissue.

Most cases of lung cancer start in the cell on the surface of the inner lining of lung tissue before striking into deeper layers.

At the early stage, due to the small size of the tumor, most patients are asymptomatic. However, at the advanced stage, besides the common symptoms shared with other types of cancer, the patients may also experience symptoms of difficult breathing, persistent cough and hoarseness, and chest pain.

Some patients may also vomit blood caused by the oversize tumor suppressing on the nearby blood vessels.

Lung cancer is diagnosed mostly in the elderly, particularly in people over 65 years of age.
The mortality rate of lung cancer is higher than the colon, breast, and prostate cancers combined.

According to the statistics, In Canada, the 5-year net survival for lung cancer is 17%.

In other words, on average, only 17% of people diagnosed with lung cancer will survive for at least 5 years after their diagnosis.

However, lung cancer at the early localized stage has 5 years of the survival rate of 60%.

Although there are many risk factors associated with the onset of lung cancer, smoking is considered epidemiologically a major cause of the disease onset.

Dr. Ozlü T, the lead scientist in the examination of smoking and lung cancer risk, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".

And, "After smoking cessation, the cumulative death risk from lung cancer decreases. Patients who continue smoking experience greater difficulties during cancer treatment. Stopping smoking may prolong survival in cancer patients, and also decreases the risk of recurrent pulmonary carcinoma".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers in the concern about the risk of inflammatory conditions of the lung such as chronic obstructive pulmonary disease (COPD) that contributes to the onset of lung cancer risk, particularly lung squamous cell carcinoma (LSCC) examined the chemopreventive effects of BioResponse diindolylmethane (DIM).

The study included a mouse model of inflammation-driven LSCC induced by N-nitroso-trischloroethylurea (NTCU) and enhanced by lipopolysaccharide (LPS), a potent pro-inflammatory agent contained in tobacco and tobacco smoke.

Before treatment of DIM, mice treated with the combination of NTCU and LPS had a 9-fold increase in the number of bronchioles with LSC.

Compared to mice treated with LPS alone, mice treated with NTCU plus LPS showed significantly increased expression of the pro-inflammatory cytokines, accompanied by the increased expression of proteins associated with the production of pro-inflammation and cancer cells initiation.

Pretreatment of DIM at a concentration of 0 μmol/g diet or 2,460 ppm) to mice treated with NTCU plus LPS reduced the incidence of LSCC by 2-fold and suppressed activation/expression of proinflammatory and procarcinogenic proteins without affecting the expression of cytokines and p53, a tumor suppressive gene.

In other words, DIM blocked the development of LSCC through cytotoxicity and gene associated with tumor suppression.

In order to reveal more information about DIM anti-lung cancer property, researchers looked into the anticancer efficacy of 1,1-bis (3'-indolyl)-1-(p-biphenyl) methane (DIM-C-pPhC₆H₅) inhalation delivery alone and in combination with i.v. docetaxel in a murine model.

According to assays, the lung weight reduction in mice treated with the drug combination was 64% compared with 40% and 47% in mice treated with DIM-C-pPhC₆H₅ aerosol and docetaxel alone, respectively.

The combination treatment inhibited the lung cancer by decreased expression of proteins associated with the pro-inflammatory cytokines, cancer cells survival, and proliferation through stimulating the production of the new blood vessels.

Furthermore, the combination also increased expression of genes involved autophagy in the tumor formation, compared to the tumor cell counts from single-agent treatment and control groups.

Dr. Ichite N, the lead scientist said, "These results suggest that DIM-C-pPhC₆H₅ aerosol enhanced the anticancer activity of docetaxel in a lung cancer model by activating multiple signaling pathways".

Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice by Song JM1, Qian X1, Teferi F1, Pan J2, Wang Y2, Kassie F. (PubMed)
(2) Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer by Ichite N1, Chougule M, Patel AR, Jackson T, Safe S, Singh M. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)

Sunday, 24 March 2019

Plantbased Bioactive Compound Sinigrin, the Anti Fungal Infection Bioactive Compound

By Kyle J. Norton

A fungus is a primitive organism, including mushrooms, mold, and mildew.found in the air, in the soil, on plants, and in water.

Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin.

People with a weakened immune system are more likely to infected by fungi, including the fungus Aspergillus which cause lung infection.

Similar to other bacterias, there are millions of different fungal species on Earth, but only about 300 are known to infect people.

Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.

If you are currently taking antibiotics for the treatment of fungal infection, please make sure that you know all possible side effects for preventive measure.

Most common symptoms of skin fungal infection are red and cracking or peeling skin accompanied by itching, depending on the location of affected skin.

In a serious case of fungal lung infection, accumulated fungus fibers, blood clots, and white blood cells may appear in the lungs or sinuses, leading to coughing up blood or fever, chest pain, and difficulty breathing, depending to the size of the accumulation.

In the seeking a natural compound for the treatment of fungal infection, researchers analyzed the antifungal infection of the roots of twelve plant spades from bath mycotrophic (hosts of YAM fungi) and non‐mycotropic (non‐hosts) families against fungus Cladosporium cucumerimun Ellis & Arch.

2 species from the Brassicaceae such as Chenopodiaceae (Spinacea oleracea L., Beta vulgaris L.) showed a significant effect on fungus compared to Brassica kaber (DC.) Wheeler, Brassica napus L., Brassica campestris L., Thlaspi arvense L., Raphanus raphasnistrum L. which showed a limit activity.

According to the TLC bioassay, Chloroform extracts of B. Kaber roots appeared to have the greatest quantity of extractable antifungal compounds.

Three antifungal compounds in chloroform extracts from B. Kaber roots were shown to be derived from glucosinolates, containing high amount sinigrin.

The finding strongly supports the use of sinigrin for the treatment of fungal infection.

Furthermore, in the differentiation of the fungitoxicity of allyl‐isothiocyanate (AITC) vapor produced from pure sinigrin against Penicillium expansum, the causal agent of blue mold on pears, 5 mg L−1 AITC‐enriched atmosphere showed the best control of blue mold by exposing fruits for 24 h.

At 1 × 103 conidia mL−1to almost 80% at 1 × 106 conidia mL−1, AITC decreased the percentage of infected wounds, compared to >98% of wounds infected in untreated fruits.

Moreover, AITC treatments were effective up to 24 h after inoculation for Conference and 48 h for Kaiser. AITC treatments also controlled a thiabendazole‐resistant strain of P. expansum, reducing the incidence of the blue mold by 90% in both cultivars.

Dr. M. Mari, at the end of the experiment, wrote, "The use of AITC produced from pure sinigrin or from Brassica junceadefatted meal may be an economically viable alternative to synthetic fungicides against P. expansum".

Taken altogether, sinigrin may be considered a supplement for the prevention and treatment of fungal infection, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Plant-based Chemical Betanin Kills Cancer Cells in Vitro

By Kyle J. Norton

Cancer is the class of diseases associated with the cells growth disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.

However, most people with some of the aforementioned risk factors have never developed cancer.

Some researchers suggested that the rise of cancers in the obese individual may correlate to the promotion of the Western diet over the past few decades.

Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".

And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a natural ingredient which reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined betanin (BET) effect in the co-administration with them.

In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).

Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.

In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.

Sadly, the study did not confirm the combination reduced the side effect caused by DOX during the experiment.

Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.

He continued, "additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".

Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)

Herbal Ginger, the Potential Anti Hyperlipidemia Functional Remedy, Researchers Find

By Kyle J. Norton

Hyperlipidemia is abnormally high levels of cholesterol in the bloodstream. The syndrome is a member of the cluster conditions of metabolic syndrome, a leading cause of cardiovascular disease.

Cholesterol, a waxy substance produced either by the liver or food intake plays a critical role in the production of vitamin D, steroid hormones and the building of the cell walls.

Overexpression cholesterol is a medical condition which causes plaque accumulated on the arterial wall, leading to narrowing the arteries in transport the oxygenated blood to the parts of the body.

In severe cases, it can cause blood flow blockage, leading to chronic ailments depending on the location of the blood clot.

There are 2 types of blood cholesterol, the low-density lipoprotein (LDL) which carries the aforementioned functions and the high-density cholesterol (HDL) which carries cholesterol from the blood back to the liver for the future re-use.

The healthy ratio of total blood cholesterol is less than 4 LDL/ 1 HDL.

Most people diagnosed with high blood cholesterol substantially higher total cholesterol ratio.

Some researchers suggested that the widespread high blood cholesterol in North America is associated with the promotion of the Western diet over the past few decades.

Dr. Kamilah Ali, the lead scientist in the assessment of the Western diet risk of high blood cholesterol in an animal model, wrote, "mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice with sex-specific changes in total plasma levels of cholesterol and other lipids".

And, "Compared to WT, the HDL of apoD−/− mice showed an increase in large, lipid-rich HDL particles and according to size various quantities and sizes of LDL particles".

The results suggested that long-term users of the Western diet may be associated with the risk of hyperlipidemia.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the trerament dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of hyperlipidemia investigated the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage.

The study included 24 Wistar male albino rats (250 ± 20 g) divided into four groups including, normal control (NC) (0.9% NaCl), ginger treated (Gt) (200 mg/Kg b.w.), alcohol-treated (At) (20% of 6g/kg b.w. alcohol), and alcohol along with Ginger treatment (At+Gt).

Before ginger administration, alcohol-induced myocardial damage rats showed an increased lipid profile except for high-density lipoprotein compared with control.

Ginger treatment significantly inhibited the alcohol-induced lipid profiles caused by the injection of alcohol except for high-density lipoproteins.

Furthermore, ginger treatment also inhibited the elevated cardiac biomarkers activity with alcohol intoxication. In other words, ginger treatment for 7-weeks significantly minimized the alcohol-induced myocardial damage.

Dr. Subbaiah GV, the lead scientist said, "ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers".

In order to reveal more information about ginger anti hypolipidemic effects, researchers examined the hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD).

The study included male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg-1·day-1) for 5 weeks (HFD+GE).

GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats.

In the depth analysis, researchers found that ginger antihyperlipidemic activity was attributed to the induction of a higher liver expression of proteins associated with a variety of metabolic processes including lipid and enhanced levels of adiponectin which plays a critical role in preventing dyslipidemia.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of hyperlipidemia with no side effects, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats by Subbaiah GV1, Mallikarjuna K2, Shanmugam B1, Ravi S1, Taj PU1, Reddy KS1. (PubMed)
(2) Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet by de Las Heras N1, Valero-Muñoz M1, Martín-Fernández B1, Ballesteros S1, López-Farré A2, Ruiz-Roso B3, Lahera V1. (PubMed)
(3) A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice by Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, 1 Bethany Riggins, 1 Susanna Nguy, 1Lisa Li, 1 Ujala Srivastava, 1 and Su Mya Mya Thinn. (PMC)