Herbal Burdock Kills Breast Cancer Cells In Vivo and Vitro

By Kyle J. Norton

Scientists may have found a whole herb which processes a significant effect in reducing risk and treatment of breast cancer with no side effects, according to some studies.

Breast cancer is a chronic condition characterized by cell growth controllably and disorderly in the breast tissue.

Most cases of breast cancer start at the cells on the surface of the inner lining tissue of the breast. At this stage, most patients may experience symptoms of lump on part of the breast, swelling, nipple pain and redness and scaliness. If you have some of the above which can not resolve within 3 weeks, please check with your doctor to rule out the possibility of breast cancer.

At the advanced stage, after penetrating into the deeper layers of the breast, malignant cells may travel a distance far the way from the breast to infect other healthy tissue and organs, through the blood and fluids circulation.

In this stage, the breast tumor is growing large enough to suppress the nearby healthy tissue and nerve cells, causing severe localized symptoms and pain.

The liver, brain, bones, or lungs are most commonly organs for breast cancer metastasis.

According to a statistic provided by the cancer society, women in Canada have a lifetime risk of breast cancer incidence rates of 11%. In other words, 11% of Canadian women will develop breast cancer by the time they reach 90 years of age.

Only 20% of breast cancers in Canada are diagnosed in women under 50, compared to almost 30% diagnosed in women over 70 years of age.

The 5 years survival rate of breast cancer is 100% compared to 89% in the 10 years survival rate.

Therefore, early diagnosis is a key factor to improve the survival rate and prevent a long-term painful
treatment with many unpleasant side effects if the cancer is found in the later stage.

Women are encouraged to examine their breast every month if you found any changes that not in 3 not recover within 3 weeks, please check with your doctor as soon as possible.

Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.

The plant has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.

The chemical ingredients of herbal Burdock include guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

In the finding the natural compound with no side effects, researchers examine the anticancer effect of arctigenin (ATG), a natural lignan product of Herbal Burdock (Arctium lappa L.), in human breast cancer MDA-MB-231 cells.

Application of arctigenin (ATG) showed potency in inhibiting the MDA-MB-231 cell growth by inducing apoptosis.

ATG stimulated the breast cancer cell death programming by reducing the ration expression of Bax/Bcl-2.

Furthermore, ATG also activated the overexpression of free radical in the induction of cytotoxicity to the breast cancer cell line.

These results suggested that ATG induced cancer apoptosis through many different mechanisms, including the pathways in stimulating the expression of ROS that causes cytotoxicity and promoting cell death.

Additionally, in the reaffirming the anti-breast cancer of herbal burdock, researchers conducted an experiment to evaluate the anti-cancer properties of Arctiin, a major lignan constituent of Arctium lappa (Burdock) in animal models.

In human breast cancer MCF-7 cells, injection of Arctiin demonstrated a significant effect in the inhibition of the breast cancer cells associated with associated with the decreasing the function of the protein in promoting the cell cycle division.

Moreover, application of Arctiin also increased the function of the protein associated with the suppressor in acting to inhibit cell proliferation and tumor development.

Taken together, Herbal Burdock may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Burdock anti-cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation by Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. (PubMed)
(2) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression by Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.(PubMed)

Herbal Andrographis Modulates Immune Function To the Body Needs, Scientists Say

By Kyle J. Norton

Herbal Andrographis paniculata may have a profound effect in enhancing the function of the immune system against diseases development, some studies found.

The immune system is a set of cells which have a unique function to protect our body against antigens or infectious agents that comprises of the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

It is a made of special cells (white blood cells), antibodies, tissues (bone marrow), and organs (the spleen) defend people against germs and microorganisms every day.

There are 3 types of immunity can be classified as the following
* The innate immunity is also known as natural immunity that every human born with.

* The adaptive immunity is the type of immunity that develops in the life of the individual.

* Passive immunity that borrows from the outside sources and can only last only a short period of time

There are 2 types of immune disorders 

* Underactive immunity or immune deficiency. People with an underactive immune system are easy

to be infected  or sick all the times

* Overactive immune system or autoimmune diseases. In this case, the immune system attacks the host tissue, causing autoimmune diseases such as rheumatoid arthritis (RA).

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

In the finding a natural ingredient or formula for the treatment of immune dysfunction with no side effects, researchers at the Prin. K. M. Kundnani College of Pharmacy, launched an investigation to examine the immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides.

The pure powder form of the mixture of andrographolides.was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models.

Application of the mixture delayed-type hypersensitivity (DTH) caused by the injection of cyclophosphamide (CYP) in the mouse model.

Where cyclophosphamide (CP) is a medication used as chemotherapy and to suppress the immune system.

HN-02 treatment elevated the depressed hemagglutination antibody (HA) titer, the antibody and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice caused by injection of CYP.

HN-02 treatment stimulated phagocytosis in the immune system and increased levels of white blood cells in the tested mice.

These results strongly indicated HN-02 has the ability to enhance immune function by modulating the immune responses which were altered during antigen interaction and reversing the immunosuppression induced by CYP.

Furthermore, according to the Amala Cancer Research Centre in the examine the natural whole herb function in the modulation of immune responses against tumor cells, Andrographis paniculata extract (APE) and its isolated compound andrographolide (ANDLE) exert a clinically significant effect on cell-mediated immune responses in normal and tumor-bearing control animals.

Treatment with APE and ANDLE significantly enhanced natural killer cell activity in normal and tumor-bearing animals on the fifth day,

Antibody-dependent cellular cytotoxicity was also increased in APE as well as ANDLE on day 11-treated normal and tumor-bearing animal compared to untreated tumor-bearing control animals.

Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 which regulates the activities of white blood cells (leukocytes, often lymphocytes) and interferon-gamma which is critical for innate and adaptive immunity in normal and Ehrlich ascites carcinoma-bearing animals.

These results firmly indicated that herbal Andrographis may be considered functional food in the enhancement of the immune function against foreign stimuli and micro pathogens.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(2) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(3) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)

Herbal Burdock, the Natural Alternative for Antibiotic with No Side Effects

By Kyle J. Norton

Herbal Burdock may be the next pharmaceutical target of extract a single ingredient for the treatment of infectious diseases, some scientists found.

Infectious diseases are a class of diseases caused by the invasion of pathogenic microorganisms, such as bacteria, viruses, parasites or fungi.

Bacteria is a type of biological cell consisted of a single cell with a simple internal structure.

Most common diseases caused by bacteria include strep throat, urinary tract infections, and tuberculosis.

Infection occurs when the bacteria successfully invade the body and start to multiply. Most cases of infectious disease caused by bacteria are treated with antibiotics.

And, most cases of infectious disease are transmitted by airborne you can get sick if you breathe into the air that carries infectious bacteria in air particles, vector-borne if you are stunk by the insect that the bacteria and vehicle-borne if you are eating food or carrying the materials contaminated by the bacteria.  

Most cases of bacterial invasion are met with the first line immune white blood cells. In the active division of bacteria in the acute phase of infectious, the immune systematic response activated the production of the proinflammatory cytokine to the site of infection with an aim to kill off all bacteria.

However, if the immune fail to kill off all the bacteria within the 3 - 8 weeks period, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.

Not all bacteria are bad, some play an important role to boost the immune function. Dr. Hsin-Jung Wu, the lead author in the study the effect of gut microbiota in immune homeostasis and autoimmunity, said, " The gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis" and " gut microbiota regulates innate and adaptive immune homeostasis, which in turn can affect the development of not only intestinal but also systemic autoimmune diseases:.

In other words, gut microbiota promotes and balances the immune system in eliminating invading pathogens, while still maintaining self-tolerance to avoid autoimmunity, the critical roles of the immune system for the body’s health. 

Burdock is the plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.

The plant has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.

The ingredients of herbal Burdock include carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.

In the finding a natural ingredient or whole foods to replace the conventional antibiotics for the treatment of bacterial infection, the research team of infectious diseases at the University of Ribeirão Preto evaluated the antibacterial activity of a phytotherapeutic agent prepared from an ethyl acetate fraction (AcOEt) extracted from Arctium lappa.

The study includes 27 maxillary canines inoculated with a mixed bacterial suspension of Pseudomonas aeruginosa, Escherichia coli, Lactobacillus acidophilus, Streptococcus mutans, and Candida albicans.

The teeth were divided into three groups and their canals filled with: 

* Group 1: calcium hydroxide and propylene glycol; 

* Group 2, a paste containing AcOEt fraction of A. lappa and propylene glycol; and

* Group 3, propylene glycol (control). 

Observation of the 7, 14 and 30 days, when three teeth from each group were opened, researchers found that group 2 treated by the Burdock extract showed a severe growth at 7 days, but no growth at 14 and 30 days, compared to mild growth in group 1 and control.

These results clearly indicated phytotherapeutic agent extracted from an AcOEt fraction of herbal Burdock process a strong antibacterial activity against the growth of all the microorganisms.

In bacterial straits Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans used for the investigation of the antimicrobial activity of rough extracts from leaves of Arctium lappa and their phases, researchers at the University of Ribeirão Preto (UNAERP) showed some bioactive compounds with chemical structures of different polarities were found to exert the effect of the extract through different phases of inhibition, depending on the target microorganisms.

Dr. Holetz FB, the lead scientist at the Universidade Estadual de Maringá in the investigation of the ethnobotanical use of the herbal species for the treatment of various infectious diseases, explained, herbal Burdock, one the Brazilian folk medicine may be used for the treatment of chronic infectious diseases induced by bacteria and yeasts.

Herbal Burdock was one out 13 herbal medicine was studied for its antimicrobial activity against bacteria and yeasts, including Pseudomonas aeruginosa, and Escherichia coli.

The evidence showed that herbal Burdock processed abundant bioactive constituents may be considered a functional herb for the prevention and treatment of infectious diseases without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References.

(1) In vitro evaluation of the antibacterial activity of Arctium lappa as a phytotherapeutic agent used in intracanal dressings by Gentil M, Pereira JV, Sousa YT, Pietro R, Neto MD, Vansan LP, de Castro França S.(PubMed)
(2) Antimicrobial activity of Arctium lappa constituents against microorganisms commonly found in endodontic infections by Pereira JV, Bergamo DC, Pereira JO, França Sde C, Pietro RC, Silva-Sousa YT.(PubMed)
(3) Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases by Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP.(PubMed)

Herbal Arnica, the Potential Colon Cancer Functional Herb

By Kyle J. Norton

Herb Arnica may be the next target of the pharmaceutical companies to identify a single ingredient medicine for the treatment of colon cancer, some scientists suggested.

Colon cancer is a slow and predictable condition characterized by irregular cell growth on the colon tissue.

The cause of colon cancer is a result of the alternation of DNA of the cells in the colon.

Most cases of colon cancer start at the cells on the surface of the inner lining of the colon tissue. At this stage, the tumor is very small and does not cause any symptoms.

However, at the later stage, colon cancer may cause symptoms of a change of bowel habits, severe rectal bleeding or blood in your stool and persistently abdominal pain.

If you experience some of the above symptoms that last more than 4 weeks, please check with your doctor to rule out the possibility of colon cancer.

According to the statistic, the 5-year survival rate of people with localized stage colorectal cancer is 90% and only 39% of patients are diagnosed at this early stage.

Researchers do not know why people with the same health condition, family history and diet pattern, some are susceptible to colon cells DNA alternation while others do not.

Out of a number of risk factors, genetic preposition has been under intensifying studies by many scientists.

Dr.Glaser EM in a finding the genetic mutation associated with the risk colon cancer said, "Colorectal cancer is one of the most common malignancies in the United States. Although both genetic and environmental factors play a role in colorectal tumorigenesis" and "single genes that confer a susceptibility to familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). Because these genes are inherited in an autosomal dominant fashion, offspring of carriers have a 50% chance of inheriting the gene mutation and its associated risk".

The genetic mutation hereditary nonpolyposis colorectal cancer (HNPCC).genes  has a prevalence rate of 1 in 500, and causes about 2% to 3% of all colorectal cancers.

More importantly, genetic testing for the FAP and HNPCC genes is now available for everyone.

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.

Besides containing contain helenalin as it main ingredient used as anti-inflammatory agent in herbal medicine, herbal Arnica also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the concerns of the aberrant crypt foci (ACF) and colon-rectal mucosal epithelial cell proliferation in patients with colon cancer, researchers at the University of São Paulo examine the anti-colon cancer of chemical compound isolated from the Lychnophora ericoides Mart. (Brazilian herbal arnica).

50 included in the study was randomly assigned to the followings Fifty male Wistar rats were randomly divided into 5 groups.
* The groups G1 to G4 were given 4 injections of the carcinogen 1,2-dimethylhydrazine (DMH).

* The G2 group received Lychnophora ericoides (LE) extracts for 6 wks.

* The groups G3 and G4 received LE for 4 wk and 2 wk, respectively, at the postinitiation and initiation phases of colonic carcinogenesis.

* The group G5 was the control.

42 days after the first injections of DMH for the neoplasic induction, researchers found that
* Groups G1 demonstrated an increase of the number of aberrant crypt foci (ACF) and cancer cells proliferation induced by DMH.

* Group G4 after treatment of LE inhibited a clinically significant decrease in the number of aberrant crypt foci (ACF) and attenuated the increase of cancer cells proliferation induced by DMH.

These results suggested that Lychnophora ericoides extracts were effective against the development of colon cancer through suppressing the initiation and progression of colonic carcinogenesis.

Continuously, to differentiate the effect of herbal Arnica effects in the inhibition of cancers, researchers examine the cytotoxicity of 21 flavonoids and 5 sesquiterpene lactones, isolated from herbal Arnica in a human small cell lung carcinoma cell line, and in COLO 320, a human colorectal cancer cell line.

Compared to cisplatin, a novel chemo drug, most flavonoids showed moderate to low cytotoxicity against COLO 320 cancer cell line.

However, flavone jaceosidin of the sesquiterpene lactones was found to be the most effective compound.in displaying the cytotoxicity.

Application of the maximum half-life concentration of 1.0 microM exerted the most cytotoxic effect against COLO 320.

Compared to GLC4, COLO 320 was more sensitive than for many flavonoids (especially for flavones).

The finding strongly indicated that herbal Arnica bioactive compounds process potential activity in inhibiting the onset and progression of colon cancer.

Therefore, herbal Arnica containing abundant bioactive compounds may have a potential in reducing risk and treatment of colon cancer, depending on the confirmation of the large sample size and multicenter in the human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis by Fernandes CR, Turatti A, Gouvea DR, Gobbo-Neto L, Diniz A, Ribeiro-Silva A, Lopes NP, Garcia SB.(PubMed)
(2) Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines by Woerdenbag HJ, Merfort I, Passreiter CM, Schmidt TJ, Willuhn G, van Uden W, Pras N, Kampinga HH, Konings AW.(PubMed)
(3) Inherited predisposition to colon cancer by Glaser EM. (PubMed)

Herbal Butterbur, The Best in the Promotion of Antioxidant Activity

By Kyle J. Norton

Herbal Butterbur may be the potential target to extract a single ingredient for the treatment of oxidative stress, some scientists suggested.

Oxidative stress is either caused by overexpression free radicals compared to levels of antioxidant or suppression of the levels of antioxidant enzymes in the host body, compared to expression of free radicals.

The imbalanced ratio of free radical and antioxidant enzymes produced by the host that counter the overexpression of free radicals has been found to facilitate the early onset of numbers of chronic ailments, such as cancers.

Free radicals are naturally produced from daily normal essential metabolic processes in the human body. However,  some external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals can also increase the expression of free radicals in the body.

Free radicals are unstable molecules with the unpaired electron in the outer ring and ready to donate or steal an electron from another molecule, leading to the chain reaction until they are stopped by the presence of the antioxidants or their outer ring are paired.

Overexpression of free radical chain reactive in the human body has been known to induce oxidative stress, causing damage to the cells,  proteins, and alternation of cell DNA. In this case, the application of an external source of antioxidants such as synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole may be helpful to restore the balance of these 2 types of  molecule.

Hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical are hight reactive and important free radical  associated with many chronic diseases.

Dr. V. Lobo, in the concern of the overexpression of free radicals in the induction of, vary human chronic illness conducted a study to examine the impacts of free radicals, antioxidants and functional foods in human health said in summary, "Free radicals damage contributes to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition".

(More importantly)" Synthetic antioxidants are recently reported to be dangerous to human health. Thus the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. In addition to endogenous antioxidant defense systems, consumption of dietary and plant-derived antioxidants appears to be a suitable alternative. Dietary and other components of plants form a major source of antioxidants".

Butterbur, found in wet, marshy, damp land, including wetland, Riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herbal plant has been used in traditional medicine as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

In the finding the natural ingredient from the botanical plants which process a significant antioxidant activity without inducing any side effects, researchers at the Second Military Medical University looked into a bioactive compound isolated from the herbal Butterbur.

Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus.

All 4 compounds demonstrated the neuroprotective activity by reversing the neurons damage exposed to oxygen-glucose deprivation and oxidative insults.

The results of this efficacy were associated with the antioxidant properties of the 4 compound in inhibiting the oxidative stress caused by the oxygen-glucose deprivation.

The finding indicated that herbal Butterbur not only processed a significant activity in protecting the brain cells against oxidative stress due to overexpression of free radical but also promoted the production of antioxidant enzymes in the host tissue.

In hyphenated HPLC techniques used to identify the structures and antioxidant activities without prior purification of compounds, researchers found that herbal Butterbur process a number of bioactive compounds, including 5-caffeoylquinic acid (5-CQA), fukinolic acid (FA), 3,5-di-O-caffeoylquinic acid (3,5-DCQA) exert a strong antioxidant free radical scavenging activity.

The greatest radical scavenging capacity was found in the leaf (23.09% of total antioxidant capacity) and root (26.47%) extracts.

The relative radical scavenging portion of quercetin-3-O-(6″-acetyl)-β-glucopyranoside (QAG) was only 3.41% in the leaves and KAG did not show any radical scavenging activity.

These results firmly suggested that herbal Butterbur processes a significant antioxidant property. However, single ingredient isolated from the herb may express different levels of antioxidant in a dose-depending manner.

Therefore, herbal Butterbur containing a high amount of antioxidant and bioactive compounds free radical scavengers may be considered a functional food for the promotion of antioxidant activity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(2) Free radicals, antioxidants and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

Herbal Aloe Vera Gobbles Up Cancer Cells in Vivo and Vitro

By Kyle J. Norton

Aloe Vera may be the next target for the pharmaceutical companies to extract a single ingredient for the treatment of cancers, some scientists suggested.

Cancers are a class of medical diseases associated with cell growth irregularly and disorderly in some specific tissue and organs.

Most cancer starts at the cell on the surface of the inner lining of organ's tissue. At the later stage, cancer cells can be found in the deeper of layers of the infected organ.

In the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy tissue and organ through the circulation of fluids and blood.

The causes of cancer are the results of the alternation of healthy cell DNA. Researchers do not why the health cells DNA are alternated.

Normally, healthy cells undergo a certain number of cell cycle divisions than die. In a cancerous cell, cell division undergoes indefinitely.

According to the statistic, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

The genetic mutation of the cancer cell may be associated with certain risk factors. Epidemiological studies suggested that long-term exposure to carcinogens, the increased in age, gender, inherited genetic defects and skin type can increase the risk the cancer onset.

Most common and general symptoms of cancer are an unintended weight loss, lump, fatigue, loss of appetite and persistent localized symptoms and localized pain in the later stage.

If you experience some of the above symptoms, please check with your doctor right the way to rule out the possibility of cancer.

Out of numbers of the risk factor, genetic preposition has been under intensive studied by many scientists.

Dr. Eric T, the lead author in the study of genetic implication on the cancer risk said, "Genetic testing for inherited cancer risk is now widely used to target individuals for screening and prevention" and


"Overall, 17,340 PVs were identified in 17,000 (6.7%) of the tested individuals. The pathogenic variants (PV) positive rate was 9.8% among individuals with a personal cancer history, compared to 4.7% in unaffected individuals. PVs were most common in BRCA1/2 (42.2%), other breast cancer (BR) genes (32.9%), and the LS genes (13.2%)".

These results clearly stated that people who carry certain mutated genes are at the substantial risk of cancer onset, compared to those who do not.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

 It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera are amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

In the finding, a natural ingredient for the treatment of breast cancer without inducing side effects, researchers at the National Chung Hsing University conducted a study to compare the efficacy of Emodin and Aloe-Emodin, the major bioactive compound found in herbal Aloe Vera.

By analyzing the estrogenic activity as phytoestrogens on the estrogen receptor α (ER α ) activation and breast cancer cell growth, application of both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by reducing the ER α protein levels which has been found in high levels in patient with breast cancer thereby suppressing ER α transcriptional (mRNA) activation..

High expression of ERα mRNA is found associated with patients with breast cancer.

Breast cancer treatment with aloe-emodin also decreases the expression of the levels of ERα associated with the protein that stimulate the division of breast cancer cells by increasing the cancer cells degradation.

The efficacy of aloe-emodin inhibited breast cancer proliferation and induced apoptosis is attributed to the breaking down the cytoplasm of ER α protein in the breast cancer cells.

The results suggested that aloe-emodin suppressed breast cell proliferation emodin by targeting ER α protein expression through distinct mechanisms.

Further demonstration of the effect of aloe-emodin on the risk of cancer, researchers examined whether aloe emodin exerts a similar effect on the growth of human cervical cancer cells, HeLa.

Human cervical cancer cells, HeLa used in the experiment was treated by different doses of aloe emodin for 1-5 days,.

Measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, aloe-emodin displays significant effects in the inhibition of the growth of HeLa cells in a dose-dependent manner at concentrations ranging between 2.5 and 40 micromol/L. 

Aloe-emodin induces HeLa cells death by disrupting the cell cycle division at the G2/M phase, according to the flow cytometric analysis.

The effects of aloe emodin inhibited the human by increasing the expression of proteins associated with cell death programming and reducing the expression of proteins associated with cancer prefiltration and survival. 

Most importantly, after taking into account co and confounders, researchers discovered, aloe-emodin also activates the enzyme associated with the break down the protein of  ER α and deactivates the enzyme associated with cell proliferation

Taken altogether,  Aloe vera with the abundant aloe-emodin may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for treatment of cancer without inducing adverse effects.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(3) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(4) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(5) Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories by (Research Gate)

Herbal Cayenne May Process A Potency to Cure Allergic Rhinitis

By Kyle J. Norton

Herbal cayenne may be a pharmaceutical target to identify the single ingredient medicine for the treatment of allergic rhinitis with no side effects, some scientists suggested.

Nonallergic rhinitis is a condition with symptoms resemble an allergy causes of rhinitis but without a known cause.

Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis.

Allergic rhinitis is caused by the immune overreaction when a person breathes in an allergen such as pollen, mold, animal dander, or dust, leading to the irritation and inflammation of the mucous membrane inside the nose.

Most common symptoms of allergic rhinitis are the stuffy nose, runny nose, sneezing, and post-nasal drip.

Contrast to general belief, allergic rhinitis is not the syndrome which comes and goes depending on the seasons.

Untreated allergic rhinitis can lead to complications of chronic nasal inflammation and obstruction, a leading cause of upper respiratory tract infection.

There is some strong evidence suggested that allergic rhinitis can affect the quality of life, productivity, and other comorbid conditions, including asthma.

The World Health Organization in the differentiation fo the condition, suggesting that the treatment of allergic rhinitis should include a combination of patient education, allergen avoidance, pharmacotherapy, and immunotherapy

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The kitchen spice has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In the finding a natural formula for the treatment of allergic rhinitis with no side effects, researchers at the University of Cincinnati College of Medicine examine the efficacy and safety of ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum and Eucalyptol, versus placebo.

In the total of Forty-two consented subjects meeting inclusion/exclusion criteria randomized to ICX72 (n = 20) or control (n = 22) administered twice daily over 2 weeks, the primary endpoint was changed in total nasal symptom scores (TNSS) from baseline to end of the study.

During the study, application of ICX72 exhibited significant differences in changes from baseline to end of study for TNSS and each ISS (P < .01), compared to placebo.

ICX72 exerted a significantly faster relief at 52.6 seconds.

The formula also improved nasal congestion, sinus pain, sinus pressure, and headache at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain.

No subjects experienced rebound congestion or impaired olfaction at the end of the study.

There is no adverse effect in the treatment group.

These result firmly suggested that intranasal capsaicin used continuously over 2 weeks, rapidly and safely improves symptoms in rhinitis subjects with a significant NAR component.

Further analysis of the effect of intranasal capsaicin, researchers conducted a double-blind double-dummy parallel groups trial to determine whether a more practical capsaicin application schedule is equally effective.

Thirty patients were randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals, followed by a placebo dummy once every second or third day for a total of five treatments 2 weeks after the capsaicin application (group A).

The other group (B) received the placebo dummy five times on the first day followed by capsaicin once every second or third day for a total of five treatments 2 weeks after the placebo application.

According to the reading, visual analog scale scores for overall nasal symptoms, group A showed significant deeper decrease rhinorrhea and nasal blockage, compared to group B.

There is a significant reduction in the cold dry air responsiveness up to 9 months after therapy in both groups, reflecting a decrease in nasal hyperreactivity.

Taken altogether, Herbal cayenne containing bioactive compound capsaicin may be considered a functional spice for the treatment of allergic rhinitis with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. (PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ. (PubMed)