Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Saturday, 16 February 2019

Herbal Cascara Sagrada (Rhamnus purshiana), the Natural Antibiotic Alternative

By Kyle J. Norton

Herbal Cascara sagrada processed a bioactive compound emodin may have a potential and profound effect on reducing the risk and treatment of bacterial infection, according to studies.

According to the statistic, infectious diseases caused the death of 9.2 million deaths in 2013 worldwide, represented 17% of all deaths.
Bacterial infection is a result of the battle of the immune system against the multiplication of bacteria in some selected tissue or organ by the pathogens after scaping the assault of white blood cell in the first line of immune defense.

Bacterial infection can be caused by the spread through infected person coughing and sneezing and contact with infected people or contaminated surfaces, food, and water.

However, the most common risk factors of bacterial infection are tissue damage or injury. Believe or not, most bacteria tries to enter the body through wound are killed off during the acute phase of infection.

At the early phase, immune not only stimulates the blood vessels constriction to produce palette to cover the wound but also activates the production of proinflammatory cytokines to the site of the damage with an aim to kill off all the micro-invaders.

Most common conventional medicine for the treatment of bacterial infection is an injection of antibotics.

Due to overuse of such medication, some bacteria have development antibiotics resistances, such as Staphylococcus aureus ('golden staph' or MRSA) and Neisseria gonorrhoeae are now resistant to benzylpenicillin.

New antibiotics may be effective, however, they can induce some side effects. Please make sure you discuss the adverse effects with your doctor if you are currently taking some antibiotic for the treament of infection.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

Researchers on finding a natural ingredient to treat bacterial infection examined the effects of emodin against Methicillin-resistant Staphylococcus aureus (MRSA), a substantial contributor to morbidity and mortality.

In 17 different strains of the bacterium selected to the study, the combined activity of EM and two antimicrobial agents (AM, OX) against all strains resulted in a fractional inhibitory concentrations index (FICI) ranging from 0.37-0.5 and from 0.37-0.75, respectively.

The effect of EM with AM and OX was found to be synergistic or partially synergistic.

Furthermore, EM reduced the minimum inhibitory concentrations of AM and OX. EM against MRSA infection.

In the comparison of the antibacterial effects of aloe- emodin and aloe and its contents of anthraquinone compounds, researchers evaluated the antibacterial activities of the extracts from the outer leaf of Aloe saponaria Haw, aloin and aloe-emodin against three Gram-negative and two Gram-positive bacteria

Anthraquinone, aloin exhibited higher antibacterial activity [inhibition diameter > (7. 1 +/- 0.15) mm] than Aloe-emodin.

The antibacterial activity of Aloe was attributed to the concentration of anthraquinone, aloin in a dose-dependent manner.

The results clearly suggested that Aloe-emodin exerts a significant antibacterial effect to a lesser extent compared to levels of anthraquinone, aloin.

Taken altogether, herbal Cascara Sagrada processed a high amounts emodin may be considered an alternative antibiotic for the treatment of bacterial infection, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References(1) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.by Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY.(PubMed)
(2) [Relationship between antibacterial activity of aloe and its anthaquinone compounds].[Article in Chinese] by Tian B, Hua YJ, Ma XQ, Wang GL.(PubMed)

Herbal Calendula, the Best in Speeding Up Wound Healing with No Side Effects

By Kyle J. Norton

Herbal may have a strong effect on speeding up wound healing, according to studies by a number of institutes.

Wound healing is a natural process of our body by restoring the function of the damage or injured tissue through several stages.

Most importantly, the early stage of wound healing is also known as an acute phase of infection, which starts as soon as the immune system sensing the tissue damage by stimulating the blood vessels to provide the damaged tissue with blood palette to cover the wound temporarily and activated the proteins associated with the production of inflammatory cytokines to the site of infection with an aim to kill off all micro invaders.

In most cases, the immune first line of defense can destroy the pathogens and speed up the recovery of the damage through inducing fiber tissue re construction, new blood vessels.

However, overproduction of a proinflammatory cytokine in this phase may cause damage and death of nearby cells, leading the formation of scars.

If the immune system can not kill off all the invaded pathogen within a set of time, normally in 3-8 weeks, it will adapt to the new change, leading to low-grade inflammation, a major cause of several chronic ailments, including diabetes, herat diseases.

If the process of wound healing is disrupted, it may also lead to improper wound healing with complications, including inadequate scar formation, excessive scar formation, and a contracture formation, an exaggeration of normal wound edge contraction forming deformities.

Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

Researchers on finding a natural ingredient for speeding up wound healing examined the effect of Calendula officinalis, an annual herb from the Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent.

Injection of C. officinalis demonstrated significantly anti-inflammatory and antibacterial activities in protecting the wound against infection.

Furthermore, C. officinalis also speed up the wound healing process by enhancing the angiogenic and fibroplastic properties.

The findings strongly suggested that herbal Calendula can act in a positive way on the inflammatory and proliferative phases of the healing process.

Moreover, in the evaluation of the effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats, compared to the control of 51.1%, oral and topical application of Calendula showed a wound closure was 90.0%.

The extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period needed for re-epithelization to 14 and 13 days, respectively compared to 17.7 days in the control.

Additonally, the extract-treated group also exhibited a significant increase in the concentration of collagen. compared to the untreated animals.

Interestingly, in a total of 36 rats and 90 embryonated eggs used to evaluate healing and angiogenic activities of extracts and fractions of Calendula, through the induction of skin wounds and the chorioallantoic membrane, respectively, researchers found that
* Injection of calendula extract exerted an angiogenic activity in speeding up wound healing in both experimental models.

* The efficacy was not attributed to the signal protein produced by cells that stimulate the formation of blood vessels, but other unknown pro-angiogenic factors.

Taken altogether, herbal Calendula may be considered a functional remedy for speeding up wound healing with no side effects.

References
(1) Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil by Parente LM1, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM.(PubMed)
(2) Angiogenic activity of Calendula officinalis flowers L. in rats by Parente LM1, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, Tresvenzol LF, Paula JR, Paulo NM.(PubMed)
(3) Wound healing activity of flower extract of Calendula officinalis by Preethi KC1, Kuttan R.(PubMed)

Herbal Chamomile, the Anti Skin Cancer Herbal Remedy

By Kyle J. Norton

Chamomile processed a high amount of antioxidant may have a profound and positive effect on reducing risk and treatment of skin cancer, according to studies.

Skin cancer is the medical condition caused by irregular cell growth in the skin tissues due to the alternation of cell DNA.

Most cases of skin cancer begin in the cell on the surface of the inner lining of skin tissues. However, at the advanced stage, the tumor cells can travel a distance away from the skin to infect other healthy tissue and organs, through lymph and blood, leading to secondary metastasis.

Organs or system which is vulnerable to skin metastasis is lymph, lung, and liver.

Although family and personal history, history of sunburn, excessive sun exposure and people who live in sunny or high-altitude climates are associated with the risks of skin cancer, some researchers suggested that skin cancer in the Western world may be attributed to the misunderstanding the risk of sun exposure and the risk of unhealthy skin, as we still can see a lots of naked skin exposed to sunlight during the Summer months in the parks.

According to the statistic, 90 percent of nonmelanoma skin cancers are associated with exposure to ultraviolet (UV) radiation from the sun. An estimated 4.3 million cases of BCC are diagnosed in the U.S. each year. causing the death of more than 3,000 people.

Dr. Honnavara N Ananthaswamy in the concern of the sunlight and risk of skin cancer wrote, " Laboratory studies have shown that UV-B region of the solar spectrum is responsible for this effect. The first step in UV skin carcinogenesis involves the induction of DNA damage".

And, "Occasional mistakes during the repair of this damage leads to the incorporation of wrong bases into the genetic material. The DNA damage that is left unrepaired may also disrupt cellular processes by obstructing the DNA and RNA synthesizing machineries and introduce wrong bases into the DNA. These types of mistakes often result in mutation leading to loss or inappropriate expression of affected genes".

The finding indicated the progression of skin cancer in long-term UV exposure and how the UV light induces the change of skin cells DNA.

Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Researchers on finding a herbal medicine for the treatment of skin cancer which not only continues to rise but also accounts for approximately 40% of all cancers reported in the United States and 9,500 deaths per year, examined the effects of chamomile against reactive oxygen species (ROS) type free radicals in the initiation of skin cancer and aging.

Compared to other herbal medicines used in the study, chamomile demonstrated skin protective effects against oxidative stress through its antioxidant activity.

In vitro, chamomile modulated the hydrogen peroxide (H2O2)-induced upregulation of ROS free radicals in normal human skin fibroblasts.

According to the flow cytometry-based assay, the free radical inhibition of chamomile was attributed to a single ingredient but varying concentrations of herbal chamomile natural components.

Additional investigation of the chamomile anti-skin cancer activity, researchers examined the bioactive compound Apigenin, major active compound from herbal chamomile which was previously found to inhibit chemically induced ornithine decarboxylase (ODC) activity and skin tumor promotion.

Increased of ornithine decarboxylase (ODC) was associated with the expression of oxidative stress in animal chemical induction.

After mouse skin carcinogenesis was induced by exposure to a total dose of 40 J/cm2 UVB over 11 weeks, application of Apigenin (5 mumoles/200 microliters DMSO:acetone, 1:9) treatment from 12 hours before until 1 hour following UVA/B exposure was effective in inhibition (25-45% inhibition) of ODC activity measured at 28 hours following UVA/B exposure.

Treatment with 10 mumoles apigenin in 200 microliters DMSO:acetone (1:9) prior to each UVB exposure showed a reduction in cancer incidence (52% inhibition) and an increase in tumor-free survival, compared to control mice.

Interestingly, in salmon sperm, Apigenin (0-100 microM) did not prevent the production of photoproducts to cause damage to the cell DNA.

The results strongly suggested that Apigenin inhibited UVA/B induced ODC activity or UVB induced skin carcinogenesis through many unknown mechanisms instead of simply absorbing ultraviolet light or decreasing DNA damage.

Taken altogether, herbal chamomile may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of skin cancer.

References
(1) The active natural anti-oxidant properties of chamomile, milk thistle, and halophilic bacterial components in human skin in vitro by Mamalis A1, Nguyen DH, Brody N, Jagdeo J.(PubMed)
(2) Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid by Birt DF1, Mitchell D, Gold B, Pour P, Pinch HC.(PubMed)
(3) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin by Lin JK1, Chen YC, Huang YT, Lin-Shiau SY.(PubMed)
(4) Sunlight and skin cancer by Honnavara N Ananthaswamy. (PMC)

Friday, 15 February 2019

Herbal Chamomile, the Best Neuro-protective Remedy

By Kyle J. Norton

Herbal Chamomile processed a high amount of antioxidant may have a strong and profound neuroprotective effect against the onset of cognitive impairment, according to studies.

Cognitive impairment is a medical condition associated with a decline in cognitive abilities, including memory and thinking skills.

Approximately 15 to 20% of cognitive impairment are diagnosed in people age 65 or older. However, if the condition of cognitive impairment gets worse over time, it eventually leads dementia that compromises social and/or occupational functioning.

In the early stage of cognitive impairment, patients may experience symptoms of hallucinations. delusions, personality changes, apathy, and some depression and anxiety symptoms.

If you are experienceing some of the above symptoms, please make you check with your doctors to rule out the possibility.

Although there are many factors associated with the onset of cognitive impairment, some researchers suggested that aging is the major cause of the condition in the Western world.

Therefore, finding a strategy for the delay of cognitive impairment in the elderly has become more urgent. Dr. Blanka Klimova, and colleagues in the dementia team at the University Hospital Hradec Kralove and University Hradec Kralove in the concern of the risk of cognitive impairment in aging wrote, " physical activities, such as walking and aerobic exercises, music therapy, adherence to Mediterranean diet, or solving crosswords, seem to be very promising lifestyle intervention tools"

And, "The results indicate that non-pharmacological lifestyle intervention activities should be intense and possibly done simultaneously in order to be effective in the prevention of cognitive decline. In addition, more longitudinal randomized controlled trials are needed in order to discover the most effective types and the duration of these intervention activities in the prevention of cognitive decline, typical of aging population groups"

Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.

The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Scientists on finding an herbal remedy which processes neuroprotective effects examined the chamomile activity against the onset of oxidative stress which is considered a key role in the pathophysiology of many neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease.

Aluminum fluoride (AlF₄⁻)-induced oxidative stress in rats selected to the study were divided randomly into group I received normal saline; group II received AlF₄⁻ (negative control); groups III, IV, and V received 100, 200, and 300 mg/kg, orally, German chamomile methanol extract (GCME) along with AlF₄⁻; and group VI received quercetin (25 mg/kg, i.p.) + AlF₄⁻, respectively.

The experiment included a 10 days treatment with GCME before the animal induced oxidative stress by administering AlF₄⁻ through drinking water for 7 days.

Administration of GCME inhibited the levels of oxidative stress through increasing the production of antioxidant enzymes produced by the host and decrease in lipid peroxidation (LPO).

Compared with the negative control group (P < 0.001), chamomile displayed a potent neuroprotective action against oxidative brain damage.

In rat induced oxidative stress by global cerebral ischemia/reperfusion (I/R) injury, application of methanolic extract showed dose-dependent neuroprotective activity by a significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) similar to that of the above study.

The treatment group also showed a significantly reduced vertebral infarction area in extract treated groups, compared to the untreated group.

Dr. Chandrashekhar VM, the lead scientists, said, "The methanolic extract of Matricaria recutita L. showed potent neuroprotective activity against global cerebral ischemia/reperfusion injury-induced oxidative stress in rats".

Taken altogether, herbal chamomile which demonstrates the brain neurons protective effect against oxidative stress in the initiation of neurodegenerative diseases, may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of dementia.

Sources
(1) Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats by Ranpariya VL1, Parmar SK, Sheth NR, Chandrashekhar VM.(PubMed)
(2) Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats vy Chandrashekhar VM1, Ranpariya VL, Ganapaty S, Parashar A, Muchandi AA(PubMed)
(3) Cognitive decline in normal aging and its prevention: a review on non-pharmacological lifestyle strategies by Blanka Klimova,1,2 Martin Valis,2 and Kamil Kuca. (PMC)

Herbal Cayenne Processes Both Hypo and Hyper Tension Function In Dose Dependent- Manner

By Kyle J. Norton

Herbal cayenne processed a significant amount of bioactive compound Capsicum may have a positive and profound effect on normalizing the levels of blood pressure, according to studies.

Hypertension is a medical condition of abnormally high blood pressure, one of the members of the cluster of conditions associated with heart disease and stroke.

Depending on the reading, some researchers suggested if you are in stage one of high blood pressure, your risk of cardiovascular disease is increased by 10% over the next 10 years.

According to the statistics, in the US, approximately 75 million people or 1 of 3 U.S. adults has high blood pressure. High blood pressure can be modified by change of lifestyle.

Most common risk factors of high blood pressure are a poor diet with high in salt and potassium and low vitamin D, physically inactive, excessive alcohol drinking, use of Non-steroidal Anti-inflammatory Drugs (NSAIDs), and aging.

However, not all people with some of the above conditions will develop high blood pressure.

Treatment of stage 1 and 2 hypertension include daily intake of diuretics which lower high blood pressure by reducing sodium and fluid through increased urinary secretion and Bumetanide (Bumex) Chlorthalidone (Hygroton) or Chlorothiazide (Diuril).

Some patients may experience side effects such as a cough, diarrhea or constipation, dizziness or nervousness, tired, weak, and nausea or vomiting.

In a serious case, high blood pressure medication may induce erectile dysfunction. If you are taking high blood pressure medications, please make sure you have discussed the side effects with your doctor.

Some researchers in the concern of the widespread of hypertension in the Western world suggested that the condition may correlate to the promotion of the Western diet over the past few decades.

Dr. Adriana Monge and colleagues examined the Western and Modern Mexican diet pattern and risk of high blood pressure, wrote, "The multivariable-adjusted odds of hypertension in the highest quartile of the Western (W) pattern were 24% higher than the odds for individuals in the lowest quartile"

And, "women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile. The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension".

These results clearly indicated a strong connection of the Western diet pattern in the increased risk of hypertension compared to the lower risk of fruits and vegetable group.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The pepper has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

Epidemiological studies linking cayenne in reducing hypertension have not been conclusive, the mechanism of this effect is still an mystery.

Researchers on finding a herbal medicine for the treatment of hypertension with no side effects examined the traditionally used medicinal plants against key enzymes relevant for hyperglycemia and hypertension.

Compared to other herbal plants, pepper (Capsicum) inhibited significantly the hypertension relevant angiotensin I-converting enzyme (ACE).

All evaluated pepper (Capsicum) genus exhibited both anti-hyperglycemia and anti-hypertension potential.

The anti-high blood pressure of cayenne probably is associated with the major compound capsaicin, chlorogenic acid, and hydroxycinnamic acid derivatives.

However, in pig study, application capsaicin isolated from the cayenne showed a significantly increased mean arterial blood pressure compared with controls, and a decrease in CGRP synthesis and release contributes to the elevated blood pressure.

Also, there are 2 cases reported of an arterial hypertensive crisis in a patient with large ingestion of peppers and chili peppers the day before and a 19-year-old Italian man with abundant ingestion of peppers and of chili peppers the preceding day.

Additonally, overdoses of cayenne not only induced arterial hypertensive crisis but also acute myocardial infarction with high levels of thyroid stimulating hormone.

The findings strongly suggested cayenne processed an antihypertensive and hypertensive effect in a dose-dependent manner.

This dual mechanisms presented in cayenne may not be explained by conventional medicine. However, traditional Chinese medicine stated cayenne, yang in nature, promotes Qi movement of blood. In a healthy individual, smooth movement of qi reduces the unnecessary blood pressure in blood transportation. On the other hand, if the movement of qi is blocked due to the presence of a high amount of cholesterol that narrows the blood vessel, in inducing higher blood pressure.

The traditional Chinese medicine continued, injection of a high amount of cayenne pepper can cause constriction of blood vessels, leading to narrowing blood flow and risk of hypertension

Taken altogether, there is no doubt that cayenne may be considered a functional remedy for the prevention and treatment of hypertension, but the amount of intake should only be prescribed by related field specialists.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America by Ranilla LG1, Kwon YI, Apostolidis E, Shetty K.(PubMed)
(2) Capsaicin and arterial hypertensive crisis by Patanè S, Marte F, La Rosa FC, La Rocca R.(PubMed)
(3) Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone by Patanè S, Marte F, Di Bella G, Cerrito M, Coglitore S.(PubMed)
(4) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)

Ginger, the Anti Cervical Cancer Functional Remedy, According to Studies

By Kyle J. Norton

Scientists may have found a natural and pungent spice for the prevention and treatment of cervical cancer, according to the studies.

Cervical cancer is a medical condition characterized by the cell growth disorderly and uncontrollably in the cervix tissue.

According to the statistics provided by the American Cancer Society, in 2018, approximately, 13,240 new cases of invasive cervical cancer were diagnosed. The disease causes the death of 4,170 women in the same year.

The 5-year survival rate for women with invasive cervical cancer is 92% if the cancer is detected at an early stage. About 46% of women with cervical cancer are diagnosed at an early stage.
Most cases of cervical cancer are detected during the annual physical exam during the Pap test.

The exact cause of cervical cancer is due to the alternation of the cells on the surface of the inner lining of the cervical tissue. Researchers do not know, Why? some women are more susceptible to the onset of cervical cancer while others do not, even they have the same health conditions and family history in the same family.

However, researchers do know that certain risk factors such as human papillomavirus (HPV) infection, the increase in age, herpes infection, smoking are associated with the onset of cervical cancer.

Ethnicity also plays a critical role in cervical cancer, the American Cancer society wrote, "In the United States, Hispanic women are most likely to get cervical cancer, followed by African-Americans, Asians and Pacific Islanders, and whites. American Indians and Alaskan natives have the lowest risk of cervical cancer in this country".

Furthermore, some researchers suggested that oral sex which refers to sexual activities involving the stimulation of the genitalia by the use of the mouth, tongue, teeth, or throat also have a strong linkage to cervical cancer. Dr. Rajiv Saini examined the link between oral sex and cervical cancer wrote, "Current research suggests that oral sex may transmit human papillomavirus (HPV), the virus implicated in the majority of cervical cancers. HPV is ubiquitous, with 120 strains isolated from human beings, about 40 of which are in the mouth and genital tracts".

Researchers on finding a natural compound for the treatment of cervical cancer examined the antitumor activities of 6-Gingerol, a potent nutraceutical isolated from the ginger on human cervical cancer (HeLa) cell lines with or without wortmannin, rapamycin, and cisplatin.

Injection of 6-Gingerol showed dose-dependent cytotoxicity on human cervical cancer (HeLa) cell lines.

Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity that was equivalent to IC50 of 6-gingerol alone.

Treatment with 6-gingerol resulted in G2-phase arrest in HeLa cells. 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of a pro-apoptotic protein in the tested cell line.

The finding strongly suggested that 6-gingerol may be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in cervical tumor cells.

In order to reveal more information of ginger anti-cervical cancer properties, researchers examined the polyphenolic alkanone, 6-Gingerol (6G), presented in the pungent extracts of ginger (Zingiber officinale Roscoe) anti-tumorigenic and pro-apoptotic activities against cervical cancer.

In vivo. 6G potently inhibited proliferation of the HPV positive cervical cancer cells.

Additionally, 6G was found to inhibit the chymotrypsin activity associated with the induced degradation of tumor suppressor proteins, reactivate the gene involved regulating cell cycle and tumor suppression and suppress the protein involved a cellular response to cytokines, chemokines, stimuli.

More interestingly, injection 6G also expressed an inhibitory activity against cervical cancer cell lines through inducing DNA damage of the tumor cell and G2/M cell cycle arrest and potentiate the cytotoxicity of cisplatin.

6G treatment induced a significant reduction of tumor volume, tumor weight, inhibition of proteasome that breaks down protein and tumor suppressive gene accumulation in HeLa xenograft tumor cells in vivo.

Dr. Rastogi N and colleagues said, " our data underscore the therapeutic and chemosensitizing effects of 6G in the management and treatment of cervical cancer".

Taken altogether, ginger with abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of cervical cancer, pending to the confirmation of large sample size and multicenter human study.

Sources

(1) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)

(2) Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells by Rastogi N1, Duggal S2, Singh SK3, Porwal K1, Srivastava VK2, Maurya R4, Bhatt ML2, Mishra DP. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)

Wednesday, 13 February 2019

Calendula, the Best Anti Cancers Herbal Remedy, According to Studies

By Kyle J. Norton

Scientists may have found a herbal remedy for the prevention and treatment of cancer, according to the studies.

Cancer is the class of diseases associated with irregular cell growth in some specific tissues and organs due to the alternation of cell DNA.

Depending on the stage and specific types of cancer, some cancers do not cause any symptoms such as liver cancer.

However, at the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized bleeding and pain accompanied by the general symptoms shared by other types of cancer.

At this stage, cancer cells may also travel a distance away from the original site to infect other healthy tissues and organs through fields and blood circulation, leading to secondary metastasis.

There are some common factors shared by many types of cancer such as family and personal history, ethnicity and gender, some researchers found that unhealthy lifestyle is one of the major risks in the induction of the diseases.

Dr. Katzke, Verena A Ph.D., the lead scientist in the concern of lifestyle and cancer risk, wrote, "Lifestyle factors, such as smoking, alcohol consumption, obesity, diet, and physical inactivity, and also reproductive and hormonal factors are considered as causes of cancer and main targets for primary prevention".

And, " While smoking, which may be responsible for around 20% to 30% of all incident cancers, is clearly the strongest lifestyle-related risk factor overall, followed by alcohol consumption and obesity, the importance of specific factors for individual cancer types and subtypes varies greatly.".

In other words, by changing to a healthy lifestyle, the risk of cancers can be reduced substantially.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

Researchers on finding natural chemotherapy for the treatment of cancer investigated the cytotoxic anti-tumor and immunomodulatory activities and in vivo antitumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae).

The tumor cell lines included in the study are derived from leukemias, melanomas, fibrosarcomas and breast, prostate, cervix, lung, pancreas and colorectal cancer.

The LACE extract showed a potent in vitro inhibition of tumor cell proliferation a wide variety of human and murine tumor cell lines, ranged from 70 to 100%.

The cancer cells inhibition was attributed to the protein associated with cell cycle arrest in G0/G1 phase and induced apoptosis.

Furthermore, the intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice.

However, human peripheral blood lymphocyte (PBL) and NKL cell lines, lACE extract exerted an opposite effect.

These results suggested that LACE aqueous extract has 2 potential anti-tumor therapeutic effects: cytotoxic tumor cell activity and lymphocyte activation on selected cancer cell lines.

Moreover, in male mice injected with B16F-10 melanoma cells through the tail vein and simultaneously treated with C.officinalis flower extract. researcher showed that

* Simultaneous administration of C. officinalis extract to tumor-bearing C57BL/6 mice reduced the lung tumor nodules by 74% with 43.3% increase in lifespan

* Elevated levels of inflammatory expression including the proinflammatory cytokines were found to be significantly lowered in the C. officinalis treated animals.

* The extract also inhibited expression of the matrix and enzymes associated with cancer proliferation and activated the family protein associated with the modulation of cancer cell transcriptional profile.

Taken altogether, herbal Calendula may be considered a safe functional remedy for the prevention and combined with primary medicine for the treatment of cancers with no side effects, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
(4) Lifestyle and Cancer Risk by Katzke, Verena A Ph.D.; Kaaks, Rudolf Ph.D.; Kühn, Tilman Ph.D. (The Cancer Journal)