Bilberry, the Potential Hepato-protective Functional Remedy, Researchers Say

By Kyle J. Norton

Bilberry may be used for the prevention and treatment of liver diseases with no side effects, according to studies.

Liver diseases are a medical condition in which the liver functions are reduced. In severe cases, liver diseases can induce liver failure.

The function of the liver is to filter out the blood from the digestive system before passing them to the cells and other parts of the body.

The largest organ also has a unique function in detoxifying the toxin in medications and drugs.

Furthermore, in the detoxification perspective, the liver also deactivates toxins by breaking down the toxins debris into a form that can be removed by the body.

Moreover, the organ performs the function of recycling old blood cells.

According to the statistics provided by the CDC and the American Liver Foundation, cirrhosis is a common liver disease which causes the death of over 31,000 people in the U.S. each year

The increase in age, gender, exposure to hepatitis viral occupation, being overweight or obese, high
blood cholesterol, hypertriglyceridemia, diabetes and long term use of certain medication such as
corticosteroids, prednisone, hydrocortisone are some prevalent risk factor of liver diseases.

In the US, the hepatitis C virus (HCV) infection is the leading cause of cirrhosis, hepatocellular carcinoma (HCC).

Dr. Vikas Khullar, the lead scientist in the examination of hepatitis C in risk of liver diseases wrote, "Despite recent advances in drugs for the treatment of hepatitis C, predictive models estimate the incidence of cirrhosis due to hepatitis C infection will continue to rise for the next two decades".

And, "There is currently an immense interest in the treatment of patients with fibrosis and early-stage cirrhosis as treatment can lead to decrease in the rates of decompensated cirrhosis, hepatocellular carcinoma and need for liver transplantation in these patients".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers with an aim to find a natural compound which processes liver protective effects investigated the bilberry extract against the 18 h restraint stress-induced serious liver damage in the animal models.

Restraint mice before injection of bilberry extract showed increased malondialdehyde (MDA) levels and lower oxygen radical absorbance capacity (ORAC) values in plasma and liver.

Oral administration of bilberry extract, containing 42.04% anthocyanins) in mice at 50, 100, and 200 mg/(kg x day) for five days, remarkably decreased plasma ALT level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg x day) and alleviated stress-induced liver damage.

Furthermore, the injection of the extract also bilberry increased antioxidant enzymes produced by the host such as glutathione (GSH) and vitamin C and significantly decreased the oxidative stress marker MDA and levels of free radicals such as nitric oxide (NO) in the liver tissues.

The findings strongly suggested that bilberry extract protects the liver against restraint stress by both scavenging free radicals activity and lipid peroxidation inhibitory effect.

Moreover, in rats induced liver damage by carbon tetrachloride (CCl4) divided into four groups: Group I (0.9% NaCl-10days), Group II (bilberry extract, 75mg/kg-10days), Group III (0,9% NaCl-9days, and on the tenth day CCl4-2ml/kg), Group IV (bilberry extract, 75mg/kg-10days and on the tenth day CCl4-2ml/kg)., researchers found that

* Injection of bilberry extract significant decreases the activity of biochemical parameters associated with liver damage, such as AST, GGT, LDH, and ALT, levels of the pro-oxidative enzyme such as xanthine oxidase, and the level of lipid peroxidation in the liver in Group IV.

* Application of bilberry extract also resulted in an increase in the number of apoptotic liver damage cells by the activity of the apoptotic protein in the liver tissue.

Dr. Popović D, the lead scientist after taking into account co and confounders wrote at the end of the experiment, "Anthocyanins from bilberry extract have strong antioxidant properties and therefore can be considered as powerful hepatoprotectives in natural products".

Taken altogether, bilberry may be considered a liver protective functional remedy for the prevention and treatment of liver damage and diseases pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References

(1) Antioxidant and hepatoprotective activity of Fagonia schweinfurthii (Hadidi) Hadidi extract in carbon tetrachloride induced hepatotoxicity in HepG2 cell line and rats by Pareek A1, Godavarthi A, Issarani R, Nagori BP. (PubMed)
(2) Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice by Bao L1, Yao XS, Yau CC, Tsi D, Chia CS, Nagai H, Kurihara H. (PubMed)
(3) Hepatitis C cirrhosis: New perspectives for diagnosis and treatment by Vikas Khullar and Roberto J Firpi. (PMC)

Phytochemical Sinigrin, the Potential Anti Bladder Cancer Bioactive Compound, Scientists Reveal

By Kyle J. Norton

Phytochemical Sinigrin may be used as a natural ingredient for the treatment of bladder cancer, according to studies.

Bladder cancer is a medical condition characterized by cell growth uncontrollably in the bladder tissue, due to the alternation of DNA.

Most cases of bladder cancer start in the cells of the inner lining of the bladder tissue. At the early, due to the small size and on the surface of the inner lining, most patients do not experience any symptoms.

However, at the advanced stage, the larger size tumor may press on the nearby blood vessels and nerve cells, leading to the symptoms of burning sensation, blood in the urine, abnormal urinary activity, particularly, severe abdominal pain and back pain on one side of the body.

If you experience some of the symptoms, please check with your doctor to rule out the possibility of bladder cancer.

Also, at this stage, the cancer cells can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

Epidemiologically, smoking, the increased in age, chronic bladder inflammation and long-term exposure to toxic chemicals are the most prevalent risk factors for bladder cancer.

Recently, some researchers start to question the risk of bladder cancer in the obese population.

Dr. Qin Q. wrote, "A total of 11 cohort studies were included in our meta-analysis, which showed that obesity was associated with an increased risk for bladder cancer in all subjects (RR=1.10, 95% CI=1.06-1.16; p=0.215 for heterogeneity; I2=24.0%). Among the 9 studies that controlled for cigarette smoking, the pooled RR was 1.09 (95% CI 1.01-1.17; p=0.131 for heterogeneity; I2=35.9%)"

Compared to the RR ratio, obesity and cigarette smoking shared the extreme close ratio of 1.09 and 1.10 respectively. In other words, if you are obese, your risk of bladder cancer is 0.01 higher compared to smokers.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a bioactive compound for the treatment of bladder cancer examined the effects of AITC-rich mustard seed powder (MSP-1) with AITC stably stored as its glucosinolate precursor (sinigrin) in MSP-1.

In a rat model, hydrated MSP-1 caused apoptosis and G(2)/M phase arrest in bladder cancer cell lines in vitro.

In the comparison of cancer activity between hydrated MSP-1 and pure sinigrin with added myrosinase, researchers surprisingly found that the anticancer effect of MSP-1 was derived principally, if not entirely, from the AITC generated from sinigrin.

In an orthotopic rat bladder cancer model, oral MSP-1 at 71.5 mg/kg (sinigrin dose of 9 μmol/kg) inhibited bladder cancer growth by 34.5% (P < 0.05) and blocked muscle invasion by 100%.

The in-depth analysis suggested that the anti-bladder cancer efficacy of MSP-1 was attributed to significant modulation of key cancer therapeutic targets, including blocking the vascular endothelial growth factor in the generation of the new blood vessels to promote cancer growth, a cyclin-associated to cancer cell division and caspase correlated with significantly increased rate of cancer recurrence and deaths.

Furthermore, the anticancer activity of  AITC delivered as MSP-1 appears to be more robust compared to that of pure AITC.

The finding strongly suggested that MSP-1 exhibited the AITC in the inhibition of bladder cancer development and progression.

Moreover, in the investigation of the effect of various dose levels of AITC on the activities of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST) in rat tissues, researchers conducted an experiment with selected rat was given high and low dose level of AITC daily for 5 days.

At low doses, AITC increased the production of antioxidant enzyme activity observed only in the urinary bladder of the rats, at a dose of AITC of only 10 micromol/kg/day.

In the activities of phase II, detoxification enzymes quinone reductase (QR), a plateau of activity of rats given the injection AITC for 21 days was reached after 15 daily doses of AITC, but GST activity continued to increase with continued exposure, and no plateau was reached after 21 doses.

Further examination of the levels of enzymes in the treated rats, researchers surprisingly found that the dose level of AITC is effective in rats approaches the level that could only be achieved through human consumption of Brassica.

The results strongly support the use of dietary approaches for the prevention and treatment of bladder cancer. Dr. the lead scientist said, "induction of phase II enzymes by food-derived isothiocyanates could contribute to the lower incidence of bladder cancer observed in individuals who regularly consume such vegetables".

Taken altogether, sinigrin, a bioactive ingredient found in the Brassica may be considered a supplement for the prevention and treatment of bladder cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion by Bhattacharya A1, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y. (PubMed)
(2) Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables by Munday R1, Munday CM. (PubMed)
(3) Obesity and risk of bladder cancer: a meta-analysis of cohort studies by Qin Q1, Xu X, Wang X, Zheng XY. (PubMed)

Phytochemical 3,3'-Diindolylmethane, May Be A Potent Anti Malignant Mesothelioma Bioactive Compound, Scientists Show

By Kyle J. Norton

The bioactive compound 3,3'-Diindolylmethane or DIM may process strong and positive effects against the risk and progression of mesothelioma, according to studies.

Mesothelioma is a medical condition characterized by irregular cell growth in the thin layer of tissue that covers the internal organs, due to cell DNA alternation.

However, according to the epidemiological studies, the most common area affected is the lining of the lungs and chest wall.

Most cases of mesothelioma start in the cell on the surface of the layered tissue. At the later stage, the cells of the larger size of the tumor can cause secondary tumors to develop in nearby organs and distant locations through the circulation of blood and fluids, leading secondary metastasis.

Most common symptoms of mesothelioma are persistent dry cough or wheezing, shortness of breath, pain in the chest or abdomen, fatigue and weakness.

In severe cases, patients may also experience symptoms of respiratory complications such as pleural effusion (fluid around the lungs).

If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Most common causes of mesothelioma are due to long-term exposure to asbestos as the disease is found in 80% of the patients. However, suggested that genetic preposition may also be the prevalent risk factor of the disease.

Dr. Ombretta Melaiu, the lead scientist in the investigation of the genetic susceptibility in the development of malignant pleural mesothelioma (MPM), wrote, "Among asbestos-exposed workers, several studies reported familial cases of MPM, suggesting that heredity could be important in the tumor development,.... the risk of developing MPM is increased of a limited extent among people exposed to asbestos with a positive history of familial cancers".

And, "In families and in animal models, mutations within BAP1 are strongly predisposing to develop MPM".

The results clearly suggested that if you carry the mutation gene BAP1, you are at a higher risk of MPM and other types of cancer.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Scientists in the concern of the malignant mesothelioma (MM), a very aggressive, lethal cancer, and its incidence is increasing worldwide examined the dietary phytochemicals which may process the potential for the treatment of MM with no side effect.

The study included several bioactive ingredients such as curcumin, epigallocatechin gallate, quercetin, genistein, pterostilbene, resveratrol, capsaicin, ellagic acid, benzyl isothiocyanate, phenethyl isothiocyanate, sulforaphane, indole-3-carbinol, 3,3'-diindolylmethane (DIM), diallyl disulfide, betulinic acid, and oleanolic acid.

DIM was found to process the anti-MM activity by boosting the function microRNA in the regulation of the genes activities.

Where MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression against the incidence of cancer. Increased expression of microRNAs is associated with numerous types of cancer.

Overexpression of miR-132 in vivo was associated with the severity in cancer patients.

Injection of DIM exerted anti mesothelioma potentials, through the expression microRNA regulatory activities.was attributed to the suppression of macrophage infiltration and pro-inflammatory cytokines.

In other words, DIM modulated the immune response against the onset and progression of mesothelioma caused by the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.

Dr. Sayeed MA the lead scientist wrote in the final report, "In addition to microRNA regulatory activities, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, phenethyl isothiocyanate, and sulforaphane have anti-mesothelioma potentials, and pterostilbene, capsaicin, ellagic acid, benzyl isothiocyanate, indole-3-carbinol, 3,3'-diindolylmethane, diallyl disulfide, betulinic acid, and oleanolic acid have potentials to inhibit cancer by regulating the expression of various genes which are also known to be aberrant in MM".

Taken altogether, DIM may be considered a supplement for the prevention and combined with primary therapy for the treatment of MM, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma by Sayeed MA1, Bracci M2, Lucarini G2, Lazzarini R2, Di Primio R2, Santarelli L. (PubMed)
(2) The genetic susceptibility in the development of malignant pleural mesothelioma by Ombretta Melaiu, Federica Gemignani, and Stefano Landi. (PMC)

Herbal Artichoke, May Process Anti Non-alcoholic Fatty Liver Disease (NAFLD) Potency, According to Studies

By Kyle J. Norton

Artichoke may be used as a herbal remedy for the treatment of nonalcoholic fatty liver disease with no side effects, according to studies.

Nonalcoholic fatty liver disease is a fatty liver disease caused by fat accumulated in the liver other than those of excessive alcohol drinking.

The disease, in most cases, is asymptomatic, however, it has been seen to slowly progress to end-stage liver disease.

According to the statistics, non-alcoholic fatty liver disease affects over 25% of the US population.  

Epidemiological studies suggested that most cases of nonalcoholic fatty liver disease are found in obese and extreme overweight adults. However, people with diabetes, high cholesterol or high triglycerides are associated with the increased risk of the diseases. Truly, 75% of obese have steatosis and 20% to 35% have nonalcoholic steatohepatitis (NASH).

As of today, there is no effective treatment in patients with NAFLD, change of diet and lifestyle to induce weight loss are the most common nonmedical treatment conventionally for management of the disease. 

Some researchers suggested that the cause of NAFLD may be associated with the promotion of the Western diet over the past few decades.

Dr. Michael D. Roberts, the lead scientist in the evaluation of the Western diet risk in NAFLD, wrote, "...sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes".

And, "diet-induced liver fibrosis and inflammation may either: a) occur much later with more chronic WD rat feeding paradigms; and/or b) may be initiated by other factors that precede eventual perturbations in local and systemic pro-inflammatory signalers with chronic WD feeding".

The results strongly suggested the Western diet pattern have a strong impact on the development of non-alcoholic fatty liver disease.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae, native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.


Scientists on finding a natural ingredient for the treatment of nonalcoholic fatty liver disease examined the artichoke (JA) potential in attenuating lipid disturbances in an animal model.

The study included Wistar of rats fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks.

After 21 days of the experiment, according to the liver samples collected, JA treatment group showed a significant improvement of a hepatic TAG accumulation, an indication of a fatty liver.

The expression of fat accumulation in the tested rats was observed by the expression of malic enzyme 1 (Me1), associated with fatty acid synthesis; decorin (Dcn), related to fibrosis altered by the FRU.

Additionally, the injection of the supplement also improved the gene associated with liver inflammation caused by FRU.

Furthermore, in order to reveal more information about artichoke anti NAFLD, researchers conducted a randomized double-blind placebo-controlled parallel-group trial in ultrasound-diagnosed NAFLD.

100 subjects were randomized to either ALE 600 mg daily or placebo for a 2-month period. 

Injection of AlE showed increased hepatic vein flow (p < .001), reduced portal vein diameter (p < .001) and liver size and levels of liver oxidative stress markers.

ALE treated group improved the liver function by reducing the expression of the levels of bilirubin.

More importantly, ALE supplementation also reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations.

The results showed that artichoke anti-NALFD via several mechanisms, including the inhibition of levels of cholesterol and liver stress markers.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of non-alcoholic fatty liver disease, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H1. (PubMed)
(2) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial by Panahi Y1, Kianpour P2, Mohtashami R3, Atkin SL4, Butler AE5, Jafari R6, Badeli R7, Sahebkar A. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector/ (PMC)

Herbal Andrographis, the Best Herbal Remedy for Malaria with No Side Effects

By Kyle J. Norton

Scientists may have found a herbal medicine for the treatment of malaria with no side effects, according to studies.

Malaria is a mosquito-borne infectious disease caused by parasitic protozoans.

People who are using the immune suppressive drug, having a weakened the immune system and infected by the HIV virus are more likely to experience severe effects of the infection.
Some researchers suggested that Women who are pregnant are at an increased risk of malaria infection.

Dr. Ebako Ndip Takem the lead scientist in the concern of malaria in pregnancy, wrote, "Pregnant women have a higher risk of malaria compared to non-pregnant women" 

And "Maternal risk factors for malaria in pregnancy (MiP) include low maternal age, low parity, and low gestational age. The main effects of MIP include maternal anemia, low birth weight (LBW), preterm delivery and increased infant and maternal mortality".

Most common symptoms of the disease are shaking chills alternated with a high fever. profuse sweating. a headache, nausea. vomiting. abdominal pain and diarrhea.

In the Western world, malaria is almost nonexistent due to sanitation and mosquitos spray. However, the disease is most prevalent in the countryside of the third world countries due to living conditions and medication.

Due to the widespread of malaria in the third, the World Health Organization has set a goal for the prevention and treatment of malaria, including the develop products that will provide: efficacy against drug-resistant strains of Plasmodium falciparum, potential for intermittent treatments (infants and pregnancy), safety in small children (less than 6 months old), safety in pregnancy, efficacy against Plasmodium vivax (including radical cure), efficacy against severe malaria, and transmission-blocking treatment.

Andrographis paniculata is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herbal plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

In the urgency of finding a natural anti-malaria herbal medicine with low cost for the treatment of malaria in the third world, researchers evaluated the effect of extracts of Andrographis paniculata (AP) and Hedyotis corymbosa (HC).

Methanolic extracts of the plants were tested in vitro on choloroquine sensitive (MRC-pf-20) and resistant (MRC-pf-303) strains of Plasmodium falciparum.

The 50% inhibitory concentration (IC50) of AP (7.2 microg/ml) was found better compared to those of the HC at a dose of 10.8 microg/ml).

Combination of these two herbal drugs showed substantial enhancements to their anti-malarial activity.

Increased in vivo potency was also observed with the combination of plant extracts, compared to the individual extracts and curcumin.

In-depth analysis of the plant extracts, researchers found the plant extracts inhibit the ring stage of the parasite and did not show any in vivo toxicity, whether they are used in isolation or in combination.

Dr. Mishra K, the lead scientist wrote on the final report, "Both these two plant extracts in combination with curcumin could be an effective, alternative source of herbal anti-malarial drugs".

Additionally, the investigation of the adulticidal and repellent activities of different solvent leaf extracts of Eclipta alba (E. alba) and Andrographis paniculata (A. paniculata) against malarial vector, Anopheles stephensi (An. stephensi) by comparing the adulticidal efficacy of the crude leaf extracts of E. alba and A. paniculata with five different solvents like benzene, hexane, ethyl acetate, methanol and chloroform was tested against the five to six day old adult female mosquitoes of An. stephensi.

Among the tested solvents the methanol extract showed a maximum efficacy compared to others. The LC(50) and LC(90) values of E. alba and A. paniculata against adults of An. stephensi were 150.36, 130.19 ppm and 285.22, 244.16 ppm.

According to the chi-square values, the methanol extract of A. paniculata produced maximum repellency against An. stephensi.

Dr. Govindarajan M and colleagues in the research team said, "the crude extract ..... A. paniculata was an excellent potential for controlling An. stephensi mosquitoes".

Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention and treatment of malaria for the third world countries where conventional medicne are expensive and hard to find with no side effects, pending to the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin by Mishra K, Dash AP, Swain BK, Dey N.(PubMed)
(2) Mosquito adulticidal and repellent activities of botanical extracts against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae) by Govindarajan M, Sivakumar R.(PubMed)
(3) Malaria in Pregnancy by Ebako Ndip Takem1 and Umberto D’Alessandro. (PMC)

Herbal Andrographis, the Natural Anti-fertility Functional Remedy with No Side Effects

By Kyle J. Norton

Scientists may have found a natural contraceptive for the prevention of conception, according to studies.

Anti-fertility is an act with intention to prevent, reduce or destroy fertility by using substances such as contraceptives, herbal medicine in under developing the world.

Contraceptives is a conventional medicine which allows you to enjoy sex without the risk of getting pregnant. The contraceptive pill is the most common contraceptive agent used in the Western world.

Many women also use a contraceptive pill for the treatment of irregular menstruation, painful or heavy periods, endometriosis, acne, and premenstrual syndrome (PMS).

Most common side effects of the contraceptive pill include gastrointestinal discomforts, intermenstrual spotting, breast tenderness, headaches, and migraine, mood changes,  missed periods and vaginal discharge.

Some women using the pill also experience symptoms of decreased libido.

Dr. Davis AR, the lead scientist in the examination of the effect of OCs on sexual functioning, wrote, " in 30 original research studies. In the retrospective, uncontrolled studies (n = 17), it was found that most women reported an increase in libido during OC use. In the uncontrolled, prospective studies (n = 4), it was found that most women reported little change in libido during OC use. In the perspective and cross-sectional controlled studies (n = 4), women using OCs reported both increased and decreased libido compared to non-OC user". and " In the most recent and well-conducted trial, a decrease in libido in OC users compared to placebo users was found".

These results strongly suggested that women may react differently to the use of the contraceptive pill, probably due to the based hormones in the body.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herbal plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

With an aim to find a natural ingredient with less cost and no side effect for males contraception, researchers at the Jamal Mohamed College examined the anti-fertility of dry leaf powder of A. paniculata in an animal model.

Dry leaf powder of A. paniculata fed orally to male albino rats, at a dose level of 20 mg powder per day for 60 days showed a significant effect on cessation of spermatogenesis, degenerative changes in the seminiferous tubules, regression of Leydig cells.

The antifertility activity also can be observed by the regressive and/or degenerative changes in the epididymis, seminal vesicle, ventral prostate and coagulating gland.

Furthermore, injection of the powder also reduced the weight and fluid content of the accessory glands.

The results of the treatment also demonstrated the accumulation of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate. 

The finding clearly suggested that dry leaf powder of A. paniculata processes an antispermatogenic and/or antiandrogenic effect on the mice.

Moreover, in albino Wistar rats, researchers tested the anti-male fertility of andrographolide, a major bioactive compound found in herbal Andrographis extract.

The testosterone levels and fertility indices in treatment groups were found to be comparable with that of the control indicating no effect on fertility.

Total sperm count and sperm motility were not affected. The testes and epididymides did not show any gross and histopathological changes.

Administering 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating.

The treated groups showed no signs of dose-dependent toxicity. The body weight gain and feed consumption were not affected at any of the dose levels.

The finding clearly suggested that the efficacy of herbal Andrographis in the induction of male infertility is not attributed to a single ingredient but all ingredients in the herbal medicine.

Taken altogether, herbal Andrographis may be considered a natural anti-male fertility or male contraceptive agent with no side effect, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographispaniculata in male Wistar rats, by Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)
(4) Oral contraceptives and libido in women by Davis AR1, Castaño PM. (PubMed)

Herbal Andrographis inhibits the Risk, Progression of Colitis

By Kyle J. Norton 

Herbal Andrographis may have potential and profound effects in reducing risk and treatment of colitis with no side effects, scientists suggested

Colitis is a condition of inflammation of the large intestine, including the colon, caecum, and rectum.

There are numbers of causes of the disease, including infection, inflammatory bowel disease, and allergic reactions.

Other types of colitis include
* Microscopic colitis a condition referred to collagenous colitis and lymphocytic colitis, two related medical conditions which cause diarrhea.

* Ischemic colitis, another colon infection which may also go away with mild treatment, such as a short-term liquid diet and antibiotics.

If you are experiencing some of the symptoms such as persistent abdominal pain, diarrhea and cramping, dehydration, selling of joint, eye inflammation and fever or chill, you may have colitis. Please check with your doctor to rule out the possibility of the disease.

Dr. Winther KV in the study to examine the survival and cause-specific mortality in ulcerative colitis, including 1160 patients diagnosed with ulcerative colitis between 1962 and 1987 was followed-up until 1997 to describe survival and cause-specific mortality.

At that span, a total of 261 deaths occurred, not significantly different from the expected number of 249 (SMR, 1.05; 95% CI, 0.92-1.19). The median age at death among men was 70 years (range, 6-96 years) and among women 74 years (range, 25-96 years).

The mortality was increased in patients with pulmonary embolism and pneumonia.

The doctor team wrote, in the final report, "Despite an overall normal life expectancy for patients with ulcerative colitis, patients >50 years of age and with extensive colitis at diagnosis had increased mortality within the first 2 years after diagnosis, owing to colitis-associated postoperative complications and comorbidity".

The results clearly suggested that patients with colitis are at increased risk to die due to the complication of other diseases, particularly, in the first 2 years of diagnosis.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.


In order to reaffirm the use of extracts of the plant Andrographis paniculata anti-inflammatory diseases in Asian countries, researchers examined the effects of HMPL-004 (A. paniculata extract) against colitis in mice model induced by injection of methylcellulose (MC).

Before application of HMPL-004, mice treated with MC developed colitis within 4-7 weeks, accompanied by weight gain and severe intestinal inflammation.

HMPL-004-treated mice inhibited lose weight and displayed only very mild intestinal inflammation.

The inflammatory cytokines caused by injection of MC alao significantly decreased after treatment of HMPL-004.

Higher percentages of naïve CD4(+) T cells in the lamina propria of HMPL-004-treated mice compared to MC mice.

Furthermore at the early timepoints HMPL-004-treated mice have significantly reduced splenic cell counts, reduced inflammatory markers, and reduced pro-inflammatory expression.

Moreover, HMPL-004 inhibited the proliferation of CD4 T cells that cause immune response differentiation into TH1/TH17 cells that have the capacity to cause inflammation and autoimmune disease in vitro.

The results firmly suggested that HMPL-004 has a potential effect on inflammatory diseases, particularly in inflammatory bowel disease and colitis.

The research team at the final report wrote, "HMPL-004 inhibits the development of chronic colitis by affecting early T-cell proliferation, differentiation, and TH(1)/TH(17) responses in a T-cell-driven model of colitis, presenting a unique mechanism of action".

Also, the Hutchison Medipharma Ltd.in a recent randomized, double-blind, multicentre, 8-week parallel group study of HMPL-004, to learn more about the anti-inflammatory activity examined the Andrographis paniculata extract against mild to moderate ulcerative colitis (UC).

Compared to 16% and 82% efficacy of 4500 mg/day of slow release mesalazine (mesalamine) granules in patients with mild-to-moderately active ulcerative colitis, application of HMPL-004 exerted a more tenant effect on 21% and 76%, respectively.

By colonoscopy, remission and response were seen in 28% and 74% of HMPL-004-treated patients and 24% and 71% of mesalazine-treated patients, respectively.

   

The finding strongly supported HMPL-004 is an efficacious alternative to mesalazine in ulcerative colitis.

Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention and treatment of colitis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses by Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR.(PubMed)
(2) Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine by Tang T1, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ. (PubMed)
(3) Survival and cause-specific mortality in ulcerative colitis: follow-up of a population-based cohort in Copenhagen County by Winther KV1, Jess T, Langholz E, Munkholm P, Binder V.(PubMed)