Anacardic acids, the Anti Pituitary Adenomas Bioactive Ingredient

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of pituitary adenomas with no side effects, according to studies.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

Pituitary adenomas are noncancerous tumors occurred in the pituitary gland.

A pituitary tumor has a negative and strong implication of the production of the thyroid-stimulating hormone, leading to a rare case of hyperthyroidism which normally induces the unintentional weight loss.

Most cases of the pituitary adenomas start in the cell of the inner lining of the tissue of the pituitary gland, due to the alternation of DNA. The tumor is well contained in the gland with no tendency of spreading.

At the early stage, patients with benign tumor do not experience any symptoms. However, when the tumor is growing larger, it may suppress the healthy tissue in the gland or nearby nerve cells, leading to symptoms of a headache, vision loss, and severe pain.

Epidemiological studies suggested that depending on the stage of the pituitary tumor, patients can experience hormone overproduction and hormone deficiency, leading to certain hormonal related diseases.

Depending on the size of the tumor and its effect on the patient's health, surgery may be the only option, if the tumor is pressing on the optic nerves or overproducing certain hormones.

In the concern of morbidity and complication of therapy in patients with pituitary adenomas, researchers examined the effect of Anacardic acids, a natural histone acetyltransferase inhibitor, on pituitary adenoma cells.

Epidemiological studies suggested that the progression of the benign pituitary tumor, if not treated, is a prevalent risk factor of the onset of malignant tumor pathogenesis.

Injection of anacardic acid exerted a significant anti antiproliferative and cytotoxic effect on pituitary adenoma cells.

According to the flow cytometry and Western blotting assays, anacardic acid inhibition of the tested cell line was associated with an increase the functions of the protein involved in a number of cellular processes in programming cell death and through cell cycle arrest on the G1 phase.

The marker used to detect cancer cell apoptosis, Annexin A5 (or annexin V), a cellular protein in the annexin group also increased after injecting the cancer cell with Anacardic acids. 

In vitro and in vivo researchers found that administration of a pan-caspase inhibitor that irreversibly inhibits enzymatic function and effective in blocking apoptosis in a variety of cell types under normal condition has failed to reverse anacardic acid-induced cell death. 

These results suggested that the bioactive induced cancer cell apoptosis through a possible nonclassical mechanism.

Furthermore, Anacardic acid the anti-cancer effect also suppressed the function of the survivin protein functions to exhibit negative regulation of apoptosis or programmed cell death and X-linked inhibitor of apoptosis protein (XIAP) associated with the anti-apoptotic function.

More importantly, the bioactive compound was found to deactivate the antiapoptotic proteins associated with cellular survival and radioresistance and radiosensitized pituitary adenoma cells.

The findings indicated that the chemical compound inhibited the onset and progression of pituitary adenomas through promoting cell cycle arrest, cancer apoptosis, programming cell death through some known and unknown mechanisms.

Taken all together, Anacardic acids may be used for the prevention and treatment of pituitary adenomas with no side effects, pending to the result of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells by Sukumari-Ramesh S, Singh N, Jensen MA, Dhandapani KM, Vender JR.(PubMed)

Phytochemical Allicin, the Natural Anti Hyper Cholesterol Bioactive Compound

By Kyle J. Norton

Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.

The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).

Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.

Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.

Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.

Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole grain have a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.

Dr. Heather D. Mann, in the discussion of a healthy in the risk of hyperlipidemia, said, " Dietary modification is effective in achieving and maintaining improved serum lipid levels".

The finding clearly suggested that if you follow the diet with a high in saturated and trans fat, red meat and processed food and low in fruits and vegetables and whole grain, you are at the increased risk of high blood cholesterol.

High blood cholesterol does not cause symptoms, the American Heart Association recommends that all adults have their cholesterol checked every 4 to 6 years, starting at age 20, the age when cholesterol levels start to go up.

In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also decreasing appetite daily.

 Other in the study of the same but with rat fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats. These result showed that allicin may be considered as a potent agent in treating hyper cholesterol in the future.

On finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.

Hypercholesterolemia in male ICR mice selected for the study was given allicin, with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks.

After week 12, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively.

Allicin fed group also showed the most decrease in daily food consumption compared to control.

Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.

These results suggested that allicin is a potential value in a cholesterol-lowering candidate, and may be used for the protection against the onset of atherosclerosis.

Moreover, in the evaluation of the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride, glucose, protein, and systolic blood pressure in rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks, and control rats were fed a normal diet researchers found that

* Rats fed with a high cholesterol diet mixed with garlic powder demonstrate a significant reduction in their serum cholesterol levels compared to the control group.

* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.

* The blood pressure of the high cholesterol diet animals was significantly higher compared to the animals receiving the control diet.

* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.

Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats.

Taken altogether, allicin on the garlic may be used daily for the prevention or treatment of high blood cholesterol with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)

Avocado-Soybean Unsaponifiables (ASUs), A Natural Treatment of Osteoarthritis, with No side Effects, Studies Showed

By Kyle J. Norton

Avocado may be considered a functional food for the prevention and treatment of osteoarthritis, some scientists suggested.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world.

The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.

According to the statistic, osteoarthritis (OA) is the most common joint disorder in the US, affecting over 10% men and 13% in women aged 60 years or older. The disease can also affect the younger population, after a traumatic injury.

. 

Epidemiological studies suggested that symptoms progress slowly and contribute to workplace disability and reduced quality of life.

Dr. Hofmann S, the lead scientist in the team of arthritis in the examine the mechanical causes of osteoarthritis in young adults suggested that that certain conditions such as femoroacetabular impingement (a condition in which extra bone grows along one or both of the bones that form the hip joint) are a very common cause of secondary osteoarthritis (OA) in the young adults" and "

It is an important co-factor in the better recognized pre-arthritic deformities such as residual hip dysplasia (RHD), Perthes disease and slipped capital femoral epiphysis (SCFE)".

These results clearly indicated genetic mutation and mechanical deformity are major causes of osteoarthritis in the younger adult besides athletic injury.

Some scientists proposed that the development of femoroacetabular impingement may be a result of a repetitive injury to the proximal femoral physis occurs during a critical period of development.

With an aim to find a natural ingredient for the prevention and treatment of osteoarthritis, a disease associated with the progressive denegation of joints, researchers at the Universities of Exeter and Plymouth assessed the anti-OA of the compounds Avocado/soybean unsaponifiables (ASU) which have shown some promise for OA.

By searching the database of medical literature, researchers found 4 randomized, placebo-controlled, double-blind trials of ASU.satisified the guideline and criteria.

The doses per day in the 4 studies are in the range between 300 mg and with 600 mg.

3 out 4 studies suggest that ASU is effective for the symptomatic treatment of OA.

Furthermore, the Hôpital Léopold Bellan launched a follow-up study to investigate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients in the hip, included 163 patients, 102 men and 61 women (mean age 63.2 +/- 8.7 years).

Participants in the study are patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm were selected entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration. 

ASU treatment group showed a lesser joint space loss compared to the significantly greater loss in the placebo group.

The clinical parameters in the 2 groups did not differ significantly throughout the study.

These results indicated a significant effect of ASU against the progression of joint loss in OA patients.

Dr,. the lead scientists said, "SU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing".

Taken altogether, avocado-soybean unsaponifiables (ASUs) may have a profound effect in reducing the symptoms and progression of osteoarthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL. (PubMed)
(4) Mechanical causes of osteoarthritis in young adults by Hofmann S, Tschauner Ch, Graf R.(PubMed)
(5) The etiology of primary femoroacetabular impingement: genetics or acquired deformity? by Jonathan D. Packer and Marc R. Safran. (PMC)

Banana, the Best Anti Hypertension Functional Fruit, According to Studies

By Kyle J. Norton

Scientists may have found an inexpensive whole fruit for the prevention and treatment of hypertension with no side effects, some studies found.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid. 

Hypertension is a medical condition characterized by the abnormally high blood pressure. one of the preventable risk factor of heart disease associated with the cluster of metabolic syndrome.

In other words, high blood pressure means the raising the pressure in your heart. the condition can be acute or chronic.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. 

Chronic high blood pressure epidemiologically can damage the arteries and causes blood clots to form in the arteries, blocking the blood flow and contributing to the onset of cardiovascular and neuro diseases.

Although certain chronic conditions such as kidney disease are found to associate with chronic hypertension which can only be treated by addressing the causable condition, the syndrome in the Western world are mostly as a result of unhealthy diet and obesity.

According to a joint study led by the Tecnológico de Monterrey, that examined the effects of 

Western and Modern Mexican dietary patterns and the incident hypertension in Mexican women, the comparison of participants who followed the diet with loaded heavily with vegetables, fruits and legumes and who follow the Western and Modern Mexican dietary patterns loaded heavily with processed meats, fast foods, and red meat; and finally the third component was loaded heavily with corn tortillas, hot peppers, and sodas suggested that 

* The multivariable-adjusted odds of hypertension in the highest quartile of the W pattern were 24% higher than the odds for individuals in the lowest quartile.

 * Women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile.

* And The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension.

These results strongly indicated high blood pressure can be prevented by following a healthy diet with high fruits and vegetables, whole grain and low saturated and trans fat, red meat and processed foods. 

On finding a natural chemical compound or whole food for the prevention and treatment of hypertension, researchers evaluate the corosolic acid (CRA) antihypertensive activity, a constituent of banana leaves.

The experiment included Six-week-old male SHR-cp rats, an animal model of metabolic syndrome were fed a high-fat diet containing 0.072% CRA for 14 weeks. 

Treatment with CRA lowered blood pressure, which was elevated in control animals, by 10% after 8 weeks, and serum free fatty acids by 21% after 2 weeks.

Oxidative stress markers thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine in the tested animal were also decreased by 27% and 59%, respectively, after 2 weeks.

Furthermore, CRA treatment also reduced the levels of myeloperoxidase markers, 3-nitrotyrosine, and 3-chlorotyrosine, by 38% and 39%, respectively, after 10 weeks, and decreased the levels of high sensitivity C-reactive protein, markers of inflammation, after 6 weeks.

The presence of a marker of inflammation is the indication of inflammation.

These results clearly suggested that CRA ameliorate hypertension, and oxidative stress caused by the inflammation in SHR-cp rats.

Dr. Yamaguchi Y, the lead scientist said, "CRA can be beneficial for preventing atherosclerosis-related diseases that are an increasing health care problem worldwide".

Moreover, In a human study to test the effect of banana on cold stress-induced hypertension, peak expiratory flow rate and plasma ACE activity, researchers showed that

*Banana treatment reduced the systolic blood pressure (P < 0.005), diastolic blood pressure (P < 0.025) and mean arterial blood pressure (P < 0.005) during cold stress in healthy volunteers compared to controls.

* There was no significant changes in heart rate and peak expiratory flow rate but only significant decrease in plasma angiotensin-converting enzyme activity after banana treatment.

Levels of plasma angiotensin-converting enzyme are high in patients with hypertension.

Dr. Sarkar C, the lead scientist said' "Banana decreased the rise of systolic blood pressure and diastolic blood pressure in healthy volunteers subjected to cold stress test without much effect on heart rate and peak expiratory flow rate".

Taken altogether, banana may be considered a functional fruit for the prevention and treatment of hypertension with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Corosolic acid prevents oxidative stress, inflammation, and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome by Yamaguchi Y1, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M.(PubMed)
(2) Effect of banana on cold stress test & peak expiratory flow rate in healthy volunteers by Sarkar C1, Bairy KL, Rao NM, Udupa EG. (PubMed)
(3) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)

Strawberries, The Potential Anti Leukemia (CEM) Functional Fruit, Researchers say

By Kyle J. Norton

Scientists may have found a whole food which contains abundantly bioactive compounds for the prevention and treatment of leukemia with no side effects, some studies suggested.

Leukemia is a medical and chronic condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system or the body's blood-forming tissues.

Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

The causes of leukemia are unknown. However, most common risk factors associated with the onset of the disease including radiation exposure, treatment chemotherapy for cancer, smoking, family history of leukemia, and exposure to certain chemicals such as benzene.

Genetic preposition, according to some researchers, also plays a critical role in the prevalent risk of leukemia.

Dr. Nazanin Heidari, the lead scientist in the investigation of the genetic impact in risk of leukemia wrote, "Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can inactivate genes involved in leukemia pathogenesis or progression".

The team continued, inactivation of the genes ASPP1, TP53, IKZF1, and P15, have been correlated with poor prognosis in acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML), respectively. And abnormal genes specifically involved in leukemogenesis such as chromosomal translocations as well as genetic or epigenetic alterations, are involved in leukemogenesis.

Therefore, people who carry the mutated or inactive genes are at an increased risk of the condition.

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin

On finding a natural ingredient or whole food for the prevention and treatment of leukemia (CEM), researchers at the Indian Institute of Science evaluated the consumption of berry fruits, including strawberries, against oxidative stress-mediated diseases.

In vivo, the methanolic extract of strawberry (MESB) fruits demonstrated a potential activity against leukemia (CEM) cell lines.

In mice models, the extract of the fruit also displayed a cancer therapeutic and chemopreventive potential.

According to the tested assay, MESB  induced cytotoxicity in cancer cells, irrespective of origin, though its antioxidant properties in a concentration- and time-dependent manner. 

Furthermore, according to the results at the end of the experience, MESB treatment affected tumor cell proliferation by activating apoptosis with no side effects.

In-depth analysis of the effect of the extract, researchers found that MESB induces cancer cell apoptosis through the enhancing the function of the tumor suppressor gene p70 in the intrinsic pathway of apoptosis bypassed the mutated tumor suppressor gene p53.

Dr. Somasagara RR, the lead author said, "strawberry fruits possess both cancer preventive and therapeutic values".

Taken altogether, strawberries with the abundant bioactive compound may be considered a functional fruit for the prevention and treatment of leukaemia (CEM) with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis by Nazanin Heidari, M.Sc,1 Saeid Abroun, Ph.D.,Jessika Bertacchini, Ph.D,3 Tina Vosoughi, M.D,1 Fakher Rahim, Ph.D. and Najmaldin Saki, Ph.D. (PMC)

Manuka Honey, the Best Anti-influenza Functional Food

By Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.

Influenza, also known as the flu, is an infectious disease caused by an influenza virus.

There are 3 types of flu influenza: A, B, and C. the influenza virus  A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of general population.

Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.

Healthy individuals who have influenza are usually recovered within one week.

However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only  associated with the risk of influenza but also increase the risk of influenza deadly complication.

Pregnant women and women up to two weeks postpartum due to change of immune system and other organs have been found to make a woman more prone to influenza and influenza complications.

Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.

Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individual associated with the impairment of the adaptive immune response at substantial risk of influenza.

The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".

"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".

Most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at the joint study led by the Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.

Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.

Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th  for their single use.

Dr.Watanabe K, the lead scientist said, "honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.

Moreover, by the re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.

By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.

* MGO exerted a promising activity against various influenza strains.

* MGO increases the effect of NA inhibitors by decreasing the to the ∼1/100(th) of their single usage.

* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.

Taken altogether, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending to a larger and multi=centers human study.

.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).

Ginger, The Potent Anti Obesity Functional Food

By Kyle J Norton

Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.

Obesity is medical disease associated with extreme overweight. 

In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

What causes obesity? Some researchers suggested that too much calories consumption and lack of physical exercise are the 2  main causes of obesity in once healthy individuals.

Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of American and the promotion of the Western diet in the past few decades.

Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern". 

And,  " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".

These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found  in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.

Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,

Diet-induced obesity was attenuated in C57BL/6J mice treated with dietary ginger extract (GE)also exhibited the increase of energy expenditure.

GE also exerted an anti-obesity effect through promoting the increased the number of Types I muscle fibers, running endurance capacity and upregulated PPARδ-targeted gene expression in skeletal muscle 

Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.

After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".

Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers at the showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).

In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.

Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".

Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)